Skip to ContentSkip to Navigation
About us Latest news News News articles

€ 500,000 grant for research into prostate cancer

03 July 2012

Three researchers from the UMCG have been awarded a grant of € 500,000 by the Dutch Cancer Society [KWF Kankerbestrijding] for research into a new treatment for prostate cancer. The focus of their research will be on boosting the ‘chemo vaccination effect’, whereby after chemotherapy, dead cancer cells help to generate an immunoreaction to living cancer cells. The project will contribute to the ongoing search for better vaccines for treating or preventing prostate cancer and other forms of cancer.

Prostate cancer is one of the most common types of cancer among men. The number of cases has risen steeply over the past years. If detected in time, prostate cancer can be cured. Surgical removal of the affected prostate is one of the treatment options, but this is a complex procedure that can lead to impotence and incontinence. However, if it has spread, the disease is almost impossible to treat and life expectancy is short.

Researchers recently discovered that the dying and dead cancer cells resulting from treatment using a certain form of chemotherapy can prompt an immunoreaction to the cancer cells that are still active. Unfortunately, this reaction (also known as the ‘chemo vaccination effect’) is too weak to suppress the disease. The aim of this research is to find ways of boosting this effect. To achieve this, it is important that certain processing cells (dendrites) in the immune system become more adept at finding the dead and dying cancer cells so that they can consume and process them more effectively.

Bearing this in mind, researchers Wijnand Helfrich and Edwin Bremer (Surgical Oncology) and oncological urologist Igle Jan de Jong have developed new recombinant protein molecules that are able to deliver certain ‘immune boosting’ signals to the surface of prostate cancer cells selectively. One of these signals is a so-called ‘eat me’ signal. Delivering this signal to cancer cells encourages the dendritic cells already present to up their game. In addition, immunological ‘bait’ is supplied in and around the prostate cancer cells to entice more dendrites towards these prostate cancer cells.

The drug study will initially be carried out in the UMCG laboratories. If the results are encouraging, the researchers will decide whether the drugs they have developed can be adapted for use in patient care. The entire study, which lasts 4 years, will take place in the UMCG.

Note for editors

More information is available from the press information officers at the UMCG, tel. +31 (0)50 361 22 00.

Last modified:13 March 2020 01.51 a.m.
View this page in: Nederlands

More news

  • 13 May 2024

    Trapping molecules

    In his laboratory, physicist Steven Hoekstra is building an experimental set-up made of two parts: one that produces barium fluoride molecules, and a second part that traps the molecules and brings them to an almost complete standstill so they can...

  • 06 May 2024

    Impact: 'URinControl', treatment of urine loss through app

    One of the three researchers nominated for the Ben Feringa Impact Award 2024 is general practicioner and researcher-epidemiologist Anne Loohuis. Loohuis conducted research on the treatment of urine loss through the self-help app URinControl'.

  • 29 April 2024

    Royal Decoration awarded to Gerard van den Berg

    The Faculty of Economics and Business is very proud to announce that Professor Gerard van den Berg has been appointed Officer of the Order of Orange-Nassau. The decoration was presented to him by Mayor Koen Schuiling of the Municipality of...