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About us Medical Sciences Research Department of Gastroenterology and Hepatology
University Medical Center Groningen

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2008
Hannivoort R et al, Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. Hepatology 2008 Aug;48(2):624-634

Schoemaker M et al, PDGF-Receptor ß-Targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Molecular Pharmaceutics 2008 May-Jun;5(3):399-406

Conde de la Rosa L et al, Carbon monoxide blocks oxidative stress-induced hepatocyte apoptosis via inhibition of the p54 JNK isoform. Free Radical Biology and Medicine 2008 April;44 (7): 1323-1333 
2007
Dijkstra G et al, Early bacterial dependent induction of inducible nitric oxide synthase (iNOS) in epithelial cells upon transfer of CD45RBhigh CD4+ T cells in a model for experimental colotis. Inflamm Bowel Dis. 2007
Blokzijl H et al, Decreased P-glycoprotein (P-gp/MDR1) Expression in inflamed human intestinal epithelium is independent of PXR protein levels. Inflamm Bowel Dis. 2007 Jun;13 (6):710-20
Pellicoro A et el, Human and Rat bile acid-CoA: Amino acid N-Acyltransferase are liver-specific peroxisomal enzymes: Implications for intracellular bile acid transport. Hepatology 2007 Feb;45(2):340-8
2006
Conde de la Rosa L et al, Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms:I nvolvement of JNK and MAP kinases. J. Hepatology 2006 May; 44 (5): 918-29
2005
Vander Borght S et al, Diagnostic and pathogenetic implications of the expression of hepatic transporters in focal lesions occurring in normal liver. J Pathol 2005 Dec;207(4):471-82
Seitz HK et al, From Alcohol Toxicity to Treatment. Alcohol Clin Exp Res 2005 Jul;29(7):1341-50

van der Woude CJ et al, Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis. J Clin Pathol 2005 Aug;58(8):811-4

