Total syntheses of (-)-borrelidin and (-)-doliculide and the development of the catalytic asymmetric addition of Grignard reagents to ketones
PhD ceremony: Mr. A.V.R. Madduri Venkata, 12.45 uur, Academiegebouw, Broerstraat 5, Groningen
Dissertation: Total syntheses of (-)-borrelidin and (-)-doliculide and the development of the catalytic asymmetric addition of Grignard reagents to ketones
Promotor(s): prof. A.J. Minnaard
Faculty: Mathematics and Natural Sciences
This thesis describes the application of copper-catalyzed asymmetric conjugate addition and ruthenium-catalyzed asymmetric hydrogenation in novel total syntheses of the macrocyclic polyketides Borrelidin and Doliculide. A second topic in the thesis comprizes the development of a novel asymmetric synthesis of chiral tertiary alcohols by copper-catalyzed addition of Grignard reagents to ketones. During the study of the latter reaction, asymmetric amplification was observed. A procedure for the copper-catalyzed conjugate addition reaction to 2-methyl cyclopentenone and 2-methyl cyclohexenone was developed as well. Finally, the already known procedure for iridium catalyzed epimerization of alcohols and amines, was extended to 1,2-amino alcohols and substrates containing multiple functional groups.
Last modified: | 13 March 2020 12.58 a.m. |
More news
-
23 April 2024
Nine MSCA Doctoral Network grants for FSE researchers
Nine researchers of the Faculty of Science and Engineering have received a Horizon Europe Marie Sklodowska Curie Doctoral Network grant.
-
22 April 2024
Charissa Roossien secures JTF subsidy to develop Health Tracker
Dr. Charissa Roossien (ENTEG) has successfully secured a Just Transition Fund (JTF) subsidy of 1.8 million euros to develop a Health Tracker for reliable respiratory and metabolic analysis.
-
16 April 2024
UG signs Barcelona Declaration on Open Research Information
In a significant stride toward advancing responsible research assessment and open science, the University of Groningen has officially signed the Barcelona Declaration on Open Research Information.