prof. dr. E. (Eelko) Hak

1. Personal details

Academic employment

2021/current      Chair department PharmacoTherapy, -Epidemiology&-                                                  Economics, Groningen Research Institute of Pharmacy, UG

2020/current      Director Education cluster Pharmacy

2015/current      Co-chair GUIDE graduate school programme PEGET

2015/current      Program Director two-year research master Medical                                                      Pharmaceutical Sciences, University Groningen

2015/current     Full professor of clinical pharmacoepidemiology                                                           Groningen Research Institute of Pharmacy, research unit                                             PharmacoTherapy, - Epidemiology& -Pharmacoeconomics,                                           University Groningen, the Netherlands.

2010-2015         Tenure track professor of clinical pharmacoepidemiology                                          Groningen Research Institute of Pharmacy, research unit                                              Pharmacoepidemiology& Pharmacoeconomics, University                                             Groningen, Netherlands.

2009-2010       Associate Professor of clinical epidemiology                                                                 University Medical Center Groningen, Department Epidemiology,                                Groningen, the Netherlands.

2008-2009      Associate Professor of clinical epidemiology                                                                  University Medical Center Utrecht, Department Julius Center,                                      Utrecht, the Netherlands.

2001-2008t     Assistant Professor of clinical epidemiology                                                                   University Medical Center Utrecht, Department Julius Center,                                       Utrecht, the Netherlands

Famous scientific executive board memberships

2021-current    Member of the Eramus+ Joint master degree programme team

2020-current    Member of the Program Board Cluster Pharmacy

2020-current     Chair of the Management Team department PTEE

2020-current    Member (as methodologist) of Medical Ethical Board (BEBO) Isala                               Hospital (the Netherlands).

2013-2018      Executive Board Member “Universal influenza vaccines secured”                               (EU-FP7 project with 11 European SMEs/governmental organisation)

2013-current    Member (as methodologist) of Medical Ethical Board (BEBO) in                                   Assen (the Netherlands), which evaluates >70% of Dutch clinical                                 phase 1 drug studies and various  phase 2 and phase 3 drug                                       studies. CROs: e.g. PRA (Groningen), QPS (Groningen), CHDR                                       (Leiden).

2010-current     Member of the Committee National Immunization Program,                                    Dutch Health Council/Gezondheidsraad.

2007- 2009      Member of Chamber K                                                                                                          Methodologist), Medical Ethical Review Board, UMC   Utrecht, the                                Netherlands.

2007-2009       Member of the Committee Influenza vaccination, Dutch Health                               Council/Gezondheidsraad.

Research projects:

• Hak is co-applicant of the EU-FP7 project: Universal Influenza vaccines Secured (2013-2018, 6,000,000 euro. He is Workpackage leader of WP6 Clinical trial program with universal influenza vaccines (about 2,000,000 euro, staff: Dr. Marcy Heng Liu, Dr. Eva van Doorn, Ms. Elske Bos, Dr. Atique Islam).
• Co-applicant of the EU Marie Curie project Pronkjewail (5,000,000 euro). Together with prof A. Huckriede he will head a research program into boosting of influenza vaccine immunity (PhD research fellow Ms. Federica Sicca).  
• Chinese CSC bursary projects (Ms. Yuanyuan Wang, Ms. Guiling Zhou, Ms Xuechun Li) 
• ZONMW project audits on various drugs as ritalin, antipsychotics and alfablockers (Mr. Jurjen van der Schans).
• Various Indonesian LPDP scholarship projects (Mr Ivan Pradipta, Mrs Sofa Dewi Alfian, Ms. Sylvi Irawati, Ms. Doti Martono, Mr. Akbar Bahar, Ms. Monika Oktora).
• ZONMW project Cost-effectiveness of pharmacogenetic screening in elderly patients with depression (600,000 euro, Ms. Lisette Berm).  
• Research fellow grant for Mrs. Maryam Darvishian for PhD research on novel methods to study influenza vaccine effectiveness.

 Selected activities

• Need for and evaluation of promising universal influenza vaccines (Keynote speaker)
• Big Data in de gezondheidszorg: van chaos naar causaliteit (Keynote speaker)
• Symposium 100 years after the 1918 pandemic (Chair)

 Publications: selection over last 5 years below; Google scholar: Total citations: >15,000; H-index 63; i-10 index 210

• Endocrine 71(2): 385-96. Thyroid function and risk of all-cause and cardiovascular mortality: a prospective population-based cohort study. DOI: 10.1007/s12020-020-02397-z
• Association between adherence to statin therapy and low-density lipoprotein cholesterol (LDL-c) response in first-time users of standard-dose and low-dose statins: the PharmLines Initiative.
  Irawati S, Emmens JE, de Vos S, Bos JHJ, de Boer R, Hak E. Curr Med Res Opin. 2021 Sep 24:1. doi: 10.1080/03007995.2021.1984222. 
• Journal of clinical epidemiology Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors. DOI: 10.1016/j.jclinepi.2021.02.008
• JAMA network open 2020, 3(1): e1919274.Association of Plasma Concentration of Vitamin B12 With All-Cause Mortality in the General Population in the Netherlands. DOI: 1001/jamanetworkopen.2019.19274
• Ann Intern Med 2020, 172(7): 453-62.Immunogenicity, Safety, and Efficacy of a Standalone Universal Influenza Vaccine, FLU-v, in Healthy Adults: A Randomized Clinical Trial. DOI: 7326/m19-0735
• Journal of Clinical Epidemiology2019,108, 44-53. A systematic review finds inconsistency in the measures used to estimate adherence and persistence to multiple cardiometabolic medications. DOI: 10.1016/j.jclinepi.2018.12.003
• Antimicrobial resistance and infection control 2019, 8(115).Treatment outcomes of drug-resistant tuberculosis in the Netherlands, 2005-2015. DOI: 10.1186/s13756-019-0561-z
• The Journal of infection 2018, 77(6): 469-78.Risk factors of multidrug-resistant tuberculosis: A global systematic review and meta-analysis. DOI: 10.1016/j.jinf.2018.10.004
• BMC Pregnancy and Childbirth 2018 29;18(1):187. Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study.DOI: 10.1186/s12884-018-1825-y.
• Lancet Respir Med 5(3):200-211. Effectiveness of seasonal influenza vaccination in community-dwelling elderly people: an individual participant data meta-analysis of test-negative design case-control studies.DOI: 10.1016/S2213-2600(17)30043-7