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Research GBB Cell Biochemistry Publications

Publications

2020

Leemans, M., Galicia, C., Deyaert, E., Daems, E., Krause, L., Paesmans, J., ... Versées, W. (2020). Allosteric modulation of the GTPase activity of a bacterial LRRK2 homologue by conformation-specific Nanobodies. Biochemical Journal, [ BCJ20190843]. https://doi.org/10.1042/BCJ20190843

2019

Sabogal-Guáqueta, A. M., Hobbie, F., Keerthi, A., Oun, A., Kortholt, A., Boddeke, E., & Dolga, A. (2019). Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 118, [109295]. https://doi.org/10.1016/j.biopha.2019.109295
Wauters, L., Versées, W., & Kortholt, A. (2019). Roco Proteins: GTPases with a Baroque Structure and Mechanism. International Journal of Molecular Sciences, 20(1), [ijms20010147]. https://doi.org/10.3390/ijms20010147

2018

Deyaert, E., Leemans, M., Singh, R. K., Gallardo, R., Steyaert, J., Kortholt, A., ... Versées, W. (2019). Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein. Biochemical Journal, 476(1), 51-66. https://doi.org/10.1042/BCJ20180803
Wauters, L., Terheyden, S., Gilsbach, B. K., Leemans, M., Athanasopoulos, P. S., Guaitoli, G., ... Kortholt, A. (2018). Biochemical and kinetic properties of the complex Roco G-protein cycle. Biological Chemistry, 399(12), 1447-1456. https://doi.org/10.1515/hsz-2018-0227
Athanasopoulos, P. S., Heumann, R., & Kortholt, A. (2018). The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2. Biological Chemistry, 399(7), 643-647. https://doi.org/10.1515/hsz-2017-0332
van Haastert, P. J. M., Keizer-Gunnink, I., & Kortholt, A. (2018). The cytoskeleton regulates symmetry transitions in moving amoeboid cells. Journal of Cell Science, 131(7), [UNSP jcs208892]. https://doi.org/10.1242/jcs.208892

2017

Liu, Y., Lacal, J., Firtel, R. A., & Kortholt, A. (2018). Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization. Small GTPases, 9(4), 360-364. https://doi.org/10.1080/21541248.2016.1235390
Xu, X., Wen, X., Veltman, D. M., Keizer-Gunnink, I., Pots, H., Kortholt, A., & Jin, T. (2017). GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis. Proceedings of the National Academy of Sciences of the United States of America, 114(47), 10092-10101. https://doi.org/10.1073/pnas.1703208114
Deyaert, E., Wauters, L., Guaitoli, G., Konijnenberg, A., Leemans, M., Terheyden, S., ... Versées, W. (2017). A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover. Nature Communications, 8(1), 1-12. [1008]. https://doi.org/10.1038/s41467-017-01103-4
Deyaert, E., Kortholt, A., & Versées, W. (2017). The LRR-Roc-COR module of the Chlorobium tepidum Roco protein: crystallization and X-ray crystallographic analysis. Acta Crystallographica Section F: Structural Biology Communications , 73(9), 520-524. https://doi.org/10.1107/S2053230X17011955
Hilbi, H., & Kortholt, A. (2017). Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection. Small GTPases. https://doi.org/10.1080/21541248.2017.1331721
van Haastert, P. J. M., Keizer-Gunnink, I., & Kortholt, A. (2017). Coupled Excitable Ras and F-actin activation mediate spontaneous pseudopod formation and directed cell movement. Molecular Biology of the Cell, 28(7), 922-934. https://doi.org/10.1091/mbc.E16-10-0733

2016

Terheyden, S., Nederveen-Schippers, L. M., & Kortholt, A. (2016). The unconventional G-protein cycle of LRRK2 and Roco proteins. Biochemical Society Transactions, 44(6), 1611-1616. https://doi.org/10.1042/BST20160224
Guaitoli, G., Raimondi, F., Gilsbach, B. K., Gómez-Llorente, Y., Deyaert, E., Renzi, F., ... Gloeckner, C. J. (2016). Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts. Proceedings of the National Academy of Sciences of the United States of America, 113(30), E4357-E4366. https://doi.org/10.1073/pnas.1523708113
Skoge, M., Wong, E., Hamza, B., Bae, A., Martel, J., Kataria, R., ... Irimia, D. (2016). A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells. PLoS ONE, 11(6), [e0154491]. https://doi.org/10.1371/journal.pone.0154491
Khanna, A., Lotfi, P., Chavan, A. J., Montaño, N. M., Bolourani, P., Weeks, G., ... Charest, P. G. (2016). The small GTPases Ras and Rap1 bind to and control TORC2 activity. Scientific Reports, 6, 1-9. [25823]. https://doi.org/10.1038/srep25823
Kamp, M. E., Liu, Y., & Kortholt, A. (2016). Function and Regulation of Heterotrimeric G Proteins during Chemotaxis. International Journal of Molecular Sciences, 17(1), [90]. https://doi.org/10.3390/ijms17010090
Plak, K., Pots, H., Van Haastert, P. J. M., & Kortholt, A. (2016). Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells. BMC Cell Biology, 17(1), 1-8. https://doi.org/10.1186/s12860-015-0078-0
Liu, Y., Lacal, J., Veltman, D. M., Fusetti, F., van Haastert, P. J. M., Firtel, R. A., & Kortholt, A. (2016). A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis. Developmental Cell, 37(5), 458-472. https://doi.org/10.1016/j.devcel.2016.05.001
Rosenbusch, K. E., & Kortholt, A. (2016). Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease. Parkinsons disease, 2016, [ID 7351985]. https://doi.org/10.1155/2016/7351985
Postma, M., & van Haastert, P. J. M. (2016). Mathematics of Experimentally Generated Chemoattractant Gradients. Methods in Molecular Biology, 1407, 381-396. https://doi.org/10.1007/978-1-4939-3480-5_26

2015

Rudi, K., Ho, F. Y., Gilsbach, B. K., Pots, H., Wittinghofer, A., Kortholt, A., & Klare, J. P. (2015). Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations. Bioscience reports, 35(5), 1-12. [e00254]. https://doi.org/10.1042/BSR20150128
Gilsbach, B. K., Messias, A. C., Ito, G., Sattler, M., Alessi, D. R., Wittinghofer, A., & Kortholt, A. (2015). Structural Characterization of LRRK2 Inhibitors. Journal of Medicinal Chemistry, 58(9), 3751−3756. https://doi.org/10.1021/jm5018779
Wu, J., Pipathsouk, A., Keizer-Gunnink, A., Fusetti, F., Alkema, W., Liu, S., ... Weiner, O. D. (2015). Homer3 regulates the establishment of neutrophil polarity. Molecular Biology of the Cell, 26(9), 1629-1639. https://doi.org/10.1091/mbc.E14-07-1197
Terheyden, S., Ho, F. Y., Gilsbach, B. K., Wittinghofer, A., & Kortholt, A. (2015). Revisiting the Roco G-protein cycle. Biochemical Journal, 465(1), 139-147. https://doi.org/10.1042/BJ20141095

2014

Plak, K., Keizer-Gunnink, I., van Haastert, P. J. M., & Kortholt, A. (2014). Rap1-dependent pathways coordinate cytokinesis in Dictyostelium. Molecular Biology of the Cell, 25(25), 4195-4204. https://doi.org/10.1091/mbc.E14-08-1285
Gilsbach, B. K., & Kortholt, A. (2014). Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation. Frontiers in Molecular Neuroscience, 7, [32]. https://doi.org/10.3389/fnmol.2014.00032

2013

Kortholt, A., Keizer-Gunnink, I., Kataria, R., & Van Haastert, P. J. M. (2013). Ras activation and symmetry breaking during Dictyostelium chemotaxis. Journal of Cell Science, 126(19), 4502-4513. https://doi.org/10.1242/jcs.132340
Kataria, R., van Haastert, P. J. M., & Kortholt, A. (2013). Reply to Tall et al. Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis. Proceedings of the National Academy of Sciences of the United States of America, 110(34), E3149-E3149. https://doi.org/10.1073/pnas.1309837110
Kataria, R., Xu, X., Fusetti, F., Keizer-Gunnink, I., Jin, T., van Haastert, P. J. M., & Kortholt, A. (2013). Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6424-6429. https://doi.org/10.1073/pnas.1301851110
Mueller-Taubenberger, A., Kortholt, A., & Eichinger, L. (2013). Simple system - substantial share: The use of Dictyosrelium in cell biology and molecular medicine. European Journal of Cell Biology, 92(2), 45-53. https://doi.org/10.1016/j.ejcb.2012.10.003
Plak, K., Veltman, D., Fusetti, F., Beeksma, J., Rivero, F., Van Haastert, P. J. M., & Kortholt, A. (2013). GxcC connects Rap and Rac signaling during Dictyostelium development. BMC Cell Biology, 14(1), 6-1-6-9. [6]. https://doi.org/10.1186/1471-2121-14-6
Koelsch, V., Shen, Z., Lee, S., Plak, K., Lotfi, P., Chang, J., ... Firtel, R. A. (2013). Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Molecular Biology of the Cell, 24(2), 100-114. https://doi.org/10.1091/mbc.E12-04-0271
Veltman, D. M., & Van Haastert, P. J. M. (2013). Extrachromosomal inducible expression. Methods in Molecular Biology, 983, 269-281. https://doi.org/10.1007/978-1-62703-302-2_14

