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How to find us V.W. (Vincent) Bloks

Research interests

Fundamental and Applied Research, aimed at understanding molecular principles of metabolic health and mechanisms underlying the development of inborn and acquired metabolic diseases

  • Cholesterol and Lipid Metabolism
  • Bileacid Metabolism
  • Microarray/RNAseq
  • Statistics/Bioinformatics

 

 

Publications

A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]

An early-life diet containing large phospholipid-coated lipid globules programs later-life postabsorptive lipid trafficking in high-fat diet but not in low-fat dietfed mice

An epigenome-wide association study identifies multiple DNA methylation markers of exposure to endocrine disruptors

Cholangiopathy and biliary fibrosis in Cyp2c70-deficient mice are fully reversed by ursodeoxycholic acid

Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Short-term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue

Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet

The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients

A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice

A HUMAN-LIKE COMPOSITION OF THE CIRCULATING BILE ACID POOL IMPACTS ON PLASMA LDL CHOLESTEROL IN MICE

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