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prof. dr. P. (Peter) Olinga

Associate professor

Research

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Postal address:
A Deusinglaan
1
Gebouw 3213, ruimte 0205
Groningen
Netherlands
Phone: +31 50 363 8373Fax: +31 50 363 2500
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  1. 2019
  2. Gore, E., Bigaeva, E., Oldenburger, A., Ook, K. Y., Rippmann, J. F., Schuppan, D., ... Olinga, P. (2019). PI3K inhibition reduces murine and human liver fibrogenesis in precision-cut liver slices. Biochemical Pharmacology, 169, [113633]. https://doi.org/10.1016/j.bcp.2019.113633
  3. Jensen, M. S., Mutsaers, H. A. M., Tingskov, S. J., Christensen, M., Madsen, M. G., Olinga, P., ... Norregaard, R. (2019). Activation of the prostaglandin E-2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta physiologica, 227(1), [e13291]. https://doi.org/10.1111/apha.13291
  4. Bigaeva, E., Bomers, J. J. M., Biel, C., Mutsaers, H. A. M., de Graaf, I. A. M., Boersema, M., & Olinga, P. (2019). Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study. Toxicology in Vitro, 59, 312-321. https://doi.org/10.1016/j.tiv.2019.05.024
  5. Bartucci, R., Salvati, A., Olinga, P., & Boersma, Y. L. (2019). Vanin 1: Its Physiological Function and Role in Diseases. International Journal of Molecular Sciences, 20(16). https://doi.org/10.3390/ijms20163891
  6. Guo, H., Verhoek, I. C., Prins, G. G. H., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., ... Dekker, F. J. (2019). Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. Journal of Medicinal Chemistry, 62(9), 4624-4637. https://doi.org/10.1021/acs.jmedchem.9b00212
  7. van Praagh, J. B., de Goffau, M. C., Bakker, I. S., van Goor, H., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2019). Mucus Microbiome of Anastomotic Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage. Annals of Surgery, 269(5), 911-916. https://doi.org/10.1097/SLA.0000000000002651
  8. de Jong, I. E. M., Matton, A. P. M., van Praagh, J. B., van Haaften, W. T., Wiersema-Buist, J., van Wijk, L. A., ... Porte, R. J. (2019). Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury. Hepatology, 69(4), 1719-1734. https://doi.org/10.1002/hep.30365
  9. van Dijk, F., Teekamp, N., Post, E., Schuppan, D., Kim, Y. O., Zuidema, J., ... Olinga, P. (2019). The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor. Journal of Controlled Release, 296, 250-257. https://doi.org/10.1016/j.jconrel.2018.12.039
  10. Prins, G. H., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M., Dekker, F. J., & Olinga, P. (2019). A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices. Nutrients, 11(3), [507]. https://doi.org/10.3390/nu11030507
  11. Karsten, R. E. H., Oosterhuis, D., van Wijk, L. A., & Olinga, P. (2019). Ex Vivo Model in Cholestasis Research. In M. Vinken (Ed.), Experimental Cholestasis Research (pp. 351-362). (Methods in Molecular Biology; Vol. 1981). New York: Humana Press. https://doi.org/10.1007/978-1-4939-9420-5_23
  12. 2018
  13. Iswandana, R., Irianti, M. I., Oosterhuis, D., Hofker, H. S., Merema, M. T., de Jager, M. H., ... Olinga, P. (2018). Regional Differences in Intestinal Drug Metabolism. Drug Metabolism and Disposition, 46(11), 1879-1885. https://doi.org/10.1124/dmd.118.083428
  14. Ruigrok, M. J. R., Xian, J-L., Frijlink, H. W., Melgert, B. N., Hinrichs, W. L. J., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. https://doi.org/10.1016/j.ejpb.2018.11.005
  15. Prins, G., Oosterhuis, D., Van Wijk, L. A., Shelton, L., & Olinga, P. (2018). Developing an Ex Vivo Non-Alcoholic Fatty Liver Disease Model Using Human Livers. Hepatology, 68, 1008A-1009A.
