The role of the farnesoid X receptor in metabolic control
PhD ceremony: Ms. J.H.M. Stroeve, 14.45 uur, Academiegebouw, Broerstraat 5, Groningen
Title: The role of the farnesoid X receptor in metabolic control
Promotor(s): prof. F. Kuipers, prof. B. Staels
Faculty: Medical Sciences
Obesity increases the risk of serious health problems, including metabolic diseases such as the metabolic syndrome, cardiovascular diseases and type 2 diabetes. The subject of this thesis was to study the role of the so-called farnesoid X receptor (FXR) in regulating various metabolic processes including those of bile acids, sugars and fats. First, the relative contribution of FXR in the intestine to the regulation of hepatic bile acid production has been determined in mice. Then the consequences of FXR-deficiency on the metabolism of bile acids, sugars and fats were studied in mouse models of obesity. Finally, the role of FXR in the development and functioning of adipose tissue was examined. Together, the results indicate that FXR is an interesting starting point to influence the regulation of various metabolic processes.
| Last modified: | 13 March 2020 01.12 a.m. |
More news
-
15 May 2024
Part of the children with ADHD can stop using Ritalin sooner
A part of children with ADHD could stop taking Ritalin after two years. This is the conclusion of Anne-Flore Matthijssen's PhD research.
-
13 May 2024
Trapping molecules
In his laboratory, physicist Steven Hoekstra is building an experimental set-up made of two parts: one that produces barium fluoride molecules, and a second part that traps the molecules and brings them to an almost complete standstill so they can...
-
06 May 2024
Impact: 'URinControl', treatment of urine loss through app
One of the three researchers nominated for the Ben Feringa Impact Award 2024 is general practicioner and researcher-epidemiologist Anne Loohuis. Loohuis conducted research on the treatment of urine loss through the self-help app URinControl'.