Antoine Rimbert:The winner of the annual Young Investigator Awards for outstanding publications during 2019

These annual EAS prizes for young scientists are intended to recognise distinction shown by publications that contribute to the advancement of knowledge in the field of atherosclerosis and linked metabolic disturbances.

https://www.eas-society.org/general/custom.asp?page=YI_awards_2020

The Clinical Science award-winning paper, with joint first authors Antoine Rimbert and Nawar Dalila, is on the subject of an intracellular process - almost exclusively studied by cellular biologists to date - in regulating plasma lipid levels and its effects on atherosclerosis in humans. The results show for the first time that endosomal recycling of lipoprotein receptors in the liver affects plasma levels of cholesterol and thereby risk of myocardial infarction and cardiovascular morbidity

The Paper:

A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor