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prof. dr. R.P. (Rob) Coppes

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Research

Research units:

1 - 50 out of 131Page size: 50
  1. 2018
  2. Nagle, P. W., Hosper, N. A., Barazzuol, L., Jellema, A. L., Baanstra, M., van Goethem, M-J., ... Coppes, R. P. (2018). Lack of DNA damage response at low radiation doses in adult stem cells contributes to organ dysfunction. Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-18-0533
  3. Pringle, S., Wang, X., Verstappen, G. M. P. J., Terpstra, J. H., Zhang, C. K., He, A., ... Kroese, F. G. M. (2018). Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's syndrome. Arthritis & Rheumatology. DOI: 10.1002/art.40659
  4. Nagle, P. W., Plukker, J. T. M., Muijs, C. T., van Luijk, P., & Coppes, R. P. (2018). Patient-derived tumor organoids for prediction of cancer treatment response. Seminars in cancer biology. DOI: 10.1016/j.semcancer.2018.06.005
  5. Coppes, R. (2018). Normal tissue stem cells and cancer stem cells in radiation response. Radiotherapy and Oncology, 127, S338-S338. DOI: 10.1016/S0167-8140(18)30946-0
  6. Peng, X., Varendi, K., Maimets, M., Andressoo, J. O., & Coppes, R. P. (2018). Role of GDNF in the modulation of SGSCs radiation response; regeneration or senescence? Radiotherapy and Oncology, 127, S304. DOI: 10.1016/S0167-8140(18)30892-2
  7. Mauthe, M., Orhon, I., Rocchi, C., Zhou, X., Luhr, M., Hijlkema, K-J., ... Reggiori, F. (2018). Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy, 14(8), 1435-1455. DOI: 10.1080/15548627.2018.1474314
  8. 2017
  9. Peng, X., Varendi, K., Maimets, M., Andressoo, J-O., & Coppes, R. P. (2017). Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation. Radiotherapy and Oncology, 124(3), 448-454. DOI: 10.1016/j.radonc.2017.07.008
  10. Wang, D., Plukker, J. T. M., & Coppes, R. P. (2017). Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer. Seminars in cancer biology, 44, 60-66. DOI: 10.1016/j.semcancer.2017.03.010
  11. Coppes, R. P., & Dubrovska, A. (2017). Targeting Stem Cells in Radiation Oncology. Clinical Oncology, 29(6), 329-334. DOI: 10.1016/j.clon.2017.03.005
  12. van Luijk, P., Langendijk, J. A., & Coppes, R. P. (2017). Understanding mechanisms yields novel approaches to reduce radiotherapy-related xerostomia. Translational Research, 5(3), 63. DOI: 10.21037/atm.2017.02.02
  13. 2016
  14. Klein Hesselink, E., Brouwers, A. H., Jong, de, J. R., van der Horst-Schrivers, A. N. A., Coppes, R. P., Lefrandt, J. D., ... Links, T. P. (2016). Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study. Journal of Nuclear Medicine, 57(11), 1685-1691. DOI: 10.2967/jnumed.115.169888
  15. Nagle, P. W., Hosper, N. A., Ploeg, E. M., van Goethem, M-J., Brandenburg, S., Langendijk, J. A., ... Coppes, R. P. (2016). The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers. International Journal of Radiation Oncology Biology Physics, 95(1), 103-111. DOI: 10.1016/j.ijrobp.2016.02.020
  16. Pringle, S., Maimets, M., van der Zwaag, M., Stokman, M. A., van Gosliga, D., Zwart, E., ... Coppes, R. P. (2016). Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands. STEM CELLS, 34(3), 640-652. DOI: 10.1002/stem.2278
  17. Wang, D., Chiu, R., Plukker, J. T., & Coppes, R. P. (2016). The role of mTOR inhibitors in targeting a putative cancer stem cell-like population in esophageal cancer. Journal of Clinical Oncology, 34(Supplement 4), [43].
