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prof. dr. R.P. (Rob) Coppes

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Research

Research units:

1 - 50 out of 114Page size: 50
  1. 2019
  2. Pringle, S., Wang, X., Verstappen, G. M. P. J., Terpstra, J. H., Zhang, C. K., He, A., ... Kroese, F. G. M. (2019). Salivary Gland Stem Cells Age Prematurely in Primary Sjogren's Syndrome. Arthritis & Rheumatology, 71(1), 133-142. https://doi.org/10.1002/art.40659
  3. 2018
  4. Nagle, P. W., Hosper, N. A., Barazzuol, L., Jellema, A. L., Baanstra, M., van Goethem, M-J., ... Coppes, R. P. (2018). Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction. Clinical Cancer Research, 24(24), 6583-6593. https://doi.org/10.1158/1078-0432.CCR-18-0533
  5. Nagle, P. W., Plukker, J. T. M., Muijs, C. T., van Luijk, P., & Coppes, R. P. (2018). Patient-derived tumor organoids for prediction of cancer treatment response. Seminars in cancer biology, 53, 258-264. https://doi.org/10.1016/j.semcancer.2018.06.005
  6. Coppes, R. (2018). Normal tissue stem cells and cancer stem cells in radiation response. Radiotherapy and Oncology, 127, S338-S338. https://doi.org/10.1016/S0167-8140(18)30946-0
  7. Peng, X., Varendi, K., Maimets, M., Andressoo, J. O., & Coppes, R. P. (2018). Role of GDNF in the modulation of SGSCs radiation response; regeneration or senescence? Radiotherapy and Oncology, 127, S304. https://doi.org/10.1016/S0167-8140(18)30892-2
  8. van Luijk, P., & Coppes, R. (2018). Preclinical Radiobiological insights to inform modelling of radiotherapy outcome. In A Guide to Outcome Modeling In Radiotherapy and Oncology: Listening to the Data
  9. Mauthe, M., Orhon, I., Rocchi, C., Zhou, X., Luhr, M., Hijlkema, K-J., ... Reggiori, F. (2018). Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy, 14(8), 1435-1455. https://doi.org/10.1080/15548627.2018.1474314
  10. Pringle, S., Wang, X., Baird, D., Vissink, A., Spijkervet, F., Bootsma, H., ... Kroese, F. (2018). Senescence of salivary gland stem cells in primary Sjogren's syndrome: the cause of persistent hyposalivation? Clinical and Experimental Rheumatology, 36(3), S245-S245.
  11. 2017
  12. Peng, X., Varendi, K., Maimets, M., Andressoo, J-O., & Coppes, R. P. (2017). Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation. Radiotherapy and Oncology, 124(3), 448-454. https://doi.org/10.1016/j.radonc.2017.07.008
  13. Wang, D., Plukker, J. T. M., & Coppes, R. P. (2017). Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer. Seminars in cancer biology, 44, 60-66. https://doi.org/10.1016/j.semcancer.2017.03.010
  14. Coppes, R. P., & Dubrovska, A. (2017). Targeting Stem Cells in Radiation Oncology. Clinical Oncology, 29(6), 329-334. https://doi.org/10.1016/j.clon.2017.03.005
  15. van Luijk, P., Langendijk, J. A., & Coppes, R. P. (2017). Understanding mechanisms yields novel approaches to reduce radiotherapy-related xerostomia. Translational Research, 5(3), [63]. https://doi.org/10.21037/atm.2017.02.02
  16. 2016
  17. Klein Hesselink, E., Brouwers, A. H., Jong, de, J. R., van der Horst-Schrivers, A. N. A., Coppes, R. P., Lefrandt, J. D., ... Links, T. P. (2016). Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study. Journal of Nuclear Medicine, 57(11), 1685-1691. https://doi.org/10.2967/jnumed.115.169888
  18. Nagle, P. W., Hosper, N. A., Ploeg, E. M., van Goethem, M-J., Brandenburg, S., Langendijk, J. A., ... Coppes, R. P. (2016). The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers. International Journal of Radiation Oncology Biology Physics, 95(1), 103-111. https://doi.org/10.1016/j.ijrobp.2016.02.020
  19. Pringle, S., Maimets, M., van der Zwaag, M., Stokman, M. A., van Gosliga, D., Zwart, E., ... Coppes, R. P. (2016). Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands. STEM CELLS, 34(3), 640-652. https://doi.org/10.1002/stem.2278
  20. Wang, D., Chiu, R., Plukker, J. T., & Coppes, R. P. (2016). The role of mTOR inhibitors in targeting a putative cancer stem cell-like population in esophageal cancer. Journal of Clinical Oncology, 34(Supplement 4), [43].
  21. Maimets, M., Rocchi, C., Bron, R., Pringle, S., Kuipers, J., Giepmans, B. N. G., ... Coppes, R. P. (2016). Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports, 6(1), 150-162. https://doi.org/10.1016/j.stemcr.2015.11.009
  22. van der Veen, S. J., Faber, H., Ghobadi, G., Brandenburg, S., Langendijk, J. A., Coppes, R. P., & van Luijk, P. (2016). Decreasing Irradiated Rat Lung Volume Changes Dose-Limiting Toxicity From Early to Late Effects. International Journal of Radiation Oncology Biology Physics, 94(1), 163-171. https://doi.org/10.1016/j.ijrobp.2015.09.034
  23. Wang, D., Chiu, R., Coppes, R., & Plukker, J. T. H. M. (2016). The Role of mTOR inhibitors in targeting a putative cancer stem cell-like population in oesophageal cancer. Journal of Clinical Oncology, 34(suppl 4), 43.
  24. 2015
  25. Ghobadi, G., Wiegman, E. M., Langendijk, J. A., Widder, J., Coppes, R. P., & van Luijk, P. (2015). A new CT-based method to quantify radiation-induced lung damage in patients. Radiotherapy and Oncology, 117(1), 4-8. https://doi.org/10.1016/j.radonc.2015.07.017
  26. van Luijk, P., Pringle, S., Deasy, J. O., Moiseenko, V. V., Faber, H., Hovan, A., ... Coppes, R. P. (2015). Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer. Science Translational Medicine, 7(305), [ARTN 305ra147]. https://doi.org/10.1126/scitranslmed.aac4441
  27. van der Veen, S. J., Ghobadi, G., de Boer, R. A., Faber, H., Cannon, M. V., Nagle, P. W., ... Coppes, R. P. (2015). ACE inhibition attenuates radiation-induced cardiopulmonary damage. Radiotherapy and Oncology, 114(1), 96-103. https://doi.org/10.1016/j.radonc.2014.11.017
  28. Vissink, A., van Luijk, P., Langendijk, J. A., & Coppes, R. P. (2015). Current ideas to reduce or salvage radiation damage to salivary glands. Oral diseases, 21(1), E1-E10. https://doi.org/10.1111/odi.12222
  29. Nagle, P., Hosper, N., Ploeg, E., van Goethem, M-J., Langendijk, H., Chiu, R., & Coppes, R. (2015). The response of three-dimensional spheroids to particle radiotherapy. Abstract from Annual NVRB Spring Meeting , Utrecht, Netherlands.
  30. 2014
  31. Nanduri, L. S. Y., Baanstra, M., Faber, H., Rocchi, C., Zwart, E., de Haan, G., ... Coppes, R. P. (2014). Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells. Stem Cell Reports, 3(6), 957-964. https://doi.org/10.1016/j.stemcr.2014.09.015
  32. de Cortie, K., Russell, N. S., Coppes, R. P., Stewart, F. A., & Scharpfenecker, M. (2014). Bone marrow-derived macrophages incorporate into the endothelium and influence vascular and renal function after irradiation. International Journal of Radiation Biology, 90(9), 769-777. https://doi.org/10.3109/09553002.2014.920967
  33. Benderitter, M., Caviggioli, F., Chapel, A., Coppes, R. P., Guha, C., Klinger, M., ... Limoli, C. L. (2014). Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects. Antioxidants & Redox Signaling, 21(2), 338-355. https://doi.org/10.1089/ars.2013.5652
  34. Scharpfenecker, M., Floot, B., Russell, N. S., Coppes, R. P., & Stewart, F. A. (2014). Thalidomide Ameliorates Inflammation and Vascular Injury but Aggravates Tubular Damage in the Irradiated Mouse Kidney. International Journal of Radiation Oncology Biology Physics, 89(3), 599-606. https://doi.org/10.1016/j.ijrobp.2014.03.039
  35. Coppes, R. P., & de Haan, G. (2014). Means and methods for obtaining salivary gland stem cells and use thereof. (Patent No. WO2014092575).
