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University Medical Center Groningen

Publications Pregnancy Immunology

Van Der Graaf AM, Paauw ND, Toering TJ, Feelisch M, Faas MM, Sutton TR, Minnion M, Lefrandt JD, Scherjon SA, Franx A, Navis G, Lely AT (2016) Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study. Am J Physiol Heart Circ Physiol; doi:10.1152/ajpheart.00010.2016

Groen B, Van der Wijk AE, Van den Berg PP, Lefrandt JD, Van den Berg G, Sollie KM, De Vos P, Links TP, Faas MM. (2015) Immunological Adaptations to Pregnancy in Women with Type 1 Diabetes. Scientific Reports; 5:13618 | DOI: 10.1038/srep13618

Faas MM, Spaans F, De Vos P. (2014) Monocytes and macrophages in pregnancy and pre-eclampsia. Frontiers in Immunology; doi:10.3389/fimmu.2014.00298

Spaans F, Melgert BN, Borghuis T, Klok PA, De Vos P, Bakker WW, Van Goor H, Faas MM. (2014) Extracellular adenosine triphosphate affects systemic and kidney immune cell populations in pregnant rats. Am J Reprod Immunol; doi:10.1111/aji.12267

Groen B, Uuldriks GA, De Vos P, Visser JT, Links TP, Faas MM. (2014) Impaired trophoblast invasion and increased numbers of immune cells at day 18 of pregnancy in the mesometrial triangle of type 1 diabetic rats. Placenta; doi:10.1016/j.placenta.2014.12.004

Buse E, Häeger JD, Svensson-Arvelund J, Markert UR, Faas MM, Ernerudh J, Dixon D, Cline JM, Pfarrer C. (2014) The placenta in toxicology. Part I: Animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis). Toxicol Pathol.: 42(2):314-26.

Göhner C, Svensson-Arvelund J, Pfarrer C, Häger JD, Faas M, Ernerudh J, Cline JM, Dixon D, Buse E, Markert UR. (2014) The placenta in toxicology. Part IV: Battery of toxicological test systems based on human placenta. Toxicol Pathol,; 42(2):345-51.

Svensson-Arvelund J, Ernerudh J, Buse E, Cline JM, Haeger JD, Dixon D, Markert UR, Pfarrer C, De Vos P, Faas MM. (2014) The placenta in toxicology. Part II: Systemic and local immune adaptations in pregnancy. Toxicol Pathol.; 42(2):327-38.

Cline JM, Dixon D, Ernerudh J, Faas MM, Göhner C, Häger JD, Markert UR, Pfarrer C, Svensson-Arvelund J, Buse E. (2014) The placenta in toxicology. Part III: Pathologic assessment of the placenta. Toxicol Pathol.; 42(2):339-44.

Spaans F, Vos PD, Bakker WW, van Goor H, Faas MM. (2014) Danger Signals From ATP and Adenosine in Pregnancy and Preeclampsia. Hypertension. 63:1154-1160

Faas MM, Kunnen A, Dekker DC, Harmsen HJ, Aarnoudse JG, Abbas F, De Vos P, Van Pampus MG. (2014) Porphyromonas Gingivalis and E-coli Induce Different Cytokine Production Patterns in Pregnant Women. PLoS One.; 22;9(1):e86355.

Holwerda KM, Burke SD, Faas MM, Zsengeller Z, Stillman IE, Kang PM, van Goor H, McCurley A, Jaffe IZ, Karumanchi SA, Lely AT. (2014) Hydrogen Sulfide Attenuates sFlt1-Induced Hypertension and Renal Damage by Upregulating Vascular Endothelial Growth Factor. J Am Soc Nephrol.; 25(4):717-25.

Wiegman MJ, Zeeman GG, Aukes AM, Bolte AC, Faas MM, Aarnoudse JG, de Groot JC. (2014) Regional distribution of cerebral white matter lesions years after preeclampsia and eclampsia. Obstet Gynecol.;123(4):790-5.

Spaans F, Melgert BN, Borghuis T, Klok PA, de Vos P, Bakker WW, van Goor H, Faas MM. (2014) Extracellular Adenosine Triphosphate Affects Systemic and Kidney Immune Cell Populations in Pregnant Rats. Am J Reprod Immunol. doi: 10.1111/aji.12267.

Faas MM, Spaans F, de Vos P. (2014) Monocytes and macrophages in pregnancy and preeclampsia. Invited review. Frontiers in Immunology 5:298; doi: 10.3389/fimmu.2014.00298.

