R. (Richard) Bruggeman

Professor in Neuropsychiatry of Psychotic Disorders

Research

  1. 2020
  2. Thygesen, J. H., Presman, A., Harju-Seppanen, J., Irizar, H., Jones, R., Kuchenbaecker, K., Lin, K., Alizadeh, B. Z., Austin-Zimmerman, I., Bartels-Velthuis, A., Bhat, A., Bruggeman, R., Cahn, W., Calafato, S., Crespo-Facorro, B., de Haan, L., de Zwarte, S. M. C., Di Forti, M., Diez-Revuelta, A., ... Bramon, E. (2020). Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study. Molecular Psychiatry. https://doi.org/10.1038/s41380-020-0820-7
  3. Burger, T. J., Schirmbeck, F., Vermeulen, J. M., Quee, P. J., de Koning, M. B., Bruggeman, R., de Haan, L., van Amelsvoort, T., Bartels-Velthuis, A. A., Cahn, W., de Haan, L., Schirmbeck, F., Simons, C. J. P., & van Os, J. (2020). Association between cognitive phenotype in unaffected siblings and prospective 3- and 6-year clinical outcome in their proband affected by psychosis. Psychological Medicine, 1-11. https://doi.org/10.1017/S0033291720000719
  4. GRP Investigators, WGSPD Consortium, Mansolf, M., Vreeker, A., Reise, S. P., Freimer, N. B., Glahn, D. C., Gur, R. E., Moore, T. M., Pato, C. N., Pato, M. T., Palotie, A., Holm, M., Suvisaari, J., Partonen, T., Kieseppa, T., Paunio, T., Boks, M., Kahn, R., ... DeGeorge, D. (2020). Extensions of Multiple-Group Item Response Theory Alignment: Application to Psychiatric Phenotypes in an International Genomics Consortium. Educational and Psychological Measurement, (5), 870-909. [0013164419897307]. https://doi.org/10.1177/0013164419897307
  5. Pharmacotherapy Monitoring, Chen, J., Patil, K. R., Weis, S., Sim, K., Nickl-Jockschat, T., Zhou, J., Aleman, A., Sommer, I. E., Liemburg, E. J., Hoffstaedter, F., Habel, U., Derntl, B., Liu, X., Fischer, J. M., Kogler, L., Regenbogen, C., Diwadkar, V. A., Stanley, J. A., ... Jorg, F. (2020). Neurobiological Divergence of the Positive and Negative Schizophrenia Subtypes Identified on a New Factor Structure of Psychopathology Using Non-negative Factorization: An International Machine Learning Study. Biological Psychiatry, 87(3), 282-293. https://doi.org/10.1016/j.biopsych.2019.08.031
  6. GRP Investigators, Rees, E., Han, J., Morgan, J., Carrera, N., Escott-Price, V., Pocklington, A. J., Duffield, M., Hall, L. S., Legge, S. E., Pardinas, A. F., Richards, A. L., Roth, J., Lezheiko, T., Kondratyev, N., Kaleda, V., Golimbet, V., Parellada, M., Gonzalez-Penas, J., & Arango, C. (2020). De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia. Nature neuroscience, 23(2), 179-184. https://doi.org/10.1038/s41593-019-0565-2
  7. GRP Investigators, Renkema, T. C., de Haan, L., Schirmbeck, F., Alizadeh, B. Z., van Amelsvoort, T., Bartels-Velthuis, A. A., van Beveren, N. J., Bruggeman, R., Cahn, W., de Haan, L., Delespaul, P., Luykx, J. J., Myin-Germeys, I., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Os, J., & van Winkel, R. (2020). Childhood trauma and coping in patients with psychotic disorders and obsessive-compulsive symptoms and in un-affected siblings. Child Abuse & Neglect, 99, [104243]. https://doi.org/10.1016/j.chiabu.2019.104243
  8. Jaya, E. S., Wüsten, C., Alizadeh, B. Z., van Amelsvoort, T., Bartels-Velthuis, A. A., van Beveren, N. J., Bruggeman, R., Cahn, W., de Haan, L., Delespaul, P., Luykx, J. J., Myin-Germeys, I., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Haren, N. E., van Os, J., van Winkel, R., Fonseca-Pedrero, E., ... Lincoln, T. M. (2020). Comparing psychotic experiences in low-and-middle-income-countries and high-income-countries with a focus on measurement invariance. Psychological Medicine, 1-8. https://doi.org/10.1017/S0033291720003323
  9. 2019
  10. Genetic Risk and Outcome of Psychosis (G.R.O.U.P.), Van Haren, N. E. M., Van Dam, D. S., & Stellato, R. K. (2019). Change in IQ in schizophrenia patients and their siblings: a controlled longitudinal study. Psychological Medicine, 49(15), 2573-2581. https://doi.org/10.1017/S0033291718003537
  11. Genetic Risk and Outcome of Psychosis (G.R.O.U.P.), Pries, L-K., Lage-Castellanos, A., Delespaul, P., Kenis, G., Luykx, J. J., Lin, B. D., Richards, A. L., Akdede, B., Binbay, T., Altinyazar, V., Yalincetin, B., Gumus-Akay, G., Cihan, B., Soygur, H., Ulas, H., Cankurtaran, E. S., Kaymak, S. U., Mihaljevic, M. M., ... Guloksuz, S. (2019). Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study. Schizophrenia Bulletin, 45(5), 960-965. https://doi.org/10.1093/schbul/sbz054
