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prof. dr. R.P. (Rob) Coppes

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prof. dr. R.P. (Rob) Coppes
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  1. 2020
  2. Aznar, M. C., Bacchus, C., Coppes, R. P., Deutsch, E., Georg, D., Haustermans, K., Hoskin, P., Krause, M., Lartigau, E. F., Löck, S., Offersen, B., Overgaard, J., I Thwaites, D., van der Kogel, A. J., van der Heide, U. A., Valentini, V., & Baumann, M. (2020). Radiation oncology in the new virtual and digital era. Radiotherapy and Oncology. https://doi.org/10.1016/j.radonc.2020.12.031
  3. Coppes, R. P. (2020). Macrophages Come To The Rescue. Cancer Research, 80(24), 5462-5463. https://doi.org/10.1158/0008-5472.CAN-20-3499
  4. Nagle, P. W., & Coppes, R. P. (2020). Current and Future Perspectives of the Use of Organoids in Radiobiology. Cells, 9(12), [2649]. https://doi.org/10.3390/cells9122649
  5. Beukinga, R. J., Wang, D., Karrenbeld, A., Dijksterhuis, W. P. M., Faber, H., Burgerhof, J. G. M., Mul, V. E. M., Slart, R. H. J. A., Coppes, R. P., & Plukker, J. T. M. (2020). Addition of HER2 and CD44 to F-18-FDG PET-based clinico-radiomic models enhances prediction of neoadjuvant chemoradiotherapy response in esophageal cancer. European Radiology. https://doi.org/10.1007/s00330-020-07439-8
  6. Steenbakkers, R., Rijn-Dekker, van, I., Stokman, M., Kierkels, R. G. J., Bosch, van den, L., Hoek, van den, A., Bijl, H., Kramer, M., Coppes, R. P., Langendijk, J. A., & Luijk, van, P. (2020). Stem cell sparing radiotherapy for head and neck cancer patients: a double-blind randomized controlled trial. Abstract from annual PhD meeting of the Cancer Research Center Groningen (CRCG), .
  7. Sondorp, L. H. J., Ogundipe, V. M. L., Groen, A. H., Kelder, W., Kemper, A., Links, T. P., Coppes, R. P., & Kruijff, S. (2020). Patient-Derived Papillary Thyroid Cancer Organoids for Radioactive Iodine Refractory Screening. Cancers, 12(11), 1-15. [3212]. https://doi.org/10.3390/cancers12113212
  8. Peng, X., Wu, Y., Brouwer, U., van Vliet, T., Wang, B., Demaria, M., Barazzuol, L., & Coppes, R. P. (2020). Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche. Cell death & disease, 11(10), [854]. https://doi.org/10.1038/s41419-020-03074-9
  9. Serrano Martinez, P., Cinat, D., van Luijk, P., Baanstra, M., de Haan, G., Pringle, S., & Coppes, R. P. (2020). Mouse parotid salivary gland organoids for the in vitro study of stem cell radiation response. Oral diseases, (1), 52-63. https://doi.org/10.1111/odi.13475
  10. Barazzuol, L., Coppes, R. P., & van Luijk, P. (2020). Prevention and treatment of radiotherapy-induced side effects. Molecular oncology, 14(7), 1538-1554. https://doi.org/10.1002/1878-0261.12750
  11. 2019
  12. Du, L., Wang, L., Gan, J., Yao, Z., Lin, W., Li, J., Guo, Y., Chen, Y., Zhou, F., Jim Yeung, S-C., Coppes, R. P., Zhang, D., & Zhang, H. (2019). MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis. iScience , 22, 353-368. https://doi.org/10.1016/j.isci.2019.11.009
  13. Vozenin, M-C., Baumann, M., Coppes, R. P., & Bourhis, J. (2019). FLASH radiotherapy International Workshop. Radiotherapy and Oncology, 139, 1-3. https://doi.org/10.1016/j.radonc.2019.07.020
  14. Wang, X., Liefers, S., Vissink, A., Spijkervet, F. K. L., Bootsma, H., Coppes, R. P., Kroese, F. G. M., & Pringle, S. (2019). Senescent progenitor cell depletion as a potential therapy for hyposalivation in primary Sjogren's syndrome? European Journal of Immunology, 49, 769-770.
