Dedicated Research Facilities
Dedicated infrastructure at GBB is strategically concentrated to create larger set-ups of advanced facilities to enhance progress in multidisciplinary fundamental research. Together with well-equipped modern molecular laboratories a sophisticated and attractive research environment is provided for undergraduate students, PhD students, postdoctoral fellows, and visiting scientists. Representative larger research facilities comprise:
- Advanced analytical equipment for the rapid high-throughput screening of large (mutant) gene, genomic, and environmental (metagenomic) DNA libraries, as well as enzyme activities and metabolites.
- Infrastructure for research dedicated to carbohydrate bioprocessing, providing an academic platform for fundamental and pre-competitive research on: i) enzymatic carbohydrate synthesis, modification, and degradation; ii) in vivo and in vitro synthesis of novel carbohydrates and tests for potential applications in food, non-food, and feed; iii) metabolic engineering of carbohydrate metabolism in microbes and plants.
- State-of-the-art instrumentation for protein structure determination and characterisation with equipment ranging from microcalorimetry (differential scanning, isothermal titration), circular dichroism spectroscopy, stopped-flow fluorescence spectroscopy, HREM single particle analysis of (membrane) protein complexes, protein crystallisation and X-ray diffraction analysis, complemented with use of synchrotron facilities.
- Dedicated in-house and access to high performance computing facilities (e.g. Bluegene computer cluster and the CAVE) for molecular dynamics simulations and integrative bioinformatics.
- A Membrane Proteomics Centre at which expertise and technologies involved in membrane proteomics are further developed and implemented. The expertise covers the whole range from controlled cultivation of microorganisms, the isolation, subfractionation, and purification (e.g. LC, 2D gels) of membrane fractions or membrane proteins, and the high resolution analysis of samples by mass spectrometry (MALDI-TOF/TOF, LTQ-Orbi-Trap).
- A state-of-the-art in-house DNA Microarray Facility that includes advanced liquid-liquid handling robotics, a DNA-arrayer, a hybridisation station, laser scanner for data acquisition, and several servers for subsequent advanced bioinformatics analyses of the results. DNA microarrays are made in-house and contain amplified DNA fragments of all the genes of Bacillus subtilis (strain 168), B. cereus (type strain), Lactococcus lactis (strains IL1403 and MG1363), and Streptococcus pneumoniae (strains TIGR4 and R6).
- State-of-the-art microscopy facilities ranging from fluorescence microscopes, advanced confocal laser scanning microscopes to HR-Cryo EM suitable for cell and protein analysis.
|Laatst gewijzigd:||08 mei 2013 13:55|