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Research GBB Molecular Cell Biology Publications

Publications 2000 - 2009

Publicaties 2000

  1. Kiel, J.A.K.W., R.E. Hilbrands, R.A.L. Bovenberg and M. Veenhuis (2000). Isolation of Penicillium chrysogenum PEX1 and PEX6 encoding AAA proteins involved in peroxisome biogenesis.Appl. Microbiol. Biotech. 54:238-242.
  2. Kiel, J.A.K.W. and M. Veenhuis (2000). Peroxisomal matrix protein import. Suppression of protein import defects in Hansenula polymorpha pex mutants by overproduction of the PTS1 receptor Pex5p. Cell Biochem. Biophys. 32:9-20.
  3. Baerends, R.J.S., K.N. Faber, J.A.K.W. Kiel, I.J. van der Klei, W. Harder and M. Veenhuis (2000). Sorting and function of peroxisomal membrane proteins. FEMS Microbiol. Rev. 24:291-301.
  4. Baerends, R.J.S., K.N. Faber, A.M. Kram, J.A.K.W. Kiel, I.J. van der Klei and M. Veenhuis (2000). A stretch of positively charged amino acids at the N-terminus of Pex3p is involved in incorporation of the protein into the peroxisomal membrane. J. Biol. Chem. 275: 9986-9995.
  5. Salomons, F.A., J.A.K.W. Kiel, K.N. Faber, M. Veenhuis and I.J. van der Klei (2000). Overproduction of Pex5p stimulates import of alcohol oxidase and dihydroxyacetone synthase in a Hansenula polymorpha pex14 null mutant. J. Biol. Chem. 275:12603-12611.
  6. van Dijk, R, K.N. Faber, J.A.K.W. Kiel, M. Veenhuis and I.J. van der Klei (2000). The methylotrophic yeast Hansenula polymorpha: a versatile cell factory. Enzyme Microbial Technol. 26:793-800.
  7. Keizer-Gunnink, I., A. Vuorela, J. Myllyharju, T. Pihlajaniemi, K.I. Kivirikko and M. Veenhuis (2000). Accumulation of properly folded human type III procollagen molecules in specific intracellular membranous compartments in the yeast Pichia pastoris. Matrix Biol. 19:29-36.
  8. Komori, M. and M. Veenhuis (2000). Hansenula polymorpha Pex14p is phosphorylated in vivo. Cell Biochem. Biophys. 32:283-284.
  9. Luttik, M.A.H., P. Kötter, F.A. Salomons, I.J. van der Klei, J.P. van Dijken and J.T. Pronk (2000). The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism. J. Bacteriol. 182:7007-7013.
  10. Prinz, W.A., L. Grzyb, M. Veenhuis, J.A. Kahana, P.A. Silver and T.A. Rapoport (2000). Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. J. Cell Biol. 150:461-474.
  11. Rehling, P., A. Skaletz-Rorowski, W. Girzalsky, T. Voorn-Brouwer, M.M. Franse, B. Distel, M. Veenhuis, W.-H. Kunau and R. Erdmann (2000). Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor Pex5p. J. Biol. Chem. 275:3593-3602.
  12. Scott, S.V., D.C. Nice III, J.J. Nau, L.S. Weisman, Y. Kamada, I. Keizer-Gunnink, T. Funakoshi, M. Veenhuis, Y. Ohsumi and D.J. Klionsky (2000). Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J. Biol. Chem. 275:25840-25849.
  13. Gorovits R, Sjollema KA, Sietsma JH, Yarden O (2000). Cellular distribution of COT1 kinase in Neurospora crassa. Fungal Genet Biol 30:63-70
  14. van Thor, J.J., R. Jeanjean, M. Havaux, K.A. Sjollema, F. Joset, K.J. Hellingwerf and H.C.P. Matthijs (2000). Salt shock-inducible Photosystem I cyclic electron transfer in Synechocystis PCC6803 relies on binding of ferredoxin:NADP+ reductase to the thylakoid membranes via its CpcD phycobilisome-linker homologous N-terminal domain. Biochem. Biophys. Acta (Bioenergetics) 1457:129-144.
  15. Veenhuis, M., F.A. Salomons and I.J. van der Klei (2000). Peroxisome biogenesis and degradation in yeast: a structure/function analysis. Microsc. Res. Tech. 51:584-600.