2012

Gilsbach, B. K., Ho, F. Y., Vetter, I. R., van Haastert, P. J. M., Wittinghofer, A., & Kortholt, A. (2012). Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proceedings of the National Academy of Sciences of the United States of America, 109(26), 10322-10327. https://doi.org/10.1073/pnas.1203223109
Kortholt, A., van Egmond, W. N., Plak, K., Bosgraaf, L., Keizer-Gunnink, I., & van Haastert, P. J. M. (2012). Multiple Regulatory Mechanisms for the Dictyostelium Roco Protein GbpC. The Journal of Biological Chemistry, 287(4), 2749-2758. https://doi.org/10.1074/jbc.M111.315739

2011

Kortholt, A., Kataria, R., Keizer-Gunnink, I., Van Egmond, W. N., Khanna, A., & Van Haastert, P. J. M. (2011). Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification. Embo Reports, 12(12), 1273-1279. https://doi.org/10.1038/embor.2011.210
Van Haastert, P. J. M. (2011). Amoeboid Cells Use Protrusions for Walking, Gliding and Swimming. PLoS ONE, 6(11), [e27532]. https://doi.org/10.1371/journal.pone.0027532
Neilson, M. P., Veltman, D. M., van Haastert, P. J. M., Webb, S. D., Mackenzie, J. A., & Insall, R. H. (2011). Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour. PLOS BIOLOGY, 9(5), [1000618]. https://doi.org/10.1371/journal.pbio.1000618
Van Haastert, P. J. M. (2011). How Cells Use Pseudopods for Persistent Movement and Navigation. Science signaling, 4(159), [6]. https://doi.org/10.1126/scisignal.2001708

2010

Kortholt, A., Bolourani, P., Rehmann, H., Keizer-Gunnink, I., Weeks, G., Wittinghofer, A., & Van Haastert, P. J. M. (2010). A Rap/Phosphatidylinositol 3-Kinase Pathway ControlsPseudopod Formation. Molecular Biology of the Cell, 21(6), 936-945. https://doi.org/10.1091/mbc.E09-03-0177
Van Haastert, P. J. M. (2010). A Stochastic Model for Chemotaxis Based on the Ordered Extension of Pseudopods. Biophysical Journal, 99(10), 3345-3354. https://doi.org/10.1016/j.bpj.2010.09.042
Van Haastert, P. J. M. (2010). Chemotaxis: insights from the extending pseudopod. Journal of Cell Science, 123(18), 3031-3037. https://doi.org/10.1242/jcs.071118
Van Haastert, P. J. M. (2010). A Model for a Correlated Random Walk Based on the Ordered Extension of Pseudopodia. PLoS Computational Biology, 6(8), [e1000874]. https://doi.org/10.1371/journal.pcbi.1000874
van Egmond, W. N., & van Haastert, P. J. M. (2010). Characterization of the Roco Protein Family in Dictyostelium discoideum. Eukaryotic Cell, 9(5), 751-761. https://doi.org/10.1128/EC.00366-09
Araki, T., van Egmond, W. N., van Haastert, P. J. M., & Williams, J. G. (2010). Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling. Journal of Cell Science, 123(6), 837-841. https://doi.org/10.1242/jcs.064436
Bosgraaf, L., & Van Haastert, P. J. M. (2010). Quimp3, an automated pseudopod-tracking algorithm. Cell Adhesion & Migration, 4(1), 46-55. https://doi.org/10.4161/cam.4.1.9953

2009

Kortholt, A. (2009). Chemotaxis: a complex netwerk of interconnecting signalling pathways and amplification loops. [S.n.].
Bosgraaf, L., & Van Haastert, P. J. M. (2009). Navigation of Chemotactic Cells by Parallel Signaling to Pseudopod Persistence and Orientation. PLoS ONE, 4(8), [6842]. https://doi.org/10.1371/journal.pone.0006842
Van Haastert, P. J. M., & Bosgraaf, L. (2009). Food Searching Strategy of Amoeboid Cells by Starvation Induced Run Length Extension. PLoS ONE, 4(8), [6814]. https://doi.org/10.1371/journal.pone.0006814
Van Haastert, P. J. M., & Bosgraaf, L. (2009). The local cell curvature guides pseudopodia towards chemoattractants. HFSP Journal, 3(4), 282-286. https://doi.org/10.2976/1.3185725
Bosgraaf, L., & Van Haastert, P. J. M. (2009). The Ordered Extension of Pseudopodia by Amoeboid Cells in the Absence of External Cues. PLoS ONE, 4(4), [5253]. https://doi.org/10.1371/journal.pone.0005253
Sato, M. J., Kuwayama, H., van Egmond, W. N., Takayama, A. L. K., Takagi, H., van Haastert, P. J. M., ... Ueda, M. (2009). Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proceedings of the National Academy of Sciences of the United States of America, 106(16), 6667-6672. https://doi.org/10.1073/pnas.0809974106
Veltman, D. M., Akar, G., Bosgraaf, L., & Van Haastert, P. J. M. (2009). A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum. Plasmid, 61(2), 110-118. https://doi.org/10.1016/j.plasmid.2008.11.003
Veltman, D. M., Keizer-Gunnink, I., & Van Haastert, P. J. M. (2009). An extrachromosomal, inducible expression system for Dictyostelium discoideum. Plasmid, 61(2), 119-125. https://doi.org/10.1016/j.plasmid.2008.11.002
Bosgraaf, L., van Haastert, P. J. M., & Bretschneider, T. (2009). Analysis of Cell Movement by Simultaneous Quantification of Local Membrane Displacement and Fluorescent Intensities Using Quimp2. Cell Motility and the Cytoskeleton, 66(3), 156-165. https://doi.org/10.1002/cm.20338

2008

Gotthardt, K., Weyand, M., Kortholt, A., Van Haastert, P. J. M., & Wittinghofer, A. (2008). Structure of the Roc-COR domain tandem of C-tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO Journal, 27(16), 2239-2249. https://doi.org/10.1038/emboj.2008.150
Kortholt, A., & van Haastert, P. J. M. (2008). Highlighting the role of Ras and Rap during Dictyostelium chemotaxis. Cellular Signalling, 20(8), 1415-1422. https://doi.org/10.1016/j.cellsig.2008.02.006
Egmond, W. N. V., Kortholt, A., Plak, K., Bosgraaf, L., Bosgraaf, S., Keizer-Gunnink, I., & Haastert, P. J. M. V. (2008). Intramolecular Activation Mechanism of the Dictyostelium LRRK2 Homolog Roco Protein GbpC. The Journal of Biological Chemistry, 283(44). https://doi.org/10.1074/jbc.M804265200
Bosgraaf, L., Keizer-Gunnink, I., & van Haastert, P. J. M. (2008). PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients. Journal of Cell Science, 121(21), 3589-3597. https://doi.org/10.1242/jcs.031781
Marin, I., van Egmond, W. N., & van Haastert, P. J. M. (2008). The Roco protein family: a functional perspective. The FASEB Journal, 22(9), 3103-3110. https://doi.org/10.1096/fj.08-111310
Veltman, D. M., Keizer-Gunnink, I., & Van Haastert, P. J. M. (2008). Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum. Journal of Cell Biology, 180(4), 747-753. https://doi.org/10.1083/jcb.200709180
Veltman, D. M., & van Haastert, P. J. M. (2008). The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming. Journal of Cell Science, 121(1), 120-127. https://doi.org/10.1242/jcs.015602

2007

Kortholt, A., King, J. S., Keizer-Gunnink, I., Harwood, A. J., & Van Haastert, P. J. M. (2007). Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis. Molecular Biology of the Cell, 18(12), 4772-4779. https://doi.org/10.1091/mbc.E07-05-0407
van Haastert, P. J. M., Keizer-Gunnink, I., & Kortholt, A. (2007). Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. Journal of Cell Biology, 177(5), 809-816. https://doi.org/10.1083/jcb.200701134
Keizer-Gunnink, I., Kortholt, A., & Van Haastert, P. J. M. (2007). Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling. Journal of Cell Biology, 177(4), 579-585. https://doi.org/10.1083/jcb.200611046
Kae, H., Kortholt, A., Rehmann, H., Insall, R., Van Haastert, P. J. M., Spiegelman, G. B., & Weeks, G. (2007). Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. Embo Reports, 8(5), 477-482. https://doi.org/10.1038/sj.embor.7400936
Loovers, H. M., Kortholt, A., de Groote, H., Whitty, L., Nussbaum, R. L., & van Haastert, P. J. M. (2007). Regulation of phagocytosis in Dictyostelium by the inositol 5-phosphatase OCRL homolog Dd5P4. Traffic, 8(5), 618 - 628. https://doi.org/10.1111/j.1600-0854.2007.00546.x
Bader, S., Kortholt, A., & van Haastert, P. J. M. (2007). Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP. Biochemical Journal, 402(1), 153 - 161. https://doi.org/10.1042/BJ20061153
van Haastert, P. J. M., & Postma, M. (2007). Biased random walk by Stochastic fluctuations of chemoattractant-receptor interactions at the lower limit of detection. Biophysical Journal, 93(5), 1787-1796. https://doi.org/10.1529/biophysj.107.104356

