A. Osipyan, MSc

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a.osipyan rug.nl

Publicaties

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

Sokolova, N., Osipyan, A., Zhang, L., Groves, M. R., Schmidt, S. & Haslinger, K., mei-2026, In: The FEBS Journal. 293, 9, blz. 2673-2691 19 blz.

Onderzoeksoutput › › peer review

Harnessing Enzymatic Diazotization for Chemoenzymatic N–N Bond Formation and Diversification

Atienza-Sanz, S., Osipyan, A., Kucsinka, B. A. & Schmidt, S., 26-jul-2026, (Submitted) ChemRxiv.

Onderzoeksoutput: Voordruk ›

Access to nitrogen-nitrogen bond-containing heterocycles through substrate promiscuity of piperazate synthases

Li, Y., Osipyan, A., de Kok, N. A. W., Schröder, S., Founti, M., Fodran, P., van Merkerk, R., Maier, A., Tischler, D. & Schmidt, S., 17-feb-2025, (Submitted) ChemRxiv.

Onderzoeksoutput: Voordruk ›

Access to Nitrogen − nitrogen Bond-Containing Heterocycles Through Substrate Promiscuity of Piperazate Synthases

Li, Y., Osipyan, A., Kok, N. A. W. D., Schröder, S., Founti, M., Fodran, P., Merkerk, R. V., Maier, A., Tischler, D. & Schmidt, S., 6-jun-2025, In: ACS Catalysis. 15, 11, blz. 8846-8854 9 blz.

Onderzoeksoutput › › peer review

Correction to “Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells”Article link copied!

Xiao, Z., Osipyan, A., Song, S., Chen, D., Schut, R. A., van Merkerk, R., van der Wouden, P. E., Cool, R. H., Quax, W. J., Melgert, B. N., Poelarends, G. J. & Dekker, F. J., 27-mrt-2025, In: Journal of Medicinal Chemistry. 68, 6, blz. 6844-6845 2 blz.

Onderzoeksoutput

Recent Developments and Challenges in the Enzymatic Formation of Nitrogen–Nitrogen Bonds

Angeli, C., Atienza-Sanz, S., Schröder, S., Hein, A., Li, Y., Argyrou, A., Osipyan, A., Terholsen, H. & Schmidt, S., 3-jan-2025, In: ACS Catalysis. 15, 1, blz. 310-342 33 blz.

Onderzoeksoutput › › peer review

Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms

Chen, D., Zhao, C., Zhang, J., Knol, C. W. J., Osipyan, A., Majerníková, N., Chen, T., Xiao, Z., Adriana, J., Griffith, A. J., Soto-Gamez, A., van der Wouden, P. E., Coppes, R. P., Dolga, A. M., Haisma, H. J. & Dekker, F. J., 27-aug-2024, In: Advanced science . 11, 32, 15 blz., e2403963.

Onderzoeksoutput › › peer review

The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors

Osipyan, A., Bulai, R. G., Wu, Z., de Witte, J., van der Velde, J. J. H., Kader, M., van der Wouden, P. E., Poelarends, G. J. & Dekker, F. J., 5-okt-2024, In: European Journal of Medicinal Chemistry. 276, 116665.

Onderzoeksoutput › › peer review

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos

Chen, D., Osipyan, A., Adriana, J., Kader, M., Gureev, M., Knol, C. W. J., Sigmund, M. C., Xiao, Z., van der Wouden, P. E., Cool, R. H., Poelarends, G. J. & Dekker, F. J., 13-jul-2023, In: Journal of Medicinal Chemistry. 66, 13, blz. 8767-8781 15 blz.

Onderzoeksoutput › › peer review