Publicaties 2001

  1. Albertini, M., W. Girzalsky, M. Veenhuis and W-.H. Kunau. Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur. J. Cell Biol. 80:257-270.
  2. Baerends, R.J.S., G.J. Sulter, T.W. Jeffries, J.M. Cregg and M. Veenhuis. Molecular characterization of the Hansenula polymorpha FLD1 gene encoding formaldehyde dehydrogenase. Yeast 15;19(1):37-42
  3. Bellu, A.R., M. Komori, I.J. van der Klei, J.A.K.W. Kiel and M. Veenhuis. Peroxisome biogenesis and selective degradation converge at Pex14p. J. Biol. Chem., in press.
  4. Bellu, A.R., A.M. Kram, J.A.K.W. Kiel, M. Veenhuis and I.J. van der Klei. Glucose-induced and nitrogen starvation-induced peroxisome degradation are distinct processes in Hansenula polymorpha that involve both common and unique genes. FEMS Yeast Res. 1:23-32.
  5. Faber, K.N., A.M. Kram, M. Ehrmann and M. Veenhuis. A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus (TEV-) protease. J. Biol. Chem. 276:36501-36507.
  6. Gellissen, G. and M. Veenhuis The methylotrophic yeast Hansenula polymorpha : its use in fundamental research and as a cell factory. Yeast 18:I-III.
  7. Gunkel, K. R. van Dijk, K.N. Faber, I.J. van der Klei and M. Veenhuis. Import and assembly of peroxisomal alcohol oxidase in the yeast Hansenula polymorpha . Yeast 18S:130 .
  8. Johnson, M.A., W.B. Snyder, J.L. Cereghino, M. Veenhuis, S. Subramani and J.M. Cregg. Pichia pastoris Pex14p, a phosphorylated peroxisomal membrane protein, is part of a PTS-receptor docking complex and interacts with many peroxins. Yeast 18:621-641.
  9. Kieboom J, Bruinenberg R, Keizer-Gunnink I, de Bont JA (2001) Transposon mutations in the flagella biosynthetic pathway of thesolvent-tolerant Pseudomonas putida S12 result in a decreased expression of solvent efflux genes. FEMS Microbiol Lett. 98(2):117-122.
  10. Monastyrska, I., M. Veenhuis and J.A.K.W. Kiel. PDD4 and PPD6 encode two novel proteins involved in selective peroxisome degradation in Hansenula polymorpha . Yeast 18S:132.
  11. Perkins, G.A., C.W. Renken, I.J. van der Klei, M.H. Ellisman, W. Neupert and T.G. Frey. Electron tomography of mitochondria after the arrest of protein import associated with Tom19 depletion. Eur. J. Cell Biol. 80:139-150.
  12. Salomons, F.A. Sorting of matrix proteins to peroxisomes in the methylotrophic yeast Hansenula polymorpha . Ph.D. Thesis (January 5), University of Groningen.
  13. Salomons, F.A., K.N. Faber, M. Veenhuis and I.J. van der Klei. Peroxisomal remnant structures in Hansenula polymorpha pex5 cells can develop into normal peroxisomes upon induction of the PTS2 protein amine oxidase. J. Biol. Chem. 276:4190-4198.
  14. van Dijk, R. Import and assembly of alcohol oxidase. Ph.D. Thesis (October 22), University of Groningen.
  15. van Dijk, R., K.N. Faber, A.T. Hammond, B.S. Glick, M. Veenhuis and J.A.K.W. Kiel. Tagging Hansenula polymorpha genes by random integration of linear DNA fragments (RALF). Mol. Gen. Genomics. 266(4):646-56.
  16. van Dijk, R., K.L. Lahchev, A.M. Kram, I.J. van der Klei and M. Veenhuis. Isolation of mutants defective in the assembly of octameric alcohol oxidase of Hansenula polymorpha. FEMS Yeast Res.1(4):257-63.
  17. Wagner, R., V. Klein, R.J.S. Baerends, M. Veenhuis and F. Pattus. A novel yeast heterologous expression system designed for membrane proteins production. Yeast 18S:287.
  18. Zlateva, T., R. Boteva, B. Filippi, M. Veenhuis and I.J. van der Klei. Deflavination of flavo-oxidases by nucleophilic reagents. Biochim. Biophys. Acta (Protein Structure and Molecular Enzymology) 1548:213-219.

