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Nollen, prof. dr. ir. Ellen

Ellen Nollen
Ellen Nollen

Medisch genetica Nollen doet bij instituut ERIBA in het kader van het Healthy Ageing-programma onderzoek naar de genetische oorzaak van het ontstaan van neurodegeneratieve ziekten als Parkinson, Alzheimer en Huntington. Eerder deed ze hier onderzoek naar aan de Northwestern University in Chicago (VS) en aan het Hubrecht-laboratorium, het KNAW-instituut van Ronald Plasterk in Utrecht.  Nollen heeft ontdekt dat het gen moag-4 de stapeling en de schadelijke effecten van ziekte-eiwitten regelt tijdens het verouderingsproces van cellen.

Ellen Nollen was de eerste onderzoekster die aan het UMCG een Rosalind Franklin Fellowship kreeg toegekend. Met de Rosalind Franklin Fellowships willen RUG en UMCG vrouwelijk onderzoekstalent in huis halen. In 2011  werd ze door de Europese organisatie voor moleculair biologisch onderzoek als enige Nederlandse onderzoeker verkozen tot EMBO Young Investigator. Dat jaar ontving ze tevens ontving een Europese ERC-subsidie van 1,5 miljoen euro voor haar onderzoek. De ERC-grants zijn bedoeld om excellente onderzoeksteams op te zetten of verder te versterken.  

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Publicaties

2024

Koopman, M., Güngördü, L., Janssen, L., Seinstra, R. I., Richmond, J. E., Okerlund, N., Wardenaar, R., Islam, P., Hogewerf, W., Brown, A. E. X., Jorgensen, E. M., & Nollen, E. A. A. (2024). Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity. Cell reports, 43(5), Article 114204. https://doi.org/10.1016/j.celrep.2024.114204

2023

Stroo, E., Janssen, L., Sin, O., Hogewerf, W., Koster, M., Harkema, L., Youssef, S. A., Beschorner, N., Wolters, A. H. G., Bakker, B., Becker, L., Garrett, L., Marschall, S., Hoelter, S. M., Wurst, W., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Thathiah, A., ... Nollen, E. A. A. (2023). Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. Life science alliance, 6(7), Article e202201730. https://doi.org/10.26508/lsa.202201730
Koopman, M., Güngördü, L., Seinstra, R. I., & Nollen, E. A. A. (2023). Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs different neuronally controlled behaviors anddecreases fecundity. microPublication biology, 2023. Advance online publication. https://doi.org/10.17912/micropub.biology.000769
Koopman, M., Güngördü, L., Seinstra, R. I., & Nollen, E. A. A. (2023). Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs motor function. microPublication biology, 2023. Advance online publication. https://doi.org/10.17912/micropub.biology.000768
Koopman, M., Güngördü, L., Seinstra, R. I., Hogewerf, W., & Nollen, E. A. A. (2023). Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies. microPublication biology, 2023. Advance online publication. https://doi.org/10.17912/micropub.biology.000767
Koopman, M., Güngördü, L., Seinstra, R. I., & Nollen, E. A. A. (2023). Neuronal overexpression of human TDP-43 in Caenorhabditis elegans causes a range of sensorimotor phenotypes. microPublication biology, 2023. Advance online publication. https://doi.org/10.17912/micropub.biology.000766

2022

Broekmans, S. A., Tornero, C. V., Toonen, L., Valls, M., Erbrink, R., Ronde, K. E., Hogewerf, W., Tolsma, L. E. D., Seinstra, R. I., Janssen, L. L. S., Nollen, E. A. A., & Valles, A. (2022). Alpha-Synuclein Lowering and Rescue of Motor Phenotype by miRNA-Based AAV Gene Therapy in In Vivo Parkinson's Disease Models. Molecular Therapy, 30(4), 10-10.
Couzijn, S., & Nollen, E. A. (2022). A sudden collapse: the disaggregation of amyloid fibres. The EMBO Journal, 41, Article e111700. https://doi.org/10.15252/embj.2022111700

