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How to find us prof. dr. P.J.M. (Peter) van Haastert

prof. dr. P.J.M. (Peter) van Haastert

Professor in Cell Biochemistry

prof. dr. P.J.M. (Peter) van Haastert
E-mail:
p.j.m.van.haastert rug.nl

Research

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Postal address:
Nijenborgh7
9747 AG
Groningen
Netherlands
Phone: +31 50 363 2400Fax: +31 50 363 2368
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  1. 2020
  2. van Haastert, P. J. M. (2020). Unified control of amoeboid pseudopod extension in multiple organisms by branched F-actin in the front and parallel F-actin/myosin in the cortex. PLoS ONE, 15(12 December), [e0243442]. https://doi.org/10.1371/journal.pone.0243442
  3. van Haastert, P. J. M. (2020). Symmetry Breaking during Cell Movement in the Context of Excitability, Kinetic Fine-Tuning and Memory of Pseudopod Formation. Cells, 9(8), [1809]. https://doi.org/10.3390/cells9081809
  4. 2018
  5. van Haastert, P. J. M., Keizer-Gunnink, I., & Kortholt, A. (2018). The cytoskeleton regulates symmetry transitions in moving amoeboid cells. Journal of Cell Science, 131(7), [UNSP jcs208892]. https://doi.org/10.1242/jcs.208892
  6. 2017
  7. Deyaert, E., Wauters, L., Guaitoli, G., Konijnenberg, A., Leemans, M., Terheyden, S., Petrovic, A., Gallardo, R., Nederveen-Schippers, L. M., Athanasopoulos, P. S., Pots, H., Van Haastert, P. J. M., Sobott, F., Gloeckner, C. J., Efremov, R., Kortholt, A., & Versées, W. (2017). A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover. Nature Communications, 8(1), 1-12. [1008]. https://doi.org/10.1038/s41467-017-01103-4
  8. van Haastert, P. J. M., Keizer-Gunnink, I., & Kortholt, A. (2017). Coupled Excitable Ras and F-actin activation mediate spontaneous pseudopod formation and directed cell movement. Molecular Biology of the Cell, 28(7), 922-934. https://doi.org/10.1091/mbc.E16-10-0733
  9. 2016
  10. Skoge, M., Wong, E., Hamza, B., Bae, A., Martel, J., Kataria, R., Keizer-Gunnink, I., Kortholt, A., Van Haastert, P. J. M., Charras, G., Janetopoulos, C., & Irimia, D. (2016). A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells. PLoS ONE, 11(6), [e0154491]. https://doi.org/10.1371/journal.pone.0154491
  11. Khanna, A., Lotfi, P., Chavan, A. J., Montaño, N. M., Bolourani, P., Weeks, G., Shen, Z., Briggs, S. P., Pots, H., Van Haastert, P. J. M., Kortholt, A., & Charest, P. G. (2016). The small GTPases Ras and Rap1 bind to and control TORC2 activity. Scientific Reports, 6, 1-9. [25823]. https://doi.org/10.1038/srep25823
  12. Plak, K., Pots, H., Van Haastert, P. J. M., & Kortholt, A. (2016). Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells. BMC Cell Biology, 17(1), 1-8. https://doi.org/10.1186/s12860-015-0078-0
  13. Liu, Y., Lacal, J., Veltman, D. M., Fusetti, F., van Haastert, P. J. M., Firtel, R. A., & Kortholt, A. (2016). A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis. Developmental Cell, 37(5), 458-472. https://doi.org/10.1016/j.devcel.2016.05.001
  14. Postma, M., & van Haastert, P. J. M. (2016). Mathematics of Experimentally Generated Chemoattractant Gradients. Methods in Molecular Biology, 1407, 381-396. https://doi.org/10.1007/978-1-4939-3480-5_26
  15. 2014
  16. Plak, K., Keizer-Gunnink, I., van Haastert, P. J. M., & Kortholt, A. (2014). Rap1-dependent pathways coordinate cytokinesis in Dictyostelium. Molecular Biology of the Cell, 25(25), 4195-4204. https://doi.org/10.1091/mbc.E14-08-1285
  17. 2013
  18. Kortholt, A., Keizer-Gunnink, I., Kataria, R., & Van Haastert, P. J. M. (2013). Ras activation and symmetry breaking during Dictyostelium chemotaxis. Journal of Cell Science, 126(19), 4502-4513. https://doi.org/10.1242/jcs.132340
  19. Kataria, R., van Haastert, P. J. M., & Kortholt, A. (2013). Reply to Tall et al. Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis. Proceedings of the National Academy of Sciences of the United States of America, 110(34), E3149-E3149. https://doi.org/10.1073/pnas.1309837110
  20. Kataria, R., Xu, X., Fusetti, F., Keizer-Gunnink, I., Jin, T., van Haastert, P. J. M., & Kortholt, A. (2013). Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6424-6429. https://doi.org/10.1073/pnas.1301851110
