Epidemiology

University Medical Center Groningen

Dr. Eva Corpeleijn

Dr. Eva Corpeleijn
Dr. Eva Corpeleijn

Dr. Eva Corpeleijn (1976) is assistant professor at the Department of Epidemiology, University Medical Centre Groningen. She initiates research on the underlying mechanisms that explain the benefits of a healthy lifestyle, mainly diet and physical activity, with a special focus on lipid metabolism and diabetes. She is also member of the ‘Lifestyle and the Kidney’ research group at the department of Nephrology (prof. Gerjan Navis, dr. SJL Bakker) and is actively involved in research on lifestyle and cardio-metabolic risk in renal transplant patients. She co-ordinates the research of a group of 6 PhD-students and 2-3 (annually changing) MSc-students.

 

Topics:

- interaction between obesity and physical activity/fitness on diabetes risk (Chinese population, adults) and metabolic syndrome (TRAILS, adolescents).

- prevention of somatic disease by lifestyle measures in psychiatric patients (ELIPS study, RCT in collaboration with GGZ Friesland).

- ACT study: RCT with combined lifestyle intervention to prevent weight gain and increased cardiometabolic risk in renal transplant patients

- perinatal epidemiology: fat distribution during pregnancy, role of very early lifestyle in childhood obesity.

- physiological and molecular mechanisms underlying the effects of lifestyle interventions, especially with regard to liver fat.

- GECKO Drenthe (project leader. This prospective birth cohort of 2700 children born in Drenthe between 2006 and 2007 aims to study early determinants of childhood obesity.

- Prediction research: researcher in PREDICCt (Biomarkers for the Prediction and Early Diagnosis of Diabetes and Diabetes-related Cardiovascular Complication), a project from the Center for Transplational Molecular Medicine (CTMM). Development and validation of prediction rules for diabetes and its renal and cardiovascular complications.

 

From 2001-2006, she performed her PhD study at the Faculty of Health, Medicine and Life Sciences, Maastricht University, on the underlying mechanisms of lifestyle intervention to prevent type 2 diabetes mellitus under the supervision of Prof. Ellen Blaak and Prof. Wim Saris. She discovered that in the lifestyle intervention study, changes in serum fatty acid profiles, but not adiponectin, were strongly related to improvements in insulin resistance. Furthermore, impairments in the capacity to regulate fat oxidation during fasting and after a meal were impaired in the prediabetic state, but improved after weight loss. In 2006-2008, she worked as a postdoc at the Maastricht University to continue her work on the underlying mechanisms of lifestyle factors on the prevention of type 2 diabetes and worked in the lab of prof. Arild Rustan – University of Oslo, Norway - to gain insight in the molecular mechanisms of ectopic fat deposition and potential biomarkers for impaired lipid metabolism in skeletal muscle. From 2008-2010, she was granted a 2-year postdoc position at the Department of Epidemiology, UMCG, to initiate research on lifestyle interventions and cardio-metabolic risk in specificat risk populations including renal patients, patients with severe mental illness and pregnant women.

 

During her career, she has been involved in teaching according to the ‘problem based learning’ approach, and supervision of MSc and PhD students. She is a member of the Netherlands Association for the Study of Obesity (NASO), the Dutch Organisation for Diabetes Reseach (NVDO), the Netherlands Organisation for Epidemiology (VvE) and is certified as a researcher in Medical Physiology, as a Biomedical Researcher in Nutritional Sciences by the Dutch Academy of Nutritional Sciences and is registered as ‘Epidemiologist B’.

 

Link to PhD thesis: http://arno.unimaas.nl/show.cgi?fid=10536 or http://dissertaties.ub.unimaas.nl/

Personal pages: http://www.linkedin.com/in/evacorpeleijn

Selected recent publications:

 

· Qin L, Corpeleijn E, Jiang C, Thomas GN, Schooling CM, Zhang W, Cheng KK, Leung GM, Stolk RP, Lam TH. Physical activity, adiposity, and diabetes risk in middle-aged and older Chinese population: the Guangzhou Biobank Cohort Study. Diabetes Care. 2010 Nov;33(11):2342-8.

 

· Konings E, Corpeleijn E, Bouwman FG, Mariman EC, Blaak EE. Expression of genes involved in lipid metabolism in men with impaired glucose tolerance: impact of insulin stimulation and weight loss. J Nutrigenet Nutrigenomics. 2010;3(1):9-17.

 

· Abbasi A, Corpeleijn E, Postmus D, Gansevoort RT, de Jong PE, Gans RO, Struck J, Hillege HL, Stolk RP, Navis G, Bakker SJ. Plasma procalcitonin is associated with obesity, insulin resistance, and the metabolic syndrome. J Clin Endocrinol Metab. 2010 Sep;95(9):E26-31.

 

· Corpeleijn E, Hessvik NP, Bakke SS, Levin K, Blaak EE, Thoresen GH, Gaster M, Rustan AC. Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids. Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E14-22.

 

· Zelle DM, Corpeleijn E, van Ree RM, Stolk RP, van der Veer E, Gans RO, Homan van der Heide JJ, Navis G, Bakker SJ. Markers of the hepatic component of the metabolic syndrome as predictors of mortality in renal transplant recipients. Am J Transplant. 2010 Jan;10(1):106-14.

 

· Corpeleijn E, Petersen L, Holst C, Saris WH, Astrup A, Langin D, MacDonald I, Martinez JA, Oppert JM, Polak J, Pedersen O, Froguel P, Arner P, Sørensen TI, Blaak EE. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. Obesity (Silver Spring). 2010 Jul;18(7):1369-77.

 

· Qin L, Knol MJ, Corpeleijn E, Stolk RP (2010) Does physical activity modify the risk of obesity for type 2 diabetes: a review of epidemiological data. Eur J Epidemiol. 2010;25(1):5-12. Review.

· Roumen C, Blaak EE, Corpeleijn E (2009) Lifestyle intervention for prevention of diabetes: determinants of success for future implementation. Nutr Rev 67: 132-146

· Corpeleijn E, Saris WH, Blaak EE (2009) Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle. Obes Rev 10: 178-193

· Corpeleijn E, Bakker SJ, Stolk RP (2009) Obesity and impaired renal function: potential for lifestyle intervention? Eur J Epidemiol 24: 275-280

· Roumen C, Corpeleijn E, Feskens EJ, Mensink M, Saris WH, Blaak EE (2008) Impact of 3-year lifestyle intervention on postprandial glucose metabolism: the SLIM study. Diabet Med 25: 597-605

· Corpeleijn E, Mensink M, Kooi ME, Roekaerts PM, Saris WH, Blaak EE (2008) Impaired Skeletal Muscle Substrate Oxidation in Glucose-intolerant Men Improves After Weight Loss. Obesity (Silver Spring) 16: 1025-1032

· Corpeleijn E, Feskens EJ, Jansen EH, Mensink M, Saris WH, Blaak EE (2007) Lifestyle intervention and adipokine levels in subjects at high risk for type 2 diabetes: the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM). Diabetes Care 30: 3125-3127

· Corpeleijn E, Feskens EJ, Jansen EH, et al. (2006) Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study. Diabetologia 49: 2392-2401

Last modified:November 19, 2012 14:47