Publications 2002

  1. Lahchev, K., Semenova, V., Tolstorukov, I.I., van der Klei, I.J. and Veenhuis, M. (2002) Isolation and properties of genetically defined strains of the methylotrophic yeast Hansenula polymorpha CBS4732. Arch. Microbiol. 177: 150-158.
  2. Baerends, R.J.S., Sulter, G.J., Jeffries, T.W., Cregg, J.M. and Veenhuis, M. (2002) Molecular characterization of the Hansenula polymorpha FLD1 gene encoding formaldehyde dehydrogenase. Yeast 19:37-42.
  3. van Dijk, R., Lahchev, K.L., Kram, A.M., van der Klei, I.J. and Veenhuis, M. (2002) Isolation of mutants defective in the assembly of octameric alcohol oxidase of Hansenula polymorpha. FEMS Yeast Research 1, 257-263.
  4. Van der Heide, M., Hollenberg, C.P., van der Klei, I.J. and Veenhuis, M. (2002) Overproduction of BiP negatively affects the secretion of Aspergillus niger glucose oxidase by the yeast Hansenula polymorpha. Appl. Microbiol. Biotechnol. 58:487-494.
  5. Faber KN, van Dijk R, Keizer-Gunnink I, Koek A, van der Klei IJ, Veenhuis M. (2002) Import of assembled PTS1 proteins into peroxisomes of the yeast Hansenula polymorpha: yes and no! Biochim Biophys Acta 1591:157-162.
  6. Voncken, F.G.J., Boxma, B., Van Hoek, A.H.A.M., Akhamanova, A.S., Vogels, G.D., Huynen, M., Veenhuis, M. and Hackstein, J.H.P. (2002) A hydrogenosomal [Fe]-hydrogenase from the anaerobic chytric Neocallymastix sp. L2. Gene 284:103-112.
  7. Voncken F, Boxma B, Tjaden J, Akhmanova A, Huynen M, Verbeek F, Tielens AG, Haferkamp I, Neuhaus HE, Vogels G, Veenhuis M, Hackstein JH. (2002) Multiple origins of hydrogenosomes: functional and phylogenetic evidence from the ADP/ATP carrier of the anaerobic chytrid Neocallimastix sp. Mol Microbiol 44:1441-1454.
  8. Veenhuis, M., Van der Klei, I.J. (2002). Peroxisomes: surprisingly versatile organelles. Biochim Biophys Acta 1555:44.
  9. Stewart MQ, van Dijk R, Veenhuis M, Goodman JM.(2002) Monomeric alcohol oxidase is preferentially digested by a novel protease from Candida boidinii. Biochim Biophys Acta. 1542:160-172.
  10. Faber KN, Haan GJ, Baerends RJ, Kram AM, Veenhuis M. (2002) Normal peroxisome development from vesicles induced by truncated Hansenula polymorpha Pex3p. J Biol Chem 277:11026-11033.
  11. Haan, G.J., Faber, K.N., Baerends, R.J.S., Koek, A., Krikken, A., Kiel, J.A.K.W., van der Klei, I.J. and Veenhuis, M. (2002) Hansenula polymorpha Pex3p is a peripheral component of the peroxisomal membrane J. Biol. Chem. 277:26609-26617.
  12. van der Klei, I.J. and Veenhuis, M. (2002) Peroxisomes: flexible and dynamic organelles. Curr. Opinion Cell Biol. 14, 500-506.
  13. Komduur JA, Leao AN, Monastyrska I, Veenhuis M, Kiel JAKW. (2002) Old yellow enzyme confers resistance of Hansenula polymorpha towards allyl alcohol. Curr Genet 41:401-406.
  14. van der Lende T, van de Kamp M, Berg M, Sjollema K, Bovenberg R, Veenhuis M, Konings W, Driessen A. (2002) delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase, that mediates the first committed step in penicillin biosynthesis, is a cytosolic enzyme. Fungal Genet Biol 37:49.
  15. FaberKN and Veenhuis M. (2002) Foreign gene expression in Hansenula polymorpha; approaches for "difficult proteins". In: Hansenula polymorpha - biology and applications, G. Gellissen (ed) Wiley-VCH Weinheim, Germany, pp 147-152.
  16. Van der Klei, I.J. and Veenhuis, M. (2002) Hansenula polymorpha: a versatile model organism in peroxisome research. In: Hansenula polymorpha - biology and applications, G. Gelissen (ed). Wiley-VCH Weinheim, Germany. pp 76-94.
  17. Haan, G.J., van Dijk, R., Kiel, J.A.K.W. and Veenhuis, M. (2002) Characterization of the Hansenula polymorpha PUR7 gene and its use as selectable marker for targeted chromosomal integration. FEMS Yeast Research 2: 17-24.
  18. Bellu AR, Salomons, FA, Kiel JAKW, Veenhuis M, Van der Klei IJ. (2002) Removal of Pex3p is an important initial stage in selective peroxisome degradation in Hansenula polymorpha. J Biol Chem. 277: 42875-42880.
  19. Sorokin DY, Tourova TP, Kolganova TV, Sjollema KA, Kuenen JG. (2002) Thioalkalispira microaerophila gen. nov., sp. nov., a novel lithoautotrophic, sulfur-oxidizing bacterium from a soda lake. Int J Syst Evol Microbiol. 52:2175-2182.

Publications 2003

  1. Postma, M., Roelofs, J., Goedhart, J., Gadella, T.W., Visser, A.J., Van Haastert, P.J. (2003) Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia Mol Biol Cell. 14(12):5019-27.
  2. Bosgraaf, L., Van Haastert, P.J. (2003) Roc, a Ras/GTPase domain in complex proteins Biochim Biophys Acta.1643(1-3):5-10.
  3. Veltman, D.M., De Boer, J.S., Van Haastert, P.J. (2003) Chemoattractant-stimulated calcium influx in Dictyostelium discoideum does not depend on cGMP. Biochim Biophys Acta. 1623(2-3):129-34.
  4. Blaauw, M, Knol, J.C., Kortholt, A,, Roelofs,J., Ruchira, Postma, M., Visser, A.J., van Haastert, P.J. (2003) Phosducin-like proteins in Dictyostelium discoideum: Implications for the phosducin family of proteins. EMBO J. 22(19):5047-57.
  5. Vischer, H.F., Granneman, J.C., Linskens, M.H., Schulz, R.W., Bogerd, J. (2003) Both recombinant African catfish LH and FSH are able to activate the African catfish FSH receptor. J Mol Endocrinol. 31(1):133-40.
  6. Veltman, D., Van Haastert, P.J. (2003) Regulation of Dictyostelium guanylyl cyclases. Protist. 154(1):33-42.
  7. Loovers, H.M., Veenstra, K., Snippe, H., Pesesse, X., Erneux, C., van Haastert, P.J. (2003) A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum. J Biol Chem. 278(8):5652-8.
  8. Roelofs, J., Smith, J.L., Van Haastert, P.J. (2003) cGMP signalling: different ways to create a pathway. Trends Genet. 19(3):132-4.