  15. Steenbakkers, R., Stokman, M. A., Kierkels, R. G. J., Schuurman, M., Hoek, A. V. D., Bijl, H., Kramer, M., Coppes, R. P., Langendijk, J. A., & van Luijk, P. (2019). Stem Cell Sparing IMRT for Head and Neck Cancer Patients: A Double-Blind Randomized Controlled Trial. International Journal of Radiation Oncology Biology Physics, 105(1), S16-S17. https://doi.org/10.1016/j.ijrobp.2019.06.411
  16. van Berlo, D., Khmelinskii, A., Gasparini, A., Salguero, F. J., Floot, B., de Wit, N., van de Ven, M., Song, J. Y., Coppes, R. P., Verheij, M., Sonke, J. J., & Vens, C. (2019). Micro cone beam computed tomography for sensitive assessment of radiation-induced late lung toxicity in preclinical models. Radiotherapy and Oncology, 138, 17-24. https://doi.org/10.1016/j.radonc.2019.05.007
  17. Yao, Z., Du, L., Xu, M., Li, K., Guo, H., Ye, G., Zhang, D., Coppes, R. P., & Zhang, H. (2019). MTA3-SOX2 Module Regulates Cancer Sternness and Contributes to Clinical Outcomes of Tongue Carcinoma. Frontiers in Oncology, 9, [816]. https://doi.org/10.3389/fonc.2019.00816
  18. Nagle, P. W., van Goethem, M-J., Kempers, M., Kiewit, H., Knopf, A., Langendijk, J. A., Brandenburg, S., van Luijk, P., & Coppes, R. P. (2019). In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field. Radiotherapy and Oncology, 137, 125-129. https://doi.org/10.1016/j.radonc.2019.04.028
  19. Wang, D., Nagle, P. W., Wang, H. H., Smit, J. K., Faber, H., Baanstra, M., Karrenbeld, A., Chiu, R. K., Plukker, J. T. M., & Coppes, R. P. (2019). Hedgehog Pathway as a Potential Intervention Target in Esophageal Cancer. Cancers, 11(6), [821]. https://doi.org/10.3390/cancers11060821
  20. Coppes, R. (2019). Radiobiology of normal tissue repair - what are the implications for reirradiation? Radiotherapy and Oncology, 133, S114. https://doi.org/10.1016/S0167-8140(19)30642-5
  21. Steenbakkers, R., Stokman, M., Kierkels, R., Schuurman, M., Van den Hoek, A., Bijl, H., Dieters, M., Coppes, R., Langendijk, J., & Van Luijk, P. (2019). Stem cell sparing IMRT for head and neck cancer patients: a double-blind randomized controlled trial. Radiotherapy and Oncology, 133, S335-S336. https://doi.org/10.1016/S0167-8140(19)31051-5
  22. Pringle, S., Wang, X., Verstappen, G. M. P. J., Terpstra, J. H., Zhang, C. K., He, A., Patel, V., Jones, R. E., Baird, D. M., Spijkervet, F. K. L., Vissink, A., Bootsma, H., Coppes, R. P., & Kroese, F. G. M. (2019). Salivary Gland Stem Cells Age Prematurely in Primary Sjogren's Syndrome. Arthritis & Rheumatology, 71(1), 133-142. https://doi.org/10.1002/art.40659
  23. 2018
  24. Nagle, P. W., Hosper, N. A., Barazzuol, L., Jellema, A. L., Baanstra, M., van Goethem, M-J., Brandenburg, S., Giesen, U., Langendijk, J. A., van Luijk, P., & Coppes, R. P. (2018). Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction. Clinical Cancer Research, 24(24), 6583-6593. https://doi.org/10.1158/1078-0432.CCR-18-0533
  25. Nagle, P. W., Plukker, J. T. M., Muijs, C. T., van Luijk, P., & Coppes, R. P. (2018). Patient-derived tumor organoids for prediction of cancer treatment response. Seminars in cancer biology, 53, 258-264. https://doi.org/10.1016/j.semcancer.2018.06.005
  26. Coppes, R. (2018). Normal tissue stem cells and cancer stem cells in radiation response. Radiotherapy and Oncology, 127, S338-S338. https://doi.org/10.1016/S0167-8140(18)30946-0
  27. Peng, X., Varendi, K., Maimets, M., Andressoo, J. O., & Coppes, R. P. (2018). Role of GDNF in the modulation of SGSCs radiation response; regeneration or senescence? Radiotherapy and Oncology, 127, S304. https://doi.org/10.1016/S0167-8140(18)30892-2
  28. van Luijk, P., & Coppes, R. (2018). Preclinical Radiobiological insights to inform modelling of radiotherapy outcome. In I. El Naqa (Ed.), A Guide to Outcome Modeling In Radiotherapy and Oncology: Listening to the Data (1st ed., pp. 47-52). (Series in Medical Physics and Biomedical Engineering). CRC Press, Taylor and Francis Group. https://doi.org/10.1201/9780429452659
  29. Mauthe, M., Orhon, I., Rocchi, C., Zhou, X., Luhr, M., Hijlkema, K-J., Coppes, R. P., Engedal, N., Mari, M., & Reggiori, F. (2018). Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy, 14(8), 1435-1455. https://doi.org/10.1080/15548627.2018.1474314
  30. Pringle, S., Wang, X., Baird, D., Vissink, A., Spijkervet, F., Bootsma, H., Coppes, R., & Kroese, F. (2018). Senescence of salivary gland stem cells in primary Sjogren's syndrome: the cause of persistent hyposalivation? Clinical and Experimental Rheumatology, 36(3), S245-S245.
