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prof. dr. J.W.A. (John) Rossen

Professor of Medical Microbiology - Personalized Molecular Microbiology
Profile picture of prof. dr. J.W.A. (John) Rossen
Telephone:
+31 50 361 3480 (Secretary)
E-mail:
j.w.a.rossen rug.nl

Research interests

Prof. dr. John W. A. Rossen is Professor of Medical Microbiology at the University of Groningen / University Medical Center Groningen, within the Department of Medical Microbiology and Infection Prevention, and Medical Head of Innovation & Science at Isala Hospital. He holds a PhD in Molecular Virology and Cell Biology (Coronavirus infections of Polarized Epithelial Cells, Utrecht University, 1996) and has co-authored ~250 peer-reviewed publications.

His research is carried out within the group Antimicrobial Resistance, Genomics, and Epidemiology (AGE) — a team of PIs, PhD students, and technicians working across three connected lines under a One Health approach. The A-line (Antimicrobial Resistance & Infectious Diseases) addresses AMR and antimicrobial stewardship, infection prevention and control, and the built environment; the G-line (Genomics & Transcriptomics) covers rapid and molecular diagnostics, sequencing, patho-/genotyping, and AI/ML interpretation; and the E-line (Epidemiology & Data Science) spans clinical and field epidemiology, surveillance and modelling, and pandemic preparedness.

His own work sits mainly in the G-line; as part of the group's coordinating team, he helps connect the three lines around their shared themes. Combining advanced molecular tools with artificial intelligence and machine learning, the group studies the dynamics of antimicrobial resistance and emerging pathogens across human, animal, and environmental domains, mapping transmission pathways and building predictive models of resistance emergence, disease outcomes, and outbreak potential. Together, this work supports antimicrobial stewardship, infection prevention and control, and evidence-based public health policy, from the region to LMIC settings.

Much of his work centres on people and partnerships. He has supervised 26 PhD students and, with colleagues, contributes to national and international training — among others through the Concilium Medical Molecular Microbiology of the NVMM. His roles reflect this collaborative focus: earlier as Director of R&D at IDbyDNA (USA) and through roles in several ESCMID study groups, and currently as Scientific Lead of the €7M Horizon Europe project DRAIGON, Member of the ESCMID Global Program Committee, Adjunct Professor at the University of Utah School of Medicine, Project Coordinator for the UMCG–Isala partnership, and active on academic freedom for the RUG (via Universiteiten van Nederland, UNL).

Publications

CefiderocolFinder: a tool for detecting genetic adaptations implicated in cefiderocol resistance

Characterizing ceftriaxone tolerance in Neisseria gonorrhoeae across in vitro and in vivo models

From imaging to infection: contrast dye contaminated with Klebsiella pneumoniae as a source of nosocomial infections

Global patterns and temporal evolution of fusidic acid resistance in Staphylococcus aureus: a genomic analysis of 2,701 resistant isolates spanning six decades

Limitations of genomic surveillance: a C. difficile case study in the Netherlands

Short Antibiotic Treatment for Coagulase-negative Staphylococcal Sepsis in Premature Infants: A Multicenter Noninferiority Study

Antimicrobial treatment affects the microbiome and resistome of both treated and untreated rehabilitating harbour seals (Phoca vitulina)

Aquatic reservoir-associated outbreaks of multi-drug-resistant bacteria: a hospital outbreak report of Pseudomonas aeruginosa in perspective from the Dutch national surveillance databases

Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance

Comparison of three commercial DNA extraction kits and assemblers for AMR determinant detection in Pseudomonas aeruginosa and Enterobacter cloacae using long-read sequencing

Press/media

MedMic Podcast: Episode Toekomst

NGS Reflex Testing Gets Boost with SeqSphere+

Seminar antimicrobiële resistentie

De laatste innovaties in DNA & RNA technologieën

Infectiediagnostiek onder de loep met metagenomics

Internationaal onderzoek naar opsporen en behandelen infecties

Crowdfunding voor nabestaanden Bert Suurd uit Leek: 'Soms is de mens achter het verhaal geen onbekende'

NGS is transforming diagnostics, but is it right for everyone?

Sustainable Development Goals

SDG 2 - Zero HungerSDG 3 - Good Health and Well-beingSDG 5 - Gender EqualitySDG 6 - Clean Water and SanitationSDG 10 - Reduced InequalitiesSDG 14 - Life Below WaterSDG 15 - Life on Land

More information about the Sustainable Development Goals.