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How to find us prof. dr. P. (Peter) Olinga

prof. dr. P. (Peter) Olinga

Professor of Translational Biopharmaceutics

Research

Research units:

Postal address:
A Deusinglaan1
Gebouw 3213, ruimte 0205
9713 AV
Groningen
Netherlands
Phone: +31 50 363 8373Fax: +31 50 363 2500
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  1. 2020
  2. Biel, C., Bigaeva, E., Hesse, M., Bomers, J. J. M., van Summeren, K., Teunis, M. A. T., Vaessen, S., Ten Klooster, J. P., & Olinga, P. (2020). Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices. Toxicology in Vitro, 69, [104974]. https://doi.org/10.1016/j.tiv.2020.104974
  3. Smith-Cortinez, N., Fagundes, R. R., Gomez, V., Kong, D., de Waart, D. R., Heegsma, J., Sydor, S., Olinga, P., de Meijer, V. E., Taylor, C. T., Bank, R., Paulusma, C. C., & Faber, K. N. (2020). Collagen release by human hepatic stellate cells requires vitamin C and is efficiently blocked by hydroxylase inhibition. The FASEB Journal. https://doi.org/10.1096/fj.202001564RR
  4. Suriguga, S., Luangmonkong, T., Mutsaers, H. A. M., Groothuis, G. M. M., & Olinga, P. (2020). Host microbiota dictates the proinflammatory impact of LPS in the murine liver. Toxicology in Vitro, 67, [104920]. https://doi.org/10.1016/j.tiv.2020.104920
  5. van Haaften, W. T., Blokzijl, T., Hofker, H. S., Olinga, P., Dijkstra, G., Bank, R. A., & Boersema, M. (2020). Intestinal stenosis in Crohn's disease shows a generalized upregulation of genes involved in collagen metabolism and recognition that could serve as novel anti-fibrotic drug targets. Therapeutic advances in gastroenterology, 13. https://doi.org/10.1177/1756284820952578
  6. Bartucci, R., Paramanandana, A., Boersma, Y. L., Olinga, P., & Salvati, A. (2020). Comparative study of nanoparticle uptake and impact in murine lung, liver and kidney tissue slices. Nanotoxicology, 14(6), 847-865. https://doi.org/10.1080/17435390.2020.1771785
  7. Bartucci, R., Åberg, C., Melgert, B. N., Boersma, Y. L., Olinga, P., & Salvati, A. (2020). Time-Resolved Quantification of Nanoparticle Uptake, Distribution, and Impact in Precision-Cut Liver Slices. Small, 16(21), [e1906523]. https://doi.org/10.1002/smll.201906523
  8. Bigaeva, E., Puerta Cavanzo, N., Stribos, E. G. D., de Jong, A. J., Biel, C., Mutsaers, H. A. M., Jensen, M. S., Nørregaard, R., Leliveld, A. M., de Jong, I. J., Hillebrands, J-L., van Goor, H., Boersema, M., Bank, R. A., & Olinga, P. (2020). Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis. Pharmaceutics, 12(5), [459]. https://doi.org/10.3390/pharmaceutics12050459
  9. Adhyatmika, A., Beljaars, L., Putri, K. S. S., Habibie, H., Boorsma, C. E., Reker-Smit, C., Luangmonkong, T., Guney, B., Haak, A., Mangnus, K. A., Post, E., Poelstra, K., Ravnskjaer, K., Olinga, P., & Melgert, B. N. (2020). Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver. Pharmaceutics, 12(5), [471]. https://doi.org/10.3390/pharmaceutics12050471
  10. Mortensen, J. H., van Haaften, W. T., Karsdal, M. A., Bay-Jensen, A-C., Olinga, P., Grønbæk, H., Hvas, C. L., Manon-Jensen, T., Dijkstra, G., & Dige, A. (2020). The Citrullinated and MMP-degraded Vimentin Biomarker (VICM) Predicts Early Response to Anti-TNFα Treatment in Crohn's Disease. Journal of clinical gastroenterology. https://doi.org/10.1097/MCG.0000000000001341
  11. van Dijk, F., Hazelhoff, C. M., Post, E., Prins, G. G. H., Rombouts, K., Poelstra, K., Olinga, P., & Beljaars, L. (2020). Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis. Pharmaceutics, 12(3), [278]. https://doi.org/10.3390/pharmaceutics12030278
  12. Gore, E., Bigaeva, E., Oldenburger, A., Jansen, Y. J. M., Schuppan, D., Boersema, M., Rippmann, J. F., Broermann, A., & Olinga, P. (2020). Investigating fibrosis and inflammation in an ex vivo NASH murine model. American Journal of Physiology. Gastrointestinal and Liver Physiology, 318(2), G336-G351. https://doi.org/10.1152/ajpgi.00209.2019
  13. Ruigrok, M., El-Amasi, K., Frijlink, H. W., Hinrichs, W., & Olinga, P. (2020). Knockdown of heat shock protein 47 (HSP47) and its effects on fibrogenesis. Poster session presented at Keystone Symposia on Fibrosis and Tissue Repair, Victoria, Canada.
