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Over ons Praktische zaken Waar vindt u ons dr. D.C.J. Spierings

Research interests

Single cell sequencing, genome instability, structural variations, ageing, stem cells, cancer, immunology

Publicaties

Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression

Drug-resilient cancer cell phenotype is acquired via polyploidization associated with early stress response coupled to HIF-2α transcriptional regulation

Extra centrosomes delay DNA damage-driven tumorigenesis

Genome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing

Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation

Transcriptional differences between vesicular hand eczema and atopic dermatitis

Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization

Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition

A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells

Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia

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Pers/media

Death receptors in normal and malignant tissues