Systems-wide Studies Uncover Commander, a Multiprotein Complex Essential to Human Development
Here, we review the synergy between large-scale proteomic efforts and focused studies in the discovery of Commander, describe its composition, structure, and function, and discuss how it illustrates the power of systems biology. Based on 3D modeling and biochemical data, we draw strong parallels between Commander and the retromer cargo-recognition complex, laying a foundation for future research into Commander's role in human developmental disorders.
| Last modified: | 29 May 2017 2.48 p.m. |
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