  16. Luangmonkong, T., Suriguga, S., Adhyatmika, A., Adlia, A., Oosterhuis, D., Suthisisang, C., ... Olinga, P. (2018). In vitro and ex vivo anti-fibrotic effects of LY2109761, a small molecule inhibitor against TGF-β. Toxicology and Applied Pharmacology, 355, 127-137. https://doi.org/10.1016/j.taap.2018.07.001
  17. Caviglia, J. M., Yan, J., Jang, M-K., Gwak, G-Y., Affo, S., Yu, L., ... Schwabe, R. F. (2018). MicroRNA-21 and Dicer are Dispensable for Hepatic Stellate Cell Activation and the Development of Liver Fibrosis. Hepatology, 67(6). https://doi.org/10.1002/hep.29627
  18. van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Zuidema, J., Steendam, R., ... Olinga, P. (2018). Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver. Journal of Controlled Release, 269, 258-265. https://doi.org/10.1016/j.jconrel.2017.11.029
  19. Broesder, A., Teekamp, N., van Dijk, F., Beljaars, E., Hinrichs, W., Poelstra, K., ... Olinga, P. (2018). Formulation of biodegradable microspheres for the sustained release of PDGFβ-receptor directed HSA targeted to fibrotic tissue. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
  20. Ruigrok, M., Xian, J. L., Frijlink, H. W., Melgert, B., Hinrichs, W., & Olinga, P. (2018). siRNA-mediated protein knockdown in precision-cut lung slices. Poster session presented at AAPS PharmSci360, Washington, United States.
  21. Ruigrok, M., Maggan, N., Frijlink, H. W., Melgert, B., Olinga, P., & Hinrichs, W. (2018). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung. Poster session presented at 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain.
  22. Luangmonkong, T., Suriguga, S., Mutsaers, H. A. M., Groothuis, G. M. M., Olinga, P., & Boersema, M. (2018). Targeting Oxidative Stress for the Treatment of Liver Fibrosis. In B. Nilius, P. DeTombe, T. Gudermann, R. Jahn, & R. Lill (Eds.), Reviews of Physiology, Biochemistry and Pharmacology (pp. 71-102). (Reviews of Physiology Biochemistry and Pharmacology; Vol. 175). Cham: Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/112_2018_10
  23. 2017
  24. Teekamp, N., Van Dijk, F., Broesder, A., Evers, M., Zuidema, J., Steendam, R., ... Hinrichs, W. L. J. (2017). Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney. International Journal of Pharmaceutics, 534(1-2), 229-236. https://doi.org/10.1016/j.ijpharm.2017.09.072
  25. Stribos, E. G. D., Seelen, M. A., van Goor, H., Olinga, P., & Mutsaers, H. A. M. (2017). Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis. Frontiers in Physiology, 8, [1026]. https://doi.org/10.3389/fphys.2017.01026
  26. Teekamp, N., Tian, Y., Visser, J. C., Olinga, P., Frijlink, H. W., Woerdenbag, H. J., & Hinrichs, W. L. J. (2017). Addition of Pullulan to Trehalose Glasses Improves the Stability of β-Galactosidase at High Moisture Conditions. Carbohydrate Polymers, 176, 374-380. https://doi.org/10.1016/j.carbpol.2017.08.084
  27. Ruigrok, M. J. R., Maggan, N., Willaert, D., Frijlink, H. W., Melgert, B. N., Olinga, P., & Hinrichs, W. L. J. (2017). siRNA-mediated RNA interference in precision-cut tissue slices prepared from mouse lung and kidney. The AAPS Journal, 19(6), 1855-1863. https://doi.org/10.1208/s12248-017-0136-y
  28. Boorsma, C. E., van der Veen, T. A., Putri, K. S. S., de Almeida, A., Draijer, C., Mauad, T., ... Melgert, B. N. (2017). A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages. Scientific Reports, 7(1), [12570]. https://doi.org/10.1038/s41598-017-12623-w
  29. Suriguga, S., Mutsaers, H., Groothuis, G., & Olinga, P. (2017). Inhibition of toll-like receptor 9 by ODN-2088 reduces inflammation in murine precision-cut liver slices. 149-1185.