  21. Plak, K., Veltman, D., Fusetti, F., Beeksma, J., Rivero, F., Van Haastert, P. J. M., & Kortholt, A. (2013). GxcC connects Rap and Rac signaling during Dictyostelium development. BMC Cell Biology, 14(1), 6-1-6-9. [6]. https://doi.org/10.1186/1471-2121-14-6
  22. Veltman, D. M., & Van Haastert, P. J. M. (2013). Extrachromosomal inducible expression. Methods in Molecular Biology, 983, 269-281. https://doi.org/10.1007/978-1-62703-302-2_14
  23. 2012
  24. Gilsbach, B. K., Ho, F. Y., Vetter, I. R., van Haastert, P. J. M., Wittinghofer, A., & Kortholt, A. (2012). Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proceedings of the National Academy of Sciences of the United States of America, 109(26), 10322-10327. https://doi.org/10.1073/pnas.1203223109
  25. Kortholt, A., van Egmond, W. N., Plak, K., Bosgraaf, L., Keizer-Gunnink, I., & van Haastert, P. J. M. (2012). Multiple Regulatory Mechanisms for the Dictyostelium Roco Protein GbpC. The Journal of Biological Chemistry, 287(4), 2749-2758. https://doi.org/10.1074/jbc.M111.315739
  26. 2011
  27. Kortholt, A., Kataria, R., Keizer-Gunnink, I., Van Egmond, W. N., Khanna, A., & Van Haastert, P. J. M. (2011). Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification. Embo Reports, 12(12), 1273-1279. https://doi.org/10.1038/embor.2011.210
  28. Van Haastert, P. J. M. (2011). Amoeboid Cells Use Protrusions for Walking, Gliding and Swimming. PLoS ONE, 6(11), [e27532]. https://doi.org/10.1371/journal.pone.0027532
  29. Neilson, M. P., Veltman, D. M., van Haastert, P. J. M., Webb, S. D., Mackenzie, J. A., & Insall, R. H. (2011). Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour. PLOS BIOLOGY, 9(5), [1000618]. https://doi.org/10.1371/journal.pbio.1000618
  30. Van Haastert, P. J. M. (2011). How Cells Use Pseudopods for Persistent Movement and Navigation. Science signaling, 4(159), [6]. https://doi.org/10.1126/scisignal.2001708
  31. 2010
  32. Van Haastert, P. J. M. (2010). A Stochastic Model for Chemotaxis Based on the Ordered Extension of Pseudopods. Biophysical Journal, 99(10), 3345-3354. https://doi.org/10.1016/j.bpj.2010.09.042
  33. Van Haastert, P. J. M. (2010). Chemotaxis: insights from the extending pseudopod. Journal of Cell Science, 123(18), 3031-3037. https://doi.org/10.1242/jcs.071118
  34. Van Haastert, P. J. M. (2010). A Model for a Correlated Random Walk Based on the Ordered Extension of Pseudopodia. PLoS Computational Biology, 6(8), [e1000874]. https://doi.org/10.1371/journal.pcbi.1000874
  35. van Egmond, W. N., & van Haastert, P. J. M. (2010). Characterization of the Roco Protein Family in Dictyostelium discoideum. Eukaryotic Cell, 9(5), 751-761. https://doi.org/10.1128/EC.00366-09
  36. Kortholt, A., Bolourani, P., Rehmann, H., Keizer-Gunnink, I., Weeks, G., Wittinghofer, A., & Van Haastert, P. J. M. (2010). A Rap/Phosphatidylinositol 3-Kinase Pathway ControlsPseudopod Formation. Molecular Biology of the Cell, 21(6), 936-945. https://doi.org/10.1091/mbc.E09-03-0177
  37. Araki, T., van Egmond, W. N., van Haastert, P. J. M., & Williams, J. G. (2010). Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling. Journal of Cell Science, 123(6), 837-841. https://doi.org/10.1242/jcs.064436
  38. Bosgraaf, L., & Van Haastert, P. J. M. (2010). Quimp3, an automated pseudopod-tracking algorithm. Cell Adhesion & Migration, 4(1), 46-55. https://doi.org/10.4161/cam.4.1.9953
  39. 2009
  40. Bosgraaf, L., & Van Haastert, P. J. M. (2009). Navigation of Chemotactic Cells by Parallel Signaling to Pseudopod Persistence and Orientation. PLoS ONE, 4(8), [6842]. https://doi.org/10.1371/journal.pone.0006842
  41. Van Haastert, P. J. M., & Bosgraaf, L. (2009). Food Searching Strategy of Amoeboid Cells by Starvation Induced Run Length Extension. PLoS ONE, 4(8), [6814]. https://doi.org/10.1371/journal.pone.0006814
  42. Van Haastert, P. J. M., & Bosgraaf, L. (2009). The local cell curvature guides pseudopodia towards chemoattractants. HFSP Journal, 3(4), 282-286. https://doi.org/10.2976/1.3185725
  43. Bosgraaf, L., & Van Haastert, P. J. M. (2009). The Ordered Extension of Pseudopodia by Amoeboid Cells in the Absence of External Cues. PLoS ONE, 4(4), [5253]. https://doi.org/10.1371/journal.pone.0005253