Spaans F, Melgert BN, Chiang C, Borghuis T, Klok PA, de Vos P, van Goor H, Bakker WW, Faas MM. (2014) Extracellular ATP decreases trophoblast invasion, spiral artery remodeling and immune cells in the mesometrial triangle in pregnant rats. Placenta 35 587e595

Groen B, Links TP, van den Berg PP, Hellinga M, Moerman S, Visser GH, Sluiter WJ, Faas MM, Schreuder MC, Visser W, Geelhoed-Duijvestijn PH, Bianchi R, Bartelink AK, de Valk HW.( 2013) Similar adverse pregnancy outcome in native and nonnative dutch women with pregestational type 2 diabetes: a multicentre retrospective study. ISRN Obstet Gynecol.; 30;2013:361435.

van der Graaf AM, Wiegman MJ, Plösch T, Zeeman GG, van Buiten A, Henning RH, Buikema H, Faas MM. (2013) Endothelium-dependent relaxation and angiotensin II sensitivity in experimental preeclampsia. PLoS One.; 6;8(11):e79884.

Kunnen A, van Pampus M, Aarnoudse J, van der Schans C, Abbas F, Faas M. (2013) The effect of Porphyromonas gingivalis lipopolysaccharide on pregnancy in the rat. Oral Dis. doi:10.1111/odi.12177

Holwerda KM, Faas MM, van Goor H, Lely AT. (2013) Gasotransmitters: a solution for the therapeutic dilemma in preeclampsia? Hypertension. 62(4):653-9.

Krikken JA, Lely AT, Bakker SJ, Borghuis T, Faas MM, van Goor H, Navis G, Bakker WW. (2013) Hemopexin activity is associated with angiotensin II responsiveness in humans. J Hypertens. doi: 10.1097/HJH.0b013e32835c1727.

Bakker WW, Spaans F, el Bakkali L, Borghuis T, van Goor H, van Dijk E, Buijnink J, Faas MM. (2013) Plasma hemopexin as a potential regulator of vascular responsiveness to angiotensin II. Reprod Sci. 20(3):234-7.

Groen B, Links TP, Lefrandt JD, van den Berg PP, de Vos P, et al. (2013) Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model. Plos One 8(6): e65490. doi:10.1371/jo urnal.pone.0065490

van der Graaf AM, Toering TJ, Faas MM, Lely AT. (2012) From preeclampsia to renal disease: a role of angiogenic factors and the renin-angiotensin aldosterone system? Nephrol Dial Transplant. 27 Suppl 3:iii51-7.

Melgert BN, Spaans F, Borghuis T, Klok PA, Groen B, et al. (2012) Pregnancy and Preeclampsia Affect Monocyte Subsets in Humans and Rats. PLoS ONE 7(9):journal.pone.0045229 e45229. doi:10.1371

Lok CA, Snijder KS, Nieuwland R, Van Der Post JA, de Vos P, Faas MM. (2011) Microparticles of Pregnant Women and Preeclamptic Patients Activate Endothelial Cells in the Presence of Monocytes. Am J Reprod Immunol doi: 10.1111/j.1600-0897.2011.01079.x. [Epub ahead of print]

Faas MM, van der Schaaf G, Borghuis T, Jongman RM, De Vos P and Bakker WW. (2010) Extracellular ATP induces proteinuria in pregnant rats. Nephrol Dial Transplant 25(8):2468-78

Faas MM, van Pampus MG, Anninga ZA, Salomons J, Westra IM, Donker RB, Aarnoudse JG, de Vos P. (2010) Plasma of preeclamptic and pregnant women can activate endothelial cells via monocyte activation in vitro. J Reprod Immunol 87(1-2):28-38.

Kunnen A, van Doormaal JJ, Abbas F, Aarnoudse JG, van Pampus MG, Faas MM. (2010) Periodontal disease and pre-eclampsia: a systematic review. J Clin Periodontol: 237(12):1075-87

Herberts C, van der Laan JW, Melgert BN, Faas MM. (2010) Adjuvanted vaccines in pregnancy. Is everything safe? A commentary review. Expert Reviews Vaccines 9(12):1411-22.

Bakker WW, Borghuis T, Jongman RM, Henning R and Faas MM. (2009) Vascular contraction and preeclampsia; down regulation of the angiotensin receptor-1 by hemopexin. Hypertension 53(6):959-64

Faas MM, Donker RB, Huls AMF, Salomons J, van Pampus MG, de Vos P, Aarnoudse JG. (2008) Plasma of pregnant and pre-eclamptic women activates monocytes in vitro. Am J Obstet Gynecol 199(1):84.e1-8

Bakker WW, Donker RB, Timmer A, van Pampus MG, van Son WJ, Aarnoudse JG, van Goor H, Niezen-Koning KE, Navis GJ, Borghuis T, Faas MM. (2007) Plasma hemopexin activity in pregnancy and pre-eclampsia. Hypertens Pregnancy: 26(2):227-39

Bouman A, Heineman MJ, Faas MM (2005) Review: Sex hormones and the immune response in humans. Human Reprod Update 11:411-23

Faas MM, Bouman A, Veenstra van Nieuwenhoven AL, van der Schaaf G, Moes H, Heineman MJ, de Vos P. (2005) Species differences in the effect of pregnancy on lymphocyte cytokine production between human and rat. J Leukocyte Biol: 78:946-953

