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Experimental Hematology

University Medical Center Groningen

Department of Experimental Hematology

labretreat 2014
labretreat 2014

The general aims of the division of Experimental Hematology are to obtain detailed knowledge on (molecular) mechanisms that determine hematopoietic stem cell self-renewal and differentiation, with the ultimate goal to deepen our insights in the development of human leukemias. We perform gene-function analyses in human hematopoietic stem and progenitor cells isolated from cordblood and bone marrow utilizing various strategies including optimized retro/lentiviral transduction protocols and inducible RNAi approaches. We have a longstanding expertise in using molecular approaches to further understand processes such as hematopoietic differentiation, proliferation, apoptosis and self-renewal. We utilize a series of cell biological in vitro and in vivo model systems to be able to translate knowledge from our molecular research lines to more general concepts of hematopoietic stem cell biology. Furthermore, we have banked large series of leukemic patient material and are currently focusing on elucidating whether leukemic stem cells exist, what their phenotype is, which mechanisms result in enhanced self-renewal and a disturbed differentiation profile, and whether we can restore the normal hematopoietic differentiation program by e.g. interfering at the genetic level or by utilizing novel therapeutical agents. We anticipate that our studies will lead to a more rational approach in the clinic of this highly malignant disorder.


LATEST NEWS!!

Vincent van den Boom and Henny Maat published their work on the non-canonical PRC1.1 complex in Cell Reports. see website

Graphical abstract Cell Reports
Graphical abstract Cell Reports
Marta's defense November 2015
Marta's defense November 2015

October 2015

Matthieu Bosman defended his thesis in October 2015.

Thesis defense Matthieu Bosman
Thesis defense Matthieu Bosman

September 2015


May 2015

Capala et al
Capala et al

Marta Capala published a paper in Plos ONE showing that RAC2 fulfils an essential role in BCR-ABL transformed cells. Time-lapse confocal microscopy surprisingly revealed very distinct localisation of RAC1 and RAC2 in human hematopoietic stem/progenitor cells. Proteome studies to identify RAC1 and RAC2 interactomes revealed that RAC2 interacts with a set of mitochondrial proteins including mitochondrial transport proteins SAM50 and Metaxin 1. Downregulation of RAC2 or SAM50 impaired self-renewal associated with a decreased mitochondrial membrane potential and impaired mitochondrial integrity as determined by EM.


May 2015

HaemMetabolome
HaemMetabolome

HaemMetabolome awarded to JJ Schuringa. Within this Marie Skłodowska-Curie Actions Innovative Training Network (H2020-ITN-EJD, 2.4M euro) we aim to unravel metabolomic changes in haematological malignancies. Besides the UMCG/Experimental Hematology, the consortium consists of Ulrich Gunther (University of Birmingham, UK; NMR-based metabolomics/fluxomics), Marta Cascante (University of Barcelona, Spain; LC-MS/MS based metabolomics) en Harold Schwalbe/Hubert Serve (University of Frankfurt, Germany; leukemias).


October 2014

Capala et al
Capala et al

Marta Capala published a paper in Plos ONE showing that Engulfment and Motility protein 1 (ELMO1) is upregulated in AML CD34+ stem/progenitor cells which predicts poor prognosis in normal karyotype AML.


October 2014

KWF
KWF

Dutch Cancer Foundation (KWF) basic science grant awarded to JJ Schuringa, Edo Vellenga and Vincent van den Boom, entitled: Functional characterization of the non-canonical PRC1.1 complex as novel target in leukemia. € 567.200,-


September 2014

Bosman et al
Bosman et al

Matthieu Bosman published a paper in Blood in which he identified TAK1 as a critical kinase that regulates leukemic stem cell self-renewal.


September 2014

Schepers et al
Schepers et al

Hein Schepers published his paper in Leukemia showing that CITED2 is critically important for leukemic stem cells.


June 2014

Sontakke et al
Sontakke et al

Publication of book chapter on ex vivo expansion protocols of human leukemic stem cells


March 2014

Wierenga et al
Wierenga et al

Bart Jan Wierenga published his paper in Plos ONE in which he studied hypoxia-induced transcriptome changes in human stem/progenitor cells and identified that TGFb and hypoxia pathways converge on cell cycle regulation.


January 2013

vandenBoometal
vandenBoometal

Vincent van den Boom published his study in Blood in which he showed that PRC1 members fulfil non-essential roles in human stem/progenitor cells.


May 2013

Bonardi et al
Bonardi et al

Francesco Bonardi published his study in Molecular and Cellular Proteomics. By performing genome-wide transcriptome and proteome studies he identified leukemia-specific plasma membrane proteins that can be used for identification and targeting of leukemic stem cells.


April 2013

Horton et al
Horton et al

Sarah Horton published her paper in Leukemia showing that fetal stem/progenitor cells readily transform along the myeloid of lymphoid lineage, depending on extrinsic cues, while adult human stem/progenitor cells can only be transformed along the myeloid lineage, in line whith what is seen in patients.


April 2013

Valent et al
Valent et al

JJ Schuringa co-authored a paper in Nature Reviews Cancer on cancer stem cells.

Last modified:January 04, 2016 16:28