Ligand-mediated transport of drug delivery devices across the blood-brain barrier
PhD ceremony: Ms. J.V. Georgieva, 14.30 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Ligand-mediated transport of drug delivery devices across the blood-brain barrier
Promotor(s): prof. D. Hoekstra
Faculty: Medical Sciences
The bottleneck for successful drug delivery into the brain is the blood-brain barrier (BBB), a physical and metabolic barrier. Nanoparticles represent drug delivery devices, that - when linked to proper targeting ligands - may penetrate the BBB and hence increase the bioavailability of medicines into the brain. Moreover, a therapeutic molecule can be incorporated in a nanoparticle, protecting if from degradation during transport to the site of action. In this project, the cellular prion protein and the monosialoganglioside GM1 as blood-brain barrier receptors were characterized regarding their potential to induce receptor-mediated transcytosis of ligand-modified nanoparticles. Novel short peptidic ligands that bind to either prion or GM1 generated phage display and grafted on the surface of polymeric nanoparticles. Nanoparticles decorated with a GM1-binding peptide showed a brain-targeting potential in vivo, together with a high transcytotic capacity in vitro and in vivo, which makes them a promising vehicle for drug delivery into the brain.
Last modified: | 13 March 2020 01.02 a.m. |
More news
-
29 April 2024
Tactile sensors
Every two weeks, UG Makers puts the spotlight on a researcher who has created something tangible, ranging from homemade measuring equipment for academic research to small or larger products that can change our daily lives. That is how UG...
-
29 April 2024
Behind the scenes: how UG and Hanze UAS students are jointly developing a Mars rover
This year the students of the Makercie team are participating in the physical edition of the European Rover Challenge in Poland. Read more about the team and the collaboration between the RUG and Hanze UAS here.
-
23 April 2024
Nine MSCA Doctoral Network grants for FSE researchers
Nine researchers of the Faculty of Science and Engineering have received a Horizon Europe Marie Sklodowska Curie Doctoral Network grant.