2006

Kortholt, A., Rehmann, H., Kae, H., Bosgraaf, L., Keizer-Gunnink, I., Weeks, G., ... Haastert, P. J. M. V. (2006). Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum. The Journal of Biological Chemistry, 281(33), 23367 - 23376. https://doi.org/10.1074/jbc.M600804200
Bader, S., Kortholt, A., Snippe, H., & van Haastert, P. J. M. (2006). DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of dictyostelium cells. The Journal of Biological Chemistry, 281(29), 20018 - 20026. https://doi.org/10.1074/jbc.M600040200
Veltman, D. M., & van Haastert, P. J. M. (2006). Guanylyl cyclase protein and cGMP product independently control front and back of chemotaxing Dictyostelium cells. Molecular Biology of the Cell, 17(9), 3921 - 3929. https://doi.org/10.1091/mbc.E06-05-0381
Loovers, H., Postma, M., Keizer-Gunnink, I., Huang, Y. E., Devreotes, P. N., & Haastert, P. J. M. V. (2006). Distinct Roles of PI(3,4,5)P3 during Chemoattractant Signaling in Dictyostelium: A Quantitative In Vivo Analysis by Inhibition of PI3-Kinase. Molecular Biology of the Cell, 17(4), 1503-1513. https://doi.org/10.1091/mbc.E05-09-0825
Engel, R., van Haastert, P. J. M., & Visser, A. J. W. G. (2006). Spectral characterization of Dictyostelium autofluorescence. Microscopy Research and Technique, 69(3), 168-174. https://doi.org/10.1002/jemt.20282
van Haastert, P. J. M. (2006). Analysis of Signal Transduction: Formation of cAMP, cGMP, and Ins(1,4,5)P3 In Vivo and In Vitro. In L. Eichinger, & F. Rivero (Eds.), Dictyostelium discoideum Protocols (pp. 369 - 392). (Methods in Molecular Biology; No. IV). Springer.
Goldberg, J. M., Wolpin, E. S., Bosgraaf, L., Clarkson, B. K., van Haastert, P. J. M., & Smith, J. L. (2006). Myosin light chain kinase A is activated by cGMP-dependent and cGMP-independent pathways. FEBS Letters, 580(8), 2059 - 2064. https://doi.org/10.1016/j.febslet.2006.03.008
Bosgraaf, L., & van Haastert, P. J. M. (2006). The regulation of myosin II in Dictyostelium. European Journal of Cell Biology, 85(9-10), 969 - 979. https://doi.org/10.1016/j.ejcb.2006.04.004

2003

Blaauw, M., Knol, JC., Kortholt, A., Roelofs, J., Ruchira, N. V., Postma, M., ... Visser, A. J. W. G. (2003). Phosducin-like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins. EMBO Journal, 22(19), 5047-5057. https://doi.org/10.1093/emboj/cdg508
Postma, M., Roelofs, J., Goedhart, J., Gadella, TWJ., Visser, AJWG., Van Haastert, PJM., ... Visser, A. J. W. G. (2003). Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia. Molecular Biology of the Cell, 14(12), 5019-5027. https://doi.org/10.1091/mbc.E03-08-0566
Veltman, DM., De Boer, JS., Van Haastert, PJM., & Boer, J. S. D. (2003). Chemoattractant-stimulated calcium influx in Dictyostelium discoideum does not depend on cGMP. Biochimica et Biophysica Acta-General Subjects, 1623(2-3), 129-134. https://doi.org/10.1016/j.bbagen.2003.08.006
Veltman, D., & Van Haastert, PJM. (2003). Regulation of Dictyostelium guanylyl cyclases. Protist, 154(1), 33-42. https://doi.org/10.1078/143446103764928477
Roelofs, J., Smith, J. L., & Haastert, P. J. M. V. (2003). cGMP signalling: different ways to create a pathway. Trends in Genetics, 19(3), 132-134. https://doi.org/10.1016/S0168-9525(02)00044-6
Loovers, HM., Veenstra, K., Snippe, H., Pesesse, N. V., Erneux, C., van Haastert, PJM., ... Pesesse, X. (2003). A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum. The Journal of Biological Chemistry, 278(8), 5652-5658. https://doi.org/10.1074/jbc.M208396200
Bosgraaf, L., & Haastert, P. J. M. V. (2003). Roc, a Ras/GTPase domain in complex proteins. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1643(1), 5 - 10. https://doi.org/10.1016/j.bbamcr.2003.08.008

2005

Bukharova, T., Weijer, G., Bosgraaf, L., Dormann, D., van Haastert, P. J., & Weijer, C. J. (2005). Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development (vol 118, pg 4295, 2005). Journal of Cell Science, 118(18), 4295 - 4310. https://doi.org/10.1242/jcs.02557
Knol, J., Engel, R., Blaauw, M., Visser, A. J. W. G., & Haastert, P. J. M. V. (2005). The Phosducin-Like Protein PhLP1 Is Essential for Gβγ Dimer Formation in Dictyostelium discoideum. Molecular and Cellular Biology, 25(18), 8393-8400. https://doi.org/10.1128/MCB.25.18.8393-8400.2005
Bosgraaf, L., Waijer, A., Engel, R., Visser, A. J. W. G., Wessels, D., Soll, D., & van Haastert, P. J. M. (2005). RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium. Journal of Cell Science, 118(9), 1899-1910. https://doi.org/10.1242/jcs.02317
Veltman, D. M., Roelofs, J., Engel, R., Visser, A. J. W. G., & Haastert, P. J. M. V. (2005). Activation of soluble guanylyl cyclase at the leading edge during Dictyostelium chemotaxis. Molecular Biology of the Cell, 16(2), 976 - 983. https://doi.org/10.1091/mbc.E04-08-0701

2004

Postma, M., Roelofs, J., Goedhart, J., Loovers, H. M., Visser, A. J. W. G., & van Haastert, P. J. M. (2004). Sensitization of Dictyostelium chemotaxis by phosphoinositide-3-kinase-mediated self-organizing signalling patches. Journal of Cell Science, 117(14), 2925-2935. https://doi.org/10.1242/jcs.01143
Lu, Y. H., Knol, J. C., Linskens, M. H. K., Friehs, K., van Haastert, P. J. M., & Flaschel, E. (2004). Production of the soluble human Fas ligand by Dictyostelium discoideum cultivated on a synthetic medium. Journal of Biotechnology, 108(3), 243-251. https://doi.org/10.1016/j.jbiotec.2003.12.006
Haastert, P. J. M. V., & Devreotes, P. N. (2004). Chemotaxis: signalling modules join hands at front and tail. Nature Reviews Molecular Cell Biology, 5(8), 626 - 634. https://doi.org/10.1038/sj.embor.7400051
Lu, Y. H., Knol, J. C., Linskens, M. H. K., Friehs, K., van Haastert, P. J. M., & Flaschel, E. (2004). Cultivation of immobilized Dictyostelium discoideum for the production of soluble human Fas ligand. Applied Microbiology and Biotechnology, 65(5), 547 - 552. https://doi.org/10.1007/s00253-004-1620-8
Verheijden, G. F. M., Metz, B., van Ravestein, A. A. M., Bos, E. S., van de Wetering, R., Westerveld, A., ... van Peij, NN. (2004). Human gonadotropins expressed in dictyostelium discoideum. Biology of Reproduction, 177 - 177.
Engel, R., Hink, M. A., Bosgraaf, L., Haastert, P. J. M. V., & Visser, A. J. W. G. (2004). Pleckstrin Homology Domain Diffusion in Dictyostelium Cytoplasm Studied Using Fluorescence Correlation Spectroscopy. The Journal of Biological Chemistry, 279(11), 10013-10019. https://doi.org/10.1074/jbc.M310039200
Veltman, D. M., Bosgraaf, L., & van Haastert, P. J. M. (2004). Unusual guanylyl cyclases and cGMP signaling in Dictyostelium discoideum. Vitamins and Hormones - Advances in Research and Applications, 69, 95-115.

2002

Roelofs, J., & Haastert, P. J. M. V. (2002). Deducing the origin of soluble adenylyl cyclase, a gene lost in multiple lineages. Molecular Biology and Evolution, 19(12), 2239-2246. https://doi.org/10.1093/oxfordjournals.molbev.a004047
Bosgraaf, L., Russcher, H., Snippe, H., Bader, S., Wind, J., & Van Haastert, PJM. (2002). Identification and characterization of two unusual cGMP-stimulated phoshodiesterases in Dictyostelium. Molecular Biology of the Cell, 13(11), 3878-3889. https://doi.org/10.1091/mbc.E02-05-0302
Bosgraaf, L., Russcher, H., Smith, J. L., Wessels, D., Soll, D. R., & Haastert, P. J. M. V. (2002). A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium. The EMBO Journal, 21(17), 4560-4570. https://doi.org/10.1093/emboj/cdf438
Goldberg, JM., Bosgraaf, L., Van Haastert, PJM., & Smith, JL. (2002). Identification of four candidate cGMP targets in Dictylostelium. Proceedings of the National Academy of Sciences of the United States of America, 99(10), 6749-6754. https://doi.org/10.1073/pnas.102167299
Roelofs, J., & Haastert, P. J. M. V. (2002). Characterization of two unusual guanylyl cyclases from Dictyostelium. The Journal of Biological Chemistry, 277(11), 9167-9174. https://doi.org/10.1074/jbc.M111437200
Bosgraaf, L., & Haastert, P. J. M. V. (2002). A model for cGMP signal transduction in Dictyostelium in perspective of 25 years of cGMP research. Journal of muscle research and cell motility, 23(7-8), 781-791.

