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About us Practical matters How to find us dr. A. (Arjan) Diepstra
University Medical Center Groningen

dr. A. (Arjan) Diepstra

academic hematopathologist and associate professor
Research interests Publications Press/media

Research interests

I am a hematopathologist at the University Medical Center Groningen and a principal investigator in the SALL (stem cells, aging, leukemia and lymphoma) program of the CRCG (Cancer Research Center Groningen). My main research interest involves malignant lymphoma, in particular Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In my PhD thesis "Classical Hodgkin lymphoma: population based studies on HLA and EBV (2007)" and follow-up studies, I discovered that the HLA system is intricately involved in Hodgkin lymphoma susceptibility, pathogenesis and prognosis and published these findings in the Lancet, Journal of Clinical Oncology and Blood. I secured three Dutch Cancer Society grants to do functional follow-up studies on these findings. Fruitful international collaborations involve the Interlymph consortium on genome wide association studies, the Lymphoma group of the EORTC and various groups in the UK, Canada and the US. My areas of expertise are: immunology, tumor cell biology, association studies and molecular diagnostics in pathology.   

Publications

Author Correction: Whole-body CD8 + T-cell PET imaging in patients with large B-cell lymphoma before and during CD19-directed CAR T-cell therapy: a phase 2 study.

de Boer, J. W., Keijzer, K., van Doesum, J. A., Smit, N. A. M., Brouwers, A. H., van Sluis, J., Lub-de Hooge, M. N., Pierik, F. R., Huls, G. A., van Dijk, L. V., Visser, L., Diepstra, A., Noordzij, W., Williams, S. P., Ungewickell, A., Elias, S. G., de Vries, E. G. E., Niezink, A. G. H. & van Meerten, T., 10-Feb-2026, In: Nature Communications. 17, 1, p. 1499

Research output: Contribution to journal › Article › Academic › peer-review

Impact of Rituximab Maintenance on Survival in Patients with Mantle Cell Lymphoma; a Population-based Cohort Study

Stedema, F. G., Brink, M., Huisman, F., Van Rijn, R., Sijs-Szabo, A., Nijhof, I. S., Diepstra, A., Vergote, V. K. J., van Gorkom, G., Flinsenberg, T. W. H., Huls, G. A., van Meerten, T., Doorduijn, J., Plattel, W. J. & Nijland, M., 4-Feb-2026, (E-pub ahead of print) In: Blood Advances.

Research output: Contribution to journal › Article › Academic › peer-review

Intra-erythrocyte creatine, plasma creatine and long-term outcomes in stable kidney transplant recipients: Results from the TransplantLines Biobank and Cohort study

Doorenbos, C. S. E., Post, A., van der Veen, Y., Franssen, C. F. M., Eisenga, M. F., Dullaart, R. P. F., Navis, G., Wu, Q., Gonzalez-Delgado, J. M., Connelly, M. A., Bakker, S. J. L., Annema, C., Berger, S. P., Blokzijl, H., Bodewes, F. A. J. A., de Boer, M. T., Damman, K., de Borst, M. H., Dielwart, I. J. C. & Diepstra, A., Dijkstra, G., Douwes, R. M., Erasmus, M. E., Gan, C. T., Neto, A. W. G., Posthumus, A. M., Hak, E., Hepkema, B. G., Jonker, J., Klont, F., Knobbe, T. J., Kremer, D., Leuvenink, H. G. D., Lexmond, W. S., de Meijer, V. E., Nieuwenhuis-Moeke, G. J., Niesters, H. G. M., van Pelt, L. J., Pol, R. A., Ranchor, A. V., Sanders, J. S. F., Siebelink, M. J., Slart, R. J. H. J. A., Swarte, J. C., Touw, D. J., van den Heuvel, M. C., van Leer-Buter, C., van Londen, M., Velde-Keyzer, C. A. T., Verschuuren, E. A. M. & Vos, M. J., Feb-2026, In: Clinical Nutrition Open Science.

Research output: Contribution to journal › Article › Academic › peer-review

Overlapping macrophage immune profiles in polymyalgia rheumatica and giant cell arteritis

Zhang, A., Jiemy, W. F., van Sleen, Y., Xu, S., Sandovici, M., Abdulahad, W. H., Diepstra, A., Hein, S., Graver, J. C., Heeringa, P., Dasgupta, B., Brouwer, E. & van der Geest, K. S. M., Feb-2026, In: Rheumatology (Oxford, England). 65, 2, 6 p., keaf629.

