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prof. dr. P. (Peter) Olinga

Associate professor

Research

Research units:

Postal address:
A Deusinglaan1
Gebouw 3213, ruimte 0205
9713 AV
Groningen
Netherlands
Phone: +31 50 363 8373Fax: +31 50 363 2500
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  1. 2020
  2. Bartucci, R., Åberg, C., Melgert, B. N., Boersma, Y. L., Olinga, P., & Salvati, A. (2020). Time-Resolved Quantification of Nanoparticle Uptake, Distribution, and Impact in Precision-Cut Liver Slices. Small, [e1906523]. https://doi.org/10.1002/smll.201906523
  3. Gore, E., Bigaeva, E., Oldenburger, A., Jansen, Y. J. M., Schuppan, D., Boersema, M., ... Olinga, P. (2020). Investigating fibrosis and inflammation in an ex vivo NASH murine model. American Journal of Physiology. Gastrointestinal and Liver Physiology, 318(2), G336-G351. https://doi.org/10.1152/ajpgi.00209.2019
  4. Ruigrok, M., El-Amasi, K., Frijlink, H. W., Hinrichs, W., & Olinga, P. (2020). Knockdown of heat shock protein 47 (HSP47) and its effects on fibrogenesis. Poster session presented at Keystone Symposia on Fibrosis and Tissue Repair, Victoria, Canada.
  5. Iswandana, R., Pham, B. T., Suriguga, S., Luangmonkong, T., van Wijk, L. A., Jansen, Y. J. M., ... Olinga, P. (2020). Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs. Inflammatory Bowel Diseases. https://doi.org/10.1093/ibd/izz329
  6. Bigaeva, E., Gore, E., Mutsaers, H. A. M., Oosterhuis, D., Kim, Y. O., Schuppan, D., ... Olinga, P. (2020). Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices. Biochimica et biophysica acta-Molecular basis of disease, 1866(1), [165582]. https://doi.org/10.1016/j.bbadis.2019.165582
  7. Bigaeva, E., Stribos, E. G. D., Mutsaers, H. A. M., Piersma, B., Leliveld, A. M., de Jong, I. J., ... Boersema, M. (2020). Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis. American journal of physiology-Renal physiology, 318(1), F117-F134. https://doi.org/10.1152/ajprenal.00108.2019
  8. 2019
  9. Bigaeva, E., Gore, E., Simon, E., Zwick, M., Oldenburger, A., de Jong, K. P., ... Olinga, P. (2019). Transcriptomic characterization of culture-associated changes in murine and human precision-cut tissue slices. Archives of toxicology, 93(12), 3549-3583. https://doi.org/10.1007/s00204-019-02611-6
  10. Ruigrok, M., Tomar, J., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2019). The effects of oxygen concentration on cell death, anti-oxidant transcription, acute inflammation, and cell proliferation in precision-cut lung slices. Scientific Reports, 9(1), [16239]. https://doi.org/10.1038/s41598-019-52813-2
  11. Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Olinga, P., & Gier, K. (2019). INDUCTION OF STEATOSIS IN HUMAN LIVER EX VIVO. Hepatology, 70, 1311A-1311A.
  12. Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Dekker, F. J., Olinga, P., & Gier, K. (2019). POLYUNSATURATED FATTY ACIDS AND 5-LIPOXYGENASE IN NON-ALCOHOLIC FATTY LIVER DISEASE. Hepatology, 70, 1311A-1311A.