  31. 2017
  32. Peng, X., Varendi, K., Maimets, M., Andressoo, J-O., & Coppes, R. P. (2017). Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation. Radiotherapy and Oncology, 124(3), 448-454. https://doi.org/10.1016/j.radonc.2017.07.008
  33. Wang, D., Plukker, J. T. M., & Coppes, R. P. (2017). Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer. Seminars in cancer biology, 44, 60-66. https://doi.org/10.1016/j.semcancer.2017.03.010
  34. Coppes, R. P., & Dubrovska, A. (2017). Targeting Stem Cells in Radiation Oncology. Clinical Oncology, 29(6), 329-334. https://doi.org/10.1016/j.clon.2017.03.005
  35. Van Luijk, P., Gorter, T. M., Willems, T. P., Coppes, R. P., Widder, J., & Langendijk, J. A. (2017). Induction of pulmonary hypertension may explain early mortality after thoracic radiotherapy. Radiotherapy and Oncology, 123, S67-S68. https://doi.org/10.1016/S0167-8140(17)30582-0
  36. van Luijk, P., Langendijk, J. A., & Coppes, R. P. (2017). Understanding mechanisms yields novel approaches to reduce radiotherapy-related xerostomia. Translational Research, 5(3), [63]. https://doi.org/10.21037/atm.2017.02.02
  37. 2016
  38. Klein Hesselink, E., Brouwers, A. H., Jong, de, J. R., van der Horst-Schrivers, A. N. A., Coppes, R. P., Lefrandt, J. D., Jager, P. L., Vissink, A., & Links, T. P. (2016). Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study. Journal of Nuclear Medicine, 57(11), 1685-1691. https://doi.org/10.2967/jnumed.115.169888
  39. Nagle, P. W., Hosper, N. A., Ploeg, E. M., van Goethem, M-J., Brandenburg, S., Langendijk, J. A., Chiu, R. K., & Coppes, R. P. (2016). The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers. International Journal of Radiation Oncology Biology Physics, 95(1), 103-111. https://doi.org/10.1016/j.ijrobp.2016.02.020
  40. Pringle, S., Maimets, M., van der Zwaag, M., Stokman, M. A., van Gosliga, D., Zwart, E., Witjes, M. J. H., de Haan, G., van Os, R., & Coppes, R. P. (2016). Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands. STEM CELLS, 34(3), 640-652. https://doi.org/10.1002/stem.2278
  41. Wang, D., Chiu, R., Plukker, J. T., & Coppes, R. P. (2016). The role of mTOR inhibitors in targeting a putative cancer stem cell-like population in esophageal cancer. Journal of Clinical Oncology, 34(Supplement 4), [43]. http://meetinglibrary.asco.org/content/158619-173
  42. Maimets, M., Rocchi, C., Bron, R., Pringle, S., Kuipers, J., Giepmans, B. N. G., Vries, R. G. J., Clevers, H., de Haan, G., van Os, R., & Coppes, R. P. (2016). Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports, 6(1), 150-162. https://doi.org/10.1016/j.stemcr.2015.11.009
  43. van der Veen, S. J., Faber, H., Ghobadi, G., Brandenburg, S., Langendijk, J. A., Coppes, R. P., & van Luijk, P. (2016). Decreasing Irradiated Rat Lung Volume Changes Dose-Limiting Toxicity From Early to Late Effects. International Journal of Radiation Oncology Biology Physics, 94(1), 163-171. https://doi.org/10.1016/j.ijrobp.2015.09.034
  44. Wang, D., Chiu, R., Coppes, R., & Plukker, J. T. H. M. (2016). The Role of mTOR inhibitors in targeting a putative cancer stem cell-like population in oesophageal cancer. Journal of Clinical Oncology, 34(suppl 4), 43. https://doi.org/10.1200/jco.2016.34.4_suppl.43
  45. 2015
