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Zhang, X., Heng, Y., Kooistra, S. M., van Weering, H. R. J., Brummer, M. L., Gerrits, E., Wesseling, E. M., Brouwer, N., Nijboer, T. W., Dubbelaar, M. L., Boddeke, E. W. G. M., & Eggen, B. J. L. (2020). Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement. Glia, (3), 1-17. [23925]. https://doi.org/10.1002/glia.23925

Kracht, L., Borggrewe, M., Eskandar, S., Brouwer, N., Chuva de Sousa Lopes, S. M., Laman, J. D., Scherjon, S. A., Prins, J. R., Kooistra, S. M., & Eggen, B. J. L. (2020). Human fetal microglia acquire homeostatic immune-sensing properties early indevelopment. Science, 369(6503), 530-537. https://doi.org/10.1126/science.aba5906

Eskandar, S., Borggrewe, M., Alsema, A. M., Brouwer, N., Meijer, M., Lopes, S. M. C. D. S., Nieveen, M. C., Kooistra, S. M., Scherjon, S. A., Prins, J. R., & Eggen, B. J. L. (2020). Human Microglia Acquire a More Mature, Homeostatic Phenotype During the Transition of the First and Second Trimester of Gestation. Reproductive Sciences, 27(SUPPL 1), 109A-109A.

Alsema, A. M., Jiang, Q., Kracht, L., Gerrits, E., Dubbelaar, M. L., Miedema, A., Brouwer, N., Hol, E. M., Middeldorp, J., van Dijk, R., Woodbury, M., Wachter, A., Xi, S., Möller, T., Biber, K. P., Kooistra, S. M., Boddeke, E. W. G. M., & Eggen, B. J. L. (2020). Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue. Frontiers in Molecular Neuroscience, 13, 1-14. https://doi.org/10.3389/fnmol.2020.00134

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Yin, Z., Raj, D. D., Schaafsma, W., van der Heijden, R. A., Kooistra, S. M., Reijne, A. C., Zhang, X., Moser, J., Brouwer, N., Heeringa, P., Yi, C-X., van Dijk, G., Laman, J. D., Boddeke, E. W. G. M., & Eggen, B. J. L. (2018). Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging. Frontiers in Molecular Neuroscience, 11, 65. [65]. https://doi.org/10.3389/fnmol.2018.00065

Schaafsma, W., Basterra, L. B., Jacobs, S., Brouwer, N., Meerlo, P., Schaafsma, A., Boddeke, E. W. G. M., & Eggen, B. J. L. (2017). Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood. Neurobiology of Disease, 106, 291-300. https://doi.org/10.1016/j.nbd.2017.07.017

Galatro, T. F., Holtman, I. R., Lerario, A. M., Vainchtein, I. D., Brouwer, N., Sola, P. R., Veras, M. M., Pereira, T. F., Leite, R. E. P., Möller, T., Wes, P. D., Sogayar, M. C., Laman, J. D., den Dunnen, W., Pasqualucci, C. A., Oba-Shinjo, S. M., Boddeke, E. W. G. M., Marie, S. K. N., & Eggen, B. J. L. (2017). Transcriptomic analysis of purified human cortical microglia reveals age-associated changes. Nature neuroscience, 20(8), 1162-1171. https://doi.org/10.1038/nn.4597

Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., Hol, E. M., Kamphuis, W., Bayer, T. A., De Deyn, P. P., & Boddeke, E. (2017). Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease. Neurobiology of Aging, 55, 115-122. https://doi.org/10.1016/j.neurobiolaging.2017.03.021

Jansen, A. H. P., van Hal, M., op den Kelder, I. C., Meier, R. T., de Ruiter, A-A., Schut, M. H., Smith, D. L., Grit, C., Brouwer, N., Kamphuis, W., Boddeke, H. W. G. M., den Dunnen, W. F. A., van Roon, W. M. C., Bates, G. P., Hol, E. M., & Reits, E. A. (2017). Frequency of Nuclear Mutant Huntingtin Inclusion Formation in Neurons and Glia is Cell-Type-Specific. Glia, 65(1), 50-61. https://doi.org/10.1002/glia.23050

