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prof. dr. R.P. (Rob) Coppes

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prof. dr. R.P. (Rob) Coppes
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  1. 2020
  2. Beukinga, R. J., Wang, D., Karrenbeld, A., Dijksterhuis, W. P. M., Faber, H., Burgerhof, J. G. M., Mul, V. E. M., Slart, R. H. J. A., Coppes, R. P., & Plukker, J. T. M. (2020). Addition of HER2 and CD44 to F-18-FDG PET-based clinico-radiomic models enhances prediction of neoadjuvant chemoradiotherapy response in esophageal cancer. European Radiology. https://doi.org/10.1007/s00330-020-07439-8
  3. Sondorp, L. H. J., Ogundipe, V. M. L., Groen, A. H., Kelder, W., Kemper, A., Links, T. P., Coppes, R. P., & Kruijff, S. (2020). Patient-Derived Papillary Thyroid Cancer Organoids for Radioactive Iodine Refractory Screening. Cancers, 12(11), 1-15. https://doi.org/10.3390/cancers12113212
  4. Peng, X., Wu, Y., Brouwer, U., van Vliet, T., Wang, B., Demaria, M., Barazzuol, L., & Coppes, R. P. (2020). Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche. Cell death & disease, 11(10), [854]. https://doi.org/10.1038/s41419-020-03074-9
  5. Serrano Martinez, P., Cinat, D., van Luijk, P., Baanstra, M., de Haan, G., Pringle, S., & Coppes, R. P. (2020). Mouse parotid salivary gland organoids for the in vitro study of stem cell radiation response. Oral diseases. https://doi.org/10.1111/odi.13475
  6. Barazzuol, L., Coppes, R. P., & van Luijk, P. (2020). Prevention and treatment of radiotherapy-induced side effects. Molecular oncology, 14(7), 1538-1554. https://doi.org/10.1002/1878-0261.12750
  7. 2019
  8. Du, L., Wang, L., Gan, J., Yao, Z., Lin, W., Li, J., Guo, Y., Chen, Y., Zhou, F., Jim Yeung, S-C., Coppes, R. P., Zhang, D., & Zhang, H. (2019). MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis. iScience , 22, 353-368. https://doi.org/10.1016/j.isci.2019.11.009
  9. Vozenin, M-C., Baumann, M., Coppes, R. P., & Bourhis, J. (2019). FLASH radiotherapy International Workshop. Radiotherapy and Oncology, 139, 1-3. https://doi.org/10.1016/j.radonc.2019.07.020
  10. Wang, X., Liefers, S., Vissink, A., Spijkervet, F. K. L., Bootsma, H., Coppes, R. P., Kroese, F. G. M., & Pringle, S. (2019). Senescent progenitor cell depletion as a potential therapy for hyposalivation in primary Sjogren's syndrome? European Journal of Immunology, 49, 769-770.
  11. Steenbakkers, R., Stokman, M. A., Kierkels, R. G. J., Schuurman, M., Hoek, A. V. D., Bijl, H., Kramer, M., Coppes, R. P., Langendijk, J. A., & van Luijk, P. (2019). Stem Cell Sparing IMRT for Head and Neck Cancer Patients: A Double-Blind Randomized Controlled Trial. International Journal of Radiation Oncology Biology Physics, 105(1), S16-S17. https://doi.org/10.1016/j.ijrobp.2019.06.411
  12. van Berlo, D., Khmelinskii, A., Gasparini, A., Salguero, F. J., Floot, B., de Wit, N., van de Ven, M., Song, J. Y., Coppes, R. P., Verheij, M., Sonke, J. J., & Vens, C. (2019). Micro cone beam computed tomography for sensitive assessment of radiation-induced late lung toxicity in preclinical models. Radiotherapy and Oncology, 138, 17-24. https://doi.org/10.1016/j.radonc.2019.05.007
  13. Yao, Z., Du, L., Xu, M., Li, K., Guo, H., Ye, G., Zhang, D., Coppes, R. P., & Zhang, H. (2019). MTA3-SOX2 Module Regulates Cancer Sternness and Contributes to Clinical Outcomes of Tongue Carcinoma. Frontiers in Oncology, 9, [816]. https://doi.org/10.3389/fonc.2019.00816