Publications 2004

  1. Gunkel K, van Dijk R, Veenhuis M, van der Klei IJ. (2004) Routing of Hansenula polymorpha alcohol oxidase: an alternative peroxisomal protein-sorting machinery. Mol Biol Cell. 15:1347-1355.
  2. Stasyk OV, Stasyk OG, Komduur J, Veenhuis M, Cregg JM, Sibirny AA. (2004) A hexose transporter homologue controls glucose repression in the methylotrophic yeast Hansenula polymorpha. J Biol Chem. 279:8116-8125.
  3. Kiel JAKW, Van den Berg M., Bovenberg RAL, Van der Klei IJ and Veenhuis M. (2004) Penicillium chrysogenum Pex5p mediates differential sorting of PTS1 proteins to microbodies of the methylotrophic yeast Hansenula polymorpha. Fungal Genet. and Biol. 41, 708-720.
  4. Otzen M, Perband U, Wang D, Baerends RJS, Kunau WH, Veenhuis M and Van der Klei IJ. (2004) Hansenula polymorpha Pex19p is essential for the formation of functional peroxisomal membranes. J Biol Chem 279:19181-19190.
  5. Ozimek P, Lahtchev K, Kiel JAKW, Veenhuis M, Van der Klei IJ (2004) Hansenula polymorpha Swi1p and Snf2p are essential for methanol utilisation. FEMS Yeast Res. 4:673-682.
  6. Machin F, Medina B, Navarro FJ, Perez MD, Veenhuis M, Tejera P, Lorenzo H,Lancha A, Siverio JM. (2004) The role of Ynt1 in nitrate and nitrite transport in the yeast Hansenula polymorpha. Yeast. 21:265-276.
  7. Leao-Helder A, Krikken A, Lunenborg M, Kiel JAKW, Veenhuis M, Van der Klei IJ.(2004) Hansenula polymorpha Tup1p is important for peroxisome degradation (2004) FEMS Yeast Research. 4, 789-794
  8. Monastryska I, Sjollema K, Van Der Klei IJ, Kiel JA, Veenhuis M. (2004) Microautophagy and macropexophagy may occur simultaneously in Hansenula polymorpha. FEBS Lett. 568:135-138.
  9. Leão-Helder, A.N., Krikken, A.M., Gellissen, G., van der Klei, I.J., Veenhuis, M. and Kiel, J.A.K.W. (2004) Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenula polymorpha. FEBS Lett. 577:491-5.
  10. Trip, H., Evers, M.E., Kiel, J.A.K.W. and Driessen, A.J.M. (2004) Uptake of the β-lactam precursor α-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease. Appl Environ Microbiol. 70:4775-8
  11. de Boer W, Leveau JH, Kowalchuk GA, Klein Gunnewiek PJ, Abeln EC, Figge MJ, Sjollema K, Janse JD, van Veen JA. (2004) Collimonas fungivorans gen. nov., sp. nov., a chitinolytic soil bacterium with the ability to grow on living fungal hyphae. Int J Syst Evol Microbiol. 54:857-864.
  12. Komduur, J., Bellu, A.R., Knoops, K., Van der Klei, I.J. and Veenhuis M. (2004) Cold-inducible selective degradation of peroxisomes in Hansenula polymorpha. FEMS Yeast Res. 5281-285.
  13. Campo, N., Tjalsma, H., Buist, G., Stepniak, D., Meijer, M., Veenhuis, M., Westerman, M., Muller, J.P., Bron, S., Kok, J., Kuipers, O.P., Jongbloed, J.D. H. (2004) Subcellular sites for bacterial protein export. Molecular Microbiology 53:1583-1599.
  14. Schäfer, A., Kerssen, D., Veenhuis, M., Kunau, W.H., Schliebs, W. (2004) Functional similarity between the peroxisomal PTS2 receptor binding protein Pex18p and the N-terminal half of the PTS1 receptor Pex5p. Mol. Cell. Biol. 24: 8895-8906
  15. Westenbroek, C., Den Boer, J.A., Veenhuis, M. and Ter Horst, G.J. (2004) Chronic stress and social housing differentially affects neurogenesis in male and female rats. Brain Research Bulletin. Brain Res Bull. 64:303-8.
  16. Stasyk OV, Stasyk OG, Komduur J, Veenhuis M, Cregg JM, Sibirny AA .(2004) A hexose transporter homologue controls glucose repression in the methylotrophic yeast Hansenula polymorpha. J Biol Chem. 279(9):8116-25
  17. Kiel, J.A.K.W. and Veenhuis, M. (2004) Selective degradation of peroxisomes in the methylotrophic yeast Hansenula polymorpha In: Autophagy.Klionsky D. (Ed.), Landes Bioscience, Georgetown, Texas, USA, pp. 140-156.

