New Key Publication: Organoids as a model to study intestinal and liver dysfunction in severe malnutrition

Highlights:

•Amino acid deficiency induces reversible loss of peroxisomes and mitochondria.

•Hepatic organoids show reversible lipid accumulation upon amino acid removal.

•Intestinal barrier permeability is compromised in the presence of low amino acids.

•Organoids are a suitable model to test metabolic function and treatment for malnutrition.

Authors:

• José M. Horcas-Nieto

• Christian J. Versloot

• Miriam Langelaar-Makkinje

• Albert Gerding

• Tjasso Blokzijl

• Mirjam H. Koster

• Mirjam Baanstra

• Ingrid A. Martini

• Robert P. Coppes

• Céline Bourdon

• Sven C.D. van Ijzendoorn

• Peter Kim

• Robert H.J. Bandsma

• Barbara M. Bakker

Read more: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease: https://www.sciencedirect.com/science/article/abs/pii/S0925443922003064