Faas MM, Moes H and de Vos P. (2004) Monocyte cytokine production during pregnancy. J Leukocyte Biol 75:153-154

Faas MM, Moes H, van der Schaaf G, Heineman MJ, de Vos P. (2004) Developing ovarian follicles inhibit the endotoxin-induced glomerular inflammatory reaction in pseudopregnant rats. Am J Reprod Immunol: 51:385-389

de Vos P, de Haan BJ, de Haan A, van Zanten J, and Faas MM (2004) Factors Influencing Functional Survival of Microencapsulated Islet Grafts. Cell Transplantation. 515–524

Bouman A, Schipper M, Heineman MJ, Faas, MM. (2004) 17b-estradiol and progesterone do not influence cytokine productive capacity of lipopolysaccharide stimulated monocytes in humans. Fertility and Sterility: 82(suppl 3):1212-1219

Faas MM, Broekema M, Moes H, Heineman MJ, de Vos P. (2003) Altered monocyte function in experimental pre-eclampsia in the rat. Am J Obstet Gynecol: 191:1192-1198

Faas MM, Moes H, van der Schaaf G, de Leij LFMH, Heineman MH. (2003) Total white blood cell counts and LPS-induced TNF╬▒ production by monocytes of pregnant, pseudopregnant and cyclic rats. J Reprod Immunol 59(1):39-52

Veenstra van Nieuwenhoven AL, Bouman A, Moes H, Heineman MJ, de Leij LF, Santema J, Faas MM. (2003) Endotoxin-induced cytokine production of monocytes of third-trimester pregnant women compared with women in the follicular phase of the menstrual cycle. Am J Obstet Gynecol. 188(4):1073-7

Veenstra van Nieuwenhoven AL, Heineman MJ, Faas MM. (2003) The immunology of successful pregnancy. Human Reprod Update. 9:347-357,

Veenstra van Nieuwenhoven AL, Bouman A, Moes H, Heineman MJ, de Leij LF, Santema J, Faas MM. (2002) Cytokine production in natural killer cells and lymphocytes in pregnant women compared with women in the follicular phase of the ovarian cycle. Fertil Steril 77(5):1032-7.

Bouman A, Moes H, Heineman MJ, de Leij LF, Faas MM. (2001) The immune response during the luteal phase of the ovarian cycle: increasing sensitivity of human monocytes to endotoxin. Fertil Steril. 76(3):555-9.

Faas MM, Bouman A, Moes H, Heineman MJ, De Leij L, Schuiling GA. (2000) Luteal phase: a Th2 type phenomen? Fertility and Sterility 74:1008-1013

Schuiling GA, Valkhof N, Faas MM (2000) Suppression by developing ovarian follicles of the low dose endotoxin-induced glomerular inflammatory reaction in the pregnant rat. Am J Obstet Gynecol 183:89-93/doi:10.1067

Faas MM, Bakker WW, Valkhof N, Schuiling GA (1999) Effect of estradiol and progesterone on the low-dose endotoxin-induced glomerular inflammatory response of the female rat. American Journal of Reproductive Immunology 41:224-231.

Faas MM, Schuiling GA, Linton EA, Sargent IL, Redman CWG (1999) Activation of peripheral leukocytes in rat pregnancy and experimental pre-eclampsia. Am J Obstet Gynecol 182:351-357

Schuiling GA, Koiter TR, Faas MM (1997) DEBATE: Pre-eclampsia: Why Pre-eclampsia? Human Reproduction 12:2087

Faas MM, Schuiling GA, Baller JFW and Bakker WW (1995) Glomerular inflammation in pregnant rats after infusion of low dose endotoxin: An immunohistological study in experimental pre-eclampsia. American Journal of Pathology 147:1510-1518.

Faas MM, Schuiling GA, Baller JFW, Visscher CA, and Bakker WW (1994) A new animal model for human pre-eclampsia: Ultralow dose endotoxin infusion in pregnant rats. Am J Obstet Gynecol 171:158-164.

Bouman A, Schipper M, Heineman MJ, de Leij,LFMH, Faas MM. Gender difference in the non-specific and specific immune response in humans. Am J Reprod Immunol: 52:19-26

Veenstra van Nieuwenhoven AL, Moes H, Heineman MJ, Santema J, Faas MM. Cytokine production by monocytes, NK cells and lymphocytes is different in preeclamptic patients as compared with normal pregnant women. Hypertens Pregnancy: 27(3):207-24

Faas MM, Bouman A, and de Vos P. The immune response in humans is affected by the sex hormones estrogens, progesterone and testosterone. In: “Female hepatology”. Publisher: Research Signpost. Editor: I. Shimizu. 129-158.

Faas MM, de Vos P, Melgert BN. (2011), Sex Hormones and Immune regulation. Invited review for Brain Immune. http://www.brainimmune.com/index.php?option=com_content&view=article&id=135:sex-hormones-and-immunoregulation&catid=78:neurohormonal-regulation-of-immunity&Itemid=421

Last modified:24 September 2018 3.17 p.m.