dr. H.H.W. (Herman) Sillje

Head Experimental Cardiology Laboratory

Faculty of Medical Sciences

Telephone:

+31 50 361 5339

E-mail:

h.h.w.sillje umcg.nl

Research Portal

Publications

Nanoparticle-Mediated Delivery of Adenosine 5′-Monophosphate Enhances 5-Oxoprolinase Activity to Mitigate Oxidative Stress in Heart Failure

Esquivel-Gaytan, A., Bomer, N., Bartolo, R., Arevalo-Gomez, K. F., Deiman, F. E., Bras, M., Honarnejad, S., Permentier, H., Dömling, A., Voors, A. A., A. Santos, H., Silljé, H. H. W. & Van der Meer, P., Jan-2026, In: Advanced Therapeutics. 9, 1, 16 p., e00263.

Research output: Contribution to journal › Article › Academic › peer-review

Cardiac remodeling pathways do not accelerate disease onset and severity in a mouse model of PLN-R14del cardiomyopathy

Sun, L., Schouten, E. M., Gomez, K. A., Teixeira, V. O. N. & Silljé, H. H. W., 9-Oct-2025, In: Scientific Reports. 15, 1, 11 p., 35393.

Research output: Contribution to journal › Article › Academic › peer-review

Combination of Captopril, Ambrisentan and Sildenafil mitigates long-term side effects of combined heart and lung irradiation

Wiedemann, J., Brouwer, U., Sillje, H., Dickinson, M., Coppes, R. P. & van Luijk, P., May-2025.

Research output: Contribution to conference › Abstract › Academic

Combination of Captopril, Ambrisentan and Sildenafil mitigates long-term side effects of combined heart and lung irradiation

Wiedemann, J., Brouwer, U., Sillje, H., Dickinson, M., Coppes, R. P. & van Luijk, P., 2025.

Research output: Contribution to conference › Abstract › Academic

Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70−/− mice

de Vries, H. D., Eijgenraam, T. R., Bloks, V. W., Mulder, N. L., van Zutphen, T., Silljé, H. H. W., Kuipers, F. & de Boer, J. F., 2025, In: Pediatric Research. 97, p. 2145–2152 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Glutathione deficiency and heart failure: a systematic review of human and animal evidence

Al-Mubarak, A. A., Esquivel-Gaytan, A., Silljé, H. H. W., van der Meer, P. & Bomer, N., Jun-2025, In: Advances in Redox Research. 15, 12 p., 100131.

Research output: Contribution to journal › Review article › peer-review

In PLN-R14del mice, SR structure restoration, rather than calcium cycling, is the dominant effector of PLN-ASO treatment

Sun, L., Eijgenraam, T. R., Amilon, C., Janzén, D., Hansson, K. M., Kubli, D. A., Später, D., Mullick, A. E., van der Meer, P., Nunes Teixeira, V. O. & Silljé, H. H. W., 1-Oct-2025, In: Cardiovascular Research. 121, 13, p. 2042-2054 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Myocardial ketone body oxidation contributes to empagliflozin-induced improvements in cardiac contractility in murine heart failure

Voorrips, S. N., Palm, C. L., Saucedo-Orozco, H., Mahmoud, B., Schouten, E. M., Feringa, A. M., Sanchez-Aguilera, P. I., Nijholt, K. T., Yurista, S. R., van der Meer, P., Silljé, H. H. W. & Westenbrink, B. D., Jul-2025, In: European Journal of Heart Failure. 27, 7, p. 1353-1358 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Nicotinamide-N-methyltransferase inhibition improves cardiac function and structure in a heart failure with preserved ejection fraction mouse model

Li, S., Rodrigues, P. G., Chakraborty, A. D., Correia, C., Schouten, E. M., Strömstedt, M., Löfgren, L., Persson, M., Fredlund, L., Rohman, M., Bergström, F., Akerud, T., Ericson, C., Kreisel, K., Guzman, M. M., Silljé, H. H. W., de Boer, R. A. & Meems, L. M. G., Jul-2025, In: Pharmacological research. 217, 15 p., 107820.

Research output: Contribution to journal › Article › Academic › peer-review

RNA Therapeutics in Heart Failure

Deiman, F. E., de Graaf, M. M., Sillje, H. H. W., Grote Beverborg, N., Bomer, N. & van der Meer, P., 30-Oct-2025, (E-pub ahead of print) In: Journal of cardiovascular translational research. 15 p.

Research output: Contribution to journal › Review article › peer-review