prof. dr. P. (Peter) Olinga
Associate professor

E-mail:
p.olinga rug.nl
Research
Research units:
Postal address:
A Deusinglaan
1
Gebouw 3213, ruimte 0205
Groningen
1
Gebouw 3213, ruimte 0205
Groningen
Netherlands
Phone: +31 50 363 8373Fax: +31 50 363 2500
1 - 50 out of 147Page size: 50
- 2020
- Bigaeva, E., Gore, E., Mutsaers, H. A. M., Oosterhuis, D., Kim, Y. O., Schuppan, D., ... Olinga, P. (2020). Exploring organ-specific features of fibrogenesis using murine precision-cut tissue slices. Biochimica et biophysica acta-Molecular basis of disease, 1866(1), 165582. https://doi.org/10.1016/j.bbadis.2019.165582
- 2019
- Bigaeva, E., Stribos, E. G. D., Mutsaers, H. A. M., Piersma, B., Leliveld, A. M., de Jong, I. J., ... Boersema, M. (2019). Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis. American journal of physiology-Renal physiology. https://doi.org/10.1152/ajprenal.00108.2019
- Ruigrok, M., Tomar, J., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2019). The effects of oxygen concentration on cell death, anti-oxidant transcription, acute inflammation, and cell proliferation in precision-cut lung slices. Scientific Reports, 9(1), [16239]. https://doi.org/10.1038/s41598-019-52813-2
- Gore, E., Bigaeva, E., Oldenburger, A., Ook, K. Y., Rippmann, J. F., Schuppan, D., ... Olinga, P. (2019). PI3K inhibition reduces murine and human liver fibrogenesis in precision-cut liver slices. Biochemical Pharmacology, 169, [113633]. https://doi.org/10.1016/j.bcp.2019.113633
- Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., ... Norregaard, R. (2019). Activation of the prostaglandin E-2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta physiologica, 227(1), [e13291]. https://doi.org/10.1111/apha.13291
- Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M., & Olinga, P. (2019). Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study. Toxicology in Vitro, 59, 312-321. https://doi.org/10.1016/j.tiv.2019.05.024
- Bartucci, R., Salvati, A., Olinga, P., & Boersma, Y. L. (2019). Vanin 1: Its Physiological Function and Role in Diseases. International Journal of Molecular Sciences, 20(16). https://doi.org/10.3390/ijms20163891
- Guo, H., Verhoek, I. C., Prins, G. G. H., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., ... Dekker, F. J. (2019). Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. Journal of Medicinal Chemistry, 62(9), 4624-4637. https://doi.org/10.1021/acs.jmedchem.9b00212
- van Praagh, J. B., de Goffau, M. C., Bakker, I. S., van Goor, H., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2019). Mucus Microbiome of Anastomotic Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage. Annals of Surgery, 269(5), 911-916. https://doi.org/10.1097/SLA.0000000000002651
- de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., ... Porte, R. J. (2019). Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury. Hepatology, 69(4), 1719-1734. https://doi.org/10.1002/hep.30365
- van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., ... Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039
- Karsten, R. E. H., Oosterhuis, D., van Wijk, L. A., & Olinga, P. (2019). Ex Vivo Model in Cholestasis Research. In M. Vinken (Ed.), Experimental Cholestasis Research (pp. 351-362). (Methods in Molecular Biology; Vol. 1981). New York: Humana Press. https://doi.org/10.1007/978-1-4939-9420-5_23
- 2018
- Iswandana, R., Irianti, M. I., Oosterhuis, D., Hofker, H. S., Merema, M. T., de Jager, M. H., ... Olinga, P. (2018). Regional Differences in Intestinal Drug Metabolism. Drug Metabolism and Disposition, 46(11), 1879-1885. https://doi.org/10.1124/dmd.118.083428
- Prins, G., Oosterhuis, D., Van Wijk, L. A., Shelton, L., & Olinga, P. (2018). Developing an Ex Vivo Non-Alcoholic Fatty Liver Disease Model Using Human Livers. Hepatology, 68, 1008A-1009A.
- Luangmonkong, T., Suriguga, S., Adhyatmika, A., Adlia, A., Oosterhuis, D., Suthisisang, C., ... Olinga, P. (2018). In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β. Toxicology and Applied Pharmacology, 355, 127-137. https://doi.org/10.1016/j.taap.2018.07.001
- Caviglia, J. M., Yan, J., Jang, M-K., Gwak, G-Y., Affo, S., Yu, L., ... Schwabe, R. F. (2018). MicroRNA-21 and Dicer are Dispensable for Hepatic Stellate Cell Activation and the Development of Liver Fibrosis. Hepatology, 67(6). https://doi.org/10.1002/hep.29627
- van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., ... Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029
- Broesder, A., Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Poelstra, K., ... Olinga, P. (2018). Formulation of biodegradable microspheres for the sustained release of PDGFβ-receptor directed HSA targeted to fibrotic tissue. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
- Ruigrok, M., Xian, J. L., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. Poster session presented at AAPS PharmSci360, Washington, United States.
