New key Publication: Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
ABSTRACT
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.
Authors:
- Anouk M. La Rose
- Anouk G. Groenen
- Benedek Halmos
- Venetia Bazioti
- Martijn G.S. Rutten
- Kishore A. Krishnamurthy
- Mirjam H. Koster
- Niels J. Kloosterhuis
- Marieke Smit
- Rick Havinga
- Gilles Mithieux
- Fabienne Rajas
- Folkert Kuipers
- Maaike H. Oosterveer
- Marit Westerterp
Read more : Molecular Genetics and Metabolism Reports
Last modified: | 25 April 2022 6.38 p.m. |
More news
-
29 April 2024
Tactile sensors
Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...
-
16 April 2024
UG signs Barcelona Declaration on Open Research Information
In a significant stride toward advancing responsible research assessment and open science, the University of Groningen has officially signed the Barcelona Declaration on Open Research Information.
-
02 April 2024
Flying on wood dust
Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...