2001

Dijken, P. V., & Haastert, P. J. M. V. (2001). Phospholipase Cδ regulates germination of Dictyostelium spores. BMC Cell Biology, 2, [25]. https://doi.org/10.1186/1471-2121-2-25
Roelofs, J., Loovers, H., & Van Haastert, PJM. (2001). GTPγS Regulation of a 12-Transmembrane Guanylyl Cyclase Is Retained after Mutation to an Adenylyl Cyclase. The Journal of Biological Chemistry, 276(44), 40740-40745. https://doi.org/10.1074/jbc.M105154200
Postma, M., & Van Haastert, PJM. (2001). A diffusion-translocation model for gradient sensing by chemotactic cells. Biophysical Journal, 81(3), 1314-1323. https://doi.org/10.1016/S0006-3495(01)75788-8
Roelofs, J., Meima, M., Schaap, P., & Van Haastert, PJM. (2001). The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase. EMBO Journal, 20(16), 4341-4348. https://doi.org/10.1093/emboj/20.16.4341
Roelofs, J., & Van Haastert, PJM. (2001). Genomics: Genes lost during evolution. Nature, 411(6841), 1013-1014. https://doi.org/10.1038/35082627
Roelofs, J., Snippe, H., Kleineidam, RG., & Van Haastert, PJM. (2001). Guanylate cyclase in Dictyostelium discoideum with the topology of mammalian adenylate cyclase. Biochemical Journal, 354(3), 697-706. https://doi.org/10.1042/0264-6021:3540697
Kuwayama, H., Snippe, H., Derks, M., Roelofs, J., & van Haastert, PJM. (2001). Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium. Biochemical Journal, 353(3), 635-644. https://doi.org/10.1042/0264-6021:3530635
Potma, E. O., Boeij, W. P. D., Haastert, P. J. M. V., & Wiersma, D. A. (2001). Real-time visualization of intracellular hydrodynamics in single living cells. Proceedings of the National Academy of Sciences, 98(4), 1577 - 1582. https://doi.org/10.1073/pnas.98.4.1577
Potma, E. O., de Boeij, W. P., Bosgraaf, L., Roelofs, J., van Haastert, P. J. M., & Wiersma, D. A. (2001). Reduced protein diffusion rate by cytoskeleton in vegetative and polarized Dictyostelium cells. Biophysical Journal, 81(4), 2010 - 2019. https://doi.org/10.1016/S0006-3495(01)75851-1

2000

Blaauw, M., Linskens, MHK., & van Haastert, PJM. (2000). Efficient control of gene expression by a tetracycline-dependent transactivator in single Dictyostelium discoideum cells. Gene, 252(1-2), 71-82. https://doi.org/10.1016/S0378-1119(00)00227-4
Vervoort, E. B., Ravestein, A. V., Peij , van, N., Heikoop, J. C., Haastert, van, P. J. M., Verheijden, G. F., & Linskens, M. H. K. (2000). Optimizing heterologous expression in Dictyostelium: importance of 5 ' codon adaptation. Nucleic Acids Research, 28(10), 2069-2074. https://doi.org/10.1093/nar/28.10.2069

1999

Linskens, M. H. K., Grootenhuis, P. D. J., Blaauw, M., Huisman-de Winkel, B., Ravestein, A. V., Haastert, P. J. M. V., & Heikoop, J. C. (1999). Random mutagenesis and screening of complex glycoproteins: expression of human gonadotropins in Dictyostelium discoideum. European Journal of Biochemistry, 256(6), 639-645.
Van Haastert, PJM., & Van Dijken, P. (1999). Biochemistry and genetics of inositol phosphate metabolism in Dictyostelium. In JP. Thiery (Ed.), MOLECULAR MECHANISMS OF TRANSCELLULAR SIGNALING (pp. 75-84). (NATO ADVANCED SCIENCE INSTITUTES SERIES, SERIES A, LIFE SCIENCES; Vol. 309). AMSTERDAM: I O S PRESS.
Van Haastert, PJM., Roelofs, J., & Kuwayama, H. (1999). CGMP as second messenger during Dictyostelium chemotaxis. In JP. Thiery (Ed.), MOLECULAR MECHANISMS OF TRANSCELLULAR SIGNALING (pp. 134-141). (NATO ADVANCED SCIENCE INSTITUTES SERIES, SERIES A, LIFE SCIENCES; Vol. 309). AMSTERDAM: I O S PRESS.

1998

Heikoop, JC., Grootenhuis, PDJ., Blaauw, M., Veldema, JS., Van Haastert', PJM., Linskens, MHK., ... Veldema, J. S. (1998). Expression of a bioactive, single-chain choriogonadotropin in Dictyostelium discoideum. European Journal of Biochemistry, 256(2), 359-363. https://doi.org/10.1046/j.1432-1327.1998.2560359.x
Otsuka, H., & Haastert, P. J. M. V. (1998). A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression. Genes & Development, 12(11), 1738-1748. https://doi.org/10.1101/gad.12.11.1738
Kuwayama, H., & van Haastert, P. J. M. (1998). Chemotactic and osmotic signals share acGMP transduction pathway in Dictyostelium discoideum. FEBS Letters, 424(3), 248-252. https://doi.org/10.1016/S0014-5793(98)00183-5
Kuwayama, H., & Haastert, P. J. M. V. (1998). cGMP potentiates receptor-stimulated Ca2+ influx in Dictyostelium discoideum. Biochimica et Biophysica Acta-Molecular Cell Research, 1402(1), 102 - 108. https://doi.org/10.1016/S0167-4889(97)00142-0

1997

Kim, JY., Soede, RDM., Schaap, P., Valkema, R., Borleis, JA., VanHaastert, PJM., ... Devreotes, P. N. (1997). Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses. The Journal of Biological Chemistry, 272(43), 27313-27318. https://doi.org/10.1074/jbc.272.43.27313
vanHaastert, PJM., & van Dijken, P. (1997). Biochemistry and genetics of inositol phosphate metabolism in Dictyostelium. FEBS Letters, 410(1), 39-43. https://doi.org/10.1016/S0014-5793(97)00415-8
vanHaastert, PJM., & Kuwayama, H. (1997). CGMP as second messenger during Dictyostelium chemotaxis. FEBS Letters, 410(1), 25-28. https://doi.org/10.1016/S0014-5793(97)00416-X
van Dijken, P., Bergsma, J. C. T., & Haastert, P. J. M. V. (1997). Phospholipase-C-independent inositol 1,4,5-trisphosphate formation in Dictyostelium cells: Activation of a plasma-membrane-bound phosphatase by receptor-stimulated Ca2+ influx. European Journal of Biochemistry, 244(1), 113-119. https://doi.org/10.1111/j.1432-1033.1997.00113.x

1996

Kuwayama, H., & VanHaastert, PJM. (1996). Regulation of guanylyl cyclase by a cGMP-binding protein during chemotaxis in Dictyostelium discoideum. The Journal of Biological Chemistry, 271(39), 23718-23724. https://doi.org/10.1074/jbc.271.39.23718
VanHaastert, P. J., Bishop, J. D., & Gomer, R. H. (1996). The cell density factor CMF regulates the chemoattractant receptor cAR1 in Dictyostelium. Journal of Cell Biology, 134(6), 1543-1549. https://doi.org/10.1083/jcb.134.6.1543
Kim, J-Y., Haastert, P. V., & Devreotes, P. N. (1996). Social senses: G-protein-coupled receptor signaling pathways in Dictyostelium discoideum. Chemistry & Biology, 3(4), 239-243. https://doi.org/10.1016/S1074-5521(96)90103-9
Dijken, P. V., Bergsma, J. C. T., Hiemstra, H. S., Vries, B. D., Kaay, J. V. D., & Haastert, P. J. M. V. (1996). Dictyostelium discoideum contains three inositol monophosphatase activities with different substrate specificities and sensitivities to lithium. Biochemical Journal, 314, 491-495.
Kuwayama, H., Ecke, M., Gerisch, G., & VanHaastert, PJM. (1996). Protection against osmotic stress by cGMP-mediated myosin phosphorylation. Science, 271(5246), 207-209. https://doi.org/10.1126/science.271.5246.207

