Colloquium Computer Science, Dr. Petra Schneider

Title: Computational analysis of human- and mouse-specific next-generation sequencing data in mixed tissue samples    

Abstract:

Blackfield is a young biotechnology company supporting pharmaceutical
companies in developing targeted cancer drugs. We offer to derive
genetic tumor profiles from next-generation sequencing (NGS) data.
Computational analysis of the raw sequencing data using proprietary
algorithms is a key step in this process, due to the massive amount of
data generated by NGS platforms. In this talk, I will outline the
generation and analysis of NGS data, and I will present the novel
strategy we integrated recently in our computational analysis pipeline
to deal with contaminated tumor samples. Artificial validation samples
demonstrate in a controlled setting how this approach influences
mutation calling or gene expression analyses.

Colloquium coordinators are Prof.dr. M. Aiello (e-mail : M.Aiello rug.nl ) and
Prof.dr. M. Biehl (e-mail: M.Biehl rug.nl )

http://www.rug.nl/research/jbi/news/colloquia/computerscience