Publications 2005

  1. Boxma B, de Graaf RM, van der Staay GW, van Alen TA, Ricard G, Gabaldon T, van Hoek AH, Moon-van der Staay SY, Koopman WJ, van Hellemond JJ, Tielens AG, Friedrich T, Veenhuis M, Huynen MA, Hackstein JH.(2005) An anaerobic mitochondrion that produces hydrogen. Nature. 434:74-9.
  2. Kiel JA, van der Klei IJ, van den Berg MA, Bovenberg RA, Veenhuis M. (2005) Overproduction of a single protein, Pc-Pex11p, results in 2-fold enhanced penicillin production by Penicillium chrysogenum. Fungal Genet Biol. 42:154-64.
  3. Monastyrska I, van der Heide M, Krikken AM, Kiel JA, van der Klei IJ, Veenhuis M. (2005) Atg8 is essential for macropexophagy in Hansenula polymorpha. Traffic. 6:66-74.
  4. Kiel, J.A.K.W., Emmrich, K., Meyer, H.E. and Kunau, W.H. (2005) Ubiquitination of the PTS1 receptor, Pex5p, suggests the presence of a quality control mechanism during peroxisomal matrix protein import. J. Biol. Chem. 280:1921-1930
  5. Kiel JA, Otzen M, Veenhuis M, van der Klei I.J. (2005) Obstruction of polyubiquitination affects PTS1 peroxisomal matrix protein import. Biochim Biophys Acta. 1745:176-86.
  6. Otzen M, Wang D, Lunenborg MG, van der Klei IJ. (2005) Hansenula polymorpha Pex20p is an oligomer that binds the peroxisomal targeting signal 2 (PTS2). J Cell Sci. 118:3409-3418.
  7. Dunn, W.A. Jr., Cregg, J.M., Kiel, J.A.K.W., Van der Klei, I.J., Oku, M., Sakai, Y., Sibirny, A.A., Stasyk, O.V. and Veenhuis, M. (2005) Pexophagy: The selective autophagy of peroxisomes. Autophagy. 1, 75-83.
  8. Monastryska, I., Kiel, J.A.K.W., Krikken, A.M., Komduur, J.A., Veenhuis, M. and Van der Klei, I.J. (2005) The Hansenula polymorpha ATG25 gene encodes a novel coiled-coil protein that is required for macropexophagy. Autophagy 1, 92-100.
  9. Gunkel, K., Veenhuis, M. and Van der Klei, I.J. (2005) Protein translocation machineries: How organelles bring in matrix proteins. FEMS Yeast Research, 5:1037-45.
  10. Ozimek, P., Veenhuis, M. and Van der Klei, I.J. (2005) A complex peroxisomal, oligomeric flavoprotein. FEMS Yeast Research 5:975-983.
  11. de Bruin EC, Duitman EH, de Boer AL, Veenhuis M, Bos IG, Hack CE. (2005) Pharmaceutical proteins from methylotrophic yeasts. Methods Mol Biol. 308:65-76.
  12. Lutz, M.V., Bovenberg, R.A., van der Klei, I.J. and Veenhuis, M. (2005)Synthesis of Penicillium chrysogenum acetyl-CoA:isopenicillin N acyltransferase in Hansenula polymorpha: First step towards the introduction of a new metabolic pathway. FEMS Yeast Res. 5:1063-1067.
  13. Gellissen, G., Kunze, G., Gaillardin, C., Cregg, J.M., Berardi, E., Veenhuis, M., van der Klei, I.J. (2005) New yeast expression platforms based on methylotrophic Hansenula polymorpha and Pichia pastoris and on dimorphic Arxula adeninivorans and Yarrowia lipolytica - A comparison. FEMS Yeast Res. 5:1079-1096
  14. Blecha A, Zarschler K, Sjollema KA, Veenhuis M, Rodel G. (2005) Expression and cytosolic assembly of the S-layer fusion protein mSbsC-EGFP in eukaryotic cells. Microb Cell Fact. 4:28.
  15. Stevens P, Monastyrska I, Leao-Helder AN, van der Klei IJ, Veenhuis M, Kiel JA. (2005) Hansenula polymorpha Vam7p is required for macropexophagy. FEMS Yeast Res. 5:985-97.
  16. Kiel, J.A.K.W. and de Boer, A.L. (2005) The 3rd Hansenula polymorpha worldwide network conference: Strengthening the connection between fundamental research and its biotechnological applications, Alghero, 2004. FEMS YEAST Res. 5:973
  17. Monastyrska I, van der Heide M, Krikken AM, Kiel JA, van der Klei, Veenhuis M. Atg8 is essential for macropexophagy in Hansenula polymorpha. Traffic. 2005 Jan;6(1):66-74