1995

Dijken, P. V., Haas, J-R. D., Craxton, A., Erneux, C., Shears, S. B., & Haastert, P. J. M. V. (1995). A Novel, Phospholipase C-independent Pathway of Inositol 1,4,5-Trisphosphate Formation in Dictyostelium and Rat Liver. The Journal of Biological Chemistry, 270(50), 29724-29731. https://doi.org/10.1074/jbc.270.50.29724
Kaay, J. V. D., Wesseling, J., & Haastert, P. J. M. V. (1995). Nucleus-associated phosphorylation of Ins(1,4,5)P3 to InsP6 in Dictyostelium. Biochemical Journal, 312, 911-917.
Kaay, J. V. D., & Haastert, P. J. M. V. (1995). Stereospecificity of inositol hexakisphosphate dephosphorylation by Paramecium phytase. Biochemical Journal, 312, 907-910.
VanHaastert, PJM. (1995). Transduction of the chemotactic cAMP signal across the plasma membrane of Dictyostelium cells. Experientia, 51(12), 1144-1154. https://doi.org/10.1007/BF01944732
Drayer, A. L., Meima, M. E., Derks, M. W. M., Tuik, R., & Haastert, P. J. M. V. (1995). Mutation of an EF-hand Ca2+-binding motif in phospholipase C of Dictyostelium discoideum: Inhibition of activity but no effect on Ca2+-dependence. Biochemical Journal, 311, 505-510.
Kuwayama, H., Viel, G. T., Ishida, S., & Haastert, P. J. M. V. (1995). Aberrant cGMP-binding activity in non-chemotactic Dictyostelium discoideum mutants. Biochimica et Biophysica Acta-Molecular Cell Research, 1268(2), 214-220. https://doi.org/10.1016/0167-4889(95)00082-4
Yuen, I. S., Jain, R., Bishop, J. D., Lindsey, D. F., Deery, W. J., van Haastert, P. J. M., & Gomer, R. H. (1995). A Density-sensing Factor Regulates Signal Transduction in Dictyostelium. The Journal of Cell Biology, 129(5), 1251-1262. https://doi.org/10.1083/jcb.129.5.1251
Wu, L., Valkema, R., van Haastert, P. J. M., & Devreotes, P. N. (1995). The G Protein β Subunit Is Essential for Multiple Responses to Chemoattractants in Dictyostelium. The Journal of Cell Biology, 129(6), 1667-1675. https://doi.org/10.1083/jcb.129.6.1667
van Dijken, P., Lammers, A. A., & van Haastert, P. (1995). In Dictyostelium discoideum inositol 1,3,4,5-tetrakisphosphate is dephosphorylated by a 3-phosphatase and a 1-phosphatase. Biochemical Journal, 308, 127-130.
Vanderkaay, J., & VANHAASTERT, PJ. (1995). DESALTING INOSITOLPOLYPHOSPHATES BY DIALYSIS. Analytical Biochemistry, 225(1), 183-185. https://doi.org/10.1006/abio.1995.1135

1994

Dijken, P. V., Lammers, A. A., Ozaki, S., Potter, B. V. L., Erneux, C., & Haastert, P. J. M. V. (1994). Phosphorylation of inositol 1,4,5-trisphosphate analogues by 3-kinase and dephosphorylation of inositol 1,3,4,5-tetrakisphosphate analogues by 5-phosphatase. European Journal of Biochemistry, 226(2), 561-566. https://doi.org/10.1111/j.1432-1033.1994.tb20081.x
Drayer, A. L., & Haastert, P. J. M. V. (1994). Transmembrane signalling in eukaryotes: A comparison between higher and lower eukaryotes. Plant Molecular Biology, 26(5), 1239-1270. https://doi.org/10.1007/BF00016473
Haastert, P. J. M. V. (1994). Intracellular adenosine 3',5'-phosphate formation is essential for down-regulation of surface adenosine 3',5'-phosphate receptors in Dictyostelium. Biochemical Journal, 303, 539-545.
Valkema, R., & Haastert, P. J. M. V. (1994). A Model for cAMP-mediated cGMP Response in Dictyostelium discoideum. Molecular Biology of the Cell, 5(5), 575-585. https://doi.org/10.1091/mbc.5.5.575
Drayer, A. L., Kaay, J. V. D., Mayr, G. W., & Haastert, P. J. M. V. (1994). Role of phospholipase C in Dictyostelium: Formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity. EMBO Journal, 13(7), 1601-1609.
Bominaar, A. A., Kesbeke, F., & Haastert, P. J. M. V. (1994). Phospholipase C in Dictyostelium discoideum: Cyclic AMP surface receptor and G-protein-regulated activity in vitro. Biochemical Journal, 297, 181-187.
Bominaar, A. A., & Haastert, P. J. M. V. (1994). Phospholipase C in Dictyostelium discoideum: Identification of stimulatory and Inhibitory surface receptors and G-proteins. Biochemical Journal, 297, 189-193.
Klerk, H., Himbergen, J. A. J. V., Musgrave, A., Haastert, P. J. M. V., & Ende, H. V. D. (1994). Dephosphorylation Pathway of D-myo-Inositol 1,4,5-trisphosphate in the Unicellular Green Alga Chlamydomonas eugametos. Phytochemistry, 35(2), 349-352. https://doi.org/10.1016/S0031-9422(00)94762-9
SNAARJAGALSKA, BE., & VANHAASTERT, PJM. (1994). G-PROTEIN ASSAYS IN DICTYOSTELIUM. In HETEROTRIMERIC G PROTEINS (pp. 387-408). (METHODS IN ENZYMOLOGY; Vol. 237). SAN DIEGO: Academic Press.
BOMINAAR, AA., & VANHAASTERT, PJM. (1994). PHOSPHOLIPASE-C ACTIVITY IN DICTYOSTELIUM-DISCOIDEUM USING ENDOGENOUS NONRADIOACTIVE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE AS SUBSTRATE. In HETEROTRIMERIC G-PROTEIN EFFECTORS (pp. 207-218). (METHODS IN ENZYMOLOGY; Vol. 238). SAN DIEGO: Academic Press.

1993

Kuwayama, H., Ishida, S., & van Haastert, P. J. M. (1993). Non-Chemotactic Dictyostelium discoideum Mutants with Altered cGMP Signal Transduction. The Journal of Cell Biology, 123(6), 1453-1462. https://doi.org/10.1083/jcb.123.6.1453
Bominaar, A. A., Molijn, A. C., Pestel, M., Veron, M., & Haastert, P. J. M. V. (1993). ACTIVATION OF G-PROTEINS BY RECEPTOR-STIMULATED NUCLEOSIDE DIPHOSPHATE KINASE IN DICTYOSTELIUM. EMBO Journal, 12(6), 2275-2279.
Bominaar, A. A., & van Haastert, P. J. M. (1993). Chemotactic antagonists of cAMP inhibit Dictyostelium phospholipase C. Journal of Cell Science, 104, 181-185.
Schaap, P., Ments-Cohen, M. V., Soede, R. D. M., Brandt, R., Firtel, R. A., Dostmann, W., ... Haastert, P. J. M. V. (1993). Cell-permeable Non-hydrolyzable cAMP Derivatives as Tools for Analysis of Signaling Pathways Controlling Gene Regulation in Dictyostelium. Default journal.

1992

Peters, D. J. M., Snaar-Jagalska, B. E., Haastert, P. J. M. V., & Schaap, P. (1992). Lithium, an inhibitor of cAMP-induced inositol 1,4,5-trisphosphate accumulation in Dictyostelium discoideum, inhibits activation of guanine-nucleotide-binding regulatory proteins, reduces activation of adenylylcyclase, but potentiates activation of guanyl. European Journal of Biochemistry, 209(1), 299-304. https://doi.org/10.1111/j.1432-1033.1992.tb17289.x
Drayer, A. L., & Haastert, P. J. M. V. (1992). Molecular Cloning and Expression of a Phosphoinositide-specific Phospholipase C of Dictyostelium discoideum. The Journal of Biological Chemistry, 267(26), 18387-18392.
van Duijn, B., & van Haastert, P. J. M. (1992). Independent control of locomotion and orientation during Dictyostelium discoideum chemotaxis. Journal of Cell Science, 102, 763-768.
Valkema, R., & Haastert, P. J. M. V. (1992). Inhibition of Receptor-Stimulated Guanylyl Cyclase by Intracellular Calcium Ions in Dictyostelium Cells. Biochemical and Biophysical Research Communications, 186(1), 263-268. https://doi.org/10.1016/S0006-291X(05)80802-2
Haastert, P. J. M. V., Wang, M., Bominaar, A. A., Devreotes, P. N., & Schaap, P. (1992). cAMP-Induced Desensitization of Surface cAMP Receptors in Dictyostelium: Different Second Messengers Mediate Receptor Phosphorylation, Loss of Ligand Binding, Degradation of Receptor, and Reduction of Receptor mRNA Levels. Molecular Biology of the Cell, 3(6), 603-612. https://doi.org/10.1091/mbc.3.6.603
Johnson, R. L., Haastert, P. J. M. V., Kimmel, A. R., Saxe III, C. L., Jastorff, B., & Devreotes, P. N. (1992). The Cyclic Nucleotide Specificity of Three cAMP Receptors in Dictyostelium. The Journal of Biological Chemistry, 267(7), 4600-4607.

