Molecular characterization of tumor vascular phenotype & pharmacology of antiangiogenic therapy

PhD ceremony: Ms. E. Langenkamp, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen

Title: Molecular characterization of tumor vascular phenotype & pharmacology of antiangiogenic therapy

Promotor(s): prof. G. Molema

Faculty: Medical Sciences

In this thesis, we characterized the morphology and expression pattern of various angiogenesis regulating genes in the vasculature of a melanoma model in different stages of growth, and compared this to the pattern in quiescent non angiogenic endothelium from healthy kidneys. This revealed that this tumor type continues to actively engage in angiogenesis during growth using the same specific pro-angiogenic repertoire.