Publications 2006

  1. van der Klei IJ, Yurimoto H, Sakai Y, Veenhuis M. (2006) The significance of peroxisomes in methanol metabolism in methylotrophic yeast. Biochim Biophys Acta. 1763(12):1767-75.
  2. van der Klei IJ, Veenhuis M. (2006) PTS1-independent sorting of peroxisomal matrix proteins by Pex5p. Biochim Biophys Acta. 1763(12):1794-800.
  3. Kiel JA, Veenhuis M, van der Klei IJ. (2006) PEX genes in fungal genomes: common, rare or redundant. Traffic 7:1291-303.
  4. Kuravi K, Nagotu S, Krikken AM, Sjollema K, Deckers M, Erdmann R, Veenhuis M, van der Klei IJ. (2006) Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. J Cell Sci. 119:3994-4001.
  5. Schliebs W, Wurtz C, Kunau WH, Veenhuis M, Rottensteiner H. (2006) A eukaryote without catalase-containing microbodies: Neurospora crassa exhibits a unique cellular distribution of its four catalases. Eukaryot Cell. 5:1490-502.
  6. de Vries B, Todde V, Stevens P, Salomons F, van der Klei IJ, Veenhuis M. (2006) Pex14p is not required for N-Starvation induced microautophagy and in catalytic amounts for macropexophagy in Hansenula polymorpha. Autophagy. 2:183-8.
  7. Allen C, Buttner S, Aragon AD, Thomas JA, Meirelles O, Jaetao JE, Benn D, Ruby SW, Veenhuis M, Madeo F, Werner-Washburne M. (2006) Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures. J Cell Biol. 174:89-100.
  8. Haan GJ, Baerends RJ, Krikken AM, Otzen M, Veenhuis M, van der Klei IJ. (2006) Reassembly of peroxisomes in Hansenula polymorpha pex3 cells on reintroduction of Pex3p involves the nuclear envelope. FEMS Yeast Res. 6(2):186-94.
  9. Lin-Cereghino GP, Godfrey L, de la Cruz BJ, Johnson S, Khuongsathiene S, Tolstorukov I, Yan M, Lin-Cereghino J, Veenhuis M, Subramani S, Cregg JM. (2006) Mxr1p, a key regulator of the methanol utilization pathway and peroxisomal genes in Pichia pastoris. Mol Cell Biol. 26:883-97.
  10. Ozimek P, Kotter P, Veenhuis M, van der Klei IJ. (2006) Hansenula polymorpha and Saccharomyces cerevisiae Pex5p's recognize different, independent peroxisomal targeting signals in alcohol oxidase. FEBS Lett. 580:46-50.
  11. Sakai Y, Oku M, van der Klei IJ, Kiel JA. (2006) Pexophagy: Autophagic degradation of peroxisomes. Biochim Biophys Acta. 1763(12):1767-75.
  12. Van der Klei, I.J., Veenhuis, M. (2006) Yeast and filamentous fungi as model organisms in microbody research. Bioch Biophys Acta. 1763(12):1364-73.
  13. Otzen, M., Krikken, A.M., Ozimek, P.Z., Kurbatova, E. Nagotu, S., Veenhuis, M., Van der Klei, I.J. (2006) In the yeast Hansenula polymorpha, peroxisome formation from the ER is independent of Pex19p, but involves the function of p24 proteins. FEMS Yeast Res. 6(8):1157-66.