  14. Iswandana, R., Pham, B. T., Suriguga, S., Luangmonkong, T., van Wijk, L. A., Jansen, Y. J. M., Oosterhuis, D., Maria Mutsaers, H. A., & Olinga, P. (2020). Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs. Inflammatory Bowel Diseases, 26(5), 678-686. https://doi.org/10.1093/ibd/izz329
  15. Bigaeva, E., Gore, E., Mutsaers, H. A. M., Oosterhuis, D., Kim, Y. O., Schuppan, D., Bank, R. A., Boersema, M., & Olinga, P. (2020). Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices. Biochimica et biophysica acta-Molecular basis of disease, 1866(1), [165582]. https://doi.org/10.1016/j.bbadis.2019.165582
  16. Bigaeva, E., Stribos, E. G. D., Mutsaers, H. A. M., Piersma, B., Leliveld, A. M., de Jong, I. J., Bank, R. A., Seelen, M. A., van Goor, H., Wollin, L., Olinga, P., & Boersema, M. (2020). Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis. American journal of physiology-Renal physiology, 318(1), F117-F134. https://doi.org/10.1152/ajprenal.00108.2019
  17. Prins, G. H., & Olinga, P. (2020). Potential implications of COVID-19 in non-alcoholic fatty liver disease. Liver International, 40(10), 2568. https://doi.org/10.1111/liv.14484
  18. 2019
  19. Bigaeva, E., Gore, E., Simon, E., Zwick, M., Oldenburger, A., de Jong, K. P., Hofker, H. S., Schlepütz, M., Nicklin, P., Boersema, M., Rippmann, J. F., & Olinga, P. (2019). Transcriptomic characterization of culture-associated changes in murine and human precision-cut tissue slices. Archives of toxicology, 93(12), 3549-3583. https://doi.org/10.1007/s00204-019-02611-6
  20. Ruigrok, M., Tomar, J., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2019). The effects of oxygen concentration on cell death, anti-oxidant transcription, acute inflammation, and cell proliferation in precision-cut lung slices. Scientific Reports, 9(1), [16239]. https://doi.org/10.1038/s41598-019-52813-2
  21. Gore, E., Bigaeva, E., Oldenburger, A., Ook, K. Y., Rippmann, J. F., Schuppan, D., Boersema, M., & Olinga, P. (2019). PI3K inhibition reduces murine and human liver fibrogenesis in precisioncut liver slices. Biochemical Pharmacology, 169, [113633]. https://doi.org/10.1016/j.bcp.2019.113633
  22. Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Olinga, P., & Gier, K. (2019). INDUCTION OF STEATOSIS IN HUMAN LIVER EX VIVO. Hepatology, 70, 1311A-1311A.
  23. Prins, G. H., Jansen, Y. J. M., Oosterhuis, D., Dekker, F. J., Olinga, P., & Gier, K. (2019). POLYUNSATURATED FATTY ACIDS AND 5-LIPOXYGENASE IN NON-ALCOHOLIC FATTY LIVER DISEASE. Hepatology, 70, 1311A-1311A.