  18. Maimets, M., Rocchi, C., Bron, R., Pringle, S., Kuipers, J., Giepmans, B. N. G., ... Coppes, R. P. (2016). Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports, 6(1), 150-162. DOI: 10.1016/j.stemcr.2015.11.009
  19. van der Veen, S. J., Faber, H., Ghobadi, G., Brandenburg, S., Langendijk, J. A., Coppes, R. P., & van Luijk, P. (2016). Decreasing Irradiated Rat Lung Volume Changes Dose-Limiting Toxicity From Early to Late Effects. International Journal of Radiation Oncology Biology Physics, 94(1), 163-171. DOI: 10.1016/j.ijrobp.2015.09.034
  20. Wang, D., Chiu, R., Coppes, R., & Plukker, J. T. H. M. (2016). The Role of mTOR inhibitors in targeting a putative cancer stem cell-like population in oesophageal cancer. Journal of Clinical Oncology, 34(suppl 4), 43.
  21. 2015
  22. Ghobadi, G., Wiegman, E. M., Langendijk, J. A., Widder, J., Coppes, R. P., & van Luijk, P. (2015). A new CT-based method to quantify radiation-induced lung damage in patients. Radiotherapy and Oncology, 117(1), 4-8. DOI: 10.1016/j.radonc.2015.07.017
  23. van Luijk, P., Pringle, S., Deasy, J. O., Moiseenko, V. V., Faber, H., Hovan, A., ... Coppes, R. P. (2015). Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer. Science Translational Medicine, 7(305), [ARTN 305ra147]. DOI: 10.1126/scitranslmed.aac4441
  24. van der Veen, S. J., Ghobadi, G., de Boer, R. A., Faber, H., Cannon, M. V., Nagle, P. W., ... Coppes, R. P. (2015). ACE inhibition attenuates radiation-induced cardiopulmonary damage. Radiotherapy and Oncology, 114(1), 96-103. DOI: 10.1016/j.radonc.2014.11.017
  25. Vissink, A., van Luijk, P., Langendijk, J. A., & Coppes, R. P. (2015). Current ideas to reduce or salvage radiation damage to salivary glands. Oral diseases, 21(1), E1-E10. DOI: 10.1111/odi.12222
  26. Nagle, P., Hosper, N., Ploeg, E., van Goethem, M-J., Langendijk, H., Chiu, R., & Coppes, R. (2015). The response of three-dimensional spheroids to particle radiotherapy. Abstract from Annual NVRB Spring Meeting , Utrecht, Netherlands.
  27. 2014
  28. Nanduri, L. S. Y., Baanstra, M., Faber, H., Rocchi, C., Zwart, E., de Haan, G., ... Coppes, R. P. (2014). Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells. Stem Cell Reports, 3(6), 957-964. DOI: 10.1016/j.stemcr.2014.09.015
  29. de Cortie, K., Russell, N. S., Coppes, R. P., Stewart, F. A., & Scharpfenecker, M. (2014). Bone marrow-derived macrophages incorporate into the endothelium and influence vascular and renal function after irradiation. International Journal of Radiation Biology, 90(9), 769-777. DOI: 10.3109/09553002.2014.920967
  30. Benderitter, M., Caviggioli, F., Chapel, A., Coppes, R. P., Guha, C., Klinger, M., ... Limoli, C. L. (2014). Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects. ANTIOXIDANTS & REDOX SIGNALING, 21(2), 338-355. DOI: 10.1089/ars.2013.5652
  31. Scharpfenecker, M., Floot, B., Russell, N. S., Coppes, R. P., & Stewart, F. A. (2014). Thalidomide Ameliorates Inflammation and Vascular Injury but Aggravates Tubular Damage in the Irradiated Mouse Kidney. International Journal of Radiation Oncology Biology Physics, 89(3), 599-606. DOI: 10.1016/j.ijrobp.2014.03.039
  32. Nagle, P., van Goethem, M-J., van Luijk, P., Langendijk, J. A., Coppes, R., & Chiu, R. (2014). Targeting DNA repair to enhance particle radiotherapy treatment. Abstract from 40th Annual meeting of the European Radiation Research Society, Rhodes, Greece.