- Ruigrok, M., Maggan, N., Frijlink, H. W., Melgert, B., Olinga, P., & Hinrichs, W. (2018). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
- Luangmonkong, T., Suriguga, S., Mutsaers, H. A. M., Groothuis, G. M. M., Olinga, P., & Boersema, M. (2018). Targeting Oxidative Stress for the Treatment of Liver Fibrosis. In B. Nilius, P. DeTombe, T. Gudermann, R. Jahn, & R. Lill (Eds.), Reviews of Physiology, Biochemistry and Pharmacology (pp. 71-102). (Reviews of Physiology Biochemistry and Pharmacology; Vol. 175). Cham: Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/112_2018_10
- 2017
- Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., ... Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072
- Stribos, E. G. D., Seelen, M. A., van Goor, H., Olinga, P., & Mutsaers, H. A. M. (2017). Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis. Frontiers in Physiology, 8, [1026]. https://doi.org/10.3389/fphys.2017.01026
- Teekamp, N., Tian, Y., Visser, J. C., Olinga, P., Frijlink, H. W., Woerdenbag, H. J., & Hinrichs, W. L. J. (2017). Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions. Carbohydrate Polymers, 176, 374-380. https://doi.org/10.1016/j.carbpol.2017.08.084
- Boorsma, C. E., van der Veen, T. A., Putri, K. S. S., de Almeida, A., Draijer, C., Mauad, T., ... Melgert, B. N. (2017). A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages. Scientific Reports, 7(1), [12570]. https://doi.org/10.1038/s41598-017-12623-w
- Pasricha, S-R., Lim, P. J., Duarte, T. L., Casu, C., Oosterhuis, D., Mleczko-Sanecka, K., ... Drakesmith, H. (2017). Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nature Communications, 8, [403]. https://doi.org/10.1038/s41467-017-00500-z
- Luangmonkong, T., Suriguga, S., Bigaeva, E., Boersema, M., Oosterhuis, D., de Jong, K. P., ... Olinga, P. (2017). Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis. British Journal of Pharmacology, 174(18), 3107-3117. https://doi.org/10.1111/bph.13945
- Pasricha, S-R., Lim, P. J., Duarte, T., Casu, C., Mleczko-Sanecka, K., Suciu, M., ... Drakesmith, H. (2017). Hepcidin is an HDAC3 regulated gene and its expression is determined by promoter-associated histone acetylation. American Journal of Hematology, 92(8), E351-E351.
- van Haaften, W. T., Mortensen, J. H., Karsdal, M. A., Bay-Jensen, A. C., Dijkstra, G., & Olinga, P. (2017). Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease. Alimentary Pharmacology & Therapeutics, 46(1), 26-39. https://doi.org/10.1111/apt.14092
- Jong, de, I., Matton, A., Suriguga, S., van Praagh, J., van Haaften, W., Wiersema-Buist, J., ... Porte, R. (2017). Precision-cut bile duct slices as a model to study regeneration of bile ducts of human donor livers after ischemic preservation injury. 187-188. Abstract from EASL Monothematic Conference, Oslo, Norway.
- Stribos, E. G. D., Nielsen, S. H., Brix, S., Karsdal, M. A., Seelen, M. A., van Goor, H., ... Genovese, F. (2017). Non-invasive quantification of collagen turnover in renal transplant recipients. PLoS ONE, 12(4), [e0175898]. https://doi.org/10.1371/journal.pone.0175898
- Gore, E., Bigaeva, E., Boersema, M., Nicklin, P., Schuppan, D., & Olinga, P. (2017). PI3K/MTOR PATHWAY INHIBITION IN EX-VIVO LIVER MODEL. Gastroenterology, 152(5), S1105-S1105. https://doi.org/10.1016/S0016-5085(17)33723-X
- Vatakuti, S., Olinga, P., Pennings, J. L. A., & Groothuis, G. M. M. (2017). Validation of precision-cut liver slices to study drug-induced cholestasis: A transcriptomics approach. Archives of toxicology, 91(3), 1401-1412. https://doi.org/10.1007/s00204-016-1778-8
- Mortensen, J. H., van Haaften, W. T., Olesen, M. L., Karsdal, M., Olinga, P., Dijkstra, G., & Bay-Jensen, A. -C. (2017). Early suppression of the serological macrophage activity biomarker VICM, and not suppression of CRP, predicts the response to infliximab in Crohn's disease patients. Journal of Crohn's and Colitis, 11, S423-S424.
- van Haaften, W. T., Mortensen, J. H., Olesen, M. L., Karsdal, M. A., Olinga, P., Bay-Jensen, A. -C., & Dijkstra, G. (2017). Serological biomarkers of tissue turnover can early identify responders to infliximab in Crohn's disease. Journal of Crohn's and Colitis, 11, S57-S57.
- Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., ... Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.
- 2016
- Stribos, E., Luangmonkong, T., Kors, A., de Jong, I., van Son, W., Hillebrands, J-L., ... Mutsaers, H. (2016). Precision-Cut Human Kidney Slices as a Model to Elucidate the Pathogenesis of Renal Fibrosis. 733-733.
- Suriguga, S., Luangmonkong, T., Bigaeva, E., Oosterhuis, D., Mutsaers, H. A., Groothuis, G. M., & Olinga, P. (2016). LPS aggravates fibrosis only in the early onset but not in the end stage of liver fibrosis. Hepatology, 64(S1), 840A. https://doi.org/10.1002/hep.28800
- Luangmonkong, T., Weymaere, J., Suriguga, S., Oosterhuis, D., Schuppan, D., Mutsaers, H. A., & Olinga, P. (2016). Pathophysiologic model of non-alcoholic fatty liver disease using precision-cut liver slices. Hepatology, 64(S1), 786A. https://doi.org/10.1002/hep.28799
- Westra, I. M., Mutsaers, H. A. M., Luangmonkong, T., Hadi, M., Oosterhuis, D., de Jong, K. P., ... Olinga, P. (2016). Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis. Toxicology in Vitro, 35, 77-85. https://doi.org/10.1016/j.tiv.2016.05.012
- van Praagh, J. B., de Goffau, M. C., Bakker, I. S., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2016). Intestinal microbiota and anastomotic leakage of stapled colorectal anastomoses: a pilot study. Surgical endoscopy and other interventional techniques, 30(6), 2259-2265. https://doi.org/10.1007/s00464-015-4508-z
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