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University Medical Center Groningen

M. (Matthijs) Luxen

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Faculty of Medical Sciences

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m.luxen umcg.nl

ORCID Research Portal

Publications

Uncovering molecular markers of the microvascular endothelial response in sepsis-associated acute kidney injury: a translational study in mice and humans

van der Aart, T. J., Molema, G., Jongman, R. M., Bouma, H. R., Koeze, J., Moser, J., van Londen, M., Hackl, M., Diendorfer, A. B., ter Maaten, J. C., van Meurs, M. & Luxen, M., 2-Sept-2025, In: Intensive Care Medicine Experimental. 13, 15 p., 92.

Research output: Contribution to journal › Article › Academic › peer-review

Heterogeneous Patterns of Endothelial NF-κB p65 and MAPK c-Jun Activation, Adhesion Molecule Expression, and Leukocyte Recruitment in Lung Microvasculature of Mice with Sepsis

Wang, Z., Dayang, E.-Z., Zwiers, P. J., Garcia, M. L. H., Luxen, M., van Meurs, M., Moser, J., Kamps, J. A. A. M. & Molema, G., 26-Jul-2024, In: Biomedicines. 12, 8, 22 p., 1672.

Research output: Contribution to journal › Article › Academic › peer-review

Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial NF-κB and MAPK pathways

Wang, Z., Dayang, E.-Z., Zwiers, P. J., Hernandez Garcia, M. L., Luxen, M., van Meurs, M., Kamps, J. A. A. M., Moser, J. & Molema, G., Dec-2024, In: Journal of Leukocyte Biology. 116, 6, p. 1479–1497 19 p.

Research output: Contribution to journal › Article › Academic › peer-review

Sepsis induces heterogeneous transcription of coagulation- and inflammation-associated genes in renal microvasculature

Luxen, M., Zwiers, P. J., Jongman, R. M., Moser, J., Pultar, M., Skalicky, S., Diendorfer, A. B., Hackl, M., van Meurs, M. & Molema, G., May-2024, In: Thrombosis Research. 237, p. 112-128 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Renal Microvascular Endothelial Heterogeneity In Sepsis: A Multiomics Approach

Luxen, M., 2023, [Groningen]: University of Groningen. 271 p.

Research output: Thesis › Thesis fully internal (DIV)

Unique miRNome and transcriptome profiles underlie microvascular heterogeneity in mouse kidney

Luxen, M., Zwiers, P. J., Meester, F., Jongman, R. M., Kuiper, T., Moser, J., Pultar, M., Skalicky, S., Diendorfer, A. B., Hackl, M., van Meurs, M. & Molema, G., 2023, In: American journal of physiology-Renal physiology. 325, 3, p. F299-F316

Research output: Contribution to journal › Article › Academic › peer-review

Pharmacological inhibition of protein tyrosine kinases axl and fyn reduces TNF-α-induced endothelial inflammatory activation in vitro

Ellermann, S. F., Jongman, R. M., Luxen, M., Kuiper, T., Plantinga, J., Moser, J., Scheeren, T. W. L., Theilmeier, G., Molema, G. & Van Meurs, M., 1-Dec-2022, In: Frontiers in Pharmacology. 13, 13 p., 992262.

Research output: Contribution to journal › Article › Academic › peer-review

Unlocking the Untapped Potential of Endothelial Kinase and Phosphatase Involvement in Sepsis for Drug Treatment Design

Luxen, M., van Meurs, M. & Molema, G., May-2022, In: Frontiers in Immunology. 13, 25 p., 867625.

Research output: Contribution to journal › Review article › peer-review

Pharmacological inhibition of focal adhesion kinase 1 (FAK1) and anaplastic lymphoma kinase (ALK) identified via kinome profile analysis attenuates lipopolysaccharide-induced endothelial inflammatory activation

Dayang, E.-Z., Luxen, M., Kuiper, T., Yan, R., Rangarajan, S., Meurs, M. V., Moser, J. & Molema, G., Jan-2021, In: Biomedicine & Pharmacotherapy. 133, 13 p., 111073.

Research output: Contribution to journal › Article › Academic › peer-review

All (9) publications

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