Scheffold, A., Holtman, I. R., Dieni, S., Brouwer, N., Katz, S-F., Jebaraj, B. M. C., Kahle, P. J., Hengerer, B., Lechel, A., Stilgenbauer, S., Boddeke, E. W. G. M., Eggen, B. J. L., Rudolph, K-L., & Biber, K. (2016). Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model. Acta neuropathologica communications, 4(87), [87]. https://doi.org/10.1186/s40478-016-0364-x

Raj, D. D. A., Moser, J., van der Pol, S. M. A., van Os, R. P., Holtman, I. R., Brouwer, N., Oeseburg, H., Schaafsma, W., Wesseling, E. M., Dunnen, den, W., Biber, K. P. H., de Vries, H. E., Eggen, B. J. L., & Boddeke, H. W. G. M. (2015). Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening. Aging Cell, 14(6), 1003-1013. https://doi.org/10.1111/acel.12370

Holtman, I. R., Noback, M., Bijlsma, M., Duong, K. N., van der Geest, M. A., Ketelaars, P. T., Brouwer, N., Vainchtein, I. D., Eggen, B. J. L., & Boddeke, H. W. G. M. (2015). Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease. Glia, 63(9), 1495-1506. https://doi.org/10.1002/glia.22810

Schaafsma, W., Zhang, X., van Zomeren, K. C., Jacobs, S., Georgieva, P. B., Wolf, S. A., Kettenmann, H., Janova, H., Saiepour, N., Hanisch, U. -K., Meerlo, P., van den Elsen, P. J., Brouwer, N., Boddeke, H. W. G. M., & Eggen, B. J. L. (2015). Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing. Brain, Behavior, and Immunity, 48, 205-221. https://doi.org/10.1016/j.bbi.2015.03.013

Ma, M-S., Brouwer, N., Wesseling, E., Raj , D., van der Want, J., Boddeke, E., Balasubramaniyan, V., & Copray, S. (2015). Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus. Molecular and Cellular Neuroscience, 65, 21-30. https://doi.org/10.1016/j.mcn.2015.02.002

Holtman, I. R., Raj, D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., Hol, E. M., Boddeke, E. W. G. M., & Eggen, B. J. L. (2015). Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta neuropathologica communications, 3, [31]. https://doi.org/10.1186/s40478-015-0203-5

Vainchtein, I. D., Vinet, J., Brouwer, N., Brendecke, S., Biagini, G., Biber, K., Boddeke, H. W. G. M., & Eggen, B. J. L. (2014). In Acute Experimental Autoimmune Encephalomyelitis, Infiltrating Macrophages Are Immune Activated, Whereas Microglia Remain Immune Suppressed. Glia, 62(10), 1724-1735. https://doi.org/10.1002/glia.22711

Raj, D. D. A., Jaarsma, D., Holtman, I. R., Olah, M., Ferreira, F. M., Schaafsma, W., Brouwer, N., Meijer, M. M., de Waard, M. C., van der Pluijm, I., Brandt, R., Kreft, K. L., Laman, J. D., de Haan, G., Biber, K. P. H., Hoeijmakers, J. H. J., Eggen, B. J. L., & Boddeke, H. W. G. M. (2014). Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiology of Aging, 35(9), 2147-2160. https://doi.org/10.1016/j.neurobiolaging.2014.03.025

Kannan, V., Brouwer, N., Hanisch, U-K., Regen, T., Eggen, B. J. L., & Boddeke, H. W. G. M. (2013). Histone deacetylase inhibitors suppress immune activation in primary mouse microglia. Journal of Neuroscience Research, 91(9), 1133-1142. https://doi.org/10.1002/jnr.23221

Vinet, J., van Zwam, M., Dijkstra, I. M., Brouwer, N., van Weering, H. R. J., Watts, A., Meijer, M., Fokkens, M. R., Kannan, V., Verzijl, D., Vischer, H. F., Smit, M. J., Leurs, R., Biber, K., & Boddeke, H. W. G. M. (2013). Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. British Journal of Pharmacology, 168(6), 1375-1387. https://doi.org/10.1111/bph.12042

Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., & Boddeke, H. W. G. M. (2012). Identification of a microglia phenotype supportive of remyelination. Glia, 60(2), 306-321. https://doi.org/10.1002/glia.21266

Vinet, J., van Weering, H. R. J., Heinrich, A., Kaelin, R. E., Wegner, A., Brouwer, N., Heppner, F. L., van Rooijen, N., Boddeke, H. W. G. M., & Biber, K. (2012). Neuroprotective function for ramified microglia in hippocampal excitotoxicity. Journal of neuroinflammation, 9, [27]. https://doi.org/10.1186/1742-2094-9-27

Olah, M., Raj, D., Brouwer, N., de Haas, A. H., Eggen, B. J. L., Den Dunnen, W. F. A., Biber, K. P. H., & Boddeke, H. W. G. M. (2012). An optimized protocol for the acute isolation of human microglia from autopsy brain samples. Glia, 60(1), 96-111. https://doi.org/10.1002/glia.21251

van Weering, H. R. J., Boddeke, H. W. G. M., Vinet, J., Brouwer, N., de Haas, A. H., van Rooijen, N., Thomsen, A. R., & Biber, K. P. H. (2011). CXCL10/CXCR3 Signaling in Glia Cells Differentially Affects NMDA-Induced Cell Death in CA and DG Neurons of the Mouse Hippocampus. Hippocampus, 21(2), 220-232. https://doi.org/10.1002/hipo.20742

Vinet, J., de Jong, E. K., Boddeke, H. W. G. M., Stanulovic, V., Brouwer, N., Granic, I., Eisel, U. L. M., Liem, R. S. B., & Biber, K. (2010). Expression of CXCL10 in cultured cortical neurons. Journal of Neurochemistry, 112(3), 703-714. https://doi.org/10.1111/j.1471-4159.2009.06495.x

Olah, M., Ping, G., De Haas, A. H., Brouwer, N., Meerlo, P., Van Der Zee, E. A., Biber, K., Boddeike, H. W. G. M., Brouwer, N., & Boddeke, H. W. G. M. (2009). Enhanced Hippocampal Neurogenesis in the Absence of Microglia T Cell Interaction and Microglia Activation in the Murine Running Wheel Model. Glia, 57, 1046-1061. https://doi.org/10.1002/glia.20828

de Jong, E. K., de Haas, A. H., Brouwer, N., van Weering, H. R. J., Hensens, M., Bechmann, I., Pratley, P., Wesseling, E., Boddeke, H. W. G. M., & Biber, K. (2008). Expression of CXCL4 in microglia in vitro and in vivo and its possible signaling through CXCR3. Journal of Neurochemistry, 105(5), 1726-1736. https://doi.org/10.1111/j.1471-4159.2008.05267.x

Sher, F., Rossler, R., Brouwer, N., Balasubramaniyan, V., Boddeke, E., & Copray, S. (2008). Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2. STEM CELLS, 26(11), 2875-2883. https://doi.org/10.1634/stemcells.2008-0121

De Haas, A. H., Boddeke, H. W. G. M., Brouwer, N., & Biber, K. (2007). Optimized isolation enables Ex vivo analysis of microglia from various central nervous system regions. Glia, 55(13), 1374-1384. https://doi.org/10.1002/glia.20554

Dijkstra, I. M., de Haas, A. H., Brouwer, N., Boddeke, H. W. G. M., & Biber, K. (2006). Challenge with innate and protein antigens induces CCR7 expression by microglia in vitro and in vivo. Glia, 54(8), 861-872. https://doi.org/10.1002/glia.20426

de Jong, EK., Dijkstra, IM., Hensens, M., Brouwer, N., van Amerongen, M., Liem, RSB., Boddeke, HWGM., & Biber, K. (2005). Vesicle-mediated transport and release of CCL21 in endangered neurons: A possible explanation for microglia activation remote from a primary lesion. The Journal of Neuroscience, 25(33), 7548-7557.

van Helden, J., & Brouwer, N. (2005). Benchmarking en prestatieverbetering in de publieke sector: Ervaringen met de bedrijfsvergelijking zuiveringsbeheer. Maandblad voor Accountancy en Bedrijfseconomie, 79(11), 573-581.

