prof. dr. F. (Folkert) Kuipers

Telephone:

E-mail:

f.kuipers umcg.nl

Research interests

- Physiology and pathophysiology of the enterohepatic circulation in humans and experimental animals: hepatic and intestinal transport systems, mechanisms of bile formation and cholestasis, (patho)physiology of biliary lipid secretion, metabolic control by bile acids via newly identified signaling cascades

- Hepatic lipid metabolism in humans and experimental animals: lipoprotein assembly and secretion, causes and consequences of hepatic steatosis, interactions between carbohydrate and lipid metabolism, inborn errors of metabolism, inflammatory pathways, role of nuclear receptors (LXR, CHREBP)

- Regulation of cholesterol synthesis and trafficking: transcription factors and nuclear receptors (SREBP/PPAR/FXR/LXR) and transporter proteins, perinatal development, metabolic programming, application of stable isotope approaches

- Quantification of metabolic fluxes by stable isotope procedures

Publications

Back to basics: Bile acids in fat absorption

Kuipers, F., Verkade, H. J. & Freark de Boer, J., 3-Feb-2026, In: Cell Metabolism. 38, 2, p. 249-251 3 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Bile Acid Detergency as Determinant of Liver Pathology in a Humanized Mouse Model of Progressive Familial Intrahepatic Cholestasis Type 3

Ke, L., Mulder, N. L., Hovingh, M. V., Havinga, R., Weersing, E., de Vries, H. D., de Bruyn, K., Ustyantsev, K., Berezikov, E., Bloks, V. W., Attema, B., Worthmann, A., Heeren, J., Wolters, J. C., Tiessen-Thomas, R., Verkade, H. J., Kuipers, F. & de Boer, J. F., 2026, In: Cellular and molecular gastroenterology and hepatology. 20, 8, 22 p., 101783.

Research output: Contribution to journal › Article › Academic › peer-review

Bile Acids and Healthy Ageing

Attema, B. & Kuipers, F., 2026, (Accepted/In press) In: Engineering. 11 p.

Research output: Contribution to journal › Review article › peer-review

Connecting fragmented aging research through the European Federation for Aging Research

European Federation for Aging Research, Schumacher, B., Scheibye-Knudsen, M., Rasmussen, L. J. & Kuipers, F., 24-Apr-2026, (E-pub ahead of print) In: Nature Aging. 6, p. 1196–1197 2 p.

Research output: Contribution to journal › Letter (Research letter) › Academic

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition

de Vries, H. D., Li, J., Ustyantsev, K., Hovingh, M. V., Mulder, N. L., Havinga, R., Palmiotti, A., de Bruyn, K., Attema, B., Weersing, E., Thomas, R. E., Bloks, V. W., Berezikov, E., van Faassen, M., Verkade, H. J., de Boer, J. F. & Kuipers, F., May-2026, In: Liver International. 46, 5, 16 p., e70632.

Research output: Contribution to journal › Article › Academic › peer-review

Generation and characterization of a mouse model for bile salt export pump deficiency with the p.E297G mutation

Felzen, A., Hof, W. F. J., de Vries, H., Hovingh, M. V., Havinga, R., Mulder, N. L., Koehorst, M., Kloosterhuis, N., Smit, M., Huijkman, N., van de Sluis, B., de Boer, J. F., Kuipers, F. & Verkade, H. J., Jan-2026, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1871, 1, 19 p., 159697.

Research output: Contribution to journal › Article › Academic › peer-review

Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis

Sachdev, V., van Loon, N. M., Kingma, J., Ottenhoff, R., Tan, J. M. E., van den Berg, M., Duijst, S., Jongejan, A., Levels, J. H. M., Rensen, P. C. N., Kooijman, S., de Boer, J.-F., Kuipers, F., Kuentzel, K. B., Kratky, D., Kwon, Y., Zeigerer, A., Hendrix, S. & Zelcer, N., 1-Jun-2026, In: Molecular metabolism. 108, 16 p., 102379.

Research output: Contribution to journal › Article › Academic › peer-review

Pretreatment serum bile acid composition and predictability of subsequent response to odevixibat in patients with bile salt export pump (BSEP) deficiency

Nomden, M., Kuipers, F., Lexmond, W. S., Gu, T., Valcheva, V., Lindström, E. & Verkade, H. J., Apr-2026, In: Hepatology. 83, 4, p. 708 - 720 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism

Evangelakos, I., Verkade, E., Rohde, J. K., Zaufel, A., Vargek, M., Heine, M., Worthmann, A., Graute, S., Manka Fuh, M., Gunasekaran, K., Kumari, M., Schwinge, D., von Bergen, M., Rolle-Kampczyk, U., Engelmann, B., Breinbauer, R., Fuerst, R., Saleem, U., de Boer, J. F.& Schlein, C., Hansen, A., Scheja, L., Kuipers, F., Moustafa, T. & Heeren, J., 1-May-2026, In: Molecular metabolism. 107, 16 p., 102363.

Research output: Contribution to journal › Article › Academic › peer-review

Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial Dysfunction

Zhang, T., Goya, M. E., Herron-Bedoya, A., van der Weerd, J. C., Tsagkari, D., Couzijn, S., Güngördü, L., Seinstra, R. I., Heiner Fokkema, M. R., Chang, M., Tavernarakis, N., Kuipers, F. & Nollen, E. A. A., 18-Nov-2025, BioRxiv, 35 p. (bioRxiv).

Research output: Working paper › Preprint › Academic