1991

Bominaar, A. A., Kesbeke, F., Snaar- Jagalska, B. E., Peters, D. J. M., Schaap, P., & van Haastert, P. J. M. (1991). Abberant chemotaxis and differentiation in Dictyostelium mutant fgdC with a defective regulation of receptor-stimulated phosphoinositidase C. Journal of Cell Science, 100, 825-831.
Peters, D. J. M., Bominaar, A. A., Snaar-Jagalska, B. E., Brandt, R., Haastert, P. J. M. V., Ceccarelli, A., ... Schaap, P. (1991). Selective induction of gene expression and second-messenger accumulation in Dictyostelium discoideum by the partial chemotactic antagonist 8-p-chlorophenylthioadenosine 3',5'-cyclic monophosphate. Proceedings of the National Academy of Sciences, 88(20), 9219-9223. https://doi.org/10.1073/pnas.88.20.9219
Johnson, R. L., Vaughan, R. A., Caterina, M. J., Haastert, P. J. M. V., & Devreotes, P. N. (1991). Overexpression of the cAMP Receptor 1 in Growing Dictyostelium Cells. Biochemistry, 30(28), 6982-6986. https://doi.org/10.1021/bi00242a025
Ments-Cohen, M. V., Genieser, H-G., Jastorff, B., Haastert, P. J. M. V., & Schaap, P. (1991). Kinetics and nucleotide specificity of a surface cAMP binding site in Dictyostelium discoideum, which is not down-regulated by cAMP. FEMS Microbiology Letters, 82(1), 9-14. https://doi.org/10.1111/j.1574-6968.1991.tb04831.x
Snaar-Jagalska, B. E., Es, S. V., Kesbeke, F., & Haastert, P. J. M. V. (1991). Activation of a pertussis-toxin-sensitive guanine-nucleotide-binding regulatory protein during desensitization of Dictyostelium discoideum cells to chemotactic signals. European Journal of Biochemistry, 195(3), 715-721. https://doi.org/10.1111/j.1432-1033.1991.tb15758.x
Bominaar, A. A., Dijken, P. V., Draijer, R., & Haastert, P. J. M. V. (1991). Developmental regulation of the Inositol 1,4,5-trisphosphate phosphatases in Dictyostelium discoideum. Differentiation, 46(1), 1-5. https://doi.org/10.1111/j.1432-0436.1991.tb00859.x
BOMINAAR, AA., VANDERKAAY, J., & VANHAASTERT, PJM. (1991). DYNAMICS AND FUNCTION OF THE INOSITOLCYCLE IN DICTYOSTELIUM-DISCOIDEUM. Developmental genetics, 12(1-2), 19-24.
Haastert, P. J. M. V., Janssens, P. M. W., & Erneux, C. (1991). Sensory transduction in eukaryotes: A comparison between Dictyosteliurn and vertebrate cells. European Journal of Biochemistry, 195(2), 289-303. https://doi.org/10.1111/j.1432-1033.1991.tb15706.x
VANHAASTERT, PJM. (1991). TRANSMEMBRANE SIGNAL TRANSDUCTION PATHWAYS IN DICTYOSTELIUM. Advances in second messenger and phosphoprotein research, 23, 185-226.

1990

Kaay, J. V. D., Draijer, R., & Haastert, P. J. M. V. (1990). Increased conversion of phosphatidylinositol to phosphatidylinositol phosphate in Dictyostelium cells expressing a mutated ras gene. Proceedings of the National Academy of Sciences of the United States of America, 87(23), 9197-9201. https://doi.org/10.1073/pnas.87.23.9197
NIBBERING, PH., ZOMERDIJK, TPL., VANHAASTERT, PJM., & VANFURTH, R. (1990). A COMPETITION BINDING ASSAY FOR DETERMINATION OF THE INOSITOL (1,4,5)-TRISPHOSPHATE CONTENT OF HUMAN-LEUKOCYTES. Biochemical and Biophysical Research Communications, 170(2), 755-762.
Sun, T. J., van Haastert, P. J. M., & Devreotes, P. N. (1990). Surface cAMP Receptors Mediate Multiple Responses during Development in Dictyostelium: Evidenced by Antisense Mutagenesis. The Journal of Cell Biology, 110(5), 1549-1554. https://doi.org/10.1083/jcb.110.5.1549
Nibbering, P. H., Zomerdijk, T. P. L., Haastert, P. J. M. V., & Furth, R. V. (1990). A Competition Binding Assay for Determination of the Inositol (1,4,5)-Trisphosphate Content of Human Leucocytes. Biochemical and Biophysical Research Communications, 170(2). https://doi.org/10.1016/0006-291X(90)92155-S
Kesbeke, F., Haastert, P. J. M. V., Wit, R. J. W. D., & Snaar-Jagalska, B. E. (1990). Chemotaxis to cyclic AMP and folic acid is mediated by different G proteins in Dictyostelium discoideum. Molecular and Cellular Biochemistry, 92(2).
Bominaar, A., van der Kaay, J., Kesbeke, F., Snaarjagalska, BE., & van Haastert, P. (1990). G-proteins and the inositol cycle in Dictyostelium discoideum. In G. MILLIGAN, MJO. WAKELAM, & J. KAY (Eds.), G-PROTEINS AND SIGNAL TRANSDUCTION (pp. 71-80). (BIOCHEMICAL SOCIETY SYMPOSIUM; Vol. 56). HIGH HOLBURN LONDON: BIOCHEMICAL SOC.
Duijn, B. V., Vogelzang, S. A., Ypey, D. L., Molen, L. G. V. D., & Haastert, P. J. M. V. (1990). Normal chemotaxis in Dictyostelium discoideum cells with a depolarized plasma membrane potential. Default journal.
Snaar-Jagalska, B. E., & Haastert, P. J. M. V. (1990). Pertussis toxin inhibits cAMP-induced desensitization of adenylate cyclase in Dictyostelium discoideum. Molecular and Cellular Biochemistry, 92(2). https://doi.org/10.1007/BF00218135

1989

Firtel, R. A., Haastert, P. J. M. V., Kimmel, A. R., & Devreotes, P. N. (1989). G-Protein Linked Signal Transduction Pathways in Development: Dictyostetium as an Experimental System. Cell, 58(2), 235-239. https://doi.org/10.1016/0092-8674(89)90837-4
Haastert, P. J. M. V., Vries, M. J. D., Penning, L. C., Roovers, E., Kaay, J. V. D., Erneux, C., & Lookeren Campagne, M. M. V. (1989). Chemoattractant and guanosine 5'-[γ-thio]triphosphate induce the accumulation of inositol 1,4,5-trisphosphate in Dictyostelium cells that are labelled with [3H]inositol by electroporation. Default journal.
Haastert, P. J. M. V. (1989). Determination of lnositol 1,4,5-Trisphosphate Levels in Dictyostelium by Isotope Dilution Assay. Analytical Biochemistry, 177(1). https://doi.org/10.1016/0003-2697(89)90024-9
Peters, D. J. M., Lookeren Campagne, M. M. V., Haastert, P. J. M. V., Spek, W., & Schaap, P. (1989). Lithium ions induce prestalk-associated gene expression and inhibit prespore gene expression in Dictyostelium discoideum. Differentiation, 44(2).
Janssens, P. M. W., de Jong, CC., Vink, A. A., & Haastert, P. J. M. V. (1989). Regulatory Properties of Magnesium-dependent Guanylate Cyclase in Dictyostelium discoideum Membranes. Default journal.
Ments-Cohen, M. V., & Haastert, P. J. M. V. (1989). The Cyclic Nucleotide Specificity of Eight cAMP-binding Proteins in Dictyostelium discoideum Is Correlated into Three Groups. Default journal.
VANHAASTERT, PJM. (1989). TRANSMEMBRANE SIGNAL TRANSDUCTION IN DICTYOSTELIUM-MUTANS. In J. NUNEZ, & JE. DUMONT (Eds.), HORMONES AND CELL REGULATION // (pp. 7-13). (COLLOQUE INSERM; Vol. 198). PARIS: INST NATL SANTE RECHERCHE MEDICALE.

1988

Snaar-Jagalska, B. E., Jakobs, K. H., & Haastert, P. J. M. V. (1988). Agonist-stimulated high-affinity GTPase in Dictyostelium membranes. FEBS Letters, 236(1). https://doi.org/10.1016/0014-5793(88)80302-8
Snaar-Jagalska, B. E., & Haastert, P. J. M. V. (1988). Dictyostelium discoideum mutant synag 7 with altered G-protein-adenylate cyclase interaction. Biochemical and Biophysical Research Communications, 156(2).
Ludérus, M. E. E., Reymond, C. D., Haastert, P. J. M. V., & Driel, R. V. (1988). Expression of a mutated ras gene in Dictyostelium discoideum alters the binding of cyclic AMP to its chemotactic receptor. Default journal.
Snaar-Jagalska, B. E., Kesbeke, F., Pupillo, M., & Haastert, P. J. M. V. (1988). Immunological Detection of G-Protein α-Subunits in Dictyostelium discoideum. Biochemical and Biophysical Research Communications, 156(2). https://doi.org/10.1016/S0006-291X(88)80908-2
Snaar-Jagalska, B. E., Devreotes, P. N., & Haastert, P. J. M. V. (1988). Ligand-induced Modification of a Surface cAMP Receptor of Dictyostelium discoideum Does Not Require Its Occupancy. FEBS Letters, 232(1).
Wang, M., Haastert, P. J. M. V., Devreotes, P. N., & Schaap, P. (1988). Localization of Chemoattractant Receptors on Dictyostelium discoideum Cells during Aggregation and Down-regulation. Developmental Biology, 128(1). https://doi.org/10.1016/0012-1606(88)90268-0
Snaar-Jagalska, B. E., Wit, R. J. W. D., & Haastert, P. J. M. V. (1988). Pertussis toxin inhibits cAMP surface receptor-stimulated binding of [35S]GTPγS to Dictyostelium discoideum membranes. FEBS Letters, 232(1). https://doi.org/10.1016/0014-5793(88)80405-8
Kesbeke, F., & Haastert, P. J. M. V. (1988). Reduced cAMP Secretion in Dictyostelium discoideum Mutant HB3. Developmental Biology, 130(2). https://doi.org/10.1016/0012-1606(88)90342-9
Peters, D. J. M., Knecht, D. A., Loomis, W. F., Lozanne, A. D., Spudich, J., & Haastert, P. J. M. V. (1988). Signal Transduction, Chemotaxis, and Cell Aggregation in Dictyostelium discoideum Cells without Myosin Heavy Chain. Developmental Biology, 128(1). https://doi.org/10.1016/0012-1606(88)90278-3
Kesbeke, F., Snaar-Jagalska, B. E., & van Haastert, P. J. M. (1988). Signal Transduction in Dictyostelium fgd A Mutants with a Defective Interaction between Surface cAMP Receptors and a GTP-binding Regulatory Protein. The Journal of Cell Biology, 107(2). https://doi.org/10.1083/jcb.107.2.521
Lookeren Campagne, M. M. V., Erneux, C., Eijk, R. V., & Haastert, P. J. M. V. (1988). Two dephosphorylation pathways of inositol 1,4,5-trisphosphate in homogenates of the cellular slime mould Dictyostelium discoideum. FEMS Microbiology Letters, 11(4).