Leegsma-Vogt, G., Venema, K., Brouwer, N., Gramsbergen, JB., Copray, S., & Korf, J. (2004). Quantitative on-line monitoring of cellular glucose and lactate metabolism in vitro with slow perfusion. Analytical Chemistry, 76(18), 5431-5435. https://doi.org/10.1021/ac040057u

Swinny, JD., Kalicharan, D., Brouwer, N., Biber, K., Shi, FX., Gramsbergen, A., & Van Der Want, JJL. (2004). The postnatal developmental expression pattern of urocortin in the rat olivocerebellar system. Journal of comparative neurology, 472(1), 40-51. https://doi.org/10.1002/cne.20062

Brouwer, N., Zuurman, MW., Wei, T., Ransohoff, RM., Boddeke, HWGM., & Biber, K. (2004). Induction of glial L-CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis. Glia, 46(1), 84-94. https://doi.org/10.1002/glia.10352

Küst, B. M., Brouwer, N., Mantingh, I. J., Boddeke, H. W. G. M., & Copray, J. C. V. M. (2003). Reduced p75NTRexpression delays disease onset only in female mice of a transgenic model of familial amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis and other motor neuron disorders, 4(2), 100-105. https://doi.org/10.1080/14660820301185

Kust, BM., Brouwer, N., Mantingh, IJ., Boddeke, HWGM., & Copray, JCVM. (2003). Reduced p75(NTR) expression delays disease onset only in female mice of a transgenic model of familial amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis and other motor neuron disorders, 4(2), 100-105.

Zuurman, MW., Heeroma, J., Brouwer, N., Boddeke, HWGM., & Biber, K. (2003). LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo. Glia, 41(4), 327-336. https://doi.org/10.1002/glia.10156

Copray, JCVM., Jaarsma, D., Kust, BM., Bruggeman, RWG., Mantingh, N. V., Brouwer, N., & Boddeke, HWGM. (2003). Expression of the low affinity neurotrophin receptor p75 in spinal motoneurons in a transgenic mouse model for amyotrophic lateral sclerosis. Neuroscience, 116(3), 685-694. https://doi.org/10.1016/S0306-4522(02)00755-8

Kust, BM., Copray, JCVM., Brouwer, N., Troost, D., & Boddeke, HWGM. (2002). Elevated levels of neurotrophins in human biceps brachii tissue of amyotrophic lateral sclerosis. Experimental Neurology, 177(2), 419-427. https://doi.org/10.1006/exnr.2002.8011

Wang, LC., Copray, S., Brouwer, N., Meek, MF., & Kernell, D. (2002). Regional distribution of slow-twitch muscle fibers after reinnervation in adult rat hindlimb muscles. MUSCLE & NERVE, 25(6), 805-815. https://doi.org/10.1002/mus.10114

Liem, RSB., Brouwer, N., & Copray, JCVM. (2001). Ultrastructural localisation of intramuscular expression of BDNF mRNA by silver-gold intensified non-radioactive in situ hybridisation. Histochemistry and cell biology, 116(6), 545-551.

Copray, JCVM., Mantingh, N. V., Brouwer, N., Biber, K., Kust, BM., Liem, RSB., Huitinga, N. V., Tilders, FJH., Van Dam, AM., & Boddeke, HWGM. (2001). Expression of interleukin-1 beta in rat dorsal root ganglia. Journal of Neuroimmunology, 118(2), 203-211.

Biber, K., Sauter, A., Brouwer, N., Copray, SCVM., & Boddeke, HWGM. (2001). Ischemia-induced neuronal expression of the microglia attracting chemokine secondary lymphoid-tissue chemokine (SLC). Glia, 34(2), 121-133.

Copray, S., Liem, R., Brouwer, N., Greenhaff, P., Habens, F., & Fernyhough, P. (2000). Contraction-induced muscle fiber damage is increased in soleus muscle of streptozotocin-diabetic rats and is associated with elevated expression of brain-derived neurotrophic factor mRNA in muscle fibers and activated satellite cells. Experimental Neurology, 161(2), 597-608.

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