2021

Koopman, M., Janssen, L., & Nollen, E. A. A. (2021). An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans. BMC Biology, 19(1), 170. https://doi.org/10.1186/s12915-021-01085-2
Perni, M., van der Goot, A., Limbocker, R., van Ham, T. J., Aprile, F. A., Xu, C. K., Flagmeier, P., Thijssen, K., Sormanni, P., Fusco, G., Chen, S. W., Challa, P. K., Kirkegaard, J. B., Laine, R. F., Ma, K. Y., Müller, M. B. D., Sinnige, T., Kumita, J. R., Cohen, S. I. A., ... Dobson, C. M. (2021). Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease. Frontiers in Cell and Developmental Biology, 9, Article 552549. https://doi.org/10.3389/fcell.2021.552549
Hardenberg, M. C., Sinnige, T., Casford, S., Dada, S., Poudel, C., Robinson, E. A., Fuxreiter, M., Kaminksi, C., Kaminski-Schierle, G. S., Nollen, E. A. A., Dobson, C. M., & Vendruscolo, M. (2021). Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies. Journal of Molecular Cell Biology, 13(4), 282-294. https://doi.org/10.1093/jmcb/mjaa075
Koopman, M., Janssen, L., & Nollen, E. A. A. (2021). Publisher Correction to: An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans. BMC Biology, 19(1), Article 216. https://doi.org/10.1186/s12915-021-01152-8
Pras, A., & Nollen, E. A. A. (2021). Regulation of Age-Related Protein Toxicity. Frontiers in Cell and Developmental Biology, 9, 1-15. Article 637084. https://doi.org/10.3389/fcell.2021.637084
Pras, A., Houben, B., Aprile, F. A., Seinstra, R., Gallardo, R., Janssen, L., Hogewerf, W., Gallrein, C., De Vleeschouwer, M., Mata-Cabana, A., Koopman, M., Stroo, E., de Vries, M., Edwards, S. L., Kirstein, J., Vendruscolo, M., Falsone, S. F., Rousseau, F., Schymkowitz, J., & Nollen, E. A. A. (2021). The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation. The EMBO Journal, 40(21), Article e107568. https://doi.org/10.15252/embj.2020107568

2020

Koopman, M., Peter, Q., Seinstra, R. I., Perni, M., Vendruscolo, M., Dobson, C. M., Knowles, T. P. J., & Nollen, E. A. A. (2020). Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform. Nature protocols, 15(6), 2071-2106. https://doi.org/10.1038/s41596-020-0321-9
Sorgdrager, F. J. H., van Der Ley, C. P., van Faassen, M., Calus, E., Nollen, E. A., Kema, I. P., van Dam, D., & De Deyn, P. P. (2020). The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer's Disease. International journal of tryptophan research, 13, Article 1178646920972657. https://doi.org/10.1177/1178646920972657

2019

Sorgdrager, F. J. H., Vermeiren, Y., Van Faassen, H. J. R., Van Der Ley, C. P., Nollen, E. A. A., Kema, I. P., & De Deyn, P. P. (2019). Age- and Disease-Specific Changes of the Kynurenine Pathway in Parkinson's and Alzheimer's Disease. Journal of Neurochemistry, 151(5), 656-668. https://doi.org/10.1111/jnc.14843
Koopman, M., Seinstra, R. I., & Nollen, E. A. A. (2019). C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques. In T. Bartels (Ed.), Alpha-Synuclein (pp. 93-112). (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-9124-2_9
Laine, R. F., Sinnige, T., Ma, K. Y., Haack, A. J., Poudel, C., Gaida, P., Curry, N., Perni, M., Nollen, E. A. A., Dobson, C. M., Vendruscolo, M., Schierle, G. S. K., & Kaminski, C. F. (2019). Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of alpha-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. ACS chemical biology, 14(7), 1628-1636. https://doi.org/10.1021/acschembio.9b00354
Koopman, M., Hetz, C., & Nollen, E. A. A. (2019). Saved by the Matrix: UPR Independent Survival under ER Stress. Cell, 179(6), 1246-1248. https://doi.org/10.1016/j.cell.2019.11.012
Janssens, G. E., Lin, X.-X., Millan-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., Stroustrup, N., Nollen, E. A. A., & Riedel, C. G. (2019). Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell reports, 27(2), 467-480.e6. https://doi.org/10.1016/j.celrep.2019.03.044
Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019). Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nature Reviews Drug Discovery, 18(8), 379-401. https://doi.org/10.1038/s41573-019-0016-5
Sorgdrager, F. J. H., Naude, P. J. W., Kema, I. P., Nollen, E. A., & De Deyn, P. P. (2019). Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target. Frontiers in Immunology, 10, Article 2565. https://doi.org/10.3389/fimmu.2019.02565