Research output: Contribution to journal › Article › Academic › peer-review

Symptom Burden and Patient-Reported Outcomes in Kidney Transplant Recipients: Results From the TransplantLines Biobank and Cohort Studies

TransplantLines Investigators, Jan-2026, In: Kidney Medicine. 8, 1, 101168.

Research output: Contribution to journal › Article › Academic › peer-review

Atezolizumab Consolidation in Patients with High Risk Diffuse Large B-cell Lymphoma in Complete Remission after R-CHOP

Nijland, M., Issa, D. E., Bult, J. A. A., Deeren, D., Velders, G. A., Nijziel, M. R., Sandberg, Y., Vergote, V. K., Oosterveld, M., Fijnheer, R., Brouwer, R., Boersma, R., Wu, K., Nieuwenhuizen, L., Vermaat, J. S., van Kampen, R. J. W., Terpstra, W. E., Snauwaert, S., van der Poel, M. W. & de Jongh, E., Durian, M., Strobbe, L., Beeker, A., Gadisseur, A. P., Van Rijn, R., Visser, O. J., Doorduijn, J., Snijders, T. J. F., Silbermann, M. H., de Jong, D., Chamuleau, M. E. D., Mous, R., Jalving, M., Visser-Wisselaar, H., Jansen van den Bergh, S., Zwezerijnen, G. J., Bremer, E., Brink, M., Diepstra, A., Chitu, D. A., Koene, H. R. & Zijlstra, J. M., 10-Jul-2025, In: Blood Advances. 9, 14, p. 3530–3539 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Dynamics of circulating tumour DNA in relapsed/refractory diffuse large B-cell lymphoma patients

Zhong, Y., Bult, J., Veltmaat, N., de Jesus, F. M., Sillje, L., Kluiver, J., van den Berg, A., Plattel, W., Diepstra, A. & Nijland, M., 18-Dec-2025, (E-pub ahead of print) In: British Journal of Haematology.

Research output: Contribution to journal › Article › Academic › peer-review

Dynamics of circulating tumour DNA in relapsed/refractory diffuse large B-cell lymphoma patients

Zhong, Y., Bult, J., Veltmaat, N., de Jesus, F. M., Sillje, L., Kluiver, J., van den Berg, A., Plattel, W., Diepstra, A. & Nijland, M., 2025, (Accepted/In press) In: British Journal of Haematology.

Research output: Contribution to journal › Article › Academic › peer-review

GM-CSF drives IL-6 production by macrophages in polymyalgia rheumatica

Jiemy, W. F., Zhang, A., Abdulahad, W. H., Reitsema, R. D., van Sleen, Y., Sandovici, M., Alegria, G. C., Cornec, D., Devauchelle-Pensec, V., Hemon, P., Quéré, B., Boukhlal, S., Roozendaal, C., Kwee, T. C., Dasgupta, B., Diepstra, A., Heeringa, P., Brouwer, E. & van der Geest, K. S. M., May-2025, In: Annals of the Rheumatic Diseases. 84, 5, p. 833-843 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

IgM Immunohistochemical Expression is a Potential Risk Factor for Extracutaneous Dissemination in Patients With Primary Cutaneous Follicle Center Lymphoma

Schrader, A. M. R., de Groen, R. A. L., Willemze, R., Jansen, P. M., Quint, K. D., van Wezel, T., van Eijk, R., Ruano, D., Tensen, C. P., Diepstra, A., van den Berg, A., Koens, L., Kakiailatu, N., Vermeer, M. H. & Vermaat, J. S. P., Sept-2025, In: American Journal of Surgical Pathology. 49, 9, p. 931-941 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Press/media

Whodunit? Het speurwerk van de patholoog bij lymfeklierkanker

Diepstra, A.

07/08/2024

Press/Media: Expert Comment › Popular

Serum TARC Levels Increased Years Prior to Hodgkin Lymphoma Diagnosis

Diepstra, A.

16/01/2024

Press/Media: Research › Academic

Serumspiegels TARC-eiwit al jaren voor diagnose Hodgkin lymfoom verhoogd

Diepstra, A.

01/12/2023

Press/Media: Research › Professional

Hodgkin lymphoma can be diagnosed much earlier

Diepstra, A.

19/10/2023

Press/Media: Research › Academic

Video Interview for the Video Journal of Haematological Oncology on TARC in Hodgkin lymphoma

Diepstra, A.

26/10/2022

Press/Media: Expert Comment › Academic

Een lab dat levens redt - a lab that saves lives

Diepstra, A.

29/04/2016

Press/Media: Public Engagement Activities › Popular

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