  30. van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Kim, Y. O., Frijlink, E., ... Olinga, P. (2017). Therapeutic proteins in the treatment of liver fibrosis: The antifibrotic potential of a sustained release formulation for a PDGF beta-receptor targeted rho-kinase inhibitor. Hepatology, 66, 217A.
  31. Pasricha, S-R., Lim, P. J., Duarte, T. L., Casu, C., Oosterhuis, D., Mleczko-Sanecka, K., ... Drakesmith, H. (2017). Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nature Communications, 8, [403]. https://doi.org/10.1038/s41467-017-00500-z
  32. Luangmonkong, T., Suriguga, S., Bigaeva, E., Boersema, M., Oosterhuis, D., de Jong, K. P., ... Olinga, P. (2017). Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis. British Journal of Pharmacology, 174(18), 3107-3117. https://doi.org/10.1111/bph.13945
  33. Pasricha, S-R., Lim, P. J., Duarte, T., Casu, C., Mleczko-Sanecka, K., Suciu, M., ... Drakesmith, H. (2017). Hepcidin is an HDAC3 regulated gene and its expression is determined by promoter-associated histone acetylation. American Journal of Hematology, 92(8), E351-E351.
  34. van Haaften, W. T., Mortensen, J. H., Karsdal, M. A., Bay-Jensen, A. C., Dijkstra, G., & Olinga, P. (2017). Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease. Alimentary Pharmacology & Therapeutics, 46(1), 26-39. https://doi.org/10.1111/apt.14092
  35. Jong, de, I., Matton, A., Suriguga, S., van Praagh, J., van Haaften, W., Wiersema-Buist, J., ... Porte, R. (2017). Precision-cut bile duct slices as a model to study regeneration of bile ducts of human donor livers after ischemic preservation injury. 187-188. Abstract from EASL Monothematic Conference, Oslo, Norway.
  36. Stribos, E. G. D., Nielsen, S. H., Brix, S., Karsdal, M. A., Seelen, M. A., van Goor, H., ... Genovese, F. (2017). Non-invasive quantification of collagen turnover in renal transplant recipients. PLoS ONE, 12(4), [e0175898]. https://doi.org/10.1371/journal.pone.0175898
  37. Gore, E., Bigaeva, E., Boersema, M., Nicklin, P., Schuppan, D., & Olinga, P. (2017). PI3K/MTOR PATHWAY INHIBITION IN EX-VIVO LIVER MODEL. Gastroenterology, 152(5), S1105-S1105. https://doi.org/10.1016/S0016-5085(17)33723-X
  38. Vatakuti, S., Olinga, P., Pennings, J. L. A., & Groothuis, G. M. M. (2017). Validation of precision-cut liver slices to study drug-induced cholestasis: A transcriptomics approach. Archives of toxicology, 91(3), 1401-1412. https://doi.org/10.1007/s00204-016-1778-8
  39. Mortensen, J. H., van Haaften, W. T., Olesen, M. L., Karsdal, M., Olinga, P., Dijkstra, G., & Bay-Jensen, A. -C. (2017). Early suppression of the serological macrophage activity biomarker VICM, and not suppression of CRP, predicts the response to infliximab in Crohn's disease patients. Journal of Crohn's and Colitis, 11, S423-S424.
  40. van Haaften, W. T., Mortensen, J. H., Olesen, M. L., Karsdal, M. A., Olinga, P., Bay-Jensen, A. -C., & Dijkstra, G. (2017). Serological biomarkers of tissue turnover can early identify responders to infliximab in Crohn's disease. Journal of Crohn's and Colitis, 11, S57-S57.
  41. Van Dijk, F., Teekamp, N., Beljaars, L., Post, E., Schuppan, D., Kim, Y. O., ... Olinga, P. (2017). Towards clinical use of targeted therapies for liver fibrosis: development of a sustained release formulation for therapeutic proteins. Journal of Hepatology, 66(1), S44-S44.