2018

Javer, A., Currie, M., Lee, C. W., Hokanson, J., Li, K., Martineau, C. N., Yemini, E., Grundy, L. J., Li, C., Ch'ng, Q., Schafer, W. R., Nollen, E. A. A., Kerr, R., & Brown, A. E. X. (2018). An open-source platform for analyzing and sharing worm-behavior data. Nature Methods, 15(9), 645-646. https://doi.org/10.1038/s41592-018-0112-1
Perni, M., Casford, S., Aprile, F. A., Nollen, E. A., Knowles, T. P. J., Vendruscolo, M., & Dobson, C. M. (2018). Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform. Journal of visualized experiments : JoVE, (141), Article 58643. https://doi.org/10.3791/58643
Sinnige, T., Laine, R. F., Ma, K. Y., Haack, A. J., Gaida, P., Curry, N., Perni, M., Nollen, E. A. A., Dobson, C. M., Vendruscolo, M., Schierle, G. S. K., & Kaminski, C. F. (2018). Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans. Biophysical Journal, 114(3), 350A.
Sin, O., Mata-Cabana, A., Seinstra, R. I., & Nollen, E. A. A. (2018). Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Lysates. JMIR research protocols, 8(19), Article 3042. https://doi.org/10.21769/BioProtoc.3042
Perni, M., Challa, P. K., Kirkegaard, J. B., Limbocker, R., Koopman, M., Hardenberg, M. C., Sormanni, P., Mueller, T., Saar, K. L., Roode, L. W. Y., Habchi, J., Vecchi, G., Fernando, N., Casford, S., Nollen, E. A. A., Vendruscolo, M., Dobson, C. M., & Knowles, T. P. J. (2018). Massively parallel C elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of Neuroscience Methods, 306, 57-67. https://doi.org/10.1016/j.jneumeth.2018.02.005
Perni, M., Flagmeier, P., Limbocker, R., Cascella, R., Aprile, F. A., Galvagnion, C., Heller, G. T., Meisl, G., Chen, S. W., Kumita, J. R., Challa, P. K., Kirkegaard, J. B., Cohen, S. I. A., Mannini, B., Barbut, D., Nollen, E. A. A., Cecchi, C., Cremades, N., Knowles, T. P. J., ... Dobson, C. M. (2018). Multistep Inhibition of alpha-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology, 13(8), 2308-2319. https://doi.org/10.1021/acschembio.8b00466
Mata-Cabana, A., Sin, O., Seinstra, R. I., & Nollen, E. A. A. (2018). Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans. JMIR research protocols, 8(20), Article 3053. https://doi.org/10.21769/BioProtoc.3053