  36. Nagle, P., van Goethem, M-J., van Luijk, P., Langendijk, J. A., Coppes, R., & Chiu, R. (2014). Targeting DNA repair to enhance particle radiotherapy treatment. Abstract from 40th Annual meeting of the European Radiation Research Society, Rhodes, Greece.
  37. 2013
  38. Scharpfenecker, M., Floot, B., Russell, N. S., Coppes, R. P., & Stewart, F. A. (2013). Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice. Radiotherapy and Oncology, 108(3), 464-468. https://doi.org/10.1016/j.radonc.2013.06.016
  39. Nanduri, L. S. Y., Lombaert, I. M. A., van der Zwaag, M., Faber, H., Brunsting, J. F., van Os, R. P., & Coppes, R. P. (2013). Salisphere derived c-Kit(+) cell transplantation restores tissue homeostasis in irradiated salivary gland. Radiotherapy and Oncology, 108(3), 458-463. https://doi.org/10.1016/j.radonc.2013.05.020
  40. Coppes, R., & van Luijk, P. (2013). Radiation-induced disease. In ERS Handbook of Respiratory Medicine (2nd ed.)
  41. Smit, J. K., Faber, H., Niemantsverdriet, M., Baanstra, M., Bussink, J., Hollema, H., ... Coppes, R. P. (2013). Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers. Radiotherapy and Oncology, 107(3), 434-441. https://doi.org/10.1016/j.radonc.2013.03.027
  42. Pringle, S., Van Os, R., & Coppes, R. P. (2013). Concise Review: Adult Salivary Gland Stem Cells and a Potential Therapy for Xerostomia. STEM CELLS, 31(4), 613-619. https://doi.org/10.1002/stem.1327
  43. 2012
  44. Niemantsverdriet, M., Nagle, P., Chiu, R. K., Langendijk, J. A., Kampinga, H. H., & Coppes, R. P. (2012). Delta Np73 Enhances Promoter Activity of TGF-beta Induced Genes. PLoS ONE, 7(12), [e50815]. https://doi.org/10.1371/journal.pone.0050815
  45. Niemantsverdriet, M., van Goethem, M-J., Bron, R., Hogewerf, W., Brandenburg, S., Langendijk, J. A., ... Coppes, R. P. (2012). High and Low LET Radiation Differentially Induce Normal Tissue Damage Signals. International Journal of Radiation Oncology Biology Physics, 83(4), 1291-1297. https://doi.org/10.1016/j.ijrobp.2011.09.057
  46. Ghobadi, G., Bartelds, B., van der Veen, S. J., Dickinson, M. G., Brandenburg, S., Berger, R. M. F., ... van Luijk, P. (2012). Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension. Thorax, 67(4), 334-341. https://doi.org/10.1136/thoraxjnl-2011-200346
  47. 2011
  48. Coppes, R. P., Muijs, C. T., Faber, H., Gross, S., Schippers, J. M., Brandenburg, S., ... van Luijk, P. (2011). Volume-Dependent Expression of In-Field and Out-of-Field Effects in the Proton-Irradiated Rat Lung. International Journal of Radiation Oncology Biology Physics, 81(1), 262-269. https://doi.org/10.1016/j.ijrobp.2011.03.021
  49. Nanduri, L. S. Y., Maimets, M., Pringle, S. A., van der Zwaag, M., van Os, R. P., & Coppes, R. P. (2011). Regeneration of irradiated salivary glands with stem cell marker expressing cells. Radiotherapy and Oncology, 99(3), 367-372. https://doi.org/10.1016/j.radonc.2011.05.085