  13. Gore, E., Bigaeva, E., Oldenburger, A., Ook, K. Y., Rippmann, J. F., Schuppan, D., ... Olinga, P. (2019). PI3K inhibition reduces murine and human liver fibrogenesis in precision-cut liver slices. Biochemical Pharmacology, 169, [113633]. https://doi.org/10.1016/j.bcp.2019.113633
  14. Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., ... Norregaard, R. (2019). Activation of the prostaglandin E-2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta physiologica, 227(1), [e13291]. https://doi.org/10.1111/apha.13291
  15. Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M., & Olinga, P. (2019). Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study. Toxicology in Vitro, 59, 312-321. https://doi.org/10.1016/j.tiv.2019.05.024
  16. Bartucci, R., Salvati, A., Olinga, P., & Boersma, Y. L. (2019). Vanin 1: Its Physiological Function and Role in Diseases. International Journal of Molecular Sciences, 20(16), [3891]. https://doi.org/10.3390/ijms20163891
  17. de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., ... Porte, R. J. (2019). Peribiliary glands are key in regeneration of the biliary epithelium after severe ischemic bile duct injury during liver transplantation. Transplantation, 103(8), 3-3. https://doi.org/10.1002/hep.30365
  18. Guo, H., Verhoek, I. C., Prins, G. G. H., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., ... Dekker, F. J. (2019). Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. Journal of Medicinal Chemistry, 62(9), 4624-4637. https://doi.org/10.1021/acs.jmedchem.9b00212
  19. van Praagh, J. B., de Goffau, M. C., Bakker, I. S., van Goor, H., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2019). Mucus Microbiome of Anastomotic Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage. Annals of Surgery, 269(5), 911-916. https://doi.org/10.1097/SLA.0000000000002651
  20. de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., ... Porte, R. J. (2019). Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury. Hepatology, 69(4), 1719-1734. https://doi.org/10.1002/hep.30365
  21. van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., ... Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039
  22. Prins, G. H., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M., Dekker, F. J., & Olinga, P. (2019). A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices. Nutrients, 11(3), [507]. https://doi.org/10.3390/nu11030507
  23. Karsten, R. E. H., Oosterhuis, D., van Wijk, L. A., & Olinga, P. (2019). Ex Vivo Model in Cholestasis Research. In M. Vinken (Ed.), Experimental Cholestasis Research (pp. 351-362). (Methods in Molecular Biology; Vol. 1981). New York: Humana Press. https://doi.org/10.1007/978-1-4939-9420-5_23
  24. 2018
  25. Iswandana, R., Irianti, M. I., Oosterhuis, D., Hofker, H. S., Merema, M. T., de Jager, M. H., ... Olinga, P. (2018). Regional Differences in Intestinal Drug Metabolism. Drug Metabolism and Disposition, 46(11), 1879-1885. https://doi.org/10.1124/dmd.118.083428
  26. Ruigrok, M. J. R., Xian, J-L., Frijlink, H. W., Melgert, B. N., Hinrichs, W. L. J., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. https://doi.org/10.1016/j.ejpb.2018.11.005
  27. Prins, G., Oosterhuis, D., Van Wijk, L. A., Shelton, L., & Olinga, P. (2018). Developing an Ex Vivo Non-Alcoholic Fatty Liver Disease Model Using Human Livers. Hepatology, 68, 1008A-1009A.
  28. Luangmonkong, T., Suriguga, S., Adhyatmika, A., Adlia, A., Oosterhuis, D., Suthisisang, C., ... Olinga, P. (2018). In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β. Toxicology and Applied Pharmacology, 355, 127-137. https://doi.org/10.1016/j.taap.2018.07.001
  29. Caviglia, J. M., Yan, J., Jang, M-K., Gwak, G-Y., Affo, S., Yu, L., ... Schwabe, R. F. (2018). MicroRNA-21 and Dicer are Dispensable for Hepatic Stellate Cell Activation and the Development of Liver Fibrosis. Hepatology, 67(6). https://doi.org/10.1002/hep.29627
  30. van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., ... Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029
  31. Broesder, A., Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Poelstra, K., ... Olinga, P. (2018). Formulation of biodegradable microspheres for the sustained release of PDGFβ-receptor directed HSA targeted to fibrotic tissue. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
  32. Ruigrok, M., Xian, J. L., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. Poster session presented at AAPS PharmSci360, Washington, United States.
  33. Ruigrok, M., Maggan, N., Frijlink, H. W., Melgert, B., Olinga, P., & Hinrichs, W. (2018). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
  34. Luangmonkong, T., Suriguga, S., Mutsaers, H. A. M., Groothuis, G. M. M., Olinga, P., & Boersema, M. (2018). Targeting Oxidative Stress for the Treatment of Liver Fibrosis. In B. Nilius, P. DeTombe, T. Gudermann, R. Jahn, & R. Lill (Eds.), Reviews of Physiology, Biochemistry and Pharmacology (pp. 71-102). (Reviews of Physiology Biochemistry and Pharmacology; Vol. 175). Cham: Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/112_2018_10
  35. 2017
  36. Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., ... Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072
  37. Stribos, E. G. D., Seelen, M. A., van Goor, H., Olinga, P., & Mutsaers, H. A. M. (2017). Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis. Frontiers in Physiology, 8, [1026]. https://doi.org/10.3389/fphys.2017.01026
  38. Teekamp, N., Tian, Y., Visser, J. C., Olinga, P., Frijlink, H. W., Woerdenbag, H. J., & Hinrichs, W. L. J. (2017). Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions. Carbohydrate Polymers, 176, 374-380. https://doi.org/10.1016/j.carbpol.2017.08.084
  39. Ruigrok, M. J. R., Maggan, N., Willaert, D., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2017). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung and kidney. The AAPS Journal, 19(6), 1855-1863. https://doi.org/10.1208/s12248-017-0136-y
  40. Boorsma, C. E., van der Veen, T. A., Putri, K. S. S., de Almeida, A., Draijer, C., Mauad, T., ... Melgert, B. N. (2017). A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages. Scientific Reports, 7(1), [12570]. https://doi.org/10.1038/s41598-017-12623-w
  41. Suriguga, S., Mutsaers, H., Groothuis, G., & Olinga, P. (2017). Inhibition of toll-like receptor 9 by ODN-2088 reduces inflammation in murine precision-cut liver slices. 149-1185.