  33. 2013
  34. Scharpfenecker, M., Floot, B., Russell, N. S., Coppes, R. P., & Stewart, F. A. (2013). Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice. Radiotherapy and Oncology, 108(3), 464-468. DOI: 10.1016/j.radonc.2013.06.016
  35. Nanduri, L. S. Y., Lombaert, I. M. A., van der Zwaag, M., Faber, H., Brunsting, J. F., van Os, R. P., & Coppes, R. P. (2013). Salisphere derived c-Kit(+) cell transplantation restores tissue homeostasis in irradiated salivary gland. Radiotherapy and Oncology, 108(3), 458-463. DOI: 10.1016/j.radonc.2013.05.020
  36. Coppes, R. (2013). Stem cell therapy for prevention of radiation-induced salivary gland toxicity. European Journal of Cancer, 49, S90-S90.
  37. Smit, J. K., Faber, H., Niemantsverdriet, M., Baanstra, M., Bussink, J., Hollema, H., ... Coppes, R. P. (2013). Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers. Radiotherapy and Oncology, 107(3), 434-441. DOI: 10.1016/j.radonc.2013.03.027
  38. Pringle, S., Van Os, R., & Coppes, R. P. (2013). Concise Review: Adult Salivary Gland Stem Cells and a Potential Therapy for Xerostomia. STEM CELLS, 31(4), 613-619. DOI: 10.1002/stem.1327
  39. 2012
  40. Niemantsverdriet, M., Nagle, P., Chiu, R. K., Langendijk, J. A., Kampinga, H. H., & Coppes, R. P. (2012). Delta Np73 Enhances Promoter Activity of TGF-beta Induced Genes. PLoS ONE, 7(12), [e50815]. DOI: 10.1371/journal.pone.0050815
  41. Niemantsverdriet, M., van Goethem, M-J., Bron, R., Hogewerf, W., Brandenburg, S., Langendijk, J. A., ... Coppes, R. P. (2012). High and Low LET Radiation Differentially Induce Normal Tissue Damage Signals. International Journal of Radiation Oncology Biology Physics, 83(4), 1291-1297. DOI: 10.1016/j.ijrobp.2011.09.057
  42. Ghobadi, G., Bartelds, B., van der Veen, S. J., Dickinson, M. G., Brandenburg, S., Berger, R. M. F., ... van Luijk, P. (2012). Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension. Thorax, 67(4), 334-341. DOI: 10.1136/thoraxjnl-2011-200346
  43. 2011
  44. Coppes, R. P., Muijs, C. T., Faber, H., Gross, S., Schippers, J. M., Brandenburg, S., ... van Luijk, P. (2011). Volume-Dependent Expression of In-Field and Out-of-Field Effects in the Proton-Irradiated Rat Lung. International Journal of Radiation Oncology Biology Physics, 81(1), 262-269. DOI: 10.1016/j.ijrobp.2011.03.021
  45. Coppes, R. P. (2011). Biological Insights. European Journal of Cancer, 47, S12-S12.
  46. Coppes, R. P. (2011). Stem Cells - Role for Radiation Response and Therapeutic Approaches. European Journal of Cancer, 47, S4-S4.
