PhD defence Iris Riemersma

Iris Riemersma (Neurobiology)

Promotores: Prof. M.J.H. Kas, Prof. R. Havekes

Making sense of autism

The role of synaptic dysfunction in shaping sensory trajectories

This thesis explores the role of sensory experiences, particularly in individuals with Autism Spectrum Disorder (ASD). Atypical responses to sensory stimuli are common in people with autism and can highly impact their daily lives. The research in this thesis, conducted using ASD mouse models for synaptic dysfunction, identifies common and specific developmental sensory phenotypes and underlying biological mechanisms. The work suggests a link between sensory sensitivity and social differences in ASD. Specifically, the protein cofilin in the somatosensory cortex, is identified as a potential substrate influencing the relationship between sensory and social functions.

This thesis contributes to the understanding of behavioral and molecular aspects of sensory symptoms in ASD mouse models for synaptic dysfunction. It also reveals a functional relationship between sensory and social functions through targeted suppression of cofilin in the somatosensory cortex.

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