P. Athanasopoulos, PhD
September 2011-November 2015: PhD student, Ruhr University of Bochum, Bochum, Germany.
April 2015-October 2015: Visiting PhD student, Burke Medical Research Institute, Weill Cornell Medical College, White Plains, USA.
2007-2009: Master student, “Biomolecular Sciences” Prestige Master Programme, University of Utrecht, The Netherlands.
2002-2007: Bachelor student, Department of Biochemistry and Biotechnology, University of Thessaly, Greece.
October 2016-todate: Postdoctoral fellow, University of Groningen, Groningen, The Netherlands.
December 2015-September 2016: Scientific collaborator (Wissenschaftlicher Mitarbeiter), Ruhr University of Bochum, Bochum, Germany.
2015: Ruhr University Bochum Research Stay Grant for a 6-month period in Weill Cornell Medical College, Cornell University, USA as a visiting PhD student.
2011-2014: ITN Marie Curie Fellowship, 7th Framework Programme, European Commision.
2009-2010: B.S.R.C Alexander Fleming Postgraduate Scholarship.
INVITED SPEAKER LECTURES
24 September-27 September 2017: ‘’Molecular Basis of Life’’ GBM Meeting, Bochum Germany. Selected poster for an oral talk.
30 August-4 September 2014: FEBS/EMBO Meeting, Paris, France. Satellite-Symposium ‘’Membrane Trafficking/Signalling/Cell mechanics’’. Transpol ITN fellow talk.
SELECTED POSTER PRESENTATIONS
9-13 November 2014: Society for Neuroscience Meeting, San Diego, US.
25-30 May 2013: ESF/EMBO symposium Molecular Perspectives On Protein-Protein Interactions , Pultusk, Poland.
Athanasopoulos P.S., Heumann R., Kortholt A. (2018) The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2. Biol. Chem. 399, 643-647
Deyaert E., Wauters L., Guaitoli G, Konijnenberg A., Leemans M., Terheyden S., Petrovic A., Gallardo R., Nederveen-Schippers L.M., Athanasopoulos P.S., Pots H., Van Haastert P.J.M., Sobott F., Gloeckner C.J., Efremov R., Kortholt A., Versées W. (2017) A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover. Nat Commun. 8, 1-12
Athanasopoulos P.S., Jacob W., Neumann S., Kutsch M., Wolters D., Tan E.K., Bichler Z., Herrmann C. and Heumann R. (2016) Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2. Biol. Chem. 397, 541-54
Armaou S., Pertesi M., Fostira F., Thodi G., Athanasopoulos PS, Kamakari S., Athanassiou A., Gogas H., Efraimidis A., Yannoukakos D., Fountzilas G. and Konstantopoulou I. (2009) Contribution of BRCA1 germ-line mutations to breast cancer in Greece: a hospital-based study of 987 unselected breast cancer cases. .Br J Cancer 101, 32-7
Complete list of Published Work in MyBibliography:
The major focus of my research is to elucidate the role of phosphatases in LRRK2-induced parkinsonism. Recently we have identified PP2A as an interacting partner of LRRK2, and demonstrated that the enzymatic activity of PP2A could have a neuroprotective effect in mutant LRRK2-induced cell death, in various cell systems.
By using Cell Biology, Biochemistry and Mass spectrometry methods, we are currently focusing in the mechanism by which PP2A could have a neuroprotective role in LRRK2 Parkinson’s Disease.
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