The research in the laboratory for Endothelial Biomedicine & Vascular Drug Targeting focuses on understanding organ specific, microvascular endothelial cell behaviour in selected (inflammatory) diseases and development of therapeutic strategies to selectively interfere with endothelial cell (dys)function.
Three lines of research are explored in an integrated manner:
1] Unraveling of the molecular responses underlying microvascular endothelial cell activation and dysfunctionin vivoand its relation to leukocyte accumulation in inflammatory conditions and cancer;
2] Studying the molecular consequences of drug treatment in the microvasculature as well as in selected microvascular segments in diseased organs and their relation to disease progression;
3] Development of targeted drug delivery strategies that selectively interfere with endothelial cell (dys)function in diseased tissues.
More information on these topics, as well as on our projects, the participating scientists and laboratory technicians, and an overview of relevant publications can be found by clicking on the links in the menu at the left.
EBVDT group december 2010
Contact information:
Grietje Molema
University Medical Center Groningen (UMCG) Dept. Pathology and Medical Biology Medical Biology division
Room U2.115
Internal postal code: EA11 Hanzeplein 19713 GZ Groningen, The Netherlands telephone: +31-50-3610115 fax: +31-50-3619911
Dr. G. Molema is one of the editors of the following book:
Drug Targeting, Organ-Specific Strategies
Molema, G. and Meijer, D. (eds.); 2001, 382 pagesISBN 3-527-29989-0, Published by Wiley-VCH, Weinheim
