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How to find us prof. dr. R.P.H. (Rainer) Bischoff

Research interests


Prof. Dr. Rainer Bischoff

Chair of the Department of Analytical Biochemistry (


Faculty of Mathematics and Natural Science, University of Groningen, the Netherlands        

Telephone: +31 50 363 3336



Field/ Discipline: Chemistry, Analytical
                         Biochemical Research Methods

Expertise:          Proteomics, Chromatography, Mass 
                         Spectrometry, Electrochemistry
                         Biopharmaceuticals, Biomarkers   


Rainer Bischoff started his career in protein-related research when joining the biotechnology company Transgene (Strasbourg, France) in 1987. He applied mass spectrometry to the characterization of recombinant proteins early on with a first paper appearing in 1990 using electrospray ionization for the analysis of alpha-1-antitrypsin and its variants. Rainer Bischoff continued his career at AstraZeneca R&D (Lund, Sweden) before joining the Faculty of Mathematics and Natural Sciences at the University of Groningen (The Netherlands) in 2001 as full professor of Analytical Biochemistry. Research interests of the Analytical Biochemistry Department focus on biomarker discovery and validation, bioinformatics (in collaboration with Prof. Horvatovich), the bioanalysis of biopharmaceutical proteins and the development of novel instrumental analytical techniques (e.g. based on the coupling of electrochemistry to mass spectrometry). The group uses state-of-the-art equipment for protein and peptide separation and identification mainly based on high-performance liquid chromatography coupled to mass spectrometry. Rainer Bischoff is responsible for the interfaculty mass spectrometry core facility housing currently 16 LC-MS/MS installations.

Rainer Bischoff served in a number of functions such as chairing the national Analytical Chemistry working group of the Dutch Scientific Research Organization (NWO) and currently being the Dutch representative of the Chromosome-Centric HPP program of HUPO.

Rainer Bischoff authored more than 200 peer-reviewed publications and book chapters and is inventor on 12 patents.

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Surface-modified electrodes in the mimicry of oxidative drug metabolism

Integrated quantification and identification of aldehydes and ketones in biological samples

A Panel of Regulated Proteins in Serum from Patients with Cervical Intraepithelial Neoplasia and Cervical Cancer

Antibody-free LC-MS/MS quantification of rhTRAIL in human and mouse serum

Boron-Doped Diamond Electrodes for the Electrochemical Oxidation and Cleavage of Peptides

Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation

Minocycline Effects on the Cerebrospinal Fluid Proteome of Experimental Autoimmune Encephalomyelitis Rats

The Impact of Delayed Storage on the Measured Proteome and Metabolome of Human Cerebrospinal Fluid

Physiology and pathophysiology of matrix metalloproteases

Protein Tyrosine Nitration: Selectivity, physicochemical and biological consequences, denitration and proteomics methods for the identification of tyrosine-nitrated proteins

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The ‘un-shrunk’ partial correlation in Gaussian graphical models - BMC Bioinformatics

New paper demonstrates Affimer® based assay for the quantification of sRAGE in COPD

Bioanalysis Zone

Elektrochemische Enzymen

Elektrochemische enzymen

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