  14. Nagle, P. W., van Goethem, M-J., Kempers, M., Kiewit, H., Knopf, A., Langendijk, J. A., Brandenburg, S., van Luijk, P., & Coppes, R. P. (2019). In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field. Radiotherapy and Oncology, 137, 125-129. https://doi.org/10.1016/j.radonc.2019.04.028
  15. Wang, D., Nagle, P. W., Wang, H. H., Smit, J. K., Faber, H., Baanstra, M., Karrenbeld, A., Chiu, R. K., Plukker, J. T. M., & Coppes, R. P. (2019). Hedgehog Pathway as a Potential Intervention Target in Esophageal Cancer. Cancers, 11(6), [821]. https://doi.org/10.3390/cancers11060821
  16. Coppes, R. (2019). Radiobiology of normal tissue repair - what are the implications for reirradiation? Radiotherapy and Oncology, 133, S114. https://doi.org/10.1016/S0167-8140(19)30642-5
  17. Steenbakkers, R., Stokman, M., Kierkels, R., Schuurman, M., Van den Hoek, A., Bijl, H., Dieters, M., Coppes, R., Langendijk, J., & Van Luijk, P. (2019). Stem cell sparing IMRT for head and neck cancer patients: a double-blind randomized controlled trial. Radiotherapy and Oncology, 133, S335-S336. https://doi.org/10.1016/S0167-8140(19)31051-5
  18. Pringle, S., Wang, X., Verstappen, G. M. P. J., Terpstra, J. H., Zhang, C. K., He, A., Patel, V., Jones, R. E., Baird, D. M., Spijkervet, F. K. L., Vissink, A., Bootsma, H., Coppes, R. P., & Kroese, F. G. M. (2019). Salivary Gland Stem Cells Age Prematurely in Primary Sjogren's Syndrome. Arthritis & Rheumatology, 71(1), 133-142. https://doi.org/10.1002/art.40659
  19. 2018
  20. Nagle, P. W., Hosper, N. A., Barazzuol, L., Jellema, A. L., Baanstra, M., van Goethem, M-J., Brandenburg, S., Giesen, U., Langendijk, J. A., van Luijk, P., & Coppes, R. P. (2018). Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction. Clinical Cancer Research, 24(24), 6583-6593. https://doi.org/10.1158/1078-0432.CCR-18-0533
  21. Nagle, P. W., Plukker, J. T. M., Muijs, C. T., van Luijk, P., & Coppes, R. P. (2018). Patient-derived tumor organoids for prediction of cancer treatment response. Seminars in cancer biology, 53, 258-264. https://doi.org/10.1016/j.semcancer.2018.06.005
  22. Coppes, R. (2018). Normal tissue stem cells and cancer stem cells in radiation response. Radiotherapy and Oncology, 127, S338-S338. https://doi.org/10.1016/S0167-8140(18)30946-0
  23. Peng, X., Varendi, K., Maimets, M., Andressoo, J. O., & Coppes, R. P. (2018). Role of GDNF in the modulation of SGSCs radiation response; regeneration or senescence? Radiotherapy and Oncology, 127, S304. https://doi.org/10.1016/S0167-8140(18)30892-2
  24. van Luijk, P., & Coppes, R. (2018). Preclinical Radiobiological insights to inform modelling of radiotherapy outcome. In I. El Naqa (Ed.), A Guide to Outcome Modeling In Radiotherapy and Oncology: Listening to the Data (1st ed., pp. 47-52). (Series in Medical Physics and Biomedical Engineering). CRC Press, Taylor and Francis Group. https://doi.org/10.1201/9780429452659
  25. Mauthe, M., Orhon, I., Rocchi, C., Zhou, X., Luhr, M., Hijlkema, K-J., Coppes, R. P., Engedal, N., Mari, M., & Reggiori, F. (2018). Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy, 14(8), 1435-1455. https://doi.org/10.1080/15548627.2018.1474314
  26. Pringle, S., Wang, X., Baird, D., Vissink, A., Spijkervet, F., Bootsma, H., Coppes, R., & Kroese, F. (2018). Senescence of salivary gland stem cells in primary Sjogren's syndrome: the cause of persistent hyposalivation? Clinical and Experimental Rheumatology, 36(3), S245-S245.
