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New key Publication: Increased atherosclerosis in a mouse model of glycogen storage disease type 1a

21 April 2022

ABSTRACT

Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.

Authors:

  • Anouk M. La Rose
  • Anouk G. Groenen
  • Benedek Halmos
  • Venetia Bazioti
  • Martijn G.S. Rutten
  • Kishore A. Krishnamurthy
  • Mirjam H. Koster
  • Niels J. Kloosterhuis
  • Marieke Smit
  • Rick Havinga
  • Gilles Mithieux
  • Fabienne Rajas
  • Folkert Kuipers
  • Maaike H. Oosterveer
  • Marit Westerterp

Read more : Molecular Genetics and Metabolism Reports

Last modified:25 April 2022 6.38 p.m.

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