Skip to ContentSkip to Navigation
About us Latest news News News articles

Advanced glycation end-products in chronic heart failure

16 May 2011

PhD ceremony: Ms. S. Willemsen, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Advanced glycation end-products in chronic heart failure

Promotor(s): prof. A.A. Voors, prof. D.J. van Veldhuisen

Faculty: Medical Sciences


The number of patients with chronic heart failure (HF) is increasing. HF is a functional cardiac disorder, impairing the ability of the ventricle to fill with or eject blood combined with symptoms of fatigue and/or breathlessness. The prognosis and quality of life are poor. In this thesis the potential role of advanced glycation end-products (AGEs; glycated proteins) accumulation in the development and progression of HF was studied. AGEs accumulate during ageing and form collagen cross links, causing stiffening of heart and vessels.

The main findings are 1) Higher levels of AGEs are associated with diastolic dysfunction; 2) Elevated AGEs levels are related to the severity of HF and its clinical outcome; 3) When used in patients with systolic HF the AGE-breaker alagebrium showed no improvement on either the exercise capacity or cardiac function. Furthermore, no changes in AGE levels were observed in the blood.


Last modified:13 March 2020 01.12 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...