  27. 2017
  28. Peng, X., Varendi, K., Maimets, M., Andressoo, J-O., & Coppes, R. P. (2017). Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation. Radiotherapy and Oncology, 124(3), 448-454. https://doi.org/10.1016/j.radonc.2017.07.008
  29. Wang, D., Plukker, J. T. M., & Coppes, R. P. (2017). Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer. Seminars in cancer biology, 44, 60-66. https://doi.org/10.1016/j.semcancer.2017.03.010
  30. Coppes, R. P., & Dubrovska, A. (2017). Targeting Stem Cells in Radiation Oncology. Clinical Oncology, 29(6), 329-334. https://doi.org/10.1016/j.clon.2017.03.005
  31. Van Luijk, P., Gorter, T. M., Willems, T. P., Coppes, R. P., Widder, J., & Langendijk, J. A. (2017). Induction of pulmonary hypertension may explain early mortality after thoracic radiotherapy. Radiotherapy and Oncology, 123, S67-S68. https://doi.org/10.1016/S0167-8140(17)30582-0
  32. van Luijk, P., Langendijk, J. A., & Coppes, R. P. (2017). Understanding mechanisms yields novel approaches to reduce radiotherapy-related xerostomia. Translational Research, 5(3), [63]. https://doi.org/10.21037/atm.2017.02.02
  33. 2016
  34. Klein Hesselink, E., Brouwers, A. H., Jong, de, J. R., van der Horst-Schrivers, A. N. A., Coppes, R. P., Lefrandt, J. D., Jager, P. L., Vissink, A., & Links, T. P. (2016). Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study. Journal of Nuclear Medicine, 57(11), 1685-1691. https://doi.org/10.2967/jnumed.115.169888
  35. Nagle, P. W., Hosper, N. A., Ploeg, E. M., van Goethem, M-J., Brandenburg, S., Langendijk, J. A., Chiu, R. K., & Coppes, R. P. (2016). The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers. International Journal of Radiation Oncology Biology Physics, 95(1), 103-111. https://doi.org/10.1016/j.ijrobp.2016.02.020
  36. Pringle, S., Maimets, M., van der Zwaag, M., Stokman, M. A., van Gosliga, D., Zwart, E., Witjes, M. J. H., de Haan, G., van Os, R., & Coppes, R. P. (2016). Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands. STEM CELLS, 34(3), 640-652. https://doi.org/10.1002/stem.2278
  37. Wang, D., Chiu, R., Plukker, J. T., & Coppes, R. P. (2016). The role of mTOR inhibitors in targeting a putative cancer stem cell-like population in esophageal cancer. Journal of Clinical Oncology, 34(Supplement 4), [43]. http://meetinglibrary.asco.org/content/158619-173
  38. Maimets, M., Rocchi, C., Bron, R., Pringle, S., Kuipers, J., Giepmans, B. N. G., Vries, R. G. J., Clevers, H., de Haan, G., van Os, R., & Coppes, R. P. (2016). Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports, 6(1), 150-162. https://doi.org/10.1016/j.stemcr.2015.11.009
  39. van der Veen, S. J., Faber, H., Ghobadi, G., Brandenburg, S., Langendijk, J. A., Coppes, R. P., & van Luijk, P. (2016). Decreasing Irradiated Rat Lung Volume Changes Dose-Limiting Toxicity From Early to Late Effects. International Journal of Radiation Oncology Biology Physics, 94(1), 163-171. https://doi.org/10.1016/j.ijrobp.2015.09.034
  40. Wang, D., Chiu, R., Coppes, R., & Plukker, J. T. H. M. (2016). The Role of mTOR inhibitors in targeting a putative cancer stem cell-like population in oesophageal cancer. Journal of Clinical Oncology, 34(suppl 4), 43. https://doi.org/10.1200/jco.2016.34.4_suppl.43
  41. 2015
  42. Ghobadi, G., Wiegman, E. M., Langendijk, J. A., Widder, J., Coppes, R. P., & van Luijk, P. (2015). A new CT-based method to quantify radiation-induced lung damage in patients. Radiotherapy and Oncology, 117(1), 4-8. https://doi.org/10.1016/j.radonc.2015.07.017
  43. van Luijk, P., Pringle, S., Deasy, J. O., Moiseenko, V. V., Faber, H., Hovan, A., Baanstra, M., van der Laan, H. P., Kierkels, R. G. J., van der Schaaf, A., Witjes, M. J., Schippers, J. M., Brandenburg, S., Langendijk, J. A., Wu, J., & Coppes, R. P. (2015). Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer. Science Translational Medicine, 7(305), [305ra147]. https://doi.org/10.1126/scitranslmed.aac4441
  44. van der Veen, S. J., Ghobadi, G., de Boer, R. A., Faber, H., Cannon, M. V., Nagle, P. W., Brandenburg, S., Langendijk, J. A., van Luijk, P., & Coppes, R. P. (2015). ACE inhibition attenuates radiation-induced cardiopulmonary damage. Radiotherapy and Oncology, 114(1), 96-103. https://doi.org/10.1016/j.radonc.2014.11.017
  45. Vissink, A., van Luijk, P., Langendijk, J. A., & Coppes, R. P. (2015). Current ideas to reduce or salvage radiation damage to salivary glands. Oral diseases, 21(1), E1-E10. https://doi.org/10.1111/odi.12222
  46. Nagle, P., Hosper, N., Ploeg, E., van Goethem, M-J., Langendijk, H., Chiu, R., & Coppes, R. (2015). The response of three-dimensional spheroids to particle radiotherapy. Abstract from Annual NVRB Spring Meeting , Utrecht, Netherlands.