  50. Coppes, R. P., & Stokman, M. A. (2011). Stem cells and the repair of radiation-induced salivary gland damage. Oral diseases, 17(2), 143-153. https://doi.org/10.1111/j.1601-0825.2010.01723.x
  51. Pringle, S., Nanduri, L., van der Zwaag, M., van Os, R., & Coppes, R. (2011). Isolation of Mouse salivary gland stem cells. JoVE (Journal of Visualized Experiments), 48(February), e2482. [2011 Feb 8;(48). pii]. https://doi.org/10.3791/2484
  52. van Goethem, M-J., Niemantsverdriet, M., Brandenburg, S., Langendijk, J. A., Coppes, R. P., & van Luijk, P. (2011). Development of a facility for high-precision irradiation of cells with carbon ions. Medical Physics, 38(1), 256-263. https://doi.org/10.1118/1.3528164
  53. 2010
  54. Vissink, A., Mitchell, J. B., Baum, B. J., Limesand, K. H., Jensen, S. B., Fox, P. C., ... Reyland, M. E. (2010). CLINICAL MANAGEMENT OF SALIVARY GLAND HYPOFUNCTION AND XEROSTOMIA IN HEAD-AND-NECK CANCER PATIENTS: SUCCESSES AND BARRIERS. International Journal of Radiation Oncology Biology Physics, 78(4), 983-991. https://doi.org/10.1016/j.ijrobp.2010.06.052
  55. Niemantsverdriet, M., de Jong, E., Langendijk, J. A., Kampinga, H. H., & Coppes, R. P. (2010). Synergistic induction of profibrotic PAI-1 by TGF-beta and radiation depends on p53. Radiotherapy and Oncology, 97(1), 33-35. https://doi.org/10.1016/j.radonc.2010.04.002
  56. Coppes, R., & van Luijk, P. (2010). Radiation-induced disease. In ERS Handbook of Respiratory Medicine
  57. Ghobadi, G., Hogeweg, L. E., Faber, H., Tukker, W. G. J., Schippers, J. M., Brandenburg, S., ... van Luijk, P. (2010). QUANTIFYING LOCAL RADIATION-INDUCED LUNG DAMAGE FROM COMPUTED TOMOGRAPHY. International Journal of Radiation Oncology Biology Physics, 76(2), 548-556. https://doi.org/10.1016/j.ijrobp.2009.08.058
  58. 2009
  59. Feng, J., van der Zwaag, M., Stokman, M. A., van Os, R., & Coppes, R. P. (2009). Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation. Radiotherapy and Oncology, 92(3), 466-471. https://doi.org/10.1016/j.radonc.2009.06.023
  60. Woodward, W. A., Bristow, R. G., Clarke, M. F., Coppes, R. P., Cristofanilli, M., Duda, D. G., ... Chen, Y. (2009). RADIATION THERAPY ONCOLOGY GROUP TRANSLATIONAL RESEARCH PROGRAM STEM CELL SYMPOSIUM: INCORPORATING STEM CELL HYPOTHESES INTO CLINICAL TRIALS. International Journal of Radiation Oncology Biology Physics, 74(5), 1580-1591. https://doi.org/10.1016/j.ijrobp.2009.03.047
  61. van Luijk, P., Faber, H., Schippers, J. M., Brandenburg, S., Langendijk, J. A., Meertens, H., & Coppes, R. P. (2009). BATH AND SHOWER EFFECTS IN THE RAT PAROTID GLAND EXPLAIN INCREASED RELATIVE RISK OF PAROTID GLAND DYSFUNCTION AFTER INTENSITY-MODULATED RADIOTHERAPY. International Journal of Radiation Oncology Biology Physics, 74(4), 1002-1005. https://doi.org/10.1016/j.ijrobp.2009.03.039
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