New key publication:Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion.
04 November 2016
Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion
Highlights
- Cholesterol is excreted in humans via biliary and direct transintestinal secretion
- In humans, TICE accounts for 35% of fecal cholesterol excretion
- Ezetimibe increases fecal cholesterol excretion primarily by activation of TICE
- The cholesterol transporter ABCG5/G8 mediates most of the TICE flux
Editorial: Of TICE in Men .
| Last modified: | 13 January 2017 07.30 a.m. |
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