New Key Publication: Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol

Authors:

• Anna Bertolini
• Vincent W. Bloks
• Marijn Wilmink
• Eline Bos
• Ivo van de Peppel
• Roos Eilers
• Sake Prins
• Rachel Thomas
• Alain de Bruin
• Henkjan Verkade
• Johan W. Jonker

Highlights

• Cystic fibrosis (CF) features bile acids, fat, and cholesterol malabsorption

• Malabsorption is associated with decreased intestinal nuclear receptor signaling

• The laxative PEG increased bile acids, fat, and cholesterol absorption in CF mice

• Concomitantly, PEG improved intestinal nuclear receptor signaling in CF mice

• PEG decreased hepatic inflammation and cholesterol synthesis in CF mice

Read more: Journal of Cystic Fibrosis: https://www.sciencedirect.com/science/article/pii/S1569199323009190