  12. GRP Investigators, Rees, E., Carrera, N., Morgan, J., Hambridge, K., Escott-Price, V., Pocklington, A. J., Richards, A. L., Pardinas, A. F., McDonald, C., Donohoe, G., Morris, D. W., Kenny, E., Kelleher, E., Gill, M., Corvin, A., Kirov, G., Walters, J. T. R., Holmans, P., ... O'Donovan, M. C. (2019). Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis. Biological Psychiatry, 85(7), 554-562. https://doi.org/10.1016/j.biopsych.2018.08.022
  13. Mansueto, G., Schruers, K., Cosci, F., van Os, J., Alizadeh, B. Z., Bartels-Velthuis, A. A., van Beveren, N. J., Bruggeman, R., Cahn, W., de Haan, L., Delespaul, P., Meijer, C. J., Myin-Germeys, I., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Haren, N. E. M., & van Winkel, R. (2019). Childhood adversities and psychotic symptoms: The potential mediating or moderating role of neurocognition and social cognition. Schizophrenia Research, 206, 183-193. https://doi.org/10.1016/j.schres.2018.11.028
  14. CommonMind Consortium, Psychiat Genomics Consortium, iPSYCH-GEMS Schizophrenia Working, Huckins, L. M., Dobbyn, A., Ruderfer, D. M., Hoffman, G., Wang, W., Pardinas, A. F., Rajagopal, V. M., Als, T. D., Nguyen, H. T., Girdhar, K., Boocock, J., Roussos, P., Fromer, M., Kramer, R., Purcell, S., Demontis, D., ... Stahl, E. A. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51(4), 659-674. https://doi.org/10.1038/s41588-019-0364-4
  15. Swets, M., van Dijk, F. A., Schirmbeck, F., Peen, J., de Haan, L., Alizadeh, B. Z., van Amelsvoort, T., Bartels-Velthuis, A. A., van Beveren, N. J., Bruggeman, R., Cahn, W., Delespaul, P., Luykx, J. J., Myin-Germeys, I., Kahn, R. S., Simons, C. J. P., van Haren, N. E., van Os, J., & van Winkel, R. (2019). Patterns of obsessive-compulsive symptoms and social functioning in schizophrenia; a replication study. Psychiatry Research, 271, 421-427. https://doi.org/10.1016/j.psychres.2018.11.071
  16. 2018
  17. Swildens, W. E., Visser, E., Bahler, M., Bruggeman, R., Delespaul, P., van der Gaag, M., de Haan, L., Keet, R., Nijssen, Y., van Os, J., Pijnenborg, G. M., Slooff, C., de Vos, A., van Weeghel, J., Wunderink, L., Mulder, C. L., & Wiersma, D. (2018). Functional Recovery of Individuals With Serious Mental Illnesses: Development and Testing of a New Short Instrument for Routine Outcome Monitoring. Psychiatric Rehabilitation Journal, 41(4), 341-350. https://doi.org/10.1037/prj0000320
  18. Genetic Risk and Outcome of Psychosis (G.R.O.U.P.), Vermeulen, J. M., Schirmbeck, F., Blankers, M., van Tricht, M., Bruggeman, R., van den Brink, W., & de Haan, L. (2018). Association Between Smoking Behavior and Cognitive Functioning in Patients With Psychosis, Siblings, and Healthy Control Subjects: Results From a Prospective 6-Year Follow-Up Study. American Journal of Psychiatry, 175(11), 1121-1128. https://doi.org/10.1176/appi.ajp.2018.18010069
  19. Genetic Risk and Outcome of Psychosis (G.R.O.U.P.), Wusten, C., Schlier, B., Jaya, E. S., Alizadeh, B. Z., Bartels-Velthuis, A. A., van Beveren, N. J., Bruggeman, R., Cahn, W., de Haan, L., Delespaul, P., Meijer, C. J., Myin-Germeys, I., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Haren, N. E., van Os, J., van Winkel, R., ... Lincoln, T. M. (2018). Psychotic Experiences and Related Distress: A Cross-national Comparison and Network Analysis Based on 7141 Participants From 13 Countries. Schizophrenia Bulletin, 44(6), 1185-1194. https://doi.org/10.1093/schbul/sby087
  20. Leendertse, P., Myin-Germeys, I., Lataster, T., Simons, C. J. P., Oorschot, M., Lardinois, M., Schneider, M., van Os, J., Reininghaus, U., Alizadeh, B. Z., Bartels-Velthuis, A. A., Van Beveren, N. J., Bruggeman, R., Cahn, W., de Haan, L., Delespaul, P., Meijer, C. J., Myin-Germeys, I., Kahn, R. S., ... van Winkel, R. (2018). Subjective quality of life in psychosis: Evidence for an association with real world functioning? Psychiatry Research, 261, 116-123. https://doi.org/10.1016/j.psychres.2017.11.074
  21. Mansueto, G., van Nierop, M., Schruers, K., Alizadeh, B. Z., Bartels-Velthuis, A. A., van Beveren, N. J., Bruggeman, R., Cahn, W., de Haan, L., Delespaul, P., Meijer, C. J., Myin-Germeys, I., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Haren, N. E. M., van Os, J., van Winkel, R., & GROUP Investigators (2018). The role of cognitive functioning in the relationship between childhood trauma and a mixed phenotype of affective-anxious-psychotic symptoms in psychotic disorders. Schizophrenia Research, 192, 262-268. https://doi.org/10.1016/j.schres.2017.04.003
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