1987

Haastert, P. J. M. V., Kesbeke, F., Reymond, C. D., Firtel, R. A., Luderus, E., & Driel, R. V. (1987). Aberrant transmembrane signal transduction in Dictyostelium cells expressing a mutated ras gene. Proceedings of the National Academy of Sciences, 84(14). https://doi.org/10.1073/pnas.84.14.4905
Haastert, P. J. M. V. (1987). Adenosine 3’,5’-Monophosphorothioate (Rp-isomer) Induces Down-regulation of Surface Cyclic AMP Receptors without Receptor Activation in Dictyostelium discoideum. Default journal.
Haastert, P. J. M. V. (1987). Alteration of Receptor/G-protein Interaction by Putative Endogenous Protein Kinase Activity in Dictyostelium discoideum Membranes. Default journal.
van Haastert, P. J. M. (1987). Differential Effects of Temperature on cAMP-induced Excitation, Adaptation, and Deadaptation of Adenylate and Guanylate Cyclase in Dictyostelium discoideum. The Journal of Cell Biology, 105(5). https://doi.org/10.1083/jcb.105.5.2301
Haastert, P. J. M. V. (1987). Down-regulation of Cell Surface Cyclic AMP Receptors and Desensitization of Cyclic AMP-stimulated Adenylate Cyclase by Cyclic AMP in Dictyostelium discoideum. Kinetics and Concentration Dependence. Differentiation, 33(3).
Haastert, P. J. M. V. (1987). Kinetics and Concentration Dependency of cAMP-Induced Desensitization of a Subpopulation of Surface cAMP Receptors in Dictyostelium discoideum. Biochemistry, 26(23). https://doi.org/10.1021/bi00397a047
Janssens, P. M. W., & Haastert, P. J. M. V. (1987). Molecular Basis of Transmembrane Signal Transduction in Dictyostelium discoideum. Proceedings of the National Academy of Sciences, 84(14).
Haastert, P. J. M. V., Snaar-Jagalska, B. E., & Janssens, P. M. W. (1987). The regulation of adenylate cyclase by guanine nucleotides in Dictyostelium discoideum membranes. European Journal of Biochemistry, 162(2). https://doi.org/10.1111/j.1432-1033.1987.tb10592.x

1986

Janssens, P. M. W., Arents, J. C., Haastert, P. J. M. V., & Driel, R. V. (1986). Forms of the Chemotactic Adenosine 3’,5’-Cyclic Phosphate Receptor in Isolated Dictyostelium discoideum Membranes and Interconversions Induced by Guanine Nucleotides. Biochemistry, 25(6), 1314-1320. https://doi.org/10.1021/bi00354a019
Van Waarde, A., & Van Haastert, P. J. M. (1986). Effect of drugs on lipid methylation, receptor-adenylate cyclase coupling and cyclic AMP secretion in Dictyostelium discoideum. Biochimica et Biophysica Acta - Molecular Cell Research, 887(2), 229-235. https://doi.org/10.1016/0167-4889(86)90059-5
Kesbeke, F., Haastert, P. J. M. V., & Schaap, P. (1986). Cyclic AMP relay and cyclic AMP-induced cyclic GMP accumulation during development of Dictyostelium discoideum. FEMS Microbiology Letters, 34(1). https://doi.org/10.1111/j.1574-6968.1986.tb01354.x
Haastert, P. J. M. V., Wit, R. J. W. D., Janssens, P. M. W., Kesbeke, F., & Goede, J. D. (1986). G-protein-mediated Interconversions of Cell-surface cAMP Receptors and Their Involvement in Excitation and Desensitization of Guanylate Cyclase in Dictyostelium discoideum. Default journal.
Wang, M., Haastert, P. J. M. V., & Schaap, P. (1986). Multiple effects of differentiation-inducing factor on prespore differentiation and cyclic-AMP signal transduction in Dictyostelium. Differentiation, 33(1), 24-28. https://doi.org/10.1111/j.1432-0436.1986.tb00406.x
Schaap, P., Lookeren Campagne, M. M. V., Driel, R. V., Spek, W., Haastert, P. J. M. V., & Pinas, J. (1986). Postaggregative Differentiation Induction by Cyclic AMP in Dictyostelium: Intracellular Transduction Pathway and Requirement for Additional Stimuli. Developmental Biology, 118(1). https://doi.org/10.1016/0012-1606(86)90072-2
Lookeren Campagne, M. M. V., Schaap, P., & Haastert, P. J. M. V. (1986). Specificity of Adenosine Inhibition of cAMP-Induced Responses in Dictyostelium Resembles That of the P Site of Higher Organisms. Developmental Biology, 117(1). https://doi.org/10.1016/0012-1606(86)90367-2

1985

Wit, R. J. W. D., & Haastert, P. J. M. V. (1985). Binding of folates to Dictyostelium discoideum cells. Demonstration of five classes of binding sites and their interconversion. Biochimica et Biophysica Acta - Biomembranes, 814(2). https://doi.org/10.1016/0005-2736(85)90438-9
Haastert, P. J. M. V. (1985). cAMP activates adenylate and guanylate cyclase of Dictyostelium discoideum cells by binding to different classes of cell-surface receptors. A study with extracellular Ca2+. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 846(3). https://doi.org/10.1016/0167-4889(85)90002-3
Haastert, P. J. M. V., Wit, R. J. W. D., & Lookeren Campagne, M. M. V. (1985). Ca2+ - or Phorbol Ester - Dependent Effect of ATP on a Subpopulation of cAMP Cell-Surface Receptors in Membranes from D. discoideum. A Role for Protein Kinase C. Biochemical and Biophysical Research Communications, 128(1). https://doi.org/10.1016/0006-291X(85)91662-6
Kesbeke, F., Baraniak, J., Bulgakov, R., Jastorff, B., Morr, M., Petridis, G., ... Haastert, P. J. M. V. (1985). Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum. European Journal of Biochemistry, 151(1). https://doi.org/10.1111/j.1432-1033.1985.tb09083.x
Kesbeke, F., & Haastert, P. J. M. V. (1985). Selective down-regulation of cell surface cAMP-binding sites and cAMP-induced responses in Dictyostelium discoideum. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 847(1). https://doi.org/10.1016/0167-4889(85)90149-1
Miot, F., Haastert, P. J. M. V., & Erneux, C. (1985). Specificity of cGMP binding to a purified cGMP-stimulated phosphodiesterase from bovine adrenal tissue. European Journal of Biochemistry, 149(1). https://doi.org/10.1111/j.1432-1033.1985.tb08893.x
Haastert, P. J. M. V. (1985). The modulation of cell surface cAMP receptors from Dictyostelium disscoideum by ammonium sulfate. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 845(2). https://doi.org/10.1016/0167-4889(85)90184-3

1984

van Waarde, A., & van Haastert, P. J. (1984). Transmethylation inhibitors decrease chemotactic sensitivity and delay cell aggregation in Dictyostelium discoideum. Journal of Bacteriology, 157(2), 368-74.
Haastert, P. J. M. V. (1984). A Method for Studying cAMP-relay in Dictyostelium discoideum: the Effect of Temperature on cAMP-relay. Microbiology, 130(10). https://doi.org/10.1099/00221287-130-10-2559
Schaap, P., Konijn, T. M., & Haastert, P. J. M. V. (1984). cAMP pulses coordinate morphogenetic movement during fruiting body formation of Dictyostelium minutum. Proceedings of the National Academy of Sciences, 81(7). https://doi.org/10.1073/pnas.81.7.2122
Haastert, P. J. M. V., Driel, R. V., Jastorff, B., Baraniak, J., Stec, W. J., & Wit, R. J. W. D. (1984). Competitive cAMP Antagonists for cAMP-Receptor Proteins. European Journal of Biochemistry, 142(2).
Haastert, P. J. M. V., & Wit, R. J. W. D. (1984). Demonstration of Receptor Heterogeneity and Affinity Modulation by Nonequilibrium Binding Experiments. The Cell Surface cAMP Receptor of Dictyostelium discoideum. Biochemical and Biophysical Research Communications, 124(2).
Haastert, P. J. M. V. (1984). Guanine Nucleotides Modulate Cell Surface cAMP-Binding Sites in Membranes from Dictyostelium discoideum. Biochemical and Biophysical Research Communications, 124(2). https://doi.org/10.1016/0006-291X(84)91596-1
Wit, R. J. W. D., Hekstra, D., Jastorff, B., Stec, W. J., Baraniak, J., Driel, R. V., & Haastert, P. J. M. V. (1984). Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. European Journal of Biochemistry, 142(2). https://doi.org/10.1111/j.1432-1033.1984.tb08279.x
van Haastert, P. J. M., & van Lookeren Campagne, M. M. (1984). Transient Kinetics of a cGMP-dependent cGMP-specific Phosphodiesterase from Dictyostelium discoideum. The Journal of Cell Biology, 98(2). https://doi.org/10.1083/jcb.98.2.709

