The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding
by:
Giorgia Benegiamo, Ludovic S. Mure, Galina Erikson, Hiep D. Le, Ermanno Moriggi, Steven A. Brown, Satchidananda Panda
In Brief:
Benegiamo et al. identify a metabolic role for the nuclear RNA-binding protein NONO. Upon feeding, NONO binds to pre-mRNAs of genes involved in glucose and fat metabolism in the liver, regulating their rhythmic expression posttranscriptionally. NONO-deficient mice exhibit disruptions in this temporal regulation and shift from glucose storage to fat oxidation.
Highlights:
- Upon feeding, NONO-containing speckle-like structures increase in liver cell nuclei
- The number of target RNAs bound by NONO increases upon feeding
- NONO binds and regulates the rhythmicity of metabolic genes post-transcriptionally
- NONO is required for normal glucose and lipid homeostasis in mice
Cell Metabolism :January 24, 2018
| Last modified: | 24 January 2018 11.25 a.m. |
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