New key publication:Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion.

Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion

Highlights

• Cholesterol is excreted in humans via biliary and direct transintestinal secretion

• In humans, TICE accounts for 35% of fecal cholesterol excretion

• Ezetimibe increases fecal cholesterol excretion primarily by activation of TICE

• The cholesterol transporter ABCG5/G8 mediates most of the TICE flux

Cell Metabolism

Editorial: Of TICE in Men .