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H. Havinga

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Faculty of Medical Sciences

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+31 50 361 2477

E-mail:

h.havinga umcg.nl

Research Portal

Publications

Bile Acid Detergency as Determinant of Liver Pathology in a Humanized Mouse Model of Progressive Familial Intrahepatic Cholestasis Type 3

Ke, L., Mulder, N. L., Hovingh, M. V., Havinga, R., Weersing, E., de Vries, H. D., de Bruyn, K., Ustyantsev, K., Berezikov, E., Bloks, V. W., Attema, B., Worthmann, A., Heeren, J., Wolters, J. C., Tiessen-Thomas, R., Verkade, H. J., Kuipers, F. & de Boer, J. F., 2026, In: Cellular and molecular gastroenterology and hepatology. 20, 8, 22 p., 101783.

Research output: Contribution to journal › Article › Academic › peer-review

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition

de Vries, H. D., Li, J., Ustyantsev, K., Hovingh, M. V., Mulder, N. L., Havinga, R., Palmiotti, A., de Bruyn, K., Attema, B., Weersing, E., Thomas, R. E., Bloks, V. W., Berezikov, E., van Faassen, M., Verkade, H. J., de Boer, J. F. & Kuipers, F., May-2026, In: Liver International. 46, 5, p. e70632

Research output: Contribution to journal › Article › Academic › peer-review

Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation

Felzen, A., Hof, W. F. J., de Vries, H., Hovingh, M. V., Havinga, R., Mulder, N. L., Koehorst, M., Kloosterhuis, N., Smit, M., Huijkman, N., van de Sluis, B., de Boer, J. F., Kuipers, F. & Verkade, H. J., Jan-2026, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1871, 1, 19 p., 159697.

Research output: Contribution to journal › Article › Academic › peer-review

Loss of Early Growth Response Protein 1 in the Liver Leads to Hepatic Lipid Accumulation Driven by an Imbalance Between Fatty Acid β-Oxidation and Oxidative Phosphorylation

Verzijl, C. R. C., Struik, D., Gerding, A., Eilers, R. E., Thomas, R. E., Koster, M., Langelaar-Makkinje, M., Smit, M., Huijkman, N., Havinga, R., Kloosterhuis, N., Bloks, V. W., Wolters, J. C., de Boer, J. F., van de Sluis, B., Bakker, B. M. & Jonker, J. W., Jan-2026, In: Gastro Hep Advances. 5, 4, 14 p., 100881.

Research output: Contribution to journal › Article › Academic › peer-review

The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice

Yntema, T., Eijgenraam, T. R., Kloosterhuis, N. J., Havinga, R., Koster, M. H., Hovingh, M. V., de Boer, J. F., Koonen, D. P. Y. & Kuipers, F., 15-Jan-2025, In: Scientific Reports. 15, 1, 11 p., 2100.

Research output: Contribution to journal › Article › Academic › peer-review

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Heida, A., van Dijk, T., Smit, M., Koehorst, M., Koster, M., Kloosterhuis, N., Havinga, R., Bloks, V. W., Wolters, J. C., de Bruin, A., Kuivenhoven, J. A., de Boer, J. F., Kuipers, F. & van de Sluis, B., Mar-2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 2, 11 p., 159445.

Research output: Contribution to journal › Article › Academic › peer-review

Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib (6675 words)

Krishnamurthy, K. A., Rutten, M. G. S., Hoogerland, J. A., Van Dijk, T. H., Bos, T., Koehorst, M., De Vries, M. P., Kloosterhuis, N. J., Havinga, H., Schomakers, B. V., van Weeghel, M., Wolters, J. C., Bakker, B. M. & Oosterveer, M. H., Jan-2024, In: Molecular metabolism. 79, 12 p., 101838.

Research output: Contribution to journal › Article › Academic › peer-review

Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70-/- Mice with a Human-like Bile Acid Composition

Palmiotti, A., de Vries, H. D., Hovingh, M. V., Koehorst, M., Mulder, N. L., Verkade, E., Veentjer, M. K., van Dijk, T. H., Bloks, V. W., Havinga, R., Verkade, H. J., de Boer, J. F. & Kuipers, F., 8-Sept-2023, In: Biomedicines. 11, 9, 15 p., 2495.

Research output: Contribution to journal › Article › Academic › peer-review

Characterization of a novel bile salt export pump deficiency mouse model with the p.E297g mutation

Felzen, A., Hovingh, M., Havinga, R., Mulder, N., Koehorst, M., van de Sluis, B., de Boer, J. F., Kuipers, F. & Verkade, H., Jun-2023, ESPGHAN 55th Annual Meeting Abstracts. Wolters Kluwer, Vol. 76. p. 671-672 2 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model

Tol, A. J. C., Hribar, K., Kruit, J., Bongiovanni, L., Vieira-Lara, M. A., Koster, M. H., Kloosterhuis, N. J., Havinga, R., Koehorst, M., de Bruin, A., Bakker, B. M., Oosterveer, M. H. & van der Beek, E. M., May-2023, In: Journal of Physiology. 601, 10, p. 1761-1780 20 p.

Research output: Contribution to journal › Article › Academic › peer-review

All (193) publications

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