Skip to ContentSkip to Navigation
About usMedical SciencesResearchPediatrics
University Medical Center Groningen

Systems-wide Studies Uncover Commander, a Multiprotein Complex Essential to Human Development

29 May 2017
Commander
Commander

Here, we review the synergy between large-scale proteomic efforts and focused studies in the discovery of Commander, describe its composition, structure, and function, and discuss how it illustrates the power of systems biology. Based on 3D modeling and biochemical data, we draw strong parallels between Commander and the retromer cargo-recognition complex, laying a foundation for future research into Commander's role in human developmental disorders.

Last modified:29 May 2017 2.48 p.m.

More news

  • 13 August 2019

    Eat, sleep, recycle

    The 51st edition of KEI week is devoted to the theme of sustainability. On Monday 12 August, around 6,000 KEI participants and KEI leaders were handed cloth bags instead of plastic ones and a KEI wristband with a chip enabling digital payments. A vegetarian...

  • 12 August 2019

    Cold winters not caused by Arctic climate change

    Recent studies into the relationship between decreases in sea ice in the Arctic and ice-cold winters in the mid-latitudes, like the Polar Vortex cold waves in North America, seem to suggest that such a connection does indeed exist. However, the mechanisms...

  • 30 July 2019

    The University of Noorderzon

    Thursday 15 August marks the start of the 10-day Noorderzon Performing Arts Festival, held in our beautiful Noorderplantsoen park. Young and old will return home from the festivities slightly smarter than they were before, thanks to the ‘University...