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University Medical Center Groningen

Murine Physiology

The normal ranges of a number of parameters in murine physiology

General Physiology
Body temperature 37 - 38° C/ 98.6 - 100.4° F
Heart rate 300 - 650 beats/min
Respiratory rate 90 - 180 breaths/min
Chromosome number (diploid) 40
Life span under laboratory conditions 1 - 3 years
Oxygen consumption 1,7 ml/gr BW/ hour
Daily food intake 5 gr/ 24 hours
Daily food intake Lactating female 10 -12 gr /24 hours
Daily water intake 5 ml/ 24 hours
Housing
Room temperature 21 - 23° C/ 69.8 - 73.4° F
Room temperature at recovery 26 - 28° C/ 78.8 - 82.4° F
Relative humidity 50 - 60% (55%)
Ventilation 15 - 20 times/ hour
Day/ night rhythm 14 - 10 hour
Floor area solitary mouse 20 gr. 60 cm²
Floor area solitary mouse 30 gr. 80 cm²
Floor area solitary mouse 40 gr. 100 cm²
Floor area mouse with litter 200 cm²
Floor area couple with litter 360 cm²
Fertile 35 - 50 days
Reproductive Physiology
Age at mating 57 - 70 days (8 - 10 weeks)
Oestrus 4 - 5 days
Duration of the partus 13 hours
Gestation period 18 - 21 days (19 days)
Length of pseudopregnancy 12 days
Postpartus oestrus < 24 hours
Postpartus gestation period 26 days
Pups/litter (depending on strain) 6 - 12 pups
Age at weaning 18 - 21 days
Body weight at birth 1 - 1.5 gr.
Body weight at weaning 10 - 12 gr.
Blood parameters
pH 7.35 ± 0.09
pCO2 42 ± 5.7 mmHg
pO2 80 - 100 mmHg
ABEc 2 mmol/L
HCO3¯ 25.5 mmol/L
tCO2 40 - 55 Vol. %
Na+ 128 -145 mmol/L
K+ 4.8 - 5.8 mmol/L
tHB 11.1 g/dl
Hctc 41.8 %
sO2 95 - 99 %
O2HB 94 - 99 %


Literature:
* Animal models in cardiovascular research David R. Gross
* Proefdierkunde (Dutch biotechnical manual) Stichting proefdierkundige informatie
Last modified:09 May 2016 11.46 a.m.