  24. Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., Kwon, T-H., & Norregaard, R. (2019). Activation of the prostaglandin E-2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta physiologica, 227(1), [e13291]. https://doi.org/10.1111/apha.13291
  25. Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M., & Olinga, P. (2019). Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study. Toxicology in Vitro, 59, 312-321. https://doi.org/10.1016/j.tiv.2019.05.024
  26. Bartucci, R., Salvati, A., Olinga, P., & Boersma, Y. L. (2019). Vanin 1: Its Physiological Function and Role in Diseases. International Journal of Molecular Sciences, 20(16), [3891]. https://doi.org/10.3390/ijms20163891
  27. de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., Oosterhuis, D., Iswandana, R., Suriguga, S., Overi, D., Lisman, T., Carpino, G., Gouw, A. S. H., Olinga, P., Gaudio, E., & Porte, R. J. (2019). Peribiliary glands are key in regeneration of the biliary epithelium after severe ischemic bile duct injury during liver transplantation. Transplantation, 103(8), 3-3. https://doi.org/10.1002/hep.30365
  28. Guo, H., Verhoek, I. C., Prins, G. G. H., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., Quax, W. J., Olinga, P., Hirsch, A. K. H., & Dekker, F. J. (2019). Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. Journal of Medicinal Chemistry, 62(9), 4624-4637. https://doi.org/10.1021/acs.jmedchem.9b00212
  29. van Praagh, J. B., de Goffau, M. C., Bakker, I. S., van Goor, H., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2019). Mucus Microbiome of Anastomotic Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage. Annals of Surgery, 269(5), 911-916. https://doi.org/10.1097/SLA.0000000000002651
  30. Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., Kwon, T-H., & Norregaard, R. (2019). Administration of a selective prostaglandin E-2 receptor agonist attenuates renal fibrosis in vitro and in vivo. FASEB Journal, 33.
  31. Mutsaers, H. A. M., Jensen, M. S., Olinga, P., & Norregaard, R. (2019). Cyclooxygenase-2 Regulates the Renal Expression of Indoleamine 2,3-dioxygenase. FASEB Journal, 33.
  32. de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., Oosterhuis, D., Iswandana, R., Suriguga, S., Overi, D., Lisman, T., Carpino, G., Gouw, A. S. H., Olinga, P., Gaudio, E., & Porte, R. J. (2019). Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury. Hepatology, 69(4), 1719-1734. https://doi.org/10.1002/hep.30365
  33. van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., Steendam, R., Klose, M. H. M., Meier-Menches, S. M., Casini, A., Horvatovich, P. L., Sijbrandi, N. J., Frijlink, H. W., Hinrichs, W. L. J., Poelstra, K., Beljaars, L., & Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039
  34. Prins, G. H., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M., Dekker, F. J., & Olinga, P. (2019). A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices. Nutrients, 11(3), [507]. https://doi.org/10.3390/nu11030507
  35. Karsten, R. E. H., Oosterhuis, D., van Wijk, L. A., & Olinga, P. (2019). Ex Vivo Model in Cholestasis Research. In M. Vinken (Ed.), Experimental Cholestasis Research (pp. 351-362). (Methods in Molecular Biology; Vol. 1981). Humana Press. https://doi.org/10.1007/978-1-4939-9420-5_23
  36. 2018
  37. Iswandana, R., Irianti, M. I., Oosterhuis, D., Hofker, H. S., Merema, M. T., de Jager, M. H., Mutsaers, H. A., & Olinga, P. (2018). Regional Differences in Intestinal Drug Metabolism. Drug Metabolism and Disposition, 46(11), 1879-1885. https://doi.org/10.1124/dmd.118.083428
  38. Ruigrok, M. J. R., Xian, J-L., Frijlink, H. W., Melgert, B. N., Hinrichs, W. L. J., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. https://doi.org/10.1016/j.ejpb.2018.11.005
  39. Prins, G., Oosterhuis, D., Van Wijk, L. A., Shelton, L., & Olinga, P. (2018). Developing an Ex Vivo Non-Alcoholic Fatty Liver Disease Model Using Human Livers. Hepatology, 68, 1008A-1009A.