  42. van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., ... Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.
  43. Pasricha, S-R., Lim, P. J., Duarte, T. L., Casu, C., Oosterhuis, D., Mleczko-Sanecka, K., ... Drakesmith, H. (2017). Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nature Communications, 8, [403]. https://doi.org/10.1038/s41467-017-00500-z
  44. Luangmonkong, T., Suriguga, S., Bigaeva, E., Boersema, M., Oosterhuis, D., de Jong, K. P., ... Olinga, P. (2017). Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis. British Journal of Pharmacology, 174(18), 3107-3117. https://doi.org/10.1111/bph.13945
  45. Pasricha, S-R., Lim, P. J., Duarte, T., Casu, C., Mleczko-Sanecka, K., Suciu, M., ... Drakesmith, H. (2017). Hepcidin is an HDAC3 regulated gene and its expression is determined by promoter-associated histone acetylation. American Journal of Hematology, 92(8), E351-E351.
  46. van Haaften, W. T., Mortensen, J. H., Karsdal, M. A., Bay-Jensen, A. C., Dijkstra, G., & Olinga, P. (2017). Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease. Alimentary Pharmacology & Therapeutics, 46(1), 26-39. https://doi.org/10.1111/apt.14092
  47. Prins, G., Luangmonkong, T., Weymaere, J., Suriguga, S., Oosterhuis, D., Schuppan, D., ... Olinga, P. (2017). Studying Non-Alcoholic Fatty Liver Disease: Development of an Ex Vivo Model. 19-20. Abstract from 1st International Conference on Fatty Liver, Seville, Spain. https://doi.org/10.1159/000478719
  48. Jong, de, I., Matton, A., Suriguga, S., van Praagh, J., van Haaften, W., Wiersema-Buist, J., ... Porte, R. (2017). Precision-cut bile duct slices as a model to study regeneration of bile ducts of human donor livers after ischemic preservation injury. 187-188. Abstract from EASL Monothematic Conference, Oslo, Norway.
  49. Stribos, E. G. D., Nielsen, S. H., Brix, S., Karsdal, M. A., Seelen, M. A., van Goor, H., ... Genovese, F. (2017). Non-invasive quantification of collagen turnover in renal transplant recipients. PLoS ONE, 12(4), [e0175898]. https://doi.org/10.1371/journal.pone.0175898
  50. Gore, E., Bigaeva, E., Boersema, M., Nicklin, P., Schuppan, D., & Olinga, P. (2017). PI3K/MTOR PATHWAY INHIBITION IN EX-VIVO LIVER MODEL. Gastroenterology, 152(5), S1105-S1105. https://doi.org/10.1016/S0016-5085(17)33723-X
  51. Vatakuti, S., Olinga, P., Pennings, J. L. A., & Groothuis, G. M. M. (2017). Validation of precision-cut liver slices to study drug-induced cholestasis: A transcriptomics approach. Archives of toxicology, 91(3), 1401-1412. https://doi.org/10.1007/s00204-016-1778-8
  52. Mortensen, J. H., van Haaften, W. T., Olesen, M. L., Karsdal, M., Olinga, P., Dijkstra, G., & Bay-Jensen, A. -C. (2017). Early suppression of the serological macrophage activity biomarker VICM, and not suppression of CRP, predicts the response to infliximab in Crohn's disease patients. Journal of Crohn's and Colitis, 11, S423-S424.
  53. van Haaften, W. T., Mortensen, J. H., Olesen, M. L., Karsdal, M. A., Olinga, P., Bay-Jensen, A. -C., & Dijkstra, G. (2017). Serological biomarkers of tissue turnover can early identify responders to infliximab in Crohn's disease. Journal of Crohn's and Colitis, 11, S57-S57.
  54. Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., ... Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.
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