  44. Sato, M. J., Kuwayama, H., van Egmond, W. N., Takayama, A. L. K., Takagi, H., van Haastert, P. J. M., Yanagida, T., & Ueda, M. (2009). Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proceedings of the National Academy of Sciences of the United States of America, 106(16), 6667-6672. https://doi.org/10.1073/pnas.0809974106
  45. Veltman, D. M., Akar, G., Bosgraaf, L., & Van Haastert, P. J. M. (2009). A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum. Plasmid, 61(2), 110-118. https://doi.org/10.1016/j.plasmid.2008.11.003
  46. Veltman, D. M., Keizer-Gunnink, I., & Van Haastert, P. J. M. (2009). An extrachromosomal, inducible expression system for Dictyostelium discoideum. Plasmid, 61(2), 119-125. https://doi.org/10.1016/j.plasmid.2008.11.002
  47. Bosgraaf, L., van Haastert, P. J. M., & Bretschneider, T. (2009). Analysis of Cell Movement by Simultaneous Quantification of Local Membrane Displacement and Fluorescent Intensities Using Quimp2. Cell Motility and the Cytoskeleton, 66(3), 156-165. https://doi.org/10.1002/cm.20338
  48. 2008
  49. Bosgraaf, L., Keizer-Gunnink, I., & van Haastert, P. J. M. (2008). PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients. Journal of Cell Science, 121(21), 3589-3597. https://doi.org/10.1242/jcs.031781
  50. Marin, I., van Egmond, W. N., & van Haastert, P. J. M. (2008). The Roco protein family: a functional perspective. The FASEB Journal, 22(9), 3103-3110. https://doi.org/10.1096/fj.08-111310
  51. Gotthardt, K., Weyand, M., Kortholt, A., Van Haastert, P. J. M., & Wittinghofer, A. (2008). Structure of the Roc-COR domain tandem of C-tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO Journal, 27(16), 2239-2249. https://doi.org/10.1038/emboj.2008.150
  52. Kortholt, A., & van Haastert, P. J. M. (2008). Highlighting the role of Ras and Rap during Dictyostelium chemotaxis. Cellular Signalling, 20(8), 1415-1422. https://doi.org/10.1016/j.cellsig.2008.02.006
  53. Veltman, D. M., Keizer-Gunnink, I., & Van Haastert, P. J. M. (2008). Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum. Journal of Cell Biology, 180(4), 747-753. https://doi.org/10.1083/jcb.200709180
  54. Veltman, D. M., & van Haastert, P. J. M. (2008). The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming. Journal of Cell Science, 121(1), 120-127. https://doi.org/10.1242/jcs.015602
  55. Egmond, W. N. V., Kortholt, A., Plak, K., Bosgraaf, L., Bosgraaf, S., Keizer-Gunnink, I., & Haastert, P. J. M. V. (2008). Intramolecular Activation Mechanism of the Dictyostelium LRRK2 Homolog Roco Protein GbpC. The Journal of Biological Chemistry, 283(44). https://doi.org/10.1074/jbc.M804265200
  56. 2007
  57. Kortholt, A., King, J. S., Keizer-Gunnink, I., Harwood, A. J., & Van Haastert, P. J. M. (2007). Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis. Molecular Biology of the Cell, 18(12), 4772-4779. https://doi.org/10.1091/mbc.E07-05-0407
  58. van Haastert, P. J. M., & Postma, M. (2007). Biased random walk by Stochastic fluctuations of chemoattractant-receptor interactions at the lower limit of detection. Biophysical Journal, 93(5), 1787-1796. https://doi.org/10.1529/biophysj.107.104356
  59. van Haastert, P. J. M., Keizer-Gunnink, I., & Kortholt, A. (2007). Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. Journal of Cell Biology, 177(5), 809-816. https://doi.org/10.1083/jcb.200701134
  60. Keizer-Gunnink, I., Kortholt, A., & Van Haastert, P. J. M. (2007). Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling. Journal of Cell Biology, 177(4), 579-585. https://doi.org/10.1083/jcb.200611046
  61. Kae, H., Kortholt, A., Rehmann, H., Insall, R., Van Haastert, P. J. M., Spiegelman, G. B., & Weeks, G. (2007). Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. Embo Reports, 8(5), 477-482. https://doi.org/10.1038/sj.embor.7400936
  62. Loovers, H. M., Kortholt, A., de Groote, H., Whitty, L., Nussbaum, R. L., & van Haastert, P. J. M. (2007). Regulation of phagocytosis in Dictyostelium by the inositol 5-phosphatase OCRL homolog Dd5P4. Traffic, 8(5), 618 - 628. https://doi.org/10.1111/j.1600-0854.2007.00546.x
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