  40. Luangmonkong, T., Suriguga, S., Adhyatmika, A., Adlia, A., Oosterhuis, D., Suthisisang, C., de Jong, K. P., Mutsaers, H. A. M., & Olinga, P. (2018). In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β. Toxicology and Applied Pharmacology, 355, 127-137. https://doi.org/10.1016/j.taap.2018.07.001
  41. Caviglia, J. M., Yan, J., Jang, M-K., Gwak, G-Y., Affo, S., Yu, L., Olinga, P., Friedman, R. A., Chen, X., & Schwabe, R. F. (2018). MicroRNA-21 and Dicer are Dispensable for Hepatic Stellate Cell Activation and the Development of Liver Fibrosis. Hepatology, 67(6). https://doi.org/10.1002/hep.29627
  42. van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., Kim, Y. O., Frijlink, H. W., Schuppand, D., Poelstra, K., Hinrichs, W. L. J., & Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029
  43. Broesder, A., Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Poelstra, K., Frijlink, H. W., & Olinga, P. (2018). Formulation of biodegradable microspheres for the sustained release of PDGFβ-receptor directed HSA targeted to fibrotic tissue. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
  44. Ruigrok, M., Xian, J. L., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. Poster session presented at AAPS PharmSci360, Washington, United States.
  45. Ruigrok, M., Maggan, N., Frijlink, H. W., Melgert, B., Olinga, P., & Hinrichs, W. (2018). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
  46. Luangmonkong, T., Suriguga, S., Mutsaers, H. A. M., Groothuis, G. M. M., Olinga, P., & Boersema, M. (2018). Targeting Oxidative Stress for the Treatment of Liver Fibrosis. In B. Nilius, P. DeTombe, T. Gudermann, R. Jahn, & R. Lill (Eds.), Reviews of Physiology, Biochemistry and Pharmacology (pp. 71-102). (Reviews of Physiology Biochemistry and Pharmacology; Vol. 175). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/112_2018_10
  47. 2017
  48. Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., Post, E., Hillebrands, J. L., Frijlink, H. W., Poelstra, K., Beljaars, L., Olinga, P., & Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072
  49. Stribos, E. G. D., Seelen, M. A., van Goor, H., Olinga, P., & Mutsaers, H. A. M. (2017). Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis. Frontiers in Physiology, 8, [1026]. https://doi.org/10.3389/fphys.2017.01026
  50. Teekamp, N., Tian, Y., Visser, J. C., Olinga, P., Frijlink, H. W., Woerdenbag, H. J., & Hinrichs, W. L. J. (2017). Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions. Carbohydrate Polymers, 176, 374-380. https://doi.org/10.1016/j.carbpol.2017.08.084
  51. Ruigrok, M. J. R., Maggan, N., Willaert, D., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2017). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung and kidney. The AAPS Journal, 19(6), 1855-1863. https://doi.org/10.1208/s12248-017-0136-y
  52. Boorsma, C. E., van der Veen, T. A., Putri, K. S. S., de Almeida, A., Draijer, C., Mauad, T., Fejer, G., Brandsma, C-A., van den Berge, M., Bossé, Y., Sin, D., Hao, K., Reithmeier, A., Andersson, G., Olinga, P., Timens, W., Casini, A., & Melgert, B. N. (2017). A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages. Scientific Reports, 7(1), [12570]. https://doi.org/10.1038/s41598-017-12623-w
  53. Suriguga, S., Mutsaers, H., Groothuis, G., & Olinga, P. (2017). Inhibition of toll-like receptor 9 by ODN-2088 reduces inflammation in murine precision-cut liver slices. 149-1185.
  54. van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., Hinrichs, W., Schuppan, D., Poelstra, K., & Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.
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