Effector mechanisms of ANCA-associated glomerulonephritis

PhD ceremony: Ms. B.S. van der Veen, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen

Thesis: Effector mechanisms of ANCA-associated glomerulonephritis

Promotor(s): prof. P. Heeringa, prof. G. Molema

Faculty: Medical Sciences

The aim of this thesis was to explore effector mechanisms involved in ANCA-associated glomerulonephritis, a rare but severe autoimmune disorder, to identify targets for more efficient therapies with less side effects. The focus was on the role of inflammatory stimuli and characteristics of the autoantibody and on the testing of experimental therapies in a model of ANCA-associated glomerulonephritis.