2017

Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limboker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., ... Dobson, C. M. (2017). A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America, 114(6), E1009-E1017. https://doi.org/10.1073/pnas.1610586114
Stroo, E., Koopman, M., Nollen, E. A. A., & Mata-Cabana, A. (2017). Cellular Regulation of Amyloid Formation in Aging and Disease. Frontiers in Neuroscience, 11, Article 64. https://doi.org/10.3389/fnins.2017.00064
Perni, M., Galvagnion, C., Maltsev, A., Meisl, G., Mueller, M. B. D., Challa, P. K., Kirkegaard, J. B., Flagmeier, P., Cohen, S. I. A., Cascella, R., Chen, S. W., Limboker, R., Sormanni, P., Heller, G. T., Aprile, F. A., Cremades, N., Cecchi, C., Chiti, F., Nollen, E. A. A., ... Dobson, C. M. (2017). Correction for Perni et al., A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity (vol 114, pg E1009, 2017). Proceedings of the National Academy of Science of the United States of America, 114(12), E2543-E2543. https://doi.org/10.1073/pnas.1701964114
Nollen, E. A. A., & Michels, H. (2017). Cysteine dioxygenase inhibitors for prolonging the lifespan of a subject. (Patent No. EP3251664). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3251664A1&KC=A1&FT=D&ND=3&date=20171206&DB=&locale=en_EP
Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., Lubbe, S. J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J. R., Nalls, M. A., Ryten, M., Botia, J. A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., ... International Parkinson’s Disease Genetics Consortium (IPGDC) (2017). Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Genome Biology, 18(22). https://doi.org/10.1186/s13059-017-1147-9
Sin, O., de Jong, T., Mata-Cabana, A., Kudron, M., Zaini, M. A., Aprile, F. A., Seinstra, R. I., Stroo, E., Prins, R. W., Martineau, C. N., Wang, H. H., Hogewerf, W., Steinhof, A., Wanker, E. E., Vendruscolo, M., Calkhoven, C. F., Reinke, V., Guryev, V., & Nollen, E. A. A. (2017). Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell, 65(6), 1096-1108. https://doi.org/10.1016/j.molcel.2017.02.022
Yoshimura, Y., Holmberg, M. A., Kukic, P., Andersen, C. B., Mata-Cabana, A., Falsone, S. F., Vendruscolo, M., Nollen, E. A. A., & Mulder, F. A. A. (2017). MOAG-4 promotes the aggregation of alpha-synuclein by competing with self-protective electrostatic interactions. The Journal of Biological Chemistry, 292(20), 8269-8278. https://doi.org/10.1074/jbc.M116.764886

2016

Habchi, J., Arosio, P., Perni, M., Costa, A. R., Yagi-Utsumi, M., Joshi, P., Chia, S., Cohen, S. I. A., Müller, M. B. D., Linse, S., Nollen, E. A. A., Dobson, C. M., Knowles, T. P. J., & Vendruscolo, M. (2016). An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science Advances, 2(2), Article e1501244. https://doi.org/10.1126/sciadv.1501244
Koopman, M., Michels, H., Dancy, B. M., Kamble, R., Mouchiroud, L., Auwerx, J., Nollen, E. A. A., & Houtkooper, R. H. (2016). A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nature protocols, 11(10), 1798-1816. https://doi.org/10.1038/nprot.2016.106
Michels, H., Seinstra, R. I., Uitdehaag, J. C. M., Koopman, M., van Faassen, M., Martineau, C. N., Kema, I. P., Buijsman, R., & Nollen, E. A. A. (2016). Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase. Scientific Reports, 6, Article 39199. https://doi.org/10.1038/srep39199
Visscher, M., De Henau, S., Wildschut, M. H. E., van Es, R. J. J., Dhondt, I., Michels, H., Kemmeren, P., Nollen, E. A., Braeckman, B. P., Burgering, B. M. T., Vos, H. R., & Dansen, T. B. (2016). Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease. Cell reports, 16(11), 3041-3051. https://doi.org/10.1016/j.celrep.2016.08.025

2015

Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., Schaap, O., Nollen, E. A., Podgorsek, A., Kosec, G., Petkovic, H., Hayflick, S., Tiranti, V., Reijngoud, D.-J., Grzeschik, N. A., & Sibon, O. C. M. (2015). Extracellular 4 '-phosphopantetheine is a source for intracellular coenzyme A synthesis. Nature Chemical Biology, 11(10), 784-792.e3. https://doi.org/10.1038/NCHEMBIO.1906
Alvarenga Fernandes Sin, O., & Nollen, E. A. A. (2015). Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes. Cellular and molecular life sciences, 72(21), 4027-4047. https://doi.org/10.1007/s00018-015-1985-0

2014

Alvarenga Fernandes Sin, O., Michels, H., & Nollen, E. A. A. (2014). Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. Biochimica et biophysica acta-Molecular basis of disease, 1842(10), 1951-1959. https://doi.org/10.1016/j.bbadis.2014.01.015

