Publications

Selected, recent publications:

 

Vasculature targeted drug delivery:

 

Adrian JE, Morselt HW, Suss R, Barnert S, Kok JW, Asgeirsdottir SA, Ruiters MHJ, Molema G, and Kamps JAAM (2010), Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells. J.Cont.Rel. 144: 341-349 [PDF]

 

Asgeirsdottir SA, Talman EG, de Graaf IA, Kamps JA, Satchell SC, Mathieson PW, Ruiters MH, and Molema G (2010), Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro - a quantitative study. J.Cont.Rel. 141: 241-251 [PDF]

 

Asgeirsdottir SA, Zwiers PJ, Morselt HW, Moorlag HE, Bakker HI, Heeringa P, Kok JW, Kallenberg CGM, Molema G, and Kamps JAAM (2008), Inhibition of inflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes (2008). Am.J.Physiol Renal Physiol 294: F554-F561   [PDF]

 

Asgeirsdottir SA, Kamps JAAM, Bakker HI, Zwiers PJ, Heeringa P, van der Weide K, Van Goor H, Petersen AH, Morselt HW, Moorlag HE, Steenbergen E, Kallenberg CGM, and Molema G (2007), Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium. Molc. Pharmacol. 72(1): 121-131 [PDF].

 

Ogawara et al. (2006) Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene. Arthritis Research & Therapy 8:R32 [PDF]

 

Endothelial dysfunction (inflammatory diseases, small vessel vasculitis, cancer):

 

van Meurs M, Fisheri NK, Wulfert FM, Asgeirsdottir SA, de Graaf IA, Satchell SC, Mathieson PW, Jongman RM, Kumpers P, Zijlstra JG, Heeringa P, and Molema G (2009), Shock induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function. Am.J Physiol Renal Physiol. 297 (2): F272-281 [PDF].

 

van Meurs M, Kümpers P, Ligtenberg JJ, Meertens JHJM, Molema G, and Zijlstra JG (2009), Bench-to-bedside-review: Angiopoietin signalling in critical illness; a future target? Crit Care 13: 207. [PDF]

 

van Meurs et al. (2008) Early organ-specific endothelial activation during hemorrhagic shock and resuscitation. Shock 29: 291-299  [PDF]

 

Peter Y. Wielinga, Gopala K. Yakala, Peter Heeringa, Robert Kleemann, Teake Kooistra: Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation. PloS One  [PDF]

 

H Tadema, CA Stegeman, CGM Kallenberg and P Heeringa: Reactivity against complementary Proteinase-3 is not increased in patients with PR3-ANCA-associated vasculitis. PloS One 2011 [PDF]. 

 

Henko Tadema, Wayel H. Abdulahad, Nikola Lepse, Coen A. Stegeman, Cees G. M. Kallenberg and Peter Heeringa: Bacterial DNA motifs trigger ANCA production in ANCA-associated vasculitis in remission. Rheumatology 2011 in press [PDF]

 

Heeringa P, Little MA: In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations. Arthritis Research &Therapy 2011, 13:204. [PDF]

 

van Timmeren MM, van der Veen BS, Stegeman CA, Petersen AH, Hellmark T, Collin M, Heeringa P: IgG glycan hydrolysis attenuates ANCA-mediated glomerulonephritis. J Am Soc Nephrol 2010, 21(7):1103-1114 [PDF].

 

Summers SA, van der Veen BS, O'Sullivan KM, Gan PY, Ooi JD, Heeringa P, Satchell SC, Mathieson PW, Saleem MA, Visvanathan K et al: Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int 2010, 78(12):1263-1274 [PDF].

 

van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, and Heeringa P (2009), Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody mediated glomerulonephritis. Clin.Exp.Immunol. 158(1): 143-153 [PDF].

 

Zeng WJ, Gouw AS, van den Heuvel MC, Poppema S, Zhang N, Plateel I, de Jong KP, and Molema G (2008), The angiogenic make up of human hepatocellular carcinoma does not favour VEGF/Angiopoietin driven neovascularization. Hepatology 48(5):1517-1527 [PDF].

 

 

Microvascular endothelial pharmacology:

 

van der Veen BS, Chen M, Muller R, van Timmeren MM, Petersen AH, Lee PA, Satchell SC, Mathieson PW, Saleem MA, Stegeman CA, Zwerina J, Molema G, and Heeringa P (2011), Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo. Ann.Rheum.Dis. 70(2):356-65 [PDF].

 

Hegeman MA, Hennus MP, van MM, Cobelens PM, Kavelaars A, Jansen NJ, Schultz MJ, van Vught AJ, Molema G, and Heijnen CJ, Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury. PLoS ONE, 5: e15653, 2010 [PDF].

 

Molema G, Heterogeneity in responses of microvascular endothelial cells during inflammation . In: Endothelial dysfunction and inflammation (Eds. Dauphinee SM and Karsan A), pp. 15-35. Birkhauser Verlag AG, Basel, Switzerland, 2010.

 

Molema G (2010), Heterogeneity in endothelial responsiveness to cytokines, molecular causes and pharmacological consequences. Sem Thromb Hemost 36: 246-264 [PDF].

 

Wagemakers M, van der Wal GE, Cuberes R, Alvarez I, Andres EM, Buxens J, Vela JM, Mooij JJA, and Molema G (2009), COX-2 inhibition combined with radiation reduces orthotopic glioma outgrowth by targeting the tumor vasculature. Translational Oncology 2 (1): 1-7 [PDF].

 

Langenkamp E and Molema G (2009). Microvascular endothelial cell heterogeneity - General concepts and pharmacological consequences for anti-angiogenic therapy of cancer. Cell Tissue Res 335 (1): 205-222. [PDF]