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About us Practical matters How to find us dr. L.C.L.T. (Léon) van Kempen
University Medical Center Groningen

dr. L.C.L.T. (Léon) van Kempen

Clinical Scientist in Molecular Pathology
Profile picture of dr. L.C.L.T. (Léon) van Kempen
Telephone:
+31 50 361 5129 (Office)
Staff assistant:
+31 50 361 0020 (Mrs. Annet Bouman - Van der Jagt)
E-mail:
l.van.kempen umcg.nl
Research interests Publications Press/media

Research interests

Clinical Scientist in Molecular Pathology, molecular diagnostic service. 

Research interests: Molecular biology and pathology of melanoma and non-small cell lung cancer. 

Publications

Radiotherapy Response Prediction in Myxofibrosarcomas and Undifferentiated Soft Tissue Sarcomas Using DNA Methylation and Copy Number Profiling

Kleijn, T. G., Ameline, B., Kooistra, W., van Kempen, L. C., Diercks, G. F. H., van Ginkel, R. J., Been, L. B., van Leeuwen, B. L., Reyners, A. K. L., Kwee, T. C., Jutte, P. C., Ploegmakers, J. J. W., Bijl, H., Vanhauten, B., Ubbels, J. F., Schuuring, E., Suurmeijer, A. J. H., de Haan, J. J., Baumhoer, D. & Cleven, A. H. G., 29-Jan-2026, (E-pub ahead of print) In: International journal of surgical pathology. p. 10668969251412902

Research output: Contribution to journal › Article › Academic › peer-review

SOX2 Is a Potential Diagnostic Biomarker and Anticancer Target in Cutaneous Squamous Cell Carcinoma in Dystrophic Epidermolysis Bullosa: A Case Series Study

Harrs, C., Bolling, M. C., van den Akker, P., Koopman, B., Horvath, B., Diercks, G. F. H. & van Kempen, L., 1-Jan-2026, In: JID Innovations. 6, 1, 13 p., 100417.

Research output: Contribution to journal › Article › Academic › peer-review

Cell-Free DNA Based Next-Generation Sequencing Does Not Differentiate Between Oligoprogression and Systemic Progression in Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors-An Explorative Study

Rozendal, P., Kievit, H., van der Leest, P., Bahce, I., Pegtel, M., Groen, H. J. M., van Kempen, L. C., Hiltermann, T. J. N. & Schuuring, E., 21-Aug-2025, In: International Journal of Molecular Sciences. 26, 16, 15 p., 8087.

Research output: Contribution to journal › Article › Academic › peer-review

Classification of Fibro-osseous Tumors in the Craniofacial Bones using DNA Methylation and Copy Number Alterations

Kleijn, T. G., Ameline, B., Schreuder, W. H., Szuhai, K., Kooistra, W., van Kempen, L., Japalagh, G. S. H., Briaire-de Bruijn, I. H., van der Meeren, S. W., Kleijwegt, M. C., Witjes, M., Pichardo, S. E. C., van Furth, W. R., Lausová, T., Breimer, G. E., Braunius, W. W., de Lange, J., van Langevelde, K., Kroon, H. M. & van den Hout, M. F. C. M., Koppes, S. A., Haefliger, S., Ooft, M. L., van Engen-van Grunsven, I. C. H., Flucke, U. E., Hiemcke-Jiwa, L., Savci-Heijink, D. C., Diercks, G. F. H., Doff, J. J., Suurmeijer, A. J. H., Bovée, J. V. M. G., von Deimling, A., Baumhoer, D. & Cleven, A. H. G., Jun-2025, In: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 38, 6, 11 p., 100717.

Research output: Contribution to journal › Article › Academic › peer-review

Detection of actionable mutations in circulating tumor DNA for non-small cell lung cancer patients

van der Leest, P., Rozendal, P., Rifaela, N., van der Wekken, A. J., Kievit, H., de Jager, V. D., Sidorenkov, G., van Kempen, L. C., Hiltermann, T. J. N. & Schuuring, E., Dec-2025, In: Communications medicine. 5, 10 p., 204.