  47. Nanduri, L. S. Y., Maimets, M., Pringle, S. A., van der Zwaag, M., van Os, R. P., & Coppes, R. P. (2011). Regeneration of irradiated salivary glands with stem cell marker expressing cells. Radiotherapy and Oncology, 99(3), 367-372. DOI: 10.1016/j.radonc.2011.05.085
  48. Coppes, R. P., & Stokman, M. A. (2011). Stem cells and the repair of radiation-induced salivary gland damage. Oral diseases, 17(2), 143-153. DOI: 10.1111/j.1601-0825.2010.01723.x
  49. Pringle, S., Nanduri, L., van der Zwaag, M., van Os, R., & Coppes, R. (2011). Isolation of Mouse salivary gland stem cells. JoVE (Journal of Visualized Experiments), 48(February), e2482. [2011 Feb 8;(48). pii]. DOI: 10.3791/2484
  50. van Goethem, M-J., Niemantsverdriet, M., Brandenburg, S., Langendijk, J. A., Coppes, R. P., & van Luijk, P. (2011). Development of a facility for high-precision irradiation of cells with carbon ions. Medical Physics, 38(1), 256-263. DOI: 10.1118/1.3528164
  51. 2010
  52. Vissink, A., Mitchell, J. B., Baum, B. J., Limesand, K. H., Jensen, S. B., Fox, P. C., ... Reyland, M. E. (2010). CLINICAL MANAGEMENT OF SALIVARY GLAND HYPOFUNCTION AND XEROSTOMIA IN HEAD-AND-NECK CANCER PATIENTS: SUCCESSES AND BARRIERS. International Journal of Radiation Oncology Biology Physics, 78(4), 983-991. DOI: 10.1016/j.ijrobp.2010.06.052
  53. Niemantsverdriet, M., de Jong, E., Langendijk, J. A., Kampinga, H. H., & Coppes, R. P. (2010). Synergistic induction of profibrotic PAI-1 by TGF-beta and radiation depends on p53. Radiotherapy and Oncology, 97(1), 33-35. DOI: 10.1016/j.radonc.2010.04.002
  54. Ghobadi, G., Hogeweg, L. E., Faber, H., Tukker, W. G. J., Schippers, J. M., Brandenburg, S., ... van Luijk, P. (2010). QUANTIFYING LOCAL RADIATION-INDUCED LUNG DAMAGE FROM COMPUTED TOMOGRAPHY. International Journal of Radiation Oncology Biology Physics, 76(2), 548-556. DOI: 10.1016/j.ijrobp.2009.08.058
  55. 2009
  56. Feng, J., van der Zwaag, M., Stokman, M. A., van Os, R., & Coppes, R. P. (2009). Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation. Radiotherapy and Oncology, 92(3), 466-471. DOI: 10.1016/j.radonc.2009.06.023
  57. Woodward, W. A., Bristow, R. G., Clarke, M. F., Coppes, R. P., Cristofanilli, M., Duda, D. G., ... Chen, Y. (2009). RADIATION THERAPY ONCOLOGY GROUP TRANSLATIONAL RESEARCH PROGRAM STEM CELL SYMPOSIUM: INCORPORATING STEM CELL HYPOTHESES INTO CLINICAL TRIALS. International Journal of Radiation Oncology Biology Physics, 74(5), 1580-1591. DOI: 10.1016/j.ijrobp.2009.03.047
  58. van Luijk, P., Faber, H., Schippers, J. M., Brandenburg, S., Langendijk, J. A., Meertens, H., & Coppes, R. P. (2009). BATH AND SHOWER EFFECTS IN THE RAT PAROTID GLAND EXPLAIN INCREASED RELATIVE RISK OF PAROTID GLAND DYSFUNCTION AFTER INTENSITY-MODULATED RADIOTHERAPY. International Journal of Radiation Oncology Biology Physics, 74(4), 1002-1005. DOI: 10.1016/j.ijrobp.2009.03.039
  59. Coppes, R. P., van der Goot, A., & Lombaert, I. M. A. (2009). Stem Cell Therapy to Reduce Radiation-Induced Normal Tissue Damage. Seminars in radiation oncology, 19(2), 112-121. DOI: 10.1016/j.semradonc.2008.11.005
  60. Burlage, F. R., Faber, H., Kampinga, H. H., Langendijk, J. A., Vissink, A., & Coppes, R. P. (2009). Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands. Radiotherapy and Oncology, 90(2), 253-256. DOI: 10.1016/j.radonc.2008.11.011
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