  47. 2014
  48. Nanduri, L. S. Y., Baanstra, M., Faber, H., Rocchi, C., Zwart, E., de Haan, G., van Os, R., & Coppes, R. P. (2014). Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells. Stem Cell Reports, 3(6), 957-964. https://doi.org/10.1016/j.stemcr.2014.09.015
  49. de Cortie, K., Russell, N. S., Coppes, R. P., Stewart, F. A., & Scharpfenecker, M. (2014). Bone marrow-derived macrophages incorporate into the endothelium and influence vascular and renal function after irradiation. International Journal of Radiation Biology, 90(9), 769-777. https://doi.org/10.3109/09553002.2014.920967
  50. Benderitter, M., Caviggioli, F., Chapel, A., Coppes, R. P., Guha, C., Klinger, M., Malard, O., Stewart, F., Tamarat, R., Van Luijk, P., & Limoli, C. L. (2014). Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects. Antioxidants & Redox Signaling, 21(2), 338-355. https://doi.org/10.1089/ars.2013.5652
  51. Scharpfenecker, M., Floot, B., Russell, N. S., Coppes, R. P., & Stewart, F. A. (2014). Thalidomide Ameliorates Inflammation and Vascular Injury but Aggravates Tubular Damage in the Irradiated Mouse Kidney. International Journal of Radiation Oncology Biology Physics, 89(3), 599-606. https://doi.org/10.1016/j.ijrobp.2014.03.039
  52. Coppes, R. P., & de Haan, G. (2014). Means and methods for obtaining salivary gland stem cells and use thereof. (Patent No. WO2014092575). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2014092575A1&KC=A1&FT=D&ND=3&date=20140619&DB=&locale=en_EP
  53. Nagle, P., van Goethem, M-J., van Luijk, P., Langendijk, J. A., Coppes, R., & Chiu, R. (2014). Targeting DNA repair to enhance particle radiotherapy treatment. Abstract from 40th Annual meeting of the European Radiation Research Society, Rhodes, Greece.
  54. 2013
  55. Scharpfenecker, M., Floot, B., Russell, N. S., Coppes, R. P., & Stewart, F. A. (2013). Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice. Radiotherapy and Oncology, 108(3), 464-468. https://doi.org/10.1016/j.radonc.2013.06.016
  56. Nanduri, L. S. Y., Lombaert, I. M. A., van der Zwaag, M., Faber, H., Brunsting, J. F., van Os, R. P., & Coppes, R. P. (2013). Salisphere derived c-Kit(+) cell transplantation restores tissue homeostasis in irradiated salivary gland. Radiotherapy and Oncology, 108(3), 458-463. https://doi.org/10.1016/j.radonc.2013.05.020
  57. Coppes, R., & van Luijk, P. (2013). Radiation-induced disease. In ERS Handbook of Respiratory Medicine (2nd ed.)
  58. Smit, J. K., Faber, H., Niemantsverdriet, M., Baanstra, M., Bussink, J., Hollema, H., van Os, R. P., Plukker, J. T. M., & Coppes, R. P. (2013). Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers. Radiotherapy and Oncology, 107(3), 434-441. https://doi.org/10.1016/j.radonc.2013.03.027
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