Adolescent idiopathic scoliosis is characterised by an S- or C-shaped lateral deviation of the spine, an axial rotation of the vertebrae, and a flattening of the sagittal curvature.
Present surgical therapy brings several disadvantages like fusion of the involved vertebrae and the necessity to wait with surgery until the end of the growth of the patient.
Therefore, a non-fusion scoliosis correction device is being developed in which the disadvantages of present systems are reduced. Furthermore, this device should correct the deformity in all three anatomical planes and should allow growth of the patient.
The focus of this thesis is on providing boundary conditions for adequate testing and application of the non-fusion scoliosis correction device rather than on testing of the device itself. For optimization of the design of the implant, a finite element model of the complete spine is being made and for the validation of this model, extensive in-vitro tests were performed and described in this thesis.
Furthermore, the implant will be tested in a porcine model and therefore part 1 of this thesis aims to answer to question whether the geometrical and biomechanical characteristics of the porcine spine are representative for the human spine.
Part 2 of this thesis focuses on the timing of the surgery. This is highly important and mainly dependent on the timing of the pubertal growth spurt of the adolescent patient. Therefore, part 2 of this thesis presents several methods for prediction of the timing and magnitude of the peak growth velocity in the individual child.
|Last modified:||04 July 2014 9.23 p.m.|
23 March 2017Regional inequality in times of globalization | Inaugural lecture Bart Los | 28 March
In recent years, evaluations of national elections have tended to focus on regional differences in the way people vote, particularly on the number of ‘protest voters’. This has led to the term ‘the geography of discontent’; the geographical distribution...
22 March 2017New ethical guidelines needed for human stem cell and embryo research
In an article published on 21 March 2017 in the journal eLife, ethicist Jeantine Lunshof from the UMCG and scientists from Harvard Medical School (USA) sketch the outlines for developing new guidelines relating to embryo research .
20 March 2017Subsidie Laura Batstra: Klassenfeestjes tegen sociale uitsluiting
Laura Batstra start een project waarbinnen kinderfeestjes voor de hele klas georganiseerd en gepropageerd worden met als doel sociale uitsluiting van kinderen tegen te gaan. Stichting Kinderpostzegels subsidieert dit initiatief.