2013

Holmberg, M., & Nollen, E. A. A. (2013). Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis. In D. M. Hatters, & A. J. Hannan (Eds.), Tandem Repeats in Genes, Proteins, and Disease (Vol. 1017, pp. 193-199). (Methods in Molecular Biology; Vol. 1017). Humana Press. https://doi.org/10.1007/978-1-62703-438-8_14
van der Goot, A. T., & Nollen, E. A. A. (2013). Tryptophan metabolism: entering the field of aging and age-related pathologies. Trends in Molecular Medicine, 19(6), 336-344. https://doi.org/10.1016/j.molmed.2013.02.007

2012

van der Goot, A. T., Zhu, W., Vazquez-Manrique, R. P., Seinstra, R. I., Dettmer, K., Michels, H., Farina, F., Krijnen, J., Melki, R., Buijsman, R. C., Silva, M. R., Thijssen, K. L., Kema, I. P., Neri, C., Oefner, P. J., & Nollen, E. A. A. (2012). Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. https://doi.org/10.1073/pnas.1203083109
Falsone, S. F., Meyer, N. H., Schrank, E., Leitinger, G., Pham, C. L. L., Fodero-Tavoletti, M. T., Holmberg, M., Dulle, M., Scicluna, B., Gesslbauer, B., Rueckert, H.-M., Wagner, G. E., Merle, D. A., Nollen, E. A., Kungl, A. J., Hill, A. F., Cappai, R., & Zangger, K. (2012). SERF Protein Is a Direct Modifier of Amyloid Fiber Assembly. Cell reports, 2(2), 358-371. https://doi.org/10.1016/j.celrep.2012.06.012

2011

Schierle, G. S. K., Bertoncini, C. W., Chan, F. T. S., van der Goot, A. T., Schwedler, S., Skepper, J., Schlachter, S., van Ham, T., Esposito, A., Kumita, J. R., Nollen, E. A. A., Dobson, C. M., & Kaminski, C. F. (2011). A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo. Chemphyschem, 12(3), 673-680. https://doi.org/10.1002/cphc.201000996
Siudeja, K., Srinivasan, B., Xu, L., Rana, A., de Jong, J., Nollen, E. A. A., Jackowski, S., Sanford, L., Hayflick, S., & Sibon, O. C. M. (2011). Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration. EMBO Molecular Medicine, 3(12), 755-766. https://doi.org/10.1002/emmm.201100180
Teuling, E., Bourgonje, A., Veenje, S., Thijssen, K., de Boer, J., van der Velde, J., Swertz, M., & Nollen, E. (2011). Modifiers of mutant huntingtin aggregation: Functional conservation of C. elegans-modifiers of polyglutamine aggregation. PLoS Currents, 3(RRN1255). https://doi.org/10.1371/currents.RRN1255

2010

van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcia-Arencibia, M., Kim, H., Du, D., Thijssen, K. L., Wiersma, M., Burggraaff, R., van Bergeijk, P., van Rheenen, J., van Veluw, G. J., Hofstra, R. M. W., Rubinsztein, D. C., & Nollen, E. A. A. (2010). Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity. Cell, 142(4), 601-612. https://doi.org/10.1016/j.cell.2010.07.020
van Ham, T. J., Esposito, A., Kumita, J. R., Hsu, S.-T. D., Schierle, G. S. K., Kaminsk, C. F., Dobson, C. M., Nollen, E. A. A., & Bertoncini, C. W. (2010). Towards Multiparametric Fluorescent Imaging of Amyloid Formation: Studies of a YFP Model of alpha-Synuclein Aggregation. Journal of Molecular Biology, 395(3), 627-642. https://doi.org/10.1016/j.jmb.2009.10.066

2009

Roodveldt, C., Bertoncini, C. W., Andersson, A., van der Goot, A. T., Hsu, S.-T., Fernandez-Montesinos, R., de Jong, J., van Ham, T. J., Nollen, E. A., Pozo, D., Christodoulou, J., & Dobson, C. M. (2009). Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip. EMBO Journal, 28(23), 3758-3770. https://doi.org/10.1038/emboj.2009.298
van Ham, T. J., Breitling, R., Swertz, M. A., & Nollen, E. A. A. (2009). Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms. EMBO Molecular Medicine, 1(8-9), 360-370. https://doi.org/10.1002/emmm.200900051