Geuken E et al, Expression of Heme Oxygenase-1 in Human Livers Before Transplantation Correlates with Graft Injury and Function After Transplantation. Am J Transplant 2005 Aug;5(8):1875-85
Svegliati-Baroni G et al, Bile Acids Induce Hepatic Stellate Cell Proliferation via Activation of the Epidermal Growth Factor Receptor. Gastroenterology 2005 Apr;128(4):1042-55
2004
Dijkstra G et al, Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxide. J Pathol 2004 Oct 8;204(3):296-303
Schoemaker et al, Defying death: the hepatocyte's survival kit. Clin Sci 2004 Jul;107(1):13-25 review
De Vries et al, Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expression. Nucl Med Biol 2004 Jul;31(5):605-612
Schoemaker et al, Tauroursodeoxycholic Acid Protects Rat Hepatocytes From Bile Acid-Induced Apoptosis via Activation of Survival Pathways. Hepatology 2004 Jun;39(6):1563-1573
Moshage, The cirrhotic hepatocyte: navigating between Scylla and Charybdis.  J Hepatology 2004 Jun;40(6):1027-1029
Schnog et al, Evidence for a metabolic shift of arginine metabolism is sickle cell disease. Ann Hematol. 2004 Jun 83(6):371-375
Van der Woude et al, Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract. Apoptosis 2004 Mar;9(2):123-130
2003
Van der Hoeven et al, Brain death induces apoptosis in donor liver of the rat. Transplantation 2003 Oct 27;76(8):1150-1154
Van der Woude et al, Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis related proteins. J. Clin. Path. 2003 Sep;56(9):699-702
Schoemaker et al, Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. J. Hepatol. 2003 Aug;39(2):153-61
Schoemaker et al, Beyond the journal comment. J Hepatol. 2003 Jun;38(6):873-5
2002
Van der Woude et al, Expression of Apoptosis-related proteins in Barrett's Metaplasia-Dysplasia-Carcinoma Sequence: A Switch to a More Resistant Phenotype. Human Pathology 2002;33:686-692
Schoemaker et al, Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes:NF-kB-regulated inhibitors of apoptosis protein 2 (cIAP2) prevents apoptosis. Journal of Hepatology 2002;36:742-750
Dijkstra et al, Increased Expression of Inducible Nitric Oxide Synthase in Circulating Monocytes from Patients with Active Inflammatory Bowel Disease. Scand. J. Gastroenterol 2002;37:546-554
2001
Ros et al,  Induction of Mdr1b Expression by Tumor Necrosis Factor-alfa in Rat Liver Cells Is Independent of p53 but Requires Nf-kB Signaling. Hepatology 2001;33:1425-1431
Moshage, Alcoholic liver disease: a matter of hormones? Journal of Hepatology 2001;35:130-133
Olinga et al, Rat liver slices as a tool to study LPS-induced inflammatory response in the liver. Journal of Hepatology 2001;35:187-194
Heeringa et al, Renal expression of endothelial and inducible nitric oxide synthase, and formation of peroxynitrite-modified proteins and reactive oxygen species in Wegener's granulomatosis. Journal of Pathology 2001;193:224-232
Van Goor, Nitric Oxide Inhibition Enhances Platalet Aggregation in Experimental Anti-Thy-1 Nephritis. Nitric Oxide 2001;5:525-533
Svegliati-Baroni et al, Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver 2001;21:1-12
2000
Brown et al, A long-Term Hepatitis B Viremia Model Generated by Transplanting Nontumorigenic Immortalized Human Hepatocytes in Rag-2-Deficient Mice. Hepatology 2000;31:173-181
Ter Maaten et al, Insulin-mediated increases in renal plasma flow are impaired in insulin-resistent normal subjects. Eur J Clin invest 2000;30(12), 1090-1098
1999
Chen et al, New Insights into the Role of Nuclear Factor-kB, a Ubiquitous Transcription Factor in the Initiation of Diseases. Clin Chem 1999;45:1 7-17
Vos et al, Regulation of Hepatic Transport Systems Involved in Bile Secretion During Liver Regeneration in Rats. Hepatology 1999;29:1833-1839
Vos et al, Expression of Inducible Nitric Oxide Synthase in Endotozemic rat Hepatocytes Is Dependent on the Cellular Glutathione Status. Hepatology 1999;29:421-426
Rutgers et al, Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease. Thorax 1999;54:576-580
1998
Moshage et al, Determination of Nitrite and Nitrate in Stored Urine. Clin Chem 1998;44:8 1780-1781
Vos et al, Up-regulation of the Multidrug Resistance Genes, Mrp1 and Mdr1b, and Down-regulation of the Organic Anion Transporter, Mrp2, and the Bile salt transporter, Spgp, in Endotoxemic Rat Liver. Hepatology 1998;28:1637-1644
Coers et al, Specificity of Antibodies to Nitric Oxide Synthase Isoforms in Human, Guinea Pig, Rat, and Mouse Tissues. The journal of Histochemistry & Cytochemistry 1998;46(12):1385-1391
Van der Hoeven et al, Extended preservation and effect of nititrc oxide production in liver transplantation. Transpl. Int. 1998;11:S171-S173
1997
Vos et al, Differential Effects of Nitric Oxide Synthase Inhibitors on Endotoxin-Induced Liver Damage in Rats. Gastroenterology 1997;113:1323-1333
Roelofsen et al, Increased Levels of the Multidrug Resistance Protein in Lateral Membranes of Proliferating Hepatocyte-Derived Cells. Gastroenterology 1997;112:511-521
Kuipers et al, Impaired Secretion of Very Low Density Lipoprotein-Triglycerides by Apolipoprotein E-deficient Mouse Hepatocytes. J.Clin.Invest. 1997;100:2915-2922
Moshage, Cytokines and the hepatic acute phase response. Journal of Pathology 1997;181:257-266
1996
Lin et al, Bile Acids Suppress the Secretion of Very-Low-Density Lipoprotein by Human hepatocytes in Primary Culture. Hepatology 1996;23:218-228

 

  

Laatst gewijzigd:19 november 2012 16:35