Research output: Contribution to journal › Article › Academic › peer-review

Enhancing precision in sarcoma diagnosis: nCounter fusion panel implementation in a middle-income country

de Paula, F. E., Bonatelli, M., dos Reis, M. T., Rodrigues, K. E. D. S., van Kempen, L. C., Teixeira, G. R. & Reis, R. M., 1-Jan-2025, In: Therapeutic advances in medical oncology. 17, 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Ferroptosis inhibition protects against α-synuclein-related neuronal cell death

Majerníková, N., Caiado, M. J., Seinstra, R. I., Couzijn, S., Goya, M. E., Salinas, C. S., Truong, H., van der Sluis, T., Miedema, A., van Kempen, L. C. L. T., McColl, G., Nollen, E. A. A., Dolga, A. M. & den Dunnen, W. F. A., 14-Dec-2025, In: Cell death & disease. 17, 1, p. 78

Research output: Contribution to journal › Article › Academic › peer-review

Genome-Wide DNA Methylation and Copy Number Alterations in Gastrointestinal Stromal Tumors

Kleijn, T. G., Ameline, B., Bleckman, R. F., Kooistra, W., van den Broek, E., Diercks, G. F. H., van Hemel, B. M., Timmer, B., Timens, W., Kats-Ugurlu, G., van Kempen, L. C., van Etten, B., Schuuring, E., Suurmeijer, A. J. H., de Haan, J. J., Baumhoer, D., Reyners, A. K. L. & Cleven, A. H. G., Mar-2025, In: Genes Chromosomes & Cancer. 64, 3, 10 p., e70046.

Research output: Contribution to journal › Article › Academic › peer-review

Large language model-based approach for low-cost, rapid and accurate automated extraction of predictive biomarker testing results from Dutch pathology reports

de Jager, V. D., van der Ree, M., Garcia, B. C., Kuijpers, C., van der Wekken, A. J., van Kempen, L. C., Schuuring, E. & Willems, S. M., 29-Nov-2025, (E-pub ahead of print) In: Virchows Archiv : an International Journal of Pathology. 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

PDGFRA::USP8 Fusion in a Cutaneous Inflammatory Myofibroblastic Tumor, Highlighting Genetic Pleiotropy of Kinase Gene Fusions in Soft Tissue Neoplasms

Vernemmen, A. I. P., van Kempen, L. C. L. T., Aarts, F., zur Hausen, A., Sciot, R. M. E., Hornick, J. L. & van den Hout, M. F. C. M., Feb-2025, In: Genes Chromosomes and Cancer. 64, 2, 7 p., e70035.

Research output: Contribution to journal › Article › Academic › peer-review

Press/media

NVVP magazine 2021-01

van Kempen, L.

31/05/2021

Press/Media: Other › Professional

Moleculaire diagnostiek voor de detectie van RET- en NTRK-fusies bij kanker

van Kempen, L.

31/03/2021

Press/Media: Other › Professional

Successful Molecular Tumor Board

Kempen, van, L.

07/10/2020

Press/Media: Other › Professional

Effectiveness of the UMCG Molecular Tumor Board

Kempen, van, L.

28/07/2020

Press/Media: Other › Professional

Detectie van fusiegenen: kwaliteitscontrole en nieuwe methodologie

Kempen, van, L.

29/05/2020

Press/Media: Expert Comment › Professional

Moleculaire Tumor Boards

Kempen, van, L. & Koopman, B.

20/05/2020

Press/Media: Other › Professional

cBioportal at HealtRI

Kempen, van, L.

19/03/2020

Press/Media: Other › Professional

Opening of the Molecualr Pathology Centre, Montreal, QC, 2014

Kempen, van, L.

19/01/2014

Press/Media: Other › Popular

Opening of the Molecular Pathology Center, Montreal, QC, Canada, 2014

Kempen, van, L.

26/11/2013

Press/Media: Other › Popular

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