Skip to ContentSkip to Navigation
About us Latest news News News articles

An adipocentric view of the development of insulin resistance

13 April 2011

PhD ceremony: Ms. E. Szalowska, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Title: An adipocentric view of the development of insulin resistance

Promotor(s): prof. R.J. Vonk

Faculty: Medical Sciences


Adipose tissue is well known for its role in energy storage. More recently, it is also acknowledged as an endocrine organ secreting numerous adipokines. In obesity, the adipokine secretory profile may change, leading to deregulation of the adipose tissue metabolism and systemic insulin resistance.The aim of this thesis was to study the role of adipose tissue in the development of insulin resistance and the expression of genes and proteins. In patients with decreased insulin sensitivity researcher Szalowska observed that metabolic genes showed a decreased expression, while expression of pro-inflammatory genes was not altered. This suggests that metabolic alterations in the adipose tissue precede inflammation. Additionally it was found that both adipose tissue and the liver display a unique pattern of gene/protein expression, suggesting that tissue specific proteins could be used as biomarkers to detect tissue specific insulin resistance.



Last modified:13 March 2020 01.12 a.m.
View this page in: Nederlands

More news

  • 29 November 2023

    UMCG opent nieuwe faciliteit voor microbioomonderzoek 

    Vandaag opent het UMCG de Groningen Microbioom Hub: een nieuwe faciliteit met state-of-the-art technologie waarin alle UMCG-expertise op het gebied van microbioomonderzoek samenkomt. Dit zorgt voor unieke mogelijkheden in onderzoek en maakt nieuwe...

  • 28 November 2023

    Science: more exciting than showbiz

    Science often seems very complicated. Most people probably don't really know what researchers do, and what it takes to make a breakthrough. That is why it is important to keep the general public informed of what is happening in science, says Iris...

  • 13 November 2023

    UMCG beantwoordt vragen patiënten met hulp van AI

    Het UMCG zet kunstmatige intelligentie (artificial intelligence, afgekort AI) in om zorgverleners te helpen bij het beantwoorden van schriftelijke vragen van patiënten. Dit gebeurt in samenwerking met andere ziekenhuizen vanuit de EPIC Nederlandse...