Murine Physiology
The normal ranges of a number of parameters in murine physiology
| General Physiology | |
|---|---|
| Body temperature | 37 - 38° C/ 98.6 - 100.4° F |
| Heart rate | 300 - 650 beats/min |
| Respiratory rate | 90 - 180 breaths/min |
| Chromosome number (diploid) | 40 |
| Life span under laboratory conditions | 1 - 3 years |
| Oxygen consumption | 1,7 ml/gr BW/ hour |
| Daily food intake | 5 gr/ 24 hours |
| Daily food intake Lactating female | 10 -12 gr /24 hours |
| Daily water intake | 5 ml/ 24 hours |
| Housing | |
| Room temperature | 21 - 23° C/ 69.8 - 73.4° F |
| Room temperature at recovery | 26 - 28° C/ 78.8 - 82.4° F |
| Relative humidity | 50 - 60% (55%) |
| Ventilation | 15 - 20 times/ hour |
| Day/ night rhythm | 14 - 10 hour |
| Floor area solitary mouse 20 gr. | 60 cm² |
| Floor area solitary mouse 30 gr. | 80 cm² |
| Floor area solitary mouse 40 gr. | 100 cm² |
| Floor area mouse with litter | 200 cm² |
| Floor area couple with litter | 360 cm² |
| Fertile | 35 - 50 days |
| Reproductive Physiology | |
| Age at mating | 57 - 70 days (8 - 10 weeks) |
| Oestrus | 4 - 5 days |
| Duration of the partus | 13 hours |
| Gestation period | 18 - 21 days (19 days) |
| Length of pseudopregnancy | 12 days |
| Postpartus oestrus | < 24 hours |
| Postpartus gestation period | 26 days |
| Pups/litter (depending on strain) | 6 - 12 pups |
| Age at weaning | 18 - 21 days |
| Body weight at birth | 1 - 1.5 gr. |
| Body weight at weaning | 10 - 12 gr. |
| Blood parameters | |
| pH | 7.35 ± 0.09 |
| pCO2 | 42 ± 5.7 mmHg |
| pO2 | 80 - 100 mmHg |
| ABEc | 2 mmol/L |
| HCO3¯ | 25.5 mmol/L |
| tCO2 | 40 - 55 Vol. % |
| Na+ | 128 -145 mmol/L |
| K+ | 4.8 - 5.8 mmol/L |
| tHB | 11.1 g/dl |
| Hctc | 41.8 % |
| sO2 | 95 - 99 % |
| O2HB | 94 - 99 % |
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Literature: * Animal models in cardiovascular research David R. Gross * Proefdierkunde (Dutch biotechnical manual) Stichting proefdierkundige informatie |
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Last modified:09 May 2016 11.46 a.m.