Oral biofilm as a reservoir for antimicrobials

PhD ceremony: Ms. M.P.T. Otten, 16.15 uur, Doopsgezinde kerk, Oude Boteringestraat 33, Groningen

Dissertation: Oral biofilm as a reservoir for antimicrobials

Promotor(s): prof. H.C. van der Mei, prof. F. Abbas, prof. H.J. Busscher

Faculty: Medical Sciences

This thesis concerns the new idea that biofilm-left-behind after brushing can be used as a reservoir for antimicrobial components of toothpastes and mouthrinses to enhance the substantive or long-lasting antimicrobial effect of these products. The reservoir function of the biofilm is studied in vitro and in vivo. It is concluded that biofilm-left-behind after brushing can act as a reservoir for antimicrobials and therewith contribute to the substantive action of antimicrobials in oral health care products.