2008

van Ham, T. J., Thijssen, K. L., Breitling, R., Hofstra, R. M. W., Plasterk, R. H. A., & Nollen, E. A. A. (2008). C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS genetics, 4(3), Article 1000027. https://doi.org/10.1371/journal.pgen.1000027

2004

van Haaften, G., Vastenhouw, N. L., Nollen, E. A. A., Plasterk, R. H. A., & Tijsterman, M. (2004). Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proceedings of the National Academy of Sciences of the United States of America, 101(35), 12992-12996. https://doi.org/10.1073/pnas.0403131101
Nollen, E. A. A., Garcia, S. M., van Haaften, G., Kim, S., Chavez, A., Morimoto, R. I., & Plasterk, R. H. A. (2004). Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proceedings of the National Academy of Sciences of the United States of America, 101(17), 6403-6408. https://doi.org/10.1073/pnas.0307697101

2002

Nollen, E. A. A., & Morimoto, R. I. (2002). Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. Journal of Cell Science, 115(14), 2809-2816. http://jcs.biologists.org/content/115/14/2809.long
Kim, S., Nollen, E. A. A., Kitagawa, K., Bindokas, V. P., & Morimoto, R. I. (2002). Polyglutamine protein aggregates are dynamic. Nature Cell Biology, 4(10), 826-831. https://doi.org/10.1038/ncb863

2001

Nollen, E. A., Salomons, F. A., Brunsting, J. F., van der Want, J. J. L., Sibon, O. C. M., & Kampinga, H. H. (2001). Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection. Proceedings of the National Academy of Sciences of the United States of America, 98(21), 12038-12043. https://doi.org/10.1073/pnas.201112398
Nollen, E. A., Kabakov, A. E., Brunsting, J. F., Kanon, B., Höhfeld, J., & Kampinga, H. H. (2001). Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1. The Journal of Biological Chemistry, 276(7), 4677-4682. https://doi.org/10.1074/jbc.M009745200

2000

Nollen, EAA., Brunsting, JF., Kampinga, HH., & Morimoto, RI. (2000). Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Molecular and Cellular Biology, 20(3), 1083-1088. https://doi.org/10.1128/MCB.20.3.1083-1088.2000
Nollen, E. A. (2000). HSP70 chaperone functions in stressed cells. s.n.

1999

van der Leij, FR., Roelofsen, H., Niezen-Koning, KE., Nollen, EAA., & Kuipers, JRG. (1999). Confocal laser scanning microscopy of human skin fibroblasts showing transient expression of a green fluorescent carnitine palmitoyltransferase 1 fusion protein. In PA. Quant, & S. Eaton (Eds.), CURRENT VIEWS OF FATTY ACID OXIDATION AND KETOGENESIS (pp. 111-115). (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY; Vol. 466). Kluwer Academic/Plenum Publishers.
Nollen, EAA., Brunsting, JF., Roelofsen, H., Weber, LA., & Kampinga, HH. (1999). In vivo chaperone activity of heat shock protein 70 and thermotolerance. Molecular and Cellular Biology, 19(3), 2069-2079. https://doi.org/10.1128/MCB.19.3.2069

1997

Martens, D. E., Nollen, E. A., Hardeveld, M., Velden-de Groot, C. A., Gooijer, C. D., Beuvery, E. C., & Tramper, J. (1997). Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers. Cytotechnology, 23(1), 61-75. https://doi.org/10.1023/B:CYTO.0000010399.23373.65

1996

Martens, D. E., Nollen, E. A., Hardeveld, M., van der Velden-de Groot, C. A., de Gooijer, C. D., Beuvery, E. C., & Tramper, J. (1996). Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers. Cytotechnology, 21(1), 45-59. https://doi.org/10.1007/BF00364836

1994

Peters, S. A., Verver, J., Nollen, E. A., van Lent, J. W., Wellink, J., & van Kammen, A. (1994). The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication. The Journal of general virology, 75 ( Pt 11), 3167-76. https://doi.org/10.1099/0022-1317-75-11-3167
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