Radiolabelled monoclonal antibodies for molecular imaging of chronic inflammatory diseases

PhD ceremony: Mr. G. Malviya, 13.15 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Radiolabelled monoclonal antibodies for molecular imaging of chronic inflammatory diseases

Promotor(s): prof. Signore, prof. R.A.J.O. Dierckx

Faculty: Medical Sciences

This thesis describes the synthesis and application of different radiolabelled monoclonal antibodies (mAbs), including anti-TNF a mAb, anti-CD20 mAb, anti-CD3 mAb and anti-HLA-DR mAb. All mAbs were radiolabelled with ^99mTc and evaluated for receptor mapping and/or therapy decision making in patients.