  42. 2016
  43. Mutsaers, H. A. M., & Olinga, P. (2016). Organ Fibrosis: Triggers, Pathways, and Cellular Plasticity. Frontiers in Medicine, 3, [55]. https://doi.org/10.3389/fmed.2016.00055
  44. Stribos, E., Luangmonkong, T., Kors, A., de Jong, I., van Son, W., Hillebrands, J-L., ... Mutsaers, H. (2016). Precision-Cut Human Kidney Slices as a Model to Elucidate the Pathogenesis of Renal Fibrosis. 733-733.
  45. Stribos, E. G. D., Hillebrands, J-L., Olinga, P., & Mutsaers, H. A. M. (2016). Renal fibrosis in precision-cut kidney slices. European Journal of Pharmacology, 790, 57-61. https://doi.org/10.1016/j.ejphar.2016.06.057
  46. Suriguga, S., Luangmonkong, T., Bigaeva, E., Oosterhuis, D., Mutsaers, H. A., Groothuis, G. M., & Olinga, P. (2016). LPS aggravates fibrosis only in the early onset but not in the end stage of liver fibrosis. Hepatology, 64(S1), 840A. https://doi.org/10.1002/hep.28800
  47. Luangmonkong, T., Weymaere, J., Suriguga, S., Oosterhuis, D., Schuppan, D., Mutsaers, H. A., & Olinga, P. (2016). Pathophysiologic model of non-alcoholic fatty liver disease using precision-cut liver slices. Hepatology, 64(S1), 786A. https://doi.org/10.1002/hep.28799
  48. Westra, I. M., Mutsaers, H. A. M., Luangmonkong, T., Hadi, M., Oosterhuis, D., de Jong, K. P., ... Olinga, P. (2016). Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis. Toxicology in Vitro, 35, 77-85. https://doi.org/10.1016/j.tiv.2016.05.012
  49. van Praagh, J. B., de Goffau, M. C., Bakker, I. S., Harmsen, H. J. M., Olinga, P., & Havenga, K. (2016). Intestinal microbiota and anastomotic leakage of stapled colorectal anastomoses: a pilot study. Surgical endoscopy and other interventional techniques, 30(6), 2259-2265. https://doi.org/10.1007/s00464-015-4508-z
  50. van Haaften, W. T., Mortensen, J. H., Karsdal, M. A., Bay-Jensen, A-C., Dijkstra, G., & Olinga, P. (2016). MMP Degraded Type III Collagen Is a Novel Serological Biomarker for Penetrating (Montreal B3) Crohn's Disease. Gastroenterology, 150(4), S50. [189]. https://doi.org/10.1016/S0016-5085(16)30290-6
  51. Stribos, E. G. D., Luangmonkong, T., Leliveld, A. M., de Jong, I. J., van Son, W. J., Hillebrands, J-L., ... Mutsaers, H. A. M. (2016). Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis. Translational Research, 170, 8-16. https://doi.org/10.1016/j.trsl.2015.11.007
  52. van Haaften, W. T., Mortensen, J. H., Karsdal, M. A., Bay-Jensen, A. -C., Dijkstra, G., & Olinga, P. (2016). MMP degraded type III collagen is a novel serological biomarker for penetrating (Montreal B3) Crohn's disease. Journal of Crohn's and Colitis, 10, S86-S86.
  53. Vatakuti, S., Pennings, J. L. A., Gore, E., Olinga, P., & Groothuis, G. M. M. (2016). Classification of cholestatic and necrotic hepatotoxicants using transcriptomics on human precision-cut liver slices. Chemical research in toxicology, 29(3), 342-351. https://doi.org/10.1021/acs.chemrestox.5b00491
  54. Iswandana, R., Pham, B. T., van Haaften, W. T., Luangmonkong, T., Oosterhuis, D., Mutsaers, H. A. M., & Olinga, P. (2016). Organ- and species-specific biological activity of rosmarinic acid. Toxicology in Vitro, 32, 261-268. https://doi.org/10.1016/j.tiv.2016.01.009
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