Publications 2007

  1. Visser NV, Wang D, Stanley WA, Groves MR, Wilmanns M, Veenhuis M, van der Klei IJ. (2007) Octameric alcohol oxidase dissociated into stable, soluble monomers upon incubation with demethylsulfoxide. Arch Biochem Biophys. 459(2):208-13
  2. Bener-Aksam, E., Koek A., Kiel JAKW., Jourdan, S., Veenhuis, M. and Van der Klei, I.J. (2007) A peroxisomal Lon protease and peroxisome degradation by autophagy play key roles in vitality of Hansenula polymorpha cells. Autophagy 3(2):96-105.
  3. Meijer WH, van der Klei IJ, Veenhuis M, Kiel JAKW. (2007) ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 3(2):106-16
  4. Managadze D, Würtz C, Sichting M, Niehaus G, Veenhuis M, Rottensteiner H. (2007) The Peroxin PEX14 of Neurospora crassa is Essential for the Biogenesis of Both Glyoxysomes and Woronin Bodies. Traffic 8 (6), 687–701
  5. Ozimek PZ, Klompmaker SH, Visser N, Veenhuis M, van der Klei IJ. (2007) The transcarboxylase domain of pyruvate carboxylase is essential for assembly of the peroxisomal flavoenzyme alcohol oxidase. FEMS Yeast Res. 7(7):1082-92.
  6. Moscicka KB, Klompmaker SH, Wang D, van der Klei IJ, Broekema EJ. (2007) The Hansenula polymorpha peroxisomal targeting signal 1 receptor, Pex5p, functions as a tetramer. FEBS Letters 581(9):1958-62.
  7. Gidijala L, van der Klei IJ, Veenhuis M, Kiel JAKW. (2007) Reprogramming Hansenula polymorpha for penicillin production: expression of the penicillium chrysogenum pcl gene. FEMS Yeast Res. 7(7):1160-7.
  8. van der Heide M, Leao AN, van der Klei IJ, Veenhuis M. (2007) Redirection of peroxisomal alcohol oxidase of Hansenula polymorpha the the secretory pathway. FEMS Yeast Res. 7(7):1093-102.
  9. Kiel JAKW, Titorenko VI, van der Klei IJ, Veenhuis M. (2007) Overproduction of translation elongation factor 1-alpha (eEF1A) suppresses the peroxisome biogenesis defect in a Hansenula polymorpha pex3 mutant via translational read-through. FEMS Yeast Res. 7(7):1114-25.
  10. Koek A, Komori M, Veenhuis M, van der Klei IJ. (2007) A comparative study of peroxisomal structures in Hansenula polymorpha pex mutants. FEMS Yeast Res. 7(7):1126-33.
  11. Pertschy B, Saveanu C, Zisser G, Lebreton V, Tengg M, Jacquier A, Liebminger E, Nobis B, Kappel L, van der Klei IJ, Högenauer G, Fromont-Racine M, Bergler H. (2007) Cytoplasmic recycling of 60S pre-ribosomal factors depends on the AAA-protein Drg1. Mol Cell Biol. 27(19):6581-92.
  12. Geerlings TH, de Boer A, Lunenborg MGJ, Veenhuis M, van der Klei IJ. (2007) A novel platform for the production of nonhydroxylated gelatins based on the methylotrophic yeast Hansenula polymorpha. FEMS Yeast Res. 7(7):1188-96.
  13. Stasyk OG, van Zutphen T, Ah Kang H, Stasyk OV, Veenhuis M, Sibirny AA. (2007) The role of Hansenula polymorpha MIG1 homologues in catabolite repression and pexophagy. FEMS Yeast Res. 7 (7), 1103–1113.
  14. de Vries B, Kiel JAKW, Scheek R, Veenhuis M, van der Klei IJ. (2007) A conserved alpha helical domain at the N-terminus of Pex14p is required for PTS1 and PTS2 protein import in Hansenula polymorpha. FEBS Letters, 581(29):5627-34.
  15. Giezen M, van der Klei I.J. Veenhuis M. Protein targetting to yeast peroxisomes, Methods in Molecular Biology, Volume 390, ISBN: 978-1-58829-702-0
  16. van der Klei I, Veenhuis M. Protein targeting to yeast peroxisomes, Methods Mol Biol. 2007; 390:373-91
  17. Kiel JA, Otzen M. The 4th Hansenula polymorpha Worldwide Network Confenrence, Haren (The Netherlands), 3-5 September 2007, FEMS Yeast Res 2007; Jan;7(1):167-71