  46. Ghobadi, G., Wiegman, E. M., Langendijk, J. A., Widder, J., Coppes, R. P., & van Luijk, P. (2015). A new CT-based method to quantify radiation-induced lung damage in patients. Radiotherapy and Oncology, 117(1), 4-8. https://doi.org/10.1016/j.radonc.2015.07.017
  47. van Luijk, P., Pringle, S., Deasy, J. O., Moiseenko, V. V., Faber, H., Hovan, A., Baanstra, M., van der Laan, H. P., Kierkels, R. G. J., van der Schaaf, A., Witjes, M. J., Schippers, J. M., Brandenburg, S., Langendijk, J. A., Wu, J., & Coppes, R. P. (2015). Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer. Science Translational Medicine, 7(305), [305ra147]. https://doi.org/10.1126/scitranslmed.aac4441
  48. van der Veen, S. J., Ghobadi, G., de Boer, R. A., Faber, H., Cannon, M. V., Nagle, P. W., Brandenburg, S., Langendijk, J. A., van Luijk, P., & Coppes, R. P. (2015). ACE inhibition attenuates radiation-induced cardiopulmonary damage. Radiotherapy and Oncology, 114(1), 96-103. https://doi.org/10.1016/j.radonc.2014.11.017
  49. Vissink, A., van Luijk, P., Langendijk, J. A., & Coppes, R. P. (2015). Current ideas to reduce or salvage radiation damage to salivary glands. Oral diseases, 21(1), E1-E10. https://doi.org/10.1111/odi.12222
  50. Nagle, P., Hosper, N., Ploeg, E., van Goethem, M-J., Langendijk, H., Chiu, R., & Coppes, R. (2015). The response of three-dimensional spheroids to particle radiotherapy. Abstract from Annual NVRB Spring Meeting , Utrecht, Netherlands.
  51. 2014
  52. Nanduri, L. S. Y., Baanstra, M., Faber, H., Rocchi, C., Zwart, E., de Haan, G., van Os, R., & Coppes, R. P. (2014). Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells. Stem Cell Reports, 3(6), 957-964. https://doi.org/10.1016/j.stemcr.2014.09.015
  53. de Cortie, K., Russell, N. S., Coppes, R. P., Stewart, F. A., & Scharpfenecker, M. (2014). Bone marrow-derived macrophages incorporate into the endothelium and influence vascular and renal function after irradiation. International Journal of Radiation Biology, 90(9), 769-777. https://doi.org/10.3109/09553002.2014.920967
  54. Benderitter, M., Caviggioli, F., Chapel, A., Coppes, R. P., Guha, C., Klinger, M., Malard, O., Stewart, F., Tamarat, R., Van Luijk, P., & Limoli, C. L. (2014). Stem Cell Therapies for the Treatment of Radiation-Induced Normal Tissue Side Effects. Antioxidants & Redox Signaling, 21(2), 338-355. https://doi.org/10.1089/ars.2013.5652
  55. Scharpfenecker, M., Floot, B., Russell, N. S., Coppes, R. P., & Stewart, F. A. (2014). Thalidomide Ameliorates Inflammation and Vascular Injury but Aggravates Tubular Damage in the Irradiated Mouse Kidney. International Journal of Radiation Oncology Biology Physics, 89(3), 599-606. https://doi.org/10.1016/j.ijrobp.2014.03.039
  56. Coppes, R. P., & de Haan, G. (2014). Means and methods for obtaining salivary gland stem cells and use thereof. (Patent No. WO2014092575). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2014092575A1&KC=A1&FT=D&ND=3&date=20140619&DB=&locale=en_EP
  57. Nagle, P., van Goethem, M-J., van Luijk, P., Langendijk, J. A., Coppes, R., & Chiu, R. (2014). Targeting DNA repair to enhance particle radiotherapy treatment. Abstract from 40th Annual meeting of the European Radiation Research Society, Rhodes, Greece.
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