1983

Haastert, P. J. M. V., & Kien, E. (1983). Binding of cAMP Derivatives to Dictyostelium discoideum Cells: Activation Mechanism of the Cell Surface cAMP Receptor. The Journal of Biological Chemistry, 258(16), 9636-9642.
Lookeren Campagne, M. M. V., & Haastert, P. J. M. V. (1983). A Sensitive Cyclic Nucleotide Phosphodiesterase Assay for Transient Enzyme Kinetics. Analytical Biochemistry, 135(1). https://doi.org/10.1016/0003-2697(83)90743-1
Haastert, P. J. M. V. (1983). Binding of cAMP and Adenosine Derivatives to Dictyostelium discoideum Cells. Relationships of Binding, Chemotactic, and Antagonistic Actitities. Default journal.
van Haastert, P. J. M., & van der Heijden, P. R. (1983). Excitation, adaption, and deadaptation of the cAMP-mediated cGMP Response in dictyostelium discoideum. The Journal of Cell Biology, 96(2). https://doi.org/10.1083/jcb.96.2.347
Bulgakov, R., & Haastert, P. J. M. V. (1983). Isolation and Partial Characterization of a Cyclic GMP-Dependent Cyclic GMP-Specific Phosphodiesterase from Dictyostelium discoideum. Biochimica et Biophysica Acta %28BBA%29 - General Subjects, 756(1). https://doi.org/10.1016/0304-4165(83)90024-7
Haastert, P. J. M. V., Lookeren Campagne, M. M. V., & Kesbeke, F. (1983). Multiple Degradation Pathways of Chemoattractant Mediated Cyclic GMP Accumulation in Dictyostelium. Biochimica et Biophysica Acta %28BBA%29 - General Subjects, 756(1). https://doi.org/10.1016/0304-4165(83)90025-9
Haastert, P. J. M. V. (1983). Relationship between Adaptation of the Folic Acid and the cAMP Mediated cGMP Response in Dictyostelium. Biochemical and Biophysical Research Communications, 115(1). https://doi.org/10.1016/0006-291X(83)90979-8
van Haastert, P. J. M. (1983). Sensory Adaptation of Dictyostelium discoideum Cells to Chemotactic Signals. The Journal of Cell Biology, 96(6). https://doi.org/10.1083/jcb.96.6.1559
Haastert, P. J. M. V., Dijkgraaf, P. A. M., Konijn, T. M., Abbad, E. G., Petridis, G., & Jastorff, B. (1983). Substrate Specificity of Cyclic Nucleotide Phosphodiesterase from Beef Heart and from Dictyostelircm discoideum. European Journal of Biochemistry, 131(3). https://doi.org/10.1111/j.1432-1033.1983.tb07314.x

1982

Haastert, P. J. M. V., Lookeren Campagne, M. M. V., & Ross, F. M. (1982). Altered cGMP-phosphodiesterase activity in chemotactic mutants of Dictyostelium discoideum. FEBS Letters, 147(2). https://doi.org/10.1016/0014-5793(82)81029-6
Haastert, P. J. M. V., Jastorff, B., Pinas, J. E., & Konijn, T. M. (1982). Analogs of Cyclic AMP as Chemoattractants and Inhibitors of Dictyostelium Chemotaxis. Default journal.
Haastert, P. J. M. V., Wit, R. J. W. D., & Konijn, T. M. (1982). Antagonists of chemoattractants reveal separate receptors for cAMP, folic acid and pterin in Dictyostelium. Experimental Cell Research, 140(2). https://doi.org/10.1016/0014-4827(82)90139-2
Haastert, P. J. M. V., Pasveer, F. J., Meer, R. C. V. D., Heijden, P. R. V. D., Walsum, H. V., & Konijn, T. M. (1982). Evidence for a Messenger Function of Cyclic GMP During Phosphodiesterase Induction in Dictyostelium discoideum. Molecular and Cellular Endocrinology, 25(2).
Haastert, P. J. M. V., Wit, R. J. W. D., Grijpma, Y., & Konijn, T. M. (1982). Identification of a pterin as the acrasin of the cellular slime mold Dictyostelium lacteum. Proceedings of the National Academy of Sciences, 79(20). https://doi.org/10.1073/pnas.79.20.6270
van Haastert, P. J. M., van Walsum, H., & Pasveer, F. J. (1982). Nonequilibrium Kinetics of a Cyclic GMP-binding Protein in Dictyostelium discoideum. The Journal of Cell Biology, 94(2). https://doi.org/10.1083/jcb.94.2.271
Haastert, P. J. M. V., Bijleveld, W., & Konijn, T. M. (1982). Phosphodiesterase Induction in Dictyostelium discoideum by Inhibition of Extracellular Phosphodiesterase Activity. Developmental Biology, 94(1). https://doi.org/10.1016/0012-1606(82)90087-2
Haastert, P. J. M. V., & Konijn, T. M. (1982). Signal Transduction in the Cellular Slime Molds. Molecular and Cellular Endocrinology, 26(1). https://doi.org/10.1016/0303-7207(82)90002-8
Haastert, P. J. M. V., Walsum, H. V., Meer, R. C. V. D., Bulgakov, R., & Konijn, T. M. (1982). Specificity of the Cyclic GMP-Binding Activity and of a Cyclic GMP-Dependent Cyclic GMP Phosphodiesterase in Dictyostelium discoideum. Molecular and Cellular Endocrinology, 25(2). https://doi.org/10.1016/0303-7207(82)90050-8

1981

Haastert, P. J. M. V. (1981). High-Performance Liquid Chromatography of Nucleobases, Nucleosides and Nucleotides: II. Mobile Phase Composition for the Separation of Charged Solutes by Ion-Exchange Chromatography. Journal of Chromatography A, 210(2), 241-254. https://doi.org/10.1016/S0021-9673(00)97834-8
Haastert, P. J. M. V., Meer, R. C. V. D., & Konijn, T. M. (1981). Evidence that the Rate of Association of Adenosine 3',5'-Monophosphate to Its Chemotactic Receptor Induces Phosphodiesterase Activity in Dictyostelium discoideum. Default journal.
Haastert, P. J. M. V. (1981). High-Performance Liquid Chromatography of Nucleobases, Nucleosides and Nucleotides: I. Mobile Phase Composition for the Separation of Charged Solutes by Reversed-Phase Chromatography. Journal of Chromatography A, 210(2), 229-240.

1978

Mato, J. M., Haastert, P. J. M. V., Krens, F. A., & Konijn, T. M. (1978). Chemotaxis in Dictyostelium discoideum: Effect of Concanavalin A on Chemoattractant Mediated Cyclic GMP Accumulation and Light Scattering Decrease. Cell Biology International Reports, 2(2). https://doi.org/10.1016/0309-1651(78)90037-1
Mato, J. M., Woelders, H., Haastert, P. J. M. V., & Konijn, T. M. (1978). Cyclic GMP Binding Activity in Dictyostelium discoideum. FEBS Letters, 90(2). https://doi.org/10.1016/0014-5793(78)80381-0

1977

Mato, J. M., Haastert, P. J. M. V., Krens, F. A., & Konijn, T. M. (1977). An Acrasin-Like Attractant from Yeast Extract Specific for Dictyostelium lacteum. Developmental Biology, 57(2). https://doi.org/10.1016/0012-1606(77)90229-9
Mato, J. M., Haastert, P. J. M. V., Krens, F. A., Rhijnsburger, E. H., Dobbe, F. C. P. M., & Konijn, T. M. (1977). Cyclic AMP and Folic Acid Mediated Cyclic GMP Accumulation in Dictyostelium discoideum. FEBS Letters, 79(2). https://doi.org/10.1016/0014-5793(77)80814-4
Mato, J. M., Krens, F. A., Haastert, P. J. M. V., & Konijn, T. M. (1977). Unified Control of Chemotaxis and cAMP Mediated cGMP Accumulation by cAMP in Dictyostelium discoideum. Biochemical and Biophysical Research Communications, 77(1). https://doi.org/10.1016/S0006-291X(77)80211-8
Mato, J. M., Krens, F. A., Haastert, P. J. M. V., & Konijn, T. M. (1977). 3': 5'-Cyclic AMP-dependent 3'. FEBS Letters, 79(2).
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