Publications 2008

  1. van den Berg MA, Albang R, Albermann K, Badger JH, Daran JM, Driessen AJ, Garcia-Estrada C, Fedorova ND, Harris DM, Heijne WH, Joardar V, Kiel JA, Kovalchuk A, Martín JF, Nierman WC, Nijland JG, Pronk JT, Roubos JA, van der Klei IJ, van Peij NN, Veenhuis M, von Döhren H, Wagner C, Wortman J, Bovenberg RA. Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum. Nat Biotechnol. 2008 Oct;26(10):1161-8.
  2. Bener Aksam E, Jungwirth H, Kohlwein SD, Ring J, Madeo F, Veenhuis M, van der Klei IJ. Absence of the peroxiredoxin Pmp20 causes peroxisomal protein leakage and necrotic cell death. Free Radic Biol Med. 2008 Oct 15;45(8):1115-24.
  3. Nagotu S, Krikken AM, Otzen M, Kiel JA, Veenhuis M, van der Klei IJ. Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission. Traffic. 2008 Sep;9(9):1471-84.
  4. Baerends RJ, de Hulster E, Geertman JM, Daran JM, van Maris AJ, Veenhuis M, van der Klei IJ, Pronk JT. Engineering and analysis of a Saccharomyces cerevisiae strain that uses formaldehyde as an auxiliary substrate. Appl Environ Microbiol. 2008 May;74(10):3182-8.
  5. Gidijala L, Bovenberg RA, Klaassen P, van der Klei IJ, Veenhuis M, Kiel JA. Production of functionally active Penicillium chrysogenum isopenicillin N synthase in the yeast Hansenula polymorpha. BMC Biotechnol. 2008 Mar 19;8:29.
  6. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G,Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb 16;4(2):151-75.
  7. Nagotu S, Saraya R, Otzen M, Veenhuis M, van der Klei IJ. Peroxisome proliferation in Hansenula polymorpha requires Dnm1p which mediates fission but not de novo formation. Biochim Biophys Acta. 2008 May;1783(5):760-9.
  8. Zutphen T, Veenhuis M, van der Klei IJ. Pex14 is the sole component of the peroxisomal translocon that is required for pexophagy. Autophagy. 2008 Jan 1;4(1):63-6.
  9. García-Estrada C, Vaca I, Fierro F, Sjollema K, Veenhuis M, Martín JF.The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing. Fungal Genet Biol. 2008 Jun;45(6):1043-52.
  10. Wortman JR, Gilsenan JM, Joardar V, Deegan J, Clutterbuck J, Andersen MR, Archer D, Bencina M, Braus G, Coutinho P, Döhren HV, Doonan J, Driessen AJ, Durek P, Espeso E, Fekete E, Flipphi M, Estrada CG, Geysens S, Goldman G, de Groot PW, Hansen K, Harris SD, Heinekamp T, Helmstaedt K, Henrissat B, Hofmann G, Homan T, Horio T, Horiuchi H, James S, Jones M, Karaffa L, Karányi Z, Kato M, Keller N, Kelly DE, Kiel JA, Kim JM, van der Klei IJ, Klis FM, Kovalchuk A, Kraševec N,Kubicek CP, Liu B, Maccabe A, Meyer V, Mirabito P, Miskei M, Mos M, Mullins J, Nelson DR, Nielsen J, Oakley BR, Osmani SA, Pakula T, Paszewski A, Paulsen I, Pilsyk S, Pócsi I, Punt PJ, Ram AF, Ren Q, Robellet X, Robson G, Seiboth B, vanSolingen P, Specht T, Sun J, Taheri-Talesh N, Takeshita N, Ussery D, Vankuyk PA, Visser H, van de Vondervoort PJ, de Vries RP, Walton J, Xiang X, Xiong Y, Zeng AP, Brandt BW, Cornell MJ, van den Hondel CA, Visser J, Oliver SG, Turner G.The 2008 update of the Aspergillus nidulans genome annotation: A community effort. Fungal Genet Biol. 2008 Dec 25. [Epub ahead of print] PMID: 19146970 [PubMed - as supplied by publisher
  11. van Zutpen T, van der Klei IJ, Kiel JA. Pexophagy in Hansenula polymorpha.methods Enzymol. 2008; 451:197-215

Publications 2009

  1. An engineered yeast efficiently secreting penicillin. Gidijala L, Kiel JA, Douma RD, Seifar RM, van Gulik WM, Bovenberg RA, Veenhuis M, van der Klei IJ. PloS One. 2009 Dec 15;4(12):e8317.
  2. p24 proteins play a role in peroxisome proliferation in yeast. Kurbatova E, Otzen M, van der Klei IJ. FEBS Lett. 2009 Oct 6;583(19):3175-80.
  3. Preserving organelle vitality: peroxisomal quality control mechanisms in yeast. Aksam EB, de Vries B, van der Klei IJ, Kiel JA. FEMS Yeast Res. 2009 Sep;9(6):808-20.
  4. Peroxicretion: a novel secretion pathway in the eukaryotic cell. Sagt CM, ten Haaft PJ, Minneboo IM, Hartog MP, Damveld RA, van der Laan JM, Akeroyd M, Wenzel TJ, Luesken FA, Veenhuis M, van der Klei I, de Winde JH. BMC Biotechnol. 2009 May 20;9:48.
  5. Hansenula polymorpha pex11 cells are affected in peroxisome retention. Krikken AM, Veenhuis M, van der Klei IJ.FEBS J. 2009 Mar;276(5):1429-39
  6. Matching the proteome to the genome: the microbody of penicillin-producing Penicillium chrysogenum cells. Kiel JA, van den Berg MA, Fusetti F, Poolman B, Bovenberg RA, Veenhuis M, van der Klei IJ. Funct Integr Genomics. 2009 May;9(2):167-84.
  7. The 2008 update of the Aspergillus nidulans genome annotation: a community effort. Wortman JR, Gilsenan JM, Joardar V, Deegan J, Clutterbuck J, et al. Fungal Genet Biol. 2009 Mar;46 Suppl 1:S2-13. Epub 2008 Dec 25.
  8. Autophagy: principles and significance in health and disease. Todde V, Veenhuis M, van der Klei IJ. Biochim Biophys Acta. 2009 Jan;1792(1):3-13.
  9. Proteins involved in microbody biogenesis and degradation in Aspergillus nidulans. Kiel JA, van der Klei IJ.Fungal Genet Biol. 2009 Mar;46 Suppl 1:S62-71.
  10. Protocols for Yeast. Gellissen G, Van Der Klei IJ, Kunze G, Berardi E, Veenhuis M. Wiley - VCH verlagsgesellschaft mbH, ISBN